共查询到20条相似文献,搜索用时 17 毫秒
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Kevin B. Cederberg Ramesh S. Iyer Apeksha Chaturvedi M. B. McCarville Janice D. McDaniel Jesse K. Sandberg Amer Shammas Susan E. Sharp Helen R. Nadel 《Pediatric blood & cancer》2023,70(Z4):e30000
Malignant primary bone tumors are uncommon in the pediatric population, accounting for 3%–5% of all pediatric malignancies. Osteosarcoma and Ewing sarcoma comprise 90% of malignant primary bone tumors in children and adolescents. This paper provides consensus-based recommendations for imaging in children with osteosarcoma and Ewing sarcoma at diagnosis, during therapy, and after therapy. 相似文献
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Rachel Eyre BSc MRes Richard G. Feltbower BSc MSc PhD Emmanuel Mubwandarikwa BSc MSc PhD Richard J.Q. McNally BSc MSc DIC PhD 《Pediatric blood & cancer》2009,53(6):941-952
Although the epidemiology of malignant bone tumours in children and young adults has been explored, no definitive causation of any specific tumour has yet been identified. We performed a literature review (1970–2008) to find all papers covering possible aetiological factors involved in the development of bone tumours in children and young adults. Several associations have been reported with some consistency: the presence of hernias and Ewing sarcoma; high fluoride exposure and osteosarcoma; and parental farming and residence on a farm, younger age at puberty and family history of cancer for all bone tumours, especially osteosarcoma. Clearly further research is needed to confirm or refute these putative risk factors. It is likely that studies of gene–environment interactions may prove to be the most fruitful of future research. Pediatr Blood Cancer 2009;53:941–952. © 2009 Wiley‐Liss, Inc. 相似文献
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Docetaxel,bevacizumab, and gemcitabine for very high risk sarcomas in adolescents and young adults: A single‐center experience 下载免费PDF全文
Christopher Kuo Paul M. Kent Antonio D. Logan Karen B. Tamulonis Kristen L. Dalton Marta Batus Karen Fernandez Rebecca E. Mcfall 《Pediatric blood & cancer》2017,64(4)
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A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma 下载免费PDF全文
Peter M. Anderson Stefan S. Bielack Richard G. Gorlick Keith Skubitz Najat C. Daw Cynthia E. Herzog Odd R. Monge Alvaro Lassaletta Erica Boldrini Zsuzanna Pápai Joseph Rubino Kumudu Pathiraja Darcy A. Hille Mark Ayers Siu‐Long Yao Michael Nebozhyn Brian Lu David Mauro 《Pediatric blood & cancer》2016,63(10):1761-1770
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Tabone MD Rodary C Oberlin O Gentet JC Pacquement H Kalifa C 《Pediatric blood & cancer》2005,45(2):207-211
To determine which factors impact on quality of life of patients with bone tumor, we used the Children Health Questionnaire French version. Thirty-seven patients (25 males, 19 osteosarcoma, 18 Ewing sarcoma) were studied. At assessment, median age was 15 years, median follow-up was 4 years. Mean scores were 60, 81, 76, 74, 70, 87 for general health, physical functioning, pain, mental health, self-esteem, and family activity, respectively. Lower results were observed for mental health in girls, for physical functioning, and self-esteem in patients with endoprosthesis, and for family activity and pain in patients who had relapsed. 相似文献
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Etoposide and carbo‐or cisplatin combination therapy in refractory or relapsed Ewing sarcoma: A large retrospective study 下载免费PDF全文
Annemiek M. van Maldegem Drs Charlotte Benson MD Piotr Rutkowski MD PhD Jean‐Yves Blay MD PhD Henk van den Berg MD PhD Joanna Placzke MD Meybrit Rasper MD Ian Judson MD PhD Heribert Juergens MD PhD Uta Dirksen MD PhD Hans Gelderblom MD PhD 《Pediatric blood & cancer》2015,62(1):40-44
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A summary of the osteosarcoma banking efforts: A report from the Children's Oncology Group and the QuadW Foundation 下载免费PDF全文
Jason Glover MD Mark Krailo PhD Tanya Tello BS Neyssa Marina MD Katherine Janeway MD Don Barkauskas PhD Timothy M. Fan DVM PhD Richard Gorlick MD Chand Khanna DVM PhD the COG Osteosarcoma Biology Group 《Pediatric blood & cancer》2015,62(3):450-455
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Front‐line window therapy with cisplatin in patients with primary disseminated Ewing sarcoma: A study by the Associazione Italiana di Ematologia ed Oncologia Pediatrica and Italian Sarcoma Group 下载免费PDF全文
Roberto Luksch Giovanni Grignani Paolo D'Angelo Arcangelo Prete Nadia Puma Marta Podda Michela Casanova Andrea Ferrari Carlo Morosi Franca Fagioli Massimo Aglietta Stefano Ferrari Piero Picci Maura Massimino 《Pediatric blood & cancer》2017,64(12)
The aim was to assess the activity of cisplatin (CDDP) in Ewing sarcoma (ES). The study consisted of front‐line window therapy with CDDP 120 mg/sqm every 3 weeks for two courses in children and young adults with primary disseminated ES. Response was assessed using the Response Evaluation Criteria in Solid Tumours criteria, and Simon's two‐stage design was applied. Twelve consecutive patients were enrolled in stage 1. Only one objective response was observed. Since the target response rate was not achieved, accrual was stopped and CDDP as a single agent in ES was judged unworthy of further assessment. 相似文献
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Pilot Study of Adding Vincristine,Topotecan, and Cyclophosphamide to Interval‐Compressed Chemotherapy in Newly Diagnosed Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group 下载免费PDF全文
Leo Mascarenhas MD MS Judy L. Felgenhauer MD Doojduen Villaluna MS Joseph Dominic Femino MD Nadia N. Laack MD Sarangarajan Ranganathan MD James Meyer MD Richard B. Womer MD Richard Gorlick MD Mark D. Krailo PhD Neyssa Marina MD 《Pediatric blood & cancer》2016,63(3):493-498
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Subir Nag Thomas Olson Frederick Ruymann Steven Teich Richard Pieters 《Pediatric blood & cancer》1995,25(6):463-469
The administration of external beam radiation therapy (EBRT) has been an integral part of the successful treatment of childhood sarcomas. However, EBRT has severe late morbidity in the developing child. In an attempt to deliver adequate tumoricidal radiation while preserving bone growth and organ function, 13 children with diverse sarcomas were treated with high dose rate brachytherapy (HDR). Seven patients had rhabdomyosarcoma and six patients had other soft tissue sarcoma variants. All patients were treated with disease-appropriate chemotherapy, usually according to the Intergroup Rhabdomyosarcoma Study. Eleven patients received fractionated 36 Gy HDR alone at a mean of 3.5 months from diagnosis. Two patients received 10–12.5 Gy intraoperative HDR brachytherapy and additional 27 Gy EBRT. Nine of 11 patients in first remission have had no recurrences. One died of recurrent pulmonary metastases. The other patient that did recur is disease-free 21 months post-recurrence. Two additional patients were treated with HDR after tumor recurrence. One patient with recurrent Ewing's sarcoma, relapsed and died. The second is disease free 3 months after autologous bone marrow transplant. Grade 1 morbidity occurred in 46%, Grade 2 in 15%, and Grade 3 in 8% of the children, while relatively good bone and organ growth was maintained. The combination of conservative surgery, chemotherapy, and HDR offers the potential for disease control in young children while preserving bone growth and organ function. © 1995 Wiley-Liss, Inc. 相似文献