绝经后女性血清脂联素与骨转换生化指标的关系

目的探讨绝经后女性血清脂联素(Adiponectin)与骨转换生化指标的关系。方法用酶联免疫吸附试验测定287名40～80岁健康绝经后女性血清脂联素以及血清骨特异性碱性磷酸酶(Bone alkaline phosphatase,BAP)和Ⅰ型胶原交联氨基末端肽(cross-linked N-telopeptide of type I collagen,NTx);用双能X线骨密度扫描仪(dual energy X-ray absorptiometry,DEXA)测定总体、腰椎正位、总髋部骨、左前臂骨密度(bone mineral density,BMD)以及体脂、瘦体质量;分析它们之间的关系。结果BAP与总体骨密度、腰椎BMD、髋部总体BMD、前臂BMD均呈负相关(r=-0.210、-0.236、-0.223、-0.226,P0.05),校正年龄和体质指数后,相关性都依然存在(r=-0.168、-0.187、-0.169、-0.175,P0.05)。NTx与总体BMD、腰椎BMD、髋部总体BMD、前臂BMD均呈负相关(r=-0.238、-0.232、-0.239、-0.221,P0.05),校正年龄和体质指数后,相关性都依然存在(r=-0.201、-0.189、-0.193、-0.185,P0.05)。脂联素与BAP、NTx均呈正相关(r=0.202、0.215,P0.05),校正年龄和体脂后,相关性都依然存在(r=0.169、0.183,P0.05)。脂联素与BAP以二次方程模型拟合程度最好,其最大决定系数(R2)为0.055;脂联素与NTx以二次方程模型拟合程度最好,其最大决定系数(R2)为0.089。绝经后骨质疏松(postmenopausal osteoporosis,PMO)女性血清脂联素水平较年龄相匹配的正常对照组增高(P0.05)。结论血清脂联素水平与骨转换生化指标呈正相关,提示脂联素可能为新型骨转换预测因子。     

低密度脂蛋白胆固醇对绝经前、后正常女性骨密度影响初探

目的观察血清低密度脂蛋白胆固醇对绝经前、后正常女性骨密度的影响。方法用常规酶法测定血清低密度脂蛋白胆固醇(LDL-C);用双能X线吸收法(DXA)骨密度仪测定腰椎前后位总体(L1-4)、左侧髋部总体(T-hip)、股骨大转子区(Troch)、股骨颈(FN)和Ward’s三角区骨密度(BMD)。结果低密度脂蛋白胆固醇与绝经前女性骨密度无关,与绝经后女性大转子区和髋部总体BMD无关,校正年龄和BMI后LDL-C与绝经前女性BMD无关,与绝经后女性髋部总体骨密度正相关。结论低密度脂蛋白胆固醇对绝经前女性骨密度无影响,对绝经后女性髋部总体骨密度可能有正性影响。     

围绝经期女性血清雌二醇及卵泡刺激素变化规律及其与腰椎、髋部和股骨颈骨密度的关系

目的探索围绝经期女性血清雌二醇(E2)、卵泡刺激素(FSH)变化规律与其腰椎、髋部、股骨颈骨密度(BMD)的关系。方法选取2014年1月-2015年1月在该院进行体检的围绝经期妇女440例为研究对象,分为绝经前组(220例)和绝经后组(220例)。测定两组血清E2、FSH水平及其腰椎、髋部、股骨颈BMD值,并进行组间比较。结果绝经后组妇女血清E2与绝经前组比较明显减少,而血清FSH与绝经前组比较明显增加,差异均有统计学意义(P0.05)。绝经后组妇女腰椎、髋部、股骨颈BMD值与绝经前组比较均有明显减少,组间差异均有统计学意义(P0.05)。绝经前低骨量组和绝经后低骨量组血清E2水平均较正常骨量组明显减少,而血清FSH水平均较正常骨量组明显增加,差异均有统计学意义(P0.05)。血清E2水平与腰椎BMD、髋部BMD、股骨颈BMD均呈正相关关系(P0.05);血清FSH水平与腰椎BMD、髋部BMD、股骨颈BMD均呈负相关关系(P0.05)。结论绝经后女性BMD明显减少,雌激素水平变化可能影响骨代谢,应引起临床的高度关注。     

神经性厌食青少年女性血清网膜素-1与骨密度的关系

目的探讨神经性厌食青少年女性血清网膜素-1(Omentin-1)浓度与骨密度（BMD）的关系。方法采用酶联免疫吸附试验（ELISA）测定26例神经性厌食症年轻女性及24例正常对照女性的Omentin-1、雌激素、脂联素（adiponectin）、瘦素（leptin）,应用双能X线骨扫描仪（DEXA）测定全身总体骨密度、腰椎和髋部骨密度及体成分。结果（1）神经性厌食症少女的Omentin-1浓度较正常对照女性（P<0.01）,雌激素、leptin浓度较正常对照女性低（P<0.01）,adiponectin浓度较正常对照女性无差异（P>0.05）;（2）Omentin-1、Adiponectin与全身总体骨密度、腰椎和髋部骨密度负相关（r= -0.659, -0.675, -0.697;r= -0.351,-0.338,-0.353（P均<0.05））。leptin浓度与全身总体骨密度、腰椎和髋部骨密度正相关（r=0.858,0.863,0.875（P均<0.01））;（3）在多元线性回归分析中,Omentin-1、BMI、瘦体重是受试人群BMD的独立预测因子。结论Omentin-1是神经性厌食的青春期患者骨密度的独立预测因子。     

女性2型糖尿病合并代谢综合征患者骨密度多因素分析

目的探讨女性2型糖尿病(T2DM)合并代谢综合征(MS)患者腰椎骨密度(BMD)的影响因素。方法 227例女性T2DM患者根据有无MS分组,分析两组腰椎BMD的变化及其影响因素。结果与无MS的女性T2DM患者相比,合并MS的女性T2DM患者BMD显著增高,t=2.033,P0.05;BMD与体质量、体质指数(BMI)呈正相关(r=0.191,P0.01;r=0.151,P0.05),与年龄呈负相关(r=-0.211,P0.01);多元逐步回归分析显示,年龄、体质量为影响腰椎BMD的独立相关因素(P0.01;P0.05)。结论女性T2DM合并MS患者的BMD及骨折发生的风险与肥胖及增龄有密切的相关性,绝对体质量对患者骨量存在一定的保护作用。     

男性吸烟烟龄和吸烟量与骨密度关系

目的探讨男性吸烟与骨密度关系。方法用DXA仪测定腰椎及髋部BMD。结果 (1)除腰椎侧位BMD外,吸烟组正位总体、髋部总体、股骨颈及Ward’s区BMD显著低于非吸烟组。(2)校正年龄与BMI后,烟龄与腰椎正位、髋部总体、股骨颈及Ward’s区BMD均呈显著负相关(P0.05)。每日吸烟量与腰椎正位及Ward’s区BMD呈显著负相关(P0.05)。结论男性吸烟者BMD下降;吸烟是骨质疏松症(OP)的一个危险因素;预防OP应提倡戒烟。     

绝经后女性瘦体重、体脂与骨密度的关系

目的 探讨绝经后女性人群瘦体重、体脂与骨密度(BMD)的关系.方法 长沙地区各工作岗位的45～81岁绝经一年以上健康女性志愿者185例,采用美国Hologic QDR-4500A型扇形束DXA仪,测量每例受试者腰椎前后位腰1至腰4及髋部总体面积BMD,单位g/cm2.用美国Hologic QDR-4500A型扇形束DXA仪作全身扫描测出头部、躯干、肋骨、骨盆、脊椎、上肢、下肢及全身的骨矿物含量、BMD、体脂含量和肌肉组织重,结合测得的指标,计算出体重、瘦体重和体脂百分比.结果 瘦体重与各个部位骨密度呈显著正相关;总体脂含量与髋部骨密度呈正相关,体脂百分比与全身骨密度呈负相关. 结论 坚持适当运动以维持瘦体重,有助于减少绝经后女性骨量的丢失.     

更年期女性骨密度及其影响因素分析

目的分析更年期女性骨密度(BMD)及其影响因素,为提高此人群骨健康提供依据。方法选择2018年1月至12月在兵器工业521医院体检的484例更年期女性为研究对象,采用调查问卷方式记录基本资料,双能X线BMD检测仪检测腰椎、髋部、前臂的BMD,多因素Logistic回归分析骨质疏松患者的相关因素。结果 484例调查对象中骨质疏松(OP)者95例(19.62%),低骨量者146例(30.17%)。骨质疏松组产次显著高于骨量正常组(t=2.547,P<0.05),而豆制品、海产品、牛奶及鸡蛋摄入率显著低于骨量正常组(χ~2值分别为14.072、14.228、5.375、6.108,均P<0.05),且户外运动、钙剂补充及使用绝经激素治疗(MHT)率均显著低于骨量正常组(χ~2值分别为6.605、21.121、4.191,均P<0.05)。多因素Logistic回归分析结果显示:多次生产是更年期女性骨质疏松的危险因素(OR=1.654,P<0.05),豆制品摄入、海产品摄入、牛奶摄入、鸡蛋摄入、户外运动、钙剂补充、使用MHT是保护因素(OR值0.274~0.580,均P<0.05)。绝经前组女性腰椎、髋部及前臂BMD均显著高于绝经后组(t值分别为2.908、2.774、2.853,均P<0.05),而低骨量和OP患病率均显著低于绝经后组(χ~2值分别为8.717、7.657,均P<0.05)。结论更年期女性骨健康受生育次数、生活习惯、钙剂补充、绝经状态及MHT等多种因素影响,此人群应监测BMD,尽早预防骨质疏松。     

绝经后女性代谢性因素与骨质疏松症的相关性研究

目的 研究绝经后女性骨质疏松症与糖脂代谢、甲状腺功能的关系，探讨绝经后女性骨质疏松症的可能代谢性危险因素。方法 选取2019年12月—2021年2月在衡阳市第一人民医院就诊的154例甲状腺功能正常的绝经后女性。使用双能X线骨密度仪测量腰椎L1～L4及双侧股骨颈骨密度(BMD),按T值分为骨质疏松症组和非骨质疏松症组，测定糖脂代谢、甲状腺功能等相关生化指标及骨代谢指标。对比骨质疏松症组与非骨质疏松症组上述指标的差异；采用Pearson相关分析法分析腰椎、股骨颈BMD与各临床指标之间的相关性，采用多因素logistic回归分析探讨绝经后女性骨质疏松症的可能危险因素。结果 与非骨质疏松症组相比，骨质疏松症组体质量指数(BMI)、促甲状腺激素(TSH)、血钙、25-羟维生素D[25(OH)D]水平偏低(均P<0.05)。Pearson相关性分析结果提示：腰椎BMD和双侧股骨颈BMD与BMI、TSH均呈正相关，腰椎BMD与总Ⅰ型胶原氨基端延长肽(PⅠNP)呈负相关(均P<0.05)。以是否骨质疏松症为因变量，筛选出BMI、TSH、血钙、糖化血红蛋白(HbA1C)、PⅠNP与Ⅰ型胶原羧基末端肽β特殊序列(β-cross)为自变量，进行logistic回归分析，结果显示：BMI较高者骨质疏松症发生风险小(OR=0.762,P<0.05),正常范围内TSH水平较高者骨质疏松症发生风险小(OR=0.381,P<0.05)。结论 绝经后女性随着BMI降低，骨质疏松症风险上升，TSH水平越低，BMD越低，患骨质疏松症的风险越高。     

CEACAM1、IGF-1水平变化与绝经后骨质疏松患者骨密度的关联性

目的分析血清癌胚抗原相关细胞粘附分子1(CEACAM1)、胰岛素样生长因子1(IGF-1)水平变化与绝经后骨质疏松(POP)患者骨密度的关联性。方法选取2015年5月至2017年3月该院收治的86例POP患者作为观察组,另选同期健康体检者80例作为对照组,检测对比两组血清CEACAM1、IGF-1水平、骨密度指标[骨矿物质密度(BMD),BMD与同族、同性别年轻人峰值骨量比(T-score),BMD与同族、同龄人峰值骨量比(Z-score)],分析血清CEACAM1、IGF-1水平与BMD相关性。结果观察组血清CEACAM1、IGF-1水平为(5.75±1.88)pg/ml、(161.15±55.36)μg/L,低于对照组的(9.81±2.06)pg/ml、(181.25±52.38)μg/L,差异均有统计学意义(均P0.05);观察组腰椎、股骨颈BMD、T-score、Z-score低于对照组,差异均有统计学意义(均P0.05);经Spearman相关分析,血清CEACAM1、IGF-1水平与腰椎BMD呈正相关(r=0.682、0.708,P0.05);与股骨颈BMD呈正相关(r=0.723、0.669、P0.05)。结论 POP患者血清CEACAM1、IGF-1水平下降且下降程度与骨密度呈正相关,可为临床诊断、评估POP程度提供重要依据。     

Circulating visfatin in obese non-diabetic patients in relation to cardiovascular risk factors,insulin resistance,and adipocytokines: A contradictory piece of the puzzle

ObjectiveObesity and insulin resistance are associated with cardiovascular risk factors. The aim of the present study was to explore the relation of circulating visfatin to insulin resistance, cardiovascular risk factors, anthropometry, and adipocytokines in obese patients without diabetes mellitus.MethodsA population of 228 obese non-diabetic outpatients was analyzed in a prospective way. All patients with a 2-wk weight-stabilization period before recruitment were enrolled. Biochemical analysis and nutritional evaluation were performed.ResultsSubjects were 62 men (27.2%) and 166 women (62.8%) with a mean age of 41.1 ± 16.4 y and a mean body mass index of 35.8 ± 3.6 kg/m². Patients were divided in two groups by median visfatin value (22.8 ng/mL), i.e., those with low values (group I) and those with high values (group II). Patients in group I had greater weight, body mass index, fat mass, fat-free mass, insulin, homeostasis model of assessment, triacylglycerol, leptin, and adiponectin than patients in group II. Patients in group II had higher total cholesterol, low-density lipoprotein cholesterol, resistin, and tumor necrosis factor-α levels than patients in group I. In a multivariate analysis with age- and sex-adjusted basal visfatin concentration as a dependent variable, only weight and leptin remained as an independent predictor in the model (F = 6.5, P < 0.05), with an inverse correlation.ConclusionTotal cholesterol, low-density lipoprotein cholesterol, tumor necrosis factor-α, and resistin levels are elevated in patients with visfatin levels above the median value. Homeostasis model of assessment, insulin, weight, fat mass, fat-free mass, triacylglycerols, leptin, and adiponectin are decreased in these patients.     

Relation of visfatin to cardiovascular risk factors and adipocytokines in patients with impaired fasting glucose

ObjectiveThe discovery of visfatin has great potential to significantly enhance our understanding of impaired fasting glucose and diabetes mellitus. The aim of the present study was to explore the relation of visfatin concentrations to cardiovascular risk factors and serum adipocytokine concentrations in patients with impaired fasting glucose.MethodsA sample of 55 patients with impaired fasting glucose was analyzed in a prospective way. All patients with a 2-wk weight-stabilization period before recruitment were enrolled. Weight, blood pressure, basal glucose, lipoprotein(a), C-reactive protein, insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerols, blood, and adipocytokines (visfatin, leptin, adiponectin, resistin, tumor necrosis factor-α [TNF-α], and interleukin-6) levels were measured. Tetrapolar impedancometry, indirect calorimetry, and prospective serial assessment of nutritional intake with 3-d written food records were performed.ResultsFourteen men (25.5%) and 41 women (74.5%), with a mean age of 57.3 ± 11.7 y and mean body mass index of 35.8 ± 3.6 kg/m², were included. Patients were divided in two groups by median visfatin value (18.2 ng/mL): group I had low values and group II had high values. Patients in group I had greater weight, body mass index, fat mass, fat-free mass, and adiponectin than patients in group II. Patients in group II had higher total cholesterol, low-density lipoprotein cholesterol, resistin, and TNF-α levels than patients in group I. In the multivariate analysis with age- and sex-adjusted basal visfatin concentration as a dependent variable, only TNF-α remained an independent predictor in the model (F = 8.4, P < 0.05), with an inverse correlation. Visfatin concentration decreased 7.33 ng/mL (95% confidence interval 2.10–12.58) for each nanogram per milligram of TNF-α increase.ConclusionOnly TNF-α is related in an independent way to serum visfatin levels.     

Effects of eicosapentaenoic acid ethyl ester on visfatin and apelin in lean and overweight (cafeteria diet-fed) rats

Previous studies have demonstrated that the n-3 fatty acid EPA improves insulin resistance induced by high-fat diets. The aim of the present study was to investigate the potential role of visfatin and apelin in the insulin-sensitising effects of EPA ethyl ester. The effects of EPA on muscle and adipose GLUT mRNA, as well as on liver glucokinase (GK) and glucose-6-phosphatase (G6Pase) activity, were investigated. Male Wistar rats fed on a standard diet or a high-fat cafeteria diet were daily treated by oral administration with EPA ethyl ester (1 g/kg) for 5 weeks. A significant decrease (P < 0.01) in white adipose tissue (WAT) visfatin mRNA levels was found in the cafeteria-fed rats, which was reversed by EPA administration (P < 0.05). Moreover, a negative relationship was observed between homeostatic model assessment (HOMA) and the visfatin:total WAT ratio. In contrast, cafeteria-diet feeding caused a significant increase (P < 0.01) in apelin mRNA in visceral WAT. EPA increased (P < 0.01) apelin gene expression, and a negative relationship between HOMA index with visceral apelin mRNA and serum apelin:total WAT ratio was also observed. EPA treatment did not induce changes in skeletal muscle GLUT1, GLUT4 or insulin receptor mRNA levels. Neither liver GK and G6Pase activity nor the GK:G6Pase ratio was modified by EPA. These data suggest that somehow the insulin-sensitising effects of EPA could be related to its stimulatory action on both visfatin and apelin gene expression in visceral fat, while changes in skeletal muscle GLUT, as well as in hepatic glucose production, are not likely to be the main contributing factors in the improvement in insulin resistance induced by EPA.     

Adipokines as uremic toxins

The adipose tissue has pleiotropic functions far beyond the mere storage of energy, and it secretes a number of hormones and cytokines, called adipokines, which have biological effects that impact heath and disease. Adipokines are markedly elevated in the plasma of uremic patients, mainly due to decreased renal excretion. They have pluripotent signaling effects on inflammation/oxidative stress (leptin, adiponectin, resistin), protein-energy wasting (leptin, adiponectin), insulin signaling (adiponectin, leptin, visfatin), endothelial dysfunction (visfatin), and vascular damage (adiponectin, leptin, resistin), which are prevalent in uremic patients. Obesity superimposed to uremia may further aggravate hyperadipokinemia, with the exception of adiponectinemia, which is mitigated by adiposity. Among adipokines and until more data become available, only leptin may be considered as a full uremic toxin owing to adverse effects on protein-energy wasting, cardiovascular damage, inflammation, and the immune system, which have been documented both clinically and experimentally. Resistin and visfatin display some features of uremic toxins, but more data are needed to consider these adipokines as true uremic toxins. In contrast, high levels of adiponectin and chemerin seen in uremia appear to be beneficial. Further research is needed to investigate whether selective removal of leptin, resistin, and visfatin and increments of adiponectin and chemerin levels may have clinical relevance in uremic patients.     

Circulating ferritin concentrations are differentially associated with serum adipokine concentrations in Japanese men and premenopausal women

Purpose

Increased iron storage, as measured by circulating ferritin, has been linked to an increased risk of various diseases including diabetes. We examined the association of circulating ferritin with serum adiponectin, leptin, resistin, plasminogen activator inhibitor-1 (PAI-1), and visfatin levels.

Methods

We conducted a cross-sectional study among 429 Japanese employees (284 men and 145 premenopausal women, mean age: 42.5 ± 10.5 years). Serum adipokines were measured using Luminex suspension bead-based multiplexed array, and serum ferritin was determined using a chemiluminescence immunoassay. Multivariable regression analysis was performed to calculate mean concentrations of adipokine according to the tertile of ferritin concentrations with adjustment for potential confounders.

Results

Leptin and visfatin concentrations increased with increasing ferritin concentrations in men after multivariable adjustment of physical activity, smoking, alcohol use, and body mass index (P for trend = 0.02 and 0.01 for leptin and visfatin, respectively). Serum ferritin concentrations were inversely and significantly associated with adiponectin in women (P for trend = 0.01). Resistin and PAI-1 were not appreciably associated with ferritin concentration.

Conclusions

Increased iron storage may be associated with higher circulating concentrations of leptin and visfatin in men and with lower concentrations of adiponectin in women.

     

2型糖尿病一级亲属中血清抵抗素、内脂素与胰岛素抵抗及胰岛p细胞功能的相关性研究

目的 了解2型糖尿病(T2DM)患者不同糖代谢状态的一级亲属血清抵抗素(RES)、内脂素(VIS)与胰岛素抵抗(IR)和胰岛β细胞功能的关系,并探讨其在T2DM发病中的作用以及临床检测的意义.方法 收集既往无糖耐量异常史的T2DM一级亲属229例,其中经75 g葡萄糖耐量试验分为糖耐量正常(NGT组)174例、空腹血糖受损(IFG)或糖耐量低减(IGT)(IFG/IGT组)55例,收集71例新发T2DM(T2DM组);同时收集上述一级亲属配偶或亲友中无糖尿病家族史的糖耐量正常者114例作为正常对照组.酶联免疫法测定上述人群的血清空腹真胰岛素(FTI)、胰岛素原(FPI)、RES和VIS水平,用HOMA-IR评价IR状态,以HOMA-β及空腹PI和PI/TI比值评价β细胞功能,同时进行人体测量学、脂代谢、肝肾功能、血尿酸及生活习惯的调查.结果 (1)血清RES水平各组间差异无统计学意义(P＞0.05),与HOMA-IR、HOMA-β和肥胖指标均未见相关性(P＞0.05).(2)T2DM组、IGT/IFG组和NGT组较正常对照组血清VIS水平降低(P＜0.05);T2DM组、IGT/IFG组和NGT组之间差异无统计学意义.血清VIS水平与HOMA-IR、肥胖指标未见相关性(P＞0.05),与空腹和2 h血糖、血压负相关(P＜0.05).结论 T2DM一级亲属在糖耐量异常发生前,具有改善糖代谢作用的VIS水平明显降低,提示上述脂肪细胞因子在IR的形成及T2DM的发病中起一定作用     

Maternal hormones linking maternal body mass index and dietary intake to birth weight

BACKGROUND: Obese women often give birth to large-for-gestational age infants (typically defined as a birth weight greater than the 90th percentile), who are at risk of birth injuries and of developing metabolic syndrome later in life. The mechanisms underlying increased fetal growth remain to be established. OBJECTIVE: We aimed to identify maternal hormones that can explain the link between dietary intake, body mass index (BMI), and birth weight. DESIGN: Pregnant women with BMIs (in kg/m(2)) ranging from 17 to 44 (n = 49) were recruited in gestational weeks 8-12. Serum hormone concentrations were measured and dietary history interviews were performed in the first and third trimesters. Multiple regression models were produced to identify hormones that correlate with birth weight and are influenced by BMI or dietary factors. RESULTS: We found a strong positive correlation between BMI and first- and third-trimester insulin and leptin concentrations and a negative correlation between BMI and first-trimester adiponectin and first- and third-trimester insulin-like growth factor binding protein-1 (IGFBP-1). Maternal total fat intake in the first trimester was positively correlated with maternal leptin and inversely correlated with adiponectin. In addition, third-trimester total fat intake was positively correlated with circulating resistin concentrations. First-trimester maternal serum resistin was positively correlated with birth weight, whereas third-trimester maternal IGFBP-1 was negatively correlated with birth weight. CONCLUSIONS: High first-trimester maternal serum resistin and low third-trimester IGFBP-1 were correlated with increased birth weight. We propose that low serum concentrations of IGFBP-1 represent a link between high BMI and increased fetal growth by increasing the bioavailability of insulin-like growth factor-I, which up-regulates placental nutrient transport.     

五味子酚对3T3-L1细胞氧化应激模型脂肪细胞因子表达的影响

目的 研究五味子酚（schisanhenol,SAL）对3T3-L1细胞脂肪因子表达的影响及其机制.方法 体外培养并诱导分化3T3-L1细胞,制作氧化应激模型,用不同浓度和作用时间的五味子酚干预,观察脂肪因子表达的变化.结果 （1）脂联素、瘦素、抵抗素和内脂素的表达随着氧化应激的程度增高递减,其中对瘦素的抑制效应最明显（25 mU/ml葡萄糖激酶组VS空白组,t=7.29,P＜0.01）;（2）4种脂肪因子的表达随着五味子酚干预浓度增加而增加（脂联素t=6.31,P＜0.01;瘦素t=5.92,P＜0.01;抵抗素t=3.77,P＜0.05;内脂素t=3.63,P＜0.05）;（3）随着五味子酚作用时间的延长,4种脂肪因子的表达均经历了先下降后上升的过程,且五味子酚对脂肪细胞因子表达的影响与氧化应激状态的改变平行.结论 五味子酚可通过抗氧化应激作用调节脂肪因子的表达,可能在五味子改善糖尿病症状过程中起到重要作用.     

The Impact of Diet and Fibre Fractions on Plasma Adipocytokine Levels in Prediabetic Adults

The impact of diet and fibre fractions on adipocytokines in obese subjects with a risk of diabetes has not been investigated in detail yet. The purpose of the study is to evaluate the effects of a 12-month lifestyle intervention with different fibre profiles (resistant starch (RS)—rich fibre, or ordinary food fibre profiles) on adipocytokine levels. Fifty participants are divided into two groups (RS group and Fibre group). The groups differ only in the percentage of the recommended level of the RS consumed as a fraction of the same total fibre amount. The applied dietary intervention includes intake of 7531 KJ/daywith a total fibre portion of 25–35 g/dayfor both groups that includes 15 g/day of RS for the RS group only. The levels of leptin, adiponectin, apelin, resistin, tumor necrosis factor (TNF)-alpha and C-reactive protein (CRP) are measured, and their relationship to anthropometric and biochemical parameters is estimated. Along with significant body weight loss, only leptin is significantly reduced by 13% in the RS group while in the Fibre group, apelin levels are significant (−21%). Polynomial regression shows a negative correlation between RS intake and adiponectin (R2 = 0.145) and resistin level (R2 = 0.461) in the RS group. This study indicates the possibility that fibre fractions differently influence the outcome of lifestyle interventions, as well as their adipocytokine levels, in obese prediabetic adults.