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1.
Z Meltem Akkurt Derya Ucmak Kenan Yildiz Safiye Kutlu Yürüker Heybet ?zkaya Celik 《Anais brasileiros de dermatologia》2014,89(1):44-50
BACKGROUND
Chilblains are rather common in winter months in our country.OBJECTIVES
Determination of demographical and clinical characteristics of patients presenting with chilblains in Diyarbakir, Turkey. Evaluation of body mass index (BMI) as risk factor for development of chilblains.METHODS
Sixty-nine patients who were diagnosed as chilblains at our outpatient clinics were included in this study. No exclusion criteria were sought. Demographical data including height and weight and answers to questions related to personal history were recorded. A control group consisting of 108 controls were chosen from among patients presenting with complaints of hair loss. Statistical analyses were conducted using SPSS 17.0.RESULTS
Of the 69 patients with chilblains, 45 (65.2%) were females and 24 (34.8%) were males. Mean age (±SD) of the patients was 21±9. 71.2% of the patients complained of itching, 51.6% of pain, 31.3% of burning in the lesions. 61.3% of the patients reported recurrence of the lesions every winter season. Mean BMI of the patients was 20.5±2.9. Mean BMI of the controls was 22.4±3.7 and the difference was statistically significant (p=0.01).CONCLUSIONS
Low BMI may be a risk factor contributing to development of chilblains in persons exposed to cold weather conditions. Apart from external factors, there seems to be a personal tendency to develop lesions, as many patients report recurrences every year. Diagnosis of chilblains requires wariness, as history of cold exposure may not be evident. 相似文献2.
150例皮肤纤维瘤组织病理与临床分析 总被引:1,自引:0,他引:1
目的 分析皮肤纤维瘤(DF)的组织病理与临床特征,探讨两者的相互联系。方法 回顾分析2017年9月至2018年8月在上海市皮肤病医院病理科经皮肤组织病理检查确诊的150例DF患者的临床和组织病理资料。结果 150例患者中,男65例,女85例,年龄(42 ± 13.8)岁,病程3个月至 > 30年,部分有伴随症状,主要表现为瘙痒,有自发痛、轻压痛,18例皮损有外伤、虫咬或感染病史。皮损主要位于四肢(107例,71.3%),以单发皮损为主(105例,70%)。病理检查前拟诊为“DF”102例,“表皮样囊肿”16例,“色痣”13例,“瘢痕疙瘩”3例,“皮肤肿物”12例,“恶性黑素瘤”1例,“黄色肉芽肿”1例,“结节性痒疹”1例,“神经纤维瘤”1例。在这些患者的169张苏木精-伊红染色切片中,66张(39.1%)为细胞性,36张(21.3%)硬化性,25张(14.8%)表现为动脉瘤样型DF,22张(13.0%)上皮样型。12张切片内可见两种或两种以上亚型并存的现象。还可见少数新的变异型,如DF伴汗腺导管增生(1例)、深在型DF(3例)、上皮样细胞与增生胶原相间的DF(1例)等。动脉瘤样型DF病程长短不一,7个月至> 30年,多表现为发生于下肢的皮肤肿物样损害。细胞性DF病程相对较短,常发现数月后就诊,好发于四肢,常伴痒痛。硬化性或萎缩性DF病程长,为数年或数十年,好发于上肢,多无伴随症状。上皮样型DF病程长短不一,临床表现多样,多发于下肢,无伴随症状。结论 DF的临床表现及病理表现均具有多样性,不同的DF皮损可有相似的典型组织病理学表现,不典型的病理表现可干扰疾病诊断。 相似文献
3.
Giulio Cesar Gequelim Cynthia Yone Kubota Sarah Sanches Daniela Dranka Marcelo Murilo Mejia Fernando Mitsuo Sumiya Juliano Vilaverde Schmitt 《Anais brasileiros de dermatologia》2013,88(6):1022-1025
Brittle Nails Syndrome is characterized by fragility of the nail plate, affecting 27%
of women. We evaluated dermatology patients in a cross-sectional study about
perception of nail fragility. One hundred and thirtyeight women were included, with
median age of 36.5 years. Nail examination showed changes in 57% and 49% reported
nail fragility. The first three fingernails were the most affected. Onychoschizia was
related to onychophagia (OR = 3.29), housework (OR = 2.95) and water contact (OR =
2.44). Onychorrhexis had the strongest association with nail fragility perception (OR
= 17.89). The fragility was more perceived by those who were black, of mixed race and
atopic, and was associated with depressed mood. 相似文献
4.
《Anais brasileiros de dermatologia》2020,95(5):627-630
Dermatofibroma is a dermal fibrohistiocytic neoplasm. The Langerhans cells are the immunocompetent cells of the epidermis, and they represent the first defense barrier of the immune system towards the environment. The objective was to immunohistologically compare the densities of S100-positive Langerhans cells in the healthy peritumoral epidermis against those in the epidermis overlying dermatofibroma (20 cases), using antibodies against the S100 molecule (the immunophenotypic hallmark of Langerhans cells). The control group (normal, healthy skin) included ten healthy age and sex-matched individuals who underwent skin biopsies for benign skin lesions. A significantly high density of Langerhans cells was observed both in the epidermis of the healthy skin (6.00 ± 0.29) and the peritumoral epidermis (6.44 ± 0.41) vs. those in the epidermis overlying the tumor (1.44 ± 0.33, p < 0.05). The quantitative deficit of Langerhans cells in the epidermis overlying dermatofibroma may be a possible factor in its development. 相似文献
5.
Juliano Vilaverde Schmitt Brunno Zeni de Lima Monique Carolina Meira do Rosário de Souza Hélio Amante Miot 《Anais brasileiros de dermatologia》2014,89(1):91-95
BACKGROUND
Acne vulgaris has an important genetic predisposition, as well as keratosis pilaris. Clinical observations suggest that patients with keratosis pilaris have less frequent or less severe acne breakouts; however, we found no studies on this regardOBJECTIVE
To determine if the presence of keratosis pilaris is associated with lower prevalence and severity of acne.METHODS
A cross-sectional study was conducted with dermatology outpatients aged between 14 and 35 years. We evaluated history and clinical grade of acne, demographic variables, history of atopy, smoking, and use of hormonal contraceptives. Two groups were defined by the presence or absence of moderate to severe keratosis pilaris on the arms and were compared by bivariate analysis and by conditional multiple logistic regression.RESULTS
We included 158 patients (66% women), with a median age of 23±11 years. Twenty-six percent of them had keratosis pilaris, which was associated with a history of atopy (odds ratio [OR]=2.80 [1.36 to 5.75]; p<0.01). Acne was present in 66% of subjects, and was related to family history of acne (OR=5.75 [2.47 to 13.37]; p<0.01). In bivariate and multivariate analysis, the group with keratosis pilaris had a less frequent history of acne (OR=0.32 [0.14 to 0.70]; p<0.01).CONCLUSION
The presence of moderate to severe keratosis pilaris on the arms was associated with lower prevalence of acne vulgaris and lower severity of facial lesions in adolescents and young adults. 相似文献6.
Vera Barreto Teixeira José Pedro Reis Ricardo Vieira óscar Tellechea Américo Figueiredo 《Anais brasileiros de dermatologia》2013,88(3):441-446
This case report involves a 20-year-old man with unilateral punctate porokeratosis. The patient presented an 8-year history of numerous asymptomatic keratotic papules and pits with linear distribution on his left pal-mar surface and fifth finger of the left hand. Histopathological examination of the keratotic plug revealed findings of distinct epidermal depressions containing cornoid lamellae. This report review draws attention to differential diagnoses of punctate porokeratosis. 相似文献
7.
Felipe Maurício Soeiro Sampaio Gustavo Vieira Gualberto Fernando Gustavo Mósca de Cerqueira Ana Maria Mósca de Cerqueira Curt Mafra Treu Thiago Jeunon de Sousa Vargas 《Anais brasileiros de dermatologia》2014,89(3):519-520
We report the case of an 11-year-old male patient with a histopathological and
immunohistochemical diagnosis of dermatofibroma with an atypical clinical
presentation on the right forearm. Although dermatofibroma is considered a
benign skin tumor, some of its differential diagnoses, such as
dermatofibrosarcoma protuberans and malignant fibrous histiocytoma, are truly
aggressive. Lesions with atypical clinical aspects and topology associated with
specific histopathological variants are some of the criteria for complete tumor
excision. 相似文献
8.
Adriane Reichert Faria Roberto Gomes Tarlé Gerson Dellatorre Marcelo Távora Mira Caio Cesar Silva de Castro 《Anais brasileiros de dermatologia》2014,89(5):784-790
In an unprecedented effort in the field of vitiligo, a global consensus resulted on asuggested new classification protocol for the disease. The main histopathologicalfinding in vitiligo is the total absence of functioning melanocytes in the lesions,while the inflammatory cells most commonly found on the edges of the lesions are CD4+and CD8+ T lymphocytes. Physical and pharmacological treatment strategies aim tocontrol the autoimmune damage and stimulate melanocyte migration from the unaffectededges of lesions and the outer hair follicle root sheath to the affected skin;moreover, surgical treatments can be combined with topical and physicaltreatments. 相似文献
9.
Rossana Ruth Garcia da Veiga Renata Silva Barros Josie Eiras Bisi dos Santos José Maria de Castro Abreu Junior Maraya de Jesus Semblano Bittencourt Mario Fernando Ribeiro de Miranda 《Anais brasileiros de dermatologia》2013,88(1):84-89
Clear cell acanthoma or Degos'' acanthoma is a distinct disease concerning itsclinical, histopathological, and immunohistochemical features. Its pathologic nature- whether neoplastic or reactive - is still under dispute among researchers. Thedisease shows a chronic course and often presents with a single papulonodular lesionon the lower limbs of adults. However, cases with multiple lesions, sometimesoccurring in an eruptive fashion, and with clear variation in the size and shape ofthe cutaneous lesions have been reported. So far, five cases in which the lesionswere exclusively located in the nipple area have been reported, all in Korean women.Four of these cases mimicked eczema and one, a polypoid nodule. The aim of thisarticle is to present clinical, histopathological, and immunohistochemical featuresof two additional cases in Brazilian women with similar nipple topography. 相似文献
10.
Anargyros Kouris Christos Christodoulou Christina Stefanaki Miltiadis Livaditis Revekka Tsatovidou Constantinos Kouskoukis Athanasios Petridis George Kontochristopoulos 《Anais brasileiros de dermatologia》2015,90(6):841-845
BACKGROUND
Psoriasis is a common, long-term skin disease associated with high levels of psychological distress and a considerable adverse impact on life. The effects of psoriasis, beyond skin affliction, are seldom recognized and often undertreated.OBJECTIVE
The aim of the study is to evaluate the quality of life, anxiety and depression, self-esteem and loneliness in patients with psoriasis.METHODS
Eighty-four patients with psoriasis were enrolled in the study. The quality of life, depression and anxiety, loneliness and self-esteem of the patient were assessed using the Dermatology Life Quality Index, Hospital Anxiety and Depression Scale, the UCLA loneliness Scale (UCLA-Version 3) and Rosenberg''s Self-esteem Scale, respectively.RESULTS
The Dermatology Quality of Life Index score among psoriasis patients was 12.61 ± 4.88. They had statistically significantly higher scores according to the Hospital Anxiety and Depression Scale -anxiety subscale (p=0.032)-compared with healthy volunteers. Moreover, a statistically significant difference was found between the two groups concerning the UCLA-scale (p=0.033) and RSES-scale (p<0.0001). Female patients presented with lower self-esteem than male patients.CONCLUSION
Psoriasis is a distressing, recurrent disorder that significantly impairs quality of life. Therefore, the recognition and future management of psoriasis may require the involvement of multi-disciplinary teams to manage the physical, psychological and social aspects of the condition, as is the case for systemic, long-term conditions. 相似文献11.
John Verrinder Veasey Beatriz de Abreu Ribeiro Machado Rute Facchini Lellis Laura Hitomi Muramatu Clarisse Zaitz 《Anais brasileiros de dermatologia》2015,90(6):907-908
Chromoblastomycosis is a chronic subcutaneous fungal infection caused bytraumatic implantation of dematiaceous fungi in the skin. The clinicalpresentation is usually a verrucous plaque lesion and the diagnosis isconfirmed by the visualization of muriform bodies at direct examination orat the histologic study. This report describes a rare case of tumoralchromoblastomycosis confirmed by histologic study and whose agent wasidentified by culture and micromorphology. 相似文献
12.
Diffuse alopecia is mainly caused by telogen effluvium, diffuse androgenetic alopecia
(female-pattern hair loss) and diffuse alopecia areata. Differential diagnosis between
the three disorders may be difficult in several occasions. In this second part of our
study, chronic telogen effluvium and diffuse alopecia areata are discussed in detail,
including clinical, dermoscopic and histological aspects. A flowchart presents a
practical and objective differential diagnostic approach to diffuse alopecia. 相似文献
13.
Luiz Guilherme Martins Castro Renato Marchiori Bakos Jo?o Pedreira Duprat Neto Flávia Vasques Bittencourt Thais Helena Bello Di Giacomo Sérgio Schrader Serpa Maria Cristina de Lorenzo Messina Walter Refkalefsky Loureiro Ricardo Silvestre e Silva Macarenco Hamilton Ometto Stolf Gabriel Gontijo 《Anais brasileiros de dermatologia》2016,91(1):49-58
The last Brazilian guidelines on melanoma were published in 2002. Development in
diagnosis and treatment made updating necessary. The coordinators elaborated ten
clinical questions, based on PICO system. A Medline search, according to
specific MeSH terms for each of the 10 questions was performed and articles
selected were classified from A to D according to level of scientific evidence.
Based on the results, recommendations were defined and classified according to
scientific strength. The present Guidelines were divided in two parts for
editorial and publication reasons. In this second part, the following clinical
questions were answered: 1) which patients with primary cutaneous melanoma
benefit from sentinel lymph node biopsy? 2) Follow-up with body mapping is
indicated for which patients? 3) Is preventive excision of acral nevi
beneficious to patients? 4) Is preventive excision of giant congenital nevi
beneficious to patients? 5) How should stages 0 and I primary cutaneous melanoma
patients be followed? 相似文献
14.
15.
Camila Bianco Pimentel Aparecida Machado de Moraes Maria Letícia Cintra 《Anais brasileiros de dermatologia》2014,89(3):410-413
BACKGROUND
Cryosurgery is an efficient therapeutic technique used to treat benign and malignant cutaneous diseases. The primary active mechanism of cryosurgery is related to vascular effects on treated tissue. After a cryosurgical procedure, exuberant granulation tissue is formed at the injection site, probably as a result of angiogenic stimulation of the cryogen and inflammatory response, particularly in endothelial cells.OBJECTIVE
To evaluate the angiogenic effects of freezing, as part of the phenomenon of healing rat skin subjected to previous injury.METHODS
Two incisions were made in each of the twenty rats, which were divided randomly into two groups of ten. After 3 days, cryosurgery with liquid nitrogen was performed in one of incisions. The rats'' samples were then collected, cut and stained to conduct histopathological examination, to assess the local angiogenesis in differing moments and situations.RESULTS
It was possible to demonstrate that cryosurgery, in spite of promoting cell death and accentuated local inflammation soon after its application, induces quicker cell proliferation in the affected tissue and maintenance of this rate in a second phase, than in tissue healing without this procedure.CONCLUSIONS
These findings, together with the knowledge that there is a direct relationship between mononuclear cells and neovascularization (the development of a rich system of new vessels in injury caused by cold), suggest that cryosurgery possesses angiogenic stimulus, even though complete healing takes longer to occur. The significance level for statistical tests was 5% (p<0,05). 相似文献16.
This study investigated the geographic distribution of dermatologists in Brazilian
municipalities in relation to the population, regions of the country and human
development index. We conducted an ecological study based on data from the 2010
census, the 2010 human development index, and the records of the Brazilian Society of
Dermatology. 5565 municipalities and 6718 dermatologists were surveyed. Only 504
(9.1%) municipalities had dermatologists, and accounted for 56.2% of the Brazilian
population. The smallest population size and lowest HDI rate that best discriminated
municipalities that did not have dermatologists were found to be 28,000 and 0.71,
respectively. The average population density of dermatologists in cities was 1/23.000
inhabitants, and variations were independently associated with the HDI, the
population of the municipalities and the region of the country. 相似文献
17.
Egberto Santos Carmo Fillipe de Oliveira Pereira Neuza Maria Cavalcante Carla Wanderley Gayoso Edeltrudes de Oliveira Lima 《Anais brasileiros de dermatologia》2013,88(3):381-385
BACKGROUND
Pityriasis versicolor is a fungal infection caused by Malassezia spp. that has frequent relapses.OBJECTIVES
The main objective of this research was to perform phase I and II clinical studies, using formulations containing essential oil of Cymbopogon citratus in patients with pityriasis versicolor.METHODS
Phase I study included twenty volunteers to ascertain the safety of the formulations. In phase II, 47 volunteers randomly received essential oil formulations at 1.25 μL/mL concentration, for forty days. The shampoo should be applied three times a week and the cream twice a day. A control group in phase II, consisting of 29 volunteers, received the same formulations but with 2% ketoconazole as the active ingredient.RESULTS
No significant adverse events were observed in volunteers during Phase I. In Phase II, 30 (63.83%) volunteers using essential oil and 18 (62.07%) using ketoconazole remained until the end of the study. We observed a predominance of lesions in disseminated form, with M. sympodialis detected as the predominant agent identified in cultures. After 40 days of treatment, the rate of mycological cure was 60% (p <0.05) for the group treated with essential oil of C. citratus and over 80% (p <0.05) for the group treated with ketoconazole formulations.CONCLUSIONS
Notwithstanding the safety and antifungal effects observed in this study after application of formulations containing the essential oil of C. citratus, further studies with larger populations should be performed to confirm the actual potential of these formulations in the treatment of patients with Pityriasis versicolor. 相似文献18.
19.
Ellen Priscilla Nunes Gadelha Sinésio Talhari Jorge Augusto de Oliveira Guerra Leandro Ourives Neves Carolina Talhari Bernardo Gontijo Roberto Moreira da Silva Junior Anette Chrusciak Talhari 《Anais brasileiros de dermatologia》2015,90(6):807-813
BACKGROUND
There have been few studies on pentamidine in the Americas; and there is no consensus regarding the dose that should be applied.OBJECTIVES
To evaluate the use of pentamidine in a single dose to treat cutaneous leishmaniasis.METHODS
Clinical trial of phase II pilot study with 20 patients. Pentamidine was used at a dose of 7 mg/kg, in a single dose. Safety and adverse effects were also assessed. Patients were reviewed one, two, and six months after the end of treatments.RESULTS
there was no difference between the treatment groups in relation to gender, age, number or location of the lesions. Pentamidine, applied in a single dose, obtained an effectiveness of 55%. Mild adverse events were reported by 17 (85%) patients, mainly transient pain at the site of applications (85%), while nausea (5%), malaise (5%) and dizziness (5%) were reported in one patient. No patient had sterile abscess after taking medication at a single dose of 7mg/kg.CONCLUSIONS
Clinical studies with larger samples of patients would enable a better clinical response of pent amidine at a single dose of 7mg, allowing the application of more powerful statistical tests, thus providing more evidences of the decrease in the effectiveness of that medication. Hence, it is important to have larger studies with new diagrams and/or new medications. 相似文献20.
Kunju Zhu Ge Shi Huan Liu Chengyao Zhu Yiming Fan 《Anais brasileiros de dermatologia》2016,91(1):45-48