丛状血管瘤

患者女,49岁。 主诉：右肘部屈侧红斑、丘疹、结节伴疼痛1年余。 现病史：患者于1年半前右肘部屈侧有一疼痛点,2个月后在该疼痛点处出现一针尖大红色丘疹,3个月后皮损缓慢增至黄豆大结节,伴明显触痛,在外院诊断为瘢痕,予以电灼切除。治疗后疼痛无缓解,切口附近出现数个类似的新结节．并逐渐扩大、融合。近3个月来自觉皮损增大较快,仍有明显触痛,偶有跳痛,日晒后局部红肿明显,疼痛加剧。[第一段]     

婴儿丛状血管瘤

报告1例婴儿丛状血管瘤.患儿女,1岁.下腹部出现红色斑块半年.皮肤科检查:下腹部至左腰髋部有一紫红色斑,质地偏硬,表面略不平,皮温稍高.皮损组织病理检查:真皮和皮下组织可见大小不等的细胞团块,毛细血管聚集成簇,并可见不规则的腔隙,高倍镜下可见内皮细胞和周皮细胞形成半月形管腔,胞核为圆形,部分呈梭形,细胞无异形性.诊断:丛状血管瘤.     

丛状血管瘤1例

患儿女,2月,左腰背部斑块伴疼痛1月。皮肤科检查可见左腰背部一9.0cm×4.0cm大紫红色斑块,中央隆起,质稍硬,触之有结节感和浸润感。组织病理检查示真皮内散在毛细血管组成的团块,呈丛状或卵圆形。可见圆形或不规则形管腔,含有较多的内皮细胞,细胞核呈卵圆形或梭形,内皮细胞可形成血管裂隙或不规则管腔,细胞无异形性。免疫组化染色示内皮细胞CD34和CD31(+),周皮细胞平滑肌肌动蛋白(SMA)表达阳性。     

丛状血管瘤1例

丛状血管瘤（tufted angioma)又名获得性丛状血管瘤或血管母细胞瘤（angioblastoma)，是一种临床上罕见的良性血管增生性疾病。2002年11月笔者所在科室门诊收治了1例该病患者，现报告如下。     

丛状血管瘤1例

患者女,64岁。右腹股沟皮疹伴间断性疼痛和瘙痒十余年。皮肤科情况:右腹股沟可见粟粒至蚕豆大花斑状红色、暗红色斑疹,部分融合,其上及其周围有粟粒至近豌豆大红色、暗红色斑丘疹、丘疹,无压痛。皮损组织病理示:表皮大致正常,真皮内散在由紧密排列的不成熟的毛细血管组成的小叶,圆形、卵圆形、细长形或不规则形,含有较多的内皮细胞和周细胞,细胞无明显异型性,小叶周围可见扩张的淋巴管;免疫组化染色示:内皮细胞CD31和CD34表达阳性,周细胞SMA表达阳性。诊断:丛状血管瘤。     

丛状血管瘤1例

患者女,12岁.因右腹部、腰部出现片状暗红色斑块2年余于2002年6月就诊.2年前,患者无意中发现右腹部有片状红斑,有轻压痛,曾到当地医院就诊,具体诊断不详,给予曲安奈德(去炎松)尿素软膏等外用,无明显效果,皮损逐渐增大,且局部出现自发性疼痛,为明确诊断遂来我院门诊就诊.患者系第1胎第1产,足月顺产.     

丛状血管瘤1例

1病历摘要 患儿女,1.5岁.因左耳后下部出现环状红斑1年余,于2008年3月27日至本科门诊就诊.患儿1年前左耳后下部被蚊虫叮咬后出现一风团,中央有小水疱,其母用针头刺破水疱后逐渐形成红色斑块,随后又出现2枚类似皮损,皮损无自觉症状.曾外用莫匹罗星软膏和复方地塞米松乳膏治疗无效.患儿患病以来饮食、两便正常,精神好.父母身体健康,家族成员中无类似疾病者.     

丛状血管瘤1例

患者女,16岁。左膝关节出现暗红色斑块伴疼痛6年,于2004年8月就诊。6年前患者无意中发现左膝关节处有数个散在分布的粟粒大红斑,摩擦后有轻微刺痛感,未予诊治。皮损逐渐扩大,增多,隆起,并融合成斑块,斑块向外扩展,中央渐凹陷。皮损颜色渐演变成暗红色,有自发性疼痛,遇冷或局部摩擦可诱发疼痛。     

丛状血管瘤1例

患者男,8岁。因左大腿内侧起一红斑3年,于2004年3月来我科就诊。患者5岁时左大腿内侧起一甲盖大红斑,未引起家人重视,3年来红斑逐渐扩大,曾在当地医院就诊,给予复方硝酸康唑霜（派瑞松）外用,效果不明显。皮损逐渐扩大,无明显疼痛及瘙痒等不适。     

丛状血管瘤11例临床及病理分析

报道11例丛状血管瘤,其中男6例,女5例,发病年龄7天～24岁.皮损主要表现为浸润性的暗紫红色斑块或结节.组织病理均表现为真皮内血管内皮细胞和血管周细胞增生形成的团块状的毛细血管丛,其周围有裂隙样管腔,无细胞异形性和核分裂相.     

小腿获得性丛状血管瘤

报告1例获得性丛状血管瘤。患者男,43岁。左小腿红色丘疹3年余,无自觉症状。皮损组织病理检查示,真皮至皮下组织散在分布细胞团块,境界清楚,细胞块由裂隙或不规则狭窄血管腔构成。组织病理学诊断：获得性丛状血管瘤。     

成人面部丛状血管瘤一例

患者，女，54岁。右下颌角多发暗红色斑疹伴刺痛1年。组织病理：真皮层散在分布成簇状毛细血管小叶，边界清楚，其内梭形细胞紧密排列，内皮细胞无异型性。免疫组化：瘤细胞CD31(+)，CD34(+)，D2-40和SMA灶状阳性。诊断：丛状血管瘤。患者拒绝治疗，目前随访中。     

成人丛状血管瘤一例

患者,女,54岁。左侧腰部皮疹伴针刺样疼痛10年。皮肤科查体：左侧腰部可见黄豆至蚕豆大暗红色斑丘疹,触摸软,边界不规则。皮损组织病理：真皮中部可见增生的血管,形状不规则,呈丛状分布,管壁可见单层内皮细胞,周围有少量纤维组织包绕。诊断：丛状血管瘤。     

Vascular tumors arising in port-wine stains: two cases of pyogenic granuloma and a case of acquired tufted angioma

Three female patients affected by intradermal vascular tumors were presented. The lesions were acquired and developed from preexisting port-wine stains (PWS). Among the three patients observed, two had a pyogenic granuloma (PG) and the third patients had tufted angiomas. As reported earlier, formation of a PG within the lesion of a PWS supports the assumption that arteriovenous anastomoses are associated with its pathogenesis. Occurrence of tufted angioma from a PWS, as well as coexisting but separate PWS has been reported. However, the tufted angiomas of our patient were located in different sites, one in the PWS and others separate from the PWS. This has never previously been reported.     

Congenital disseminated tufted angioma

Tufted angioma represents a rare vascular tumor that can develop in children and young adults. It usually presents as solitary plaque or large tumor on the extremities, trunk or other anatomic sites. Histopathologically, it is characterized by proliferation of closely packed capillaries in the dermis in a ‘cannonball’ distribution. We described a 2‐month‐old child who developed widespread disseminated red papules since her birth. Eight lesions were excised for histopathology, seven of which showed typical cannonball‐like distribution of proliferative capillaries, characteristic of tufted angioma, and one on the hand which showed focal disseminated proliferation of endothelial cells. Immunohistochemistry showed focal D2‐40 positivity in one lesion and was negative in the other seven. Expression of Prox1 and Glut‐1 was negative in all lesions. This case represented a disseminated form of tufted angioma.     

The relationship between angioblastoma (Nakagawa) and tufted angioma: report of four cases with angioblastoma and a literature-based comparison of the two conditions

We report four recent cases of angioblastoma (Nakagawa). Histopathologic examinations of all cases revealed dispersed islets of clear marginal lobules of varying sizes in the dermis. Neoplastic endothelioid cells with moderate atypia and enlarged capillaries containing erythrocytes were found in the conglomerates. Recently, the features of this disease have been compared to the tufted angioma that has been reported in Europe and the U.S. Our evaluation suggests that these two diseases are very likely the same. We suggest that this disease should be called "angioblastoma" in agreement with the first report of this disease by Nakagawa.     

Tacrolimus ointment for the treatment of superficial kaposiform hemangioendothelioma and tufted angioma

Kaposiform hemangioendothelioma (KHE) and tufted angioma (TA) are rare infiltrative vascular tumors. Currently, no standard treatment regimens exist for KHE/TA. The purpose of our study was to evaluate the efficacy and safety of topical application of tacrolimus for superficial KHE/TA. We examined six patients with superficial KHE/TA. All patients were treated with tacrolimus 0.1% ointment twice daily for at least 12 months. The response rate was 100%, including three nearly complete remissions. Only one patient experienced local pruritus during treatment. The data constituted an intriguing rationale for clinical trials of topical tacrolimus in the treatment of superficial KHE/TA.     

Acquired tufted angioma: a unique vascular lesion not previously reported in the oral mucosa

We describe two patients with acquired tufted angioma, a unique vascular lesion not previously reported in the oral mucosa. In one patient, the lesion manifested as a purple-red papule and, in the other, as a blue submucosal swelling. Both lesions were non-painful and neither was associated with a history of trauma. The histopathological features consisted of scattered, irregularly shaped tufts, primarily composed of poorly formed capillary spaces and slit-like vascular channels. Capillary spaces were often closely packed, producing solid areas which stained for smooth muscle actin. Staining for factor VIII-related antigen was positive only within endothelial cells lining well-formed vascular channels. Both lesions were treated by excision; short-term follow-up of one patient revealed no evidence of recurrence. Similarities between this and other vascular processes may have resulted in misdiagnosis of this lesion in the past. The clinical significance of acquired tufted angioma in the oral mucosa is not known.