鼻中隔恶性黑色素瘤1例并文献复习

目的 探讨鼻中隔恶性黑色素瘤的临床病理特点和鉴别诊断。方法 对1例鼻中隔恶性黑色素进行光镜和免疫组化诊断。结果 肿瘤位于鼻中隔，豌豆大小，与周围组织分界不清，红黑色，易出血，光镜下示主要为梭形细胞和上皮样细胞，呈巢状分布，免疫组化：CK（-）、HMB45（＋）、S-100（＋）。结论 恶性黑色素瘤属于恶性肿瘤，预后差，其诊断主要依靠常规HE和临床资料辅以免疫组化结果。     

阴道恶性黑色素瘤1例并文献复习

原发性阴道恶性黑色素瘤（primary vaginal malignant melanoma,PVMM）是一种起源于女性阴道黏膜基底层黑素细胞的罕见肿瘤,具有恶性程度高、生长速度快、侵袭性强、生存率低的特点。本文通过回顾1例PVMM患者的诊治过程,对术后标本苏木精-伊红染色及免疫组织化学染色进行临床病理特征及免疫表型观察,并复习相关文献,探讨PVMM的临床病理特点、鉴别诊断、治疗及预后。     

肺原发性恶性黑色素瘤1例并文献复习

<正>黑色素瘤是起源于黑色素细胞的恶性肿瘤,多见于皮肤及黏膜。原发于肺的恶性黑色素瘤及其罕见,仅占肺肿瘤的0.01%^[1]。本院收治一例左肺占位患者,经纤支镜病理检查确诊为肺原发性恶性黑色素瘤(primary malignantmelanoma of the lung,PMML),现结合文献报道如下。1病例报告1.1病例资料女,30岁,间断咯血1月,当地医院CT提示“左肺上叶占位”。门诊以“左肺上叶癌”收入院。查体：双肺呼吸音清晰,双肺未闻及干湿啰音,未发现皮肤及其他部位的黑痣及色素沉着。查CT提示：(1)左肺上叶支气管闭塞并肿块,     

胸膜恶性黑色素瘤1例报道并文献复习

目的 探讨胸膜恶性黑色素瘤的临床特点,以提高对本病的认识。方法 报道1例胸膜恶性黑色素瘤的详细临床及病理资料,并结合文献,对该病的诊断与鉴别诊断、影像学及病理学特点进行分析。结果 胸膜恶性黑色素瘤临床表现无特异性,常见症状如咳嗽、胸痛、胸闷、气喘等,胸部X线片和CT常显示一侧大量胸腔积液伴胸膜不规则增厚,确诊有赖于病理形态学证据及免疫组织化学技术。结论 胸膜恶性黑色素瘤为一罕见疾病,误诊率高,预后差,胸膜活检是早期确诊简便易行的方法。     

鼻中隔恶性黑色素瘤1例并文献复习

目的探讨鼻中隔恶性黑色素瘤的临床病理特点和鉴别诊断。方法对1例鼻中隔恶性黑色素进行光镜和免疫组化诊断。结果肿瘤位于鼻中隔,豌豆大小,与周围组织分界不清,红黑色,易出血,光镜下示主要为梭形细胞和上皮样细胞,呈巢状分布,免疫组化:CK(-)、HMB45(+)、S-100(+)。结论恶性黑色素瘤属于恶性肿瘤,预后差,其诊断主要依靠常规HE和临床资料辅以免疫组化结果。     

肛管直肠恶性黑色素瘤1例并文献复习

目的：探讨发生在肛管直肠的恶性黑色素瘤的临床、病理诊断及鉴别诊断。方法：通过常规HE染色及免疫组化染色，对直肠肛管恶性黑色素瘤进行组织学观察并文献复习。结果：肛管直肠恶性黑色素瘤临床表现无特异性，易与谊部位的癌、恶性淋巴瘤或间质肿瘤相混淆，免疫组化是必不可少的鉴别手段。结论：肛管直肠恶性黑色素瘤是一种侵袭性强、愈后极差的恶性肿瘤，常用的免疫抗体有Vim，S—100和HMB45，其中HMB45对其有特异性。     

尿道外口恶性黑色素瘤2例报告并文献复习

<正>恶性黑色素瘤多发生于皮肤,罕见发生于泌尿系统,而原发于尿道外口的恶性黑色素瘤更为少见,国内外报道较少。因肿瘤生长于尿道外口,常常误诊为尿道外口肉阜、尿道旁腺囊肿等良性肿瘤,延误患者的治疗,故应引起首诊医师注意。对于高度怀疑尿道黑色素瘤,术前应完善腹股沟区彩超,胸部CT等检查明确有无转移,术中行快速病理检查明确肿物性质,及时行根治性手术,避免错过患者最佳治疗时机。1 病例资料病例1,患者女,56岁,     

胃体恶性黑色素瘤1例并文献复习

恶性黑色素瘤是一种恶性程度较高的黑色素细胞肿瘤,可以发生于全身许多器官及组织,但以皮肤最常见,高峰发病年龄为40岁-69岁。现我院发现胃体恶性黑色素瘤1例,报告如下。     

原发性食管恶性黑色素瘤一例并文献复习

食管原发性恶性黑色素瘤（ primary malignant melanoma of esophagus, PMME）十分罕见,约占食管原发肿瘤的0．1％-0．2％^[1],国内报道50余例。2008年9月我院收治1例食管恶性黑色素瘤,现报告如下并结合文献复习,探讨该疾病的临床诊断及治疗。     

原发性肛管直肠恶性黑色素瘤1例报道并文献复习

原发性肛管直肠恶性黑色素瘤是一种临床少见、恶性程度高、病死率高的疾病.由于本病缺乏特异性的临床表现及认识不足,且容易误诊误治,待确诊时往往已为中晚期,错过了最佳的手术时机,严重影响患者预后.本文报道1例经病理及影像学检查证实的原发性肛管直肠恶性黑色素瘤,旨在提高临床医师对原发性肛管直肠恶性黑色素瘤的认识,避免延误治疗.     

Primary malignant melanoma of the lung in the elderly: case report and literature review

Malignant melanoma involving the respiratory tract, which is predominantly found in the skin, is nearly metastatic and true primary tumours are very rare） To date, only 32 cases have been reported in English literature and 22 cases of primary malignant melanoma of the lung have been reported in Chinese literature.     

A fast growing conjunctival malignant melanoma

To the editor:We present a fast growing conjunctival melanoma within 3 weeks after injury from the earthquake,which from a rice-size (about 3.0 mm x 4.0 mm) one proliferated rapidly into a giant mass with a size of 5.7 cm x 3.4 cm. A 76-year-old female who lived in Dujiangyan city,Sichuan,China,near the epicenter of the Wenchuan earthquake,was admitted into hospital for a fast growing big mass in the right orbit within 3 weeks.More than half a year ago,the patient found "a painless,rice-size,brown spot" (about 3.0 mm × 4.0 mm) in the temporal surface of right conjunctiva,and it did not change much.Three weeks ago,the Wenchuan earthquake happened,she fell down,the "rice-size brown spot" abrasion,and subconjunctival hemorrhage in the right eye occurred.Two weeks ago,the original rice-size spot grew into a big mass with discharge on the surface.     

从肝辨证论治复发性恶性黑色素瘤验案两则

恶性黑色素瘤(简称恶黑)是一种起源于痣细胞和黑色素细胞的高度恶性肿瘤,其恶性黑色素瘤恶化程度高,治疗难度大,预后差.目前西医治疗主要是通过手术切除、药物治疗、局部放疗等方式,但所产生的不良反应仍然加剧了患者的痛苦.近年来,医家开始探索中医药对恶黑的临床治疗,以延长生存期.文章将李仝教授从肝经论治复发性恶黑的两则验案进行...     

Intraoral malignant melanoma

Primary oral mucosal melanoma is a rare aggressive neoplasm and accounts for only 0.2-8% of all reported melanomas. It is a malignant neoplasm of melanocytes that may arise from a benign melanocytic lesion or de novo from melanocytes within normal skin or mucosa. It is considered to be the most deadly and biologically unpredictable of all human neoplasms, having the worst prognosis. In this article, we report a case of oral melanoma in a 52-year-old female patient with a chief complaint of black discolouration of the maxillary gingiva and palate.     

快中子治疗恶性黑色素瘤

目的：观察快中子治疗恶性黑色素瘤的疗效。方法：复习１９９１年１２月至１９９８年１月用快中子治疗的２１例恶赤色素瘤。结果：２１例患者中存活１年以上者１１例,存活３年以上者７例,２例存活５年以上。结论：快中子是治疗恶性黑色素瘤的一种有效的方法。     

A case of conjunctival malignant melanoma with local recurrence

Malignant melanoma of the conjunctiva is a rare tumour of middle and old age. It is seen predominantly in whites, and is rare in those of pigmented ethnicity. Its clinical presentation varies, and making a clinical diagnosis may be difficult. The tumour is potentially fatal and displays a high rate of recurrence, which can be attributed to delay in diagnosis, as well as inadequate surgical approach. The literature on this melanoma is scanty, even in the West, particularly regarding the precise surgical technique.We report a case of malignant melanoma of the conjunctiva which showed a local recurrence one year after the primary surgery. However, there was no evidence of distant metastasis on either occasion. This case highlights the need for care in making a diagnosis, meticulous attention to the surgical technique, and careful follow-up to detect further disease activity.     

肢端恶性黑素瘤局部切除疗效观察

目的 观察21例肢端恶性黑素瘤(acral malignant melanoma,AMM)局部切除后疗效.方法 7例切除后直接缝合;13例较大损害,切除后植皮,切除范围距病灶0.5～3 cm;1例甲周损害截趾.结果 病理肢端原位黑素瘤8例全部存活;侵袭性黑素瘤13例,存活11例,死亡2例,5～11年存活率84.6%.结论 肢端恶性黑素瘤(AMM)依据损害形态,初步确定是原位或侵袭性,再确定切除范围,侵袭性恶性黑素瘤(MM)术后5～11年存活率为84.6%;原位恶性黑素瘤术后存活率100%.     

Primary malignant melanoma of the lung in the elderly: case report and literature review

Malignant melanoma involving the respiratory tract, which is predominantly found in the skin, is nearly metastatic and true primary tumours are very rare.1 To date, only 32 cases have been reported in English literature and 22 cases of primary malignant melanoma of the lung have been reported in Chinese literature.     

恶性黑色素瘤免疫组化观察——附12例报告

目的： 探讨波形蛋白（Ｖｉｍｅｎｔｉｎ） 、Ｓ １００ 、ＨＭＢ４５ 、细胞角蛋白（Ｃｙｔｏｋｅｒａｔｉｎ） 的表达在恶性黑色素瘤（ 下称恶黑） 鉴别诊断中的意义。方法：１２ 例恶黑取石蜡切片各一张,用免疫组化链霉素 生物素（ＬＳＡＢ） 法,分别作Ｖｉ ｍｅｎｔｉｎ 、ＨＭＢ４５ 、Ｓ １００ 、Ｃｙｔｏｋｅｒａｔｉｎ 染色。结果： 每例Ｖｉｍｅｎｔｉｎ 、Ｓ １００ 、ＨＭＢ４５ 标记均呈阳性表达。Ｃｙｔｏｋｅｒａｔｉｎ 表达情况为,皮肤原发恶黑９ 例中有４ 例阳性,阳性者中２ 例为无色素性恶黑;３ 例淋巴结内转移性恶黑１ 例阳性。结论： Ｃｙｔｏｋｅｒａｔｉｎ 阳性不能排除恶黑的诊断