新的一年再接再厉

时间荏苒,转眼间2006年已经过去,每当新年来临之际,我们都会想起多年来关心和支持本刊的新老朋友,感谢您多年来对本刊的支持与厚爱!     

心肺血管病杂志被《美国化学文摘》(CA)收录

《心肺血管病杂志》2006年被《美国化学文摘》（CA）收录。感谢广大读者和作者多年来对本刊的支持，我们全体编辑人员一定继续努力办好本刊，更好地为读者和作者服务。欢迎订阅《心肺血管病杂志》，欢迎向本刊投稿。     

读者·作者·编者

心肺血管病杂志被《美国化学文摘》(CA)收录《心肺血管病杂志》2006年被《美国化学文摘》(CA)收录。感谢广大读者和作者多年来对本刊的支持,我们全体编辑人员一定继续努力办好本刊,更好地为读者和作者服务。欢迎订阅《心肺血管病杂志》,欢迎向本刊投稿。本刊编辑部《吴英恺回忆     

感谢良好的建议

转眼我刊已创办4年了,4年来广大的编者、读者对本刊的支持、传播及介绍防治心血管病的知识和经验。增加对社会良好的效应,不断受到社会群体的表扬和上级领导的赞赏。这些对勤勤恳恳耕耘这本刊物的广大员工,既是得到无限的安慰,亦是得到热情的鼓舞。多年来热爱本刊的人士     

《地方病通报》办刊20周年纪念

20世纪80年代，在卫生部领导的关心指导下，在西北五省区卫生厅、地方病防治研究所、医学院校和卫生防疫站领导和专家的热心支持下，新疆维吾尔自治区地方病防治研究所于1986年创办了《地方病通报》。做为新疆的优秀科技期刊，1992年成为全国基础医学核心期刊及预防医学和内科学专业期刊。本刊的发展也得到中华预防医学会领导的帮助，2001年本刊被批准为中华预防医学会系列杂志，同年被评为系列杂志优秀期刊。办刊20年来，新疆维吾尔自治区卫生厅领导始终给予了关心和支持。在此，本刊编辑部向全国各地给予本刊帮助的各级领导和专家们表示衷…     

承前启后 继往开来——新世纪献辞

新春伊始 ,随着第一缕曙光洒向大地 ,充满着希望的新世纪、新千年开始了 !在这令人振奋的时刻 ,我们《心电学杂志》编委会和全体工作人员 ,向始终关心、支持本刊工作的广大读者、作者、专家和教授致以诚挚的感谢和节日的问候。感谢大家多年来对本刊的关心、爱护、信任和支持 ,祝愿大家新年身体健康 ,万事如意 ,事业有成 ,阖家欢乐 !《心电学杂志》创刊于１９８２年。２０年来 ,她的读者日益增多 ,论文质量不断提高 ,编辑水平有了长足进步 ,被重要检索系统收录频率探测连年增高。在以往的岁月里 ,她始终坚持理论与实践相结合 ,普及与提高并重…     

新春寄语

新春寄语在春节即将到来之际，本刊编辑部的全体编辑向本刊的各位顾委、编委、特约编委，向热爱本刊的作者及读者们恭贺新春佳节，并衷心地感谢您们在过去的一年里对本刊的关心、支持和爱护。回顾１９９５年我们在办刊上较前迈出了改革的重要一步，使杂志的质量又上了一个...     

我们的决心和期盼

我们的决心和期盼朱元珏王娟前不久，在中国科协组织的第二届全国优秀科技期刊评比中，本刊荣获二等奖。在此向本刊的广大读者、作者以及全体编审人员报喜。衷心感谢你们多年来对本刊的爱护和支持！读者是杂志的主体。广大读者朋友们，正由于你们多年来的厚爱，我们杂志的...     

共担历史使命,共创期刊未来

星移斗转,世纪翻新.转瞬已进入2021年的春天.值此梅花吐蕊,飞雪迎春之际,我谨代表《中华结直肠疾病电子杂志》第二届编委会及编辑同仁向多年来一直关心、支持本刊发展的各界朋友致以新春的问候,惟愿和顺致祥、幸福美满. 作为医学领域的结直肠专业学术期刊,自2012年创刊起,《中华结直肠疾病电子杂志》始终秉承着基础与临床互动,...     

重视读者，服务作者，搭建高质量学术交流平台

伴随2011年辞旧钟声的响起，我们进入了2012年。新年伊始，衷心感谢各界人士一直以来对本刊的关注!回首过去的一年，本刊取得的成绩离不开广大读者、作者和专家的支持和厚爱．在此辞旧迎新之际，谨致以诚挚的谢意和美好的祝愿!     

Cytochrome 1A1 and 1B1 gene diversity in the Zanzibar islands

Amodiaquine (AQ) is a 4‐aminoquinoline widely used in the treatment of malaria as part of the artemisinin combination therapy (ACT). AQ is metabolised towards its main metabolite desethylamodiaquine mainly by cytochrome P450 2C8 (CYP2C8). CYP1A1 and CYP1B1 play a minor role in the metabolism but they seem to be significantly involved in the formation of the short‐lived quinine‐imine. To complete the genetic variation picture of the main genes involved in AQ metabolism in the Zanzibar population, previously characterised for CYP2C8, we analysed in this study CYP1A1 and CYP1B1 main genetic polymorphisms. The results obtained show a low frequency of the CYP1A1*2B/C allele (2.4%) and a high frequency of CYP1B1*6 (approximately 42%) followed by CYP1B1*2 (approximately 27%) in Zanzibar islands. Genotype data for CYP1A1 and CYP1B1 show a low incidence of fast metabolisers, revealing a relatively safe genetic background in Zanzibar’s population regarding the appearance of adverse effects.     

CYP1A1 , GSTM1 , GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men

AIM: To investigate the role of functional genetic poly-morphisms of metabolic enzymes of tobacco carcinogens in the development of colorectal adenomas. METHODS: The study subjects were 455 patients with colorectal adenomas and 1052 controls with no polyps who underwent total colonoscopy in a preretirement health examination at two Self Defense Forces hospitals. The genetic polymorphisms studied wereCYP1A1*2A (rs 4646903), CYP1A1*2C (rs 1048943), GSTM1 (null or non-null genotype), GSTT1 (null or non-null genotype) and NQO1 C609T (rs 1800566). Genotypes were determined by the polymerase chain reaction (PCR)-restriction fragment length polymorphism or PCR method using genomic DNA extracted from the buffy coat. Cigarette smoking and other life-style factors were ascertained by a self-administered questionnaire. The associations of the polymorphisms with colorectal adenomas were examined by means of OR and 95%CI, which were derived from logistic regression analysis. Statistical adjustment was made for smoking, alcohol use, body mass index and other factors. The gene-gene interaction and effect modification of smoking were evaluated by the likelihood ratio test. RESULTS: None of the five polymorphisms showed a significant association with colorectal adenomas, nor was the combination of GSTM1 and GSTT1 . A borderline significant interaction was observed for the combination of CYP1A1*2C and NQO1 (P = 0.051). The OR associated with CYP1A1*2C was significantly lower than unity among individuals with the NQO1 609CC genotype. The adjusted OR for the combination of the CYP1A1*2C allele and NQO1 609CC genotype was 0.61 (95%CI: 0.42-0.91). Although the interaction was not statistically significant (P = 0.24), the OR for individuals carrying the CYP1A1*2C allele and GSTT1 null genotype decreased significantly compared with those who had neither CYP1A1*2C allele nor GSTT1 null genotype (adjusted OR: 0.69, 95%CI: 0.49-0.97). Smoking did not modify the associations of the individual polymorphisms with colorectal adenomas. There w     

Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin

Abstract:  Administration of melatonin to rodents decreases the incidence of tumorigenesis initiated by benzo[ a ]pyrene or 7,12-dimethylbenz[ a ]anthracene, which requires bioactivation by cytochrome P450 enzymes, such as CYP1A1, CYP1A2 and CYP1B1, to produce carcinogenic metabolites. The present study tested the hypothesis that melatonin is a modulator of human CYP1 catalytic activity and gene expression. As a comparison, we also investigated the effect of melatonin on the catalytic activity of CYP2A6, which is also a procarcinogen-bioactivating enzyme. Melatonin (3–300 μ m ) decreased 7-ethoxyresorufin O -dealkylation catalyzed by human hepatic microsomes and recombinant CYP1A1, CYP1A2 and CYP1B1, whereas it did not affect coumarin 7-hydroxylation catalyzed by hepatic microsomes or recombinant CYP2A6. Melatonin inhibited CYP1 enzymes by mixed inhibition, with apparent K _i values (mean ± S.E.M.) of 59 ± 1 (CYP1A1), 12 ± 1 (CYP1A2), 14 ± 2 (CYP1B1) and 46 ± 8 μ m (hepatic microsomes). Additional experiments indicated that melatonin decreased benzo[ a ]pyrene hydroxylation catalyzed by hepatic microsomes and CYP1A2 but not by CYP1A1 or CYP1B1. Treatment of MCF-10A human mammary epithelial cells with melatonin (up to 300 μ m ) did not affect basal or benzo[ a ]pyrene-inducible CYP1A1 or CYP1B1 gene expression. Consistent with this finding, melatonin did not influence reporter activity in aryl hydrocarbon receptor-dependent pGudluc6.1-transfected MCF-10A cells treated with or without benzo[ a ]pyrene, as assessed in an in vitro cell-based luciferase reporter gene assay. Overall, melatonin is an in vitro inhibitor of human CYP1 catalytic activity, and it may be useful to develop potent analogues of melatonin as potential cancer chemopreventive agents that block CYP1-mediated chemical carcinogenesis.     

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

Ezetimibe is a potent inhibitor of cholesterol absorption that has been approved for the treatment of hypercholesterolemia, but its molecular target has been elusive. Using a genetic approach, we recently identified Niemann-Pick C1-Like 1 (NPC1L1) as a critical mediator of cholesterol absorption and an essential component of the ezetimibe-sensitive pathway. To determine whether NPC1L1 is the direct molecular target of ezetimibe, we have developed a binding assay and shown that labeled ezetimibe glucuronide binds specifically to a single site in brush border membranes and to human embryonic kidney 293 cells expressing NPC1L1. Moreover, the binding affinities of ezetimibe and several key analogs to recombinant NPC1L1 are virtually identical to those observed for native enterocyte membranes. KD values of ezetimibe glucuronide for mouse, rat, rhesus monkey, and human NPC1L1 are 12,000, 540, 40, and 220 nM, respectively. Last, ezetimibe no longer binds to membranes from NPC1L1 knockout mice. These results unequivocally establish NPC1L1 as the direct target of ezetimibe and should facilitate efforts to identify the molecular mechanism of cholesterol transport.     

Interleukin 1 (IL 1)

Interleukin 1 is an essential factor of macrophage dependent T cell activation and has a large quantity of other biological activities. This paper gives a review of present knowledge of Interleukin 1. In addition to biochemical properties, the IL 1 production and IL 1 activities, methods for determining of IL 1 and inhibitory factors of IL 1 induced T cell proliferation are described.     

Pandemic H1N1 influenza

The 2009 H1N1 influenza A virus that has targeted not only those with chronic medical illness, the very young and old, but also a large segment of the patient population that has previously been afforded relative protection - those who are young, generally healthy, and immune naive. The illness is mild in most, but results in hospitalization and severe ARDS in an important minority. Among those who become critically ill, 20-40% will die, predominantly of severe hypoxic respiratory failure. However, and potentially in part due to the young age of those affected, intensive care with aggressive oxygenation support will allow most people to recover. The volume of patients infected and with critical illness placed substantial strain on the capacity of the health care system and critical care most specifically. Despite this, the 2009 pandemic has engaged our specialty and highlighted its importance like no other. Thus far, the national and global critical care response has been brisk, collaborative and helpful - not only for this pandemic, but for subsequent challenges in years ahead.