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女性痤疮血清性激素及胰岛素样生长因子-1的研究 总被引:4,自引:2,他引:2
目的:探讨性激素和生长激素在痤疮发病中的作用。方法:采用放射免疫法检测了30例女性痤疮患者血清睾酮(T)游离睾酮(FT)、二氢睾酮(DHT)、脱氢表雄酮(DHEA)、雌二醇(E2)、孕酮(Pr)、泌乳素(PRL)和胰岛素样生长因子-1(IGF-1)水平。结果:女性痤疮患者血清DHT、DHEA、IGF-1明显高于正常对照(P〈0.05),其余指标无显著差异;轻、中、重型痤疮的激素水平无显著差异;IGF-1与性激素水平无显著相关(P〉0.05)。结论:性激素尤其雄激素和生长激素在痤疮的发病中起了一定的作用。 相似文献
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用放射免疫分析法(RIA)和放射受体分析法(RRA)检测34例系统性红斑狼疮(SLE)患者和20例正常人血清生长激素(GH)和泌乳素(PRL)水平及其生长激素受体(GH-R)容量。结果显示SLE患者血清GH和PRL水平均显著高于正常对照组,血清GH-R容量与正常对照组相比无显著差异。SLE患者血清GH增高与病情活动度和抗dsDNA抗体水平增高密切相关,而PRL无此关系。我们推测在SLE的发病过程中 相似文献
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麻风菌重组融合蛋白α—抗原的血清学活性 总被引:3,自引:0,他引:3
用麻风2的血清(L38份、B19份、T36份)比较了α1-ELISA、α2--ELISA与PGL-I-ELISA法,结果各型患者血清中的抗何不工分别为:α1-抗原〉α2-抗原〉PGL-I,尽管LG 血清中α1-怕的滴度明显高于其它两种抗原,但其阳性率在三种方法之间统计学上没有差别,分别为97%,92%和94%;B和T型血清α1-ELISA法的阳性率明显高于其它两种方法,分别为84%、58%、68% 相似文献
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用麻风患者的血清(L38份、B19份、T36份)比较了α1-ELISA、α2--ELISA与PGL-I-ELISA法,结果各型患者血清中的抗体滴度分别为:α1-抗原>α2-抗原>PGL-I,尽管L型的血清中抗α1-抗原的滴度明显高于其它两种抗原,但其阳性率在三种方法之间统计学上没有差别,分别为97%,92%和94%;B和T型血清α1-ELISA法的阳性率明显高于其它两种方法,分别为84%、58%、68%和47%、38%、30%,以α1-ELISA法的敏感性最高。提示α1-ELISA在麻风血清诊断中有很大潜力,值得进一步扩大样本进行评价 相似文献
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目的;以重组麻风杆菌α2融合蛋白为抗原,建立酶联免疫吸附试验,即α2-ELISA。方法:用麻风病人和健康正常人的血清评价了α2-ELISA中有关试剂及最适浓度,其敏感性与PGL-1-ELISA进行了比较。结果:(1)挥发性缓冲液醋酸铵碳酸盐为α2抗原最佳包被液;(2)重组α2融合蛋白的最适包被浓度为5μg/ml;(3)显色剂OPD的敏感性大于TMB;(4)YSS MQ UGM W TLD IGE 相似文献
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目的 探讨白细胞流变性和细胞粘附分子(CAMS)表达与银屑病的关系。方法 采用ELISA法、红细胞变形能力测定 体外血栓血小板粘附两用仪检测了115例银屑2和89例健康人白细胞CD18表达、血清可溶性细胞间粘附分子-1(sICAM-1)浓度、白细胞滤过指数(LFI)和白细胞粘附率(AR)的变化。结果 银屑病患者白细胞CD18表达、sICAM-1浓度、LFI和LAR均明显增高,与对照组比较差异均有 相似文献
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选35例单用DDS治愈平均已18.6年的病人,相隔一年取两次耳垂血;1994和1995年共取血清70份,分别用PGL-1和LAM-β抗原做ELISA。IgG-LAM-βOD值〉).18,IgM_PGL-1〉0.16为阳性,IgG-LAM-β,BL-LL组23份阳性(48%)BT-TT组5份阳性(23%)。IgM-LAM-1,BL-LL组24份阳性(50%),BT-TT组6份阳性(27.6%)。所有 相似文献
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推广应用MDT后用NT-O-BSA-ELISA检测了1715名麻风接触者和6例新病人血中的抗PGI-IgM抗体。1715例接触者中的抗体阳性率分别为:开始MDT前33.4%,用MDT2-24个月32.82%,用MDT后48个月21.84%(P<0.001);6例新病人在推广MDT5年时OD下降72.74%;连续观察243例抗体阳性的接触者,2-5年共发病7例(BT1例,BL4例,LL2例)。结果说 相似文献
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Smith KC 《Dermatologic therapy》2007,20(6):388-393
ABSTRACT: Two new collagen-based lidocaine-containing dermal fillers, ArteSense™/ArteFill™ (Artes Medical, San Diego, CA) and Evolence® (Colbar LifeScience Ltd., Herzliya, Israel), have proved to be of particular interest to men, many of whom seek a long-lasting or permanent correction. ArteFill™ has been available in the United States since 2006, and it is expected that Evolence® will reach the American market in 2008. The properties of the two products will be described, and experience based on the administration of many hundreds of syringes of both products by a Canadian dermatologist will be detailed here, with tips and precautions to optimize patient outcomes. 相似文献
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It is generally believed that ablative laser therapies result in prolonged healing and greater adverse events when compared with nonablative lasers for skin resurfacing. To evaluate the efficacy of ablative laser use for skin resurfacing and adverse events as a consequence of treatment in comparison to other modalities, a PRISMA‐compliant systematic review (Systematic Review Registration Number: 204016) of twelve electronic databases was conducted for the terms “ablative laser” and “skin resurfacing” from March 2002 until July 2020. Studies included meta‐analyses, randomized control trials, cohort studies, and case reports to facilitate evaluation of the data. All articles were evaluated for bias. The search strategy produced 34 studies. Of 1093 patients included in the studies of interest, adverse events were reported in a total of 106 patients (9.7%). Higher rates of adverse events were described in nonablative therapies (12.2% ± 2.19%, 31 events) when compared with ablative therapy (8.28% ± 2.46%, 81 events). 147 patients (13.4%) reported no side effects, 68 (6.22%) reported expected, transient self‐resolving events, and five (0.046%) presented with hypertrophic scarring. Excluding transient events, ablative lasers had fewer complications overall when compared with nonablative lasers (2.56% ± 2.19% vs 7.48% ± 3.29%). This systematic review suggests ablative laser use for skin resurfacing is a safe and effective modality to treat a range of pathologies from photodamage and acne scars to hidradenitis suppurativa and posttraumatic scarring from basal cell carcinoma excision. Further studies are needed, but these results suggest that ablative lasers are a superior, safe, and effective modality to treat damaged skin. 相似文献
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Joan A. Puig‐Butillé Celia Badenas Zighereda Ogbah Cristina Carrera Paula Aguilera Josep Malvehy Susana Puig 《Experimental dermatology》2013,22(2):148-150
Studies integrating clinicopathological and genetic features have revealed distinct patterns of genomic aberrations in Melanoma. Distributions of BRAF or NRAS mutations and gains of several oncogenes differ among melanoma subgroups, while 9p21 deletions are found in all melanoma subtypes. In the study, status of genes involved in cell cycle progression and apoptosis was evaluated in a panel of 17 frozen primary acral melanomas. NRAS mutations were found in 17% of the tumors. In contrast, BRAF mutations were not found. Gains of AURKA gene (20q13.3) were detected in 37.5% of samples, gains of CCND1 gene (11q13) or TERT gene (5p15.33) in 31.2% and gains of NRAS gene (1p13.2) in 25%. Alterations in 9p21 were identified in 69% of tumors. Gains of 11q13 and 20q13 were mutually exclusive, and 1p13.2 gain was associated with 5p15.33. Our findings showed that alterations in RAS‐related pathways are present in 87.5% of acral lentiginous melanomas. 相似文献
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Milissa U. Jones MD Michelle S. Flores MD Rasheda J. Vereen MD MBS Sabrina R. Szabo DO Nicholas F. Logemann DO Matthew D. Eberly MD 《Pediatric dermatology》2018,35(4):e248-e250
A 7‐week‐old girl, born at 30 weeks' gestational age, presented to clinic for evaluation of a crop of vesicular lesions that were noted after removal of a bandage that had been in place for 4 days. A punch biopsy of the lesion revealed fungal elements that were later identified as Rhizopus spp. The lesion began to self‐resolve, and no further treatment was needed, with full resolution of the lesion by 1 month after presentation. Clinicians should be aware of the variable presentations of mucormycosis and consider fungal infection in the differential diagnosis when evaluating vulnerable patients with skin eruptions. 相似文献
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Philip R. Cohen 《The Journal of dermatology》1996,23(4):290-292
A black woman with the concurrent onset of two subcutaneous nodules located on the digits of her upper extremities is described. Initially, a single systemic disorder was considered; yet, the lesions differed in morphology and consistency. Microscopic examination of the nodules showed a giant cell tumor of tendon sheath and a lipoma. Although Occam's “razor” suggests that multiple lesions in the same person are more likely to represent variable manifestations of a single disorder than several different diseases in that individual, the simultaneously appearing lesions in this patient represented two different conditions. 相似文献