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《Clinical gastroenterology and hepatology》2023,21(2):370-379
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Salvatore Petta Giada Sebastiani Mauro Viganò Javier Ampuero Vincent Wai-Sun Wong Jerome Boursier Annalisa Berzigotti Elisabetta Bugianesi Anna Ludovica Fracanzani Calogero Cammà Marco Enea Marraud des Grottes Vito Di Marco Ramy Younes Aline Keyrouz Sergio Mazzola Yuly Mendoza Grazia Pennisi Victor de Ledinghen 《Clinical gastroenterology and hepatology》2021,19(4):806-815.e5
Background & AimsPatients with advanced fibrosis related to nonalcoholic fatty liver disease (NAFLD) are at risk of developing hepatic and extrahepatic complications. We investigated whether, in a large cohort of patients with NAFLD and compensated advanced chronic liver disease, baseline liver stiffness measurements (LSMs) and their changes can be used to identify patients at risk for liver-related and extrahepatic events.MethodsWe performed a retrospective analysis of consecutive patients with NAFLD (n = 1039) with a histologic diagnosis of F3–F4 fibrosis and/or LSMs>10 kPa, followed for at least 6 months, from medical centers in 6 countries. LSMs were made by FibroScan using the M or XL probe and recorded at baseline and within 1 year from the last follow-up examination. Differences between follow up and baseline LSMs were categorized as: improvement (reduction of more than 20%), stable (reduction of 20% to an increase of 20%), impairment (an increase of 20% or more). We recorded hepatic events (such as liver decompensation, ascites, encephalopathy, variceal bleeding, jaundice, or hepatocellular carcinoma [HCC]) and overall and liver-related mortality during a median follow-up time of 35 months (interquartile range, 19–63 months).ResultsBased on Cox regression analysis, baseline LSM was independently associated with occurrence of hepatic decompensation (hazard ratio [HR], 1.03; 95% CI, 1.02–1.04; P < .001), HCC (HR, 1.03; 95% CI, 1.00–1.04; P = .003), and liver-related death (HR, 1.02; 95% CI, 1.02–1.03; P = .005). In 533 patients with available LSMs during the follow-up period, change in LSM was independently associated with hepatic decompensation (HR, 1.56; 95% CI, 1.05–2.51; P = .04), HCC (HR, 1.72; 95% CI, 1.01–3.02; P = .04), overall mortality (HR, 1.73; 95% CI, 1.11–2.69; P = .01), and liver-related mortality (HR, 1.96; 95% CI, 1.10–3.38; P = .02).ConclusionsIn patients with NAFLD and compensated advanced chronic liver disease, baseline LSM and change in LSM are associated with risk of liver-related events and mortality. 相似文献
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《Clinical gastroenterology and hepatology》2023,21(6):1523-1532.e1
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《Clinical gastroenterology and hepatology》2023,21(5):1154-1168
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《Clinical gastroenterology and hepatology》2023,21(3):694-703.e8
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Alessio Gerussi Davide Paolo Bernasconi Sarah Elisabeth O'Donnell Willem J. Lammers Henk Van Buuren Gideon Hirschfield Harry Janssen Christophe Corpechot Anna Reig Albert Pares Pier Maria Battezzati Massimo Giovanni Zuin Nora Cazzagon Annarosa Floreani Frederik Nevens Nikolaos Gatselis George Dalekos Marlyn J. Mayo Marco Carbone 《Clinical gastroenterology and hepatology》2021,19(8):1688-1697.e14
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《Clinical gastroenterology and hepatology》2022,20(5):e1135-e1148
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Qiwei Ge Zhigang Qi Zhengcheng Xu Min Li Huiyan Zheng Xiaoyang Duan Minjie Chu Xun Zhuang 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2021,31(3):793-801
Background and aimsTo compare the relationships of five obesity-related routine anthropometric indicators (body mass index (BMI), body adiposity index (BAI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR)) for hypertension in both sexes and among different age groups of the Chinese population.Methods and resultsA total of 12,064 adult participants (5638 males and 6426 females) were included. Odds ratios (OR) and 95% confidence intervals were used with binary logistic regression models to estimate the risk of hypertension for each obesity index. For the males, WHtR had the highest OR value in all age groups. The degrees of correlation between hypertension and the obesity indices for different age groups were different among the females. WC, BMI, and WHtR were the highest in the 18–44, 45–59, and ≥60 years age groups, respectively. Furthermore, we compared the area under the ROC curve (AUC) of each obesity index for the criterion of hypertension under the influence of risk factors. For the males, the AUC of WHtR was the largest (0.814, 0.710, and 0.662). WC (AUC = 0.820), BMI (AUC = 0.765), and WHtR (AUC = 0.668) tended to be the best criteria for hypertension among females in the 18–44, 45–59, and ≥60 years age groups respectively. In addition, BAI, as an obesity indicator proposed in recent years, has a positive association with hypertension except in 18–44 years women, which was not stronger than other obesity indicators.ConclusionsFor males, WHtR appears to be the best obesity index related with hypertension. For young, middle-aged, and elderly women, the best obesity indices related with hypertension are WC, BMI, and WHtR, respectively. 相似文献