福建省胃癌和十二指肠溃疡患者白细胞介素1基因多态性的比较

目的了解福建省胃癌和十二指肠溃疡患者中白细胞介素1（IL-1）基因多态性的分布并进行比较。方法病理确诊的144例胃癌及排除非甾体类抗炎药服用史的102例十二指肠溃疡患者，采用PCR—RFLP分析检测IL-1基因多态性。结果（1）胃癌患者中，IL-1B-511基因型CC、CT、rlT分别占18．1％、48．6％和33，3％，IL-1RN等位基因检测到A1、A2、A4三种，基因型A1／A1、A1／A4、A1／A2、A2／A2分别占88．9％、1．4％、9．0％、0，7％；十二指肠溃疡患者中，IL-1B-511基因型CC、CT、TT分别占19．6％、59，8％和20．6％，IL-1RN等位基因检测到A1、A2两种，基因型A1／A1、A1／A2分别占90，2％、9，8％。（2）IL．1B-511 TT基因型在胃癌患者中的比例与在十二指肠溃疡患者中的比例差异显著（x^2=4.806，P=0．028）；不同IL-1 RN基因型在胃癌的比例与在十二指肠溃疡中的比例无统计学差异。结论福建省胃癌和十二指肠溃疡患者IL-1基因型均以IL-1B-511基因CT型、IL-1RN基因型以A1／A1为主。IL-1 B-511 TT基因型可能与福建省胃癌的高发有关。     

Long-term follow-up of 2529 patients reveals gastric ulcers rarely become malignant

To examine the relationship between peptic ulcer and gastric cancer, we investigated 2529 patients with peptic ulcer diagnosed from 1963 to 1975. During the follow-up period of 9–23 years, we found 38 in whom gastric cancer developed or who died of gastric cancer. Included were nine in whom gastric cancer was detected at the same site as the gastric ulcer initially diagnosed, and 22 in whom the gastric cancer was detected at another site. In the remaining seven, gastric cancer was given on the death certificate, but the details were unknown. When the data on gastric ulcer initially diagnosed were reevaluated, gastric cancer was suspected or could not be completely ruled out in seven of the nine in whom gastric cancer was detected at the same site. In the remaining two, a diagnosis of benign ulcer was made even when the initial data were reviewed. In these two, however, there was the possibility that the initially diagnosed gastric ulcer represents a phase of the malignant cycle. The number of deaths from gastric cancer in patients with gastric ulcer was significantly low, compared with that expected and computed by the age- and sex-matched general population. These results suggest that gastric ulcers rarely become malignant.     

Interleukin-1B and interleukin-1 RN polymorphisms and gastric carcinoma risk: a meta-analysis

Background and Aim: We aimed to explore the role of interleukin (IL)‐1B cluster gene polymorphisms at positions ?511, ?31, and +3954 and the receptor IL‐1RN variable number tandem repeat polymorphisms in the susceptibility to gastric carcinoma through a systematic review and meta‐analysis. Methods: Each initially included article was scored for quality appraisal. The desirable data were extracted and registered into databases. Studies that deviated from Hardy–Weinberg equilibrium were excluded. Eighteen studies were ultimately eligible for the meta‐analysis of IL1B–511, 21 studies for IL1B‐31, 10 studies for IL1B+3954, and 20 studies for IL1RN variable number tandem repeat genetic polymorphisms, respectively. Original groups were collapsed and re‐grouping was adopted in line with the most probably appropriate genetic models. Potential sources of heterogeneity were sought out via stratification and sensitivity analyses, and biases across studies were estimated. Results: The pooled odds ratios (95% confidence intervals, P‐value) associated with IL‐1B ?511 T carriers versus CC genotypes and with RN *2 carriers versus L/L were 1.23 (1.04–1.45, P = 0.015) and 1.26 (1.06–1.51, P = 0.010), respectively, for overall gastric carcinoma; 1.31 (1.04–1.64, P = 0.020) and 1.47 (1.21–1.79, P = 0.000), respectively, for non‐cardia gastric cancer; 1.55 (1.05–2.28, P = 0.026) and 1.66 (1.23–2.25, P = 0.001), respectively, for intestinal type gastric carcinoma; and 1.33 (1.04–1.71, P = 0.023) and 1.31 (1.07–1.61, P = 0.010), respectively, in Caucasians for overall gastric carcinoma. The pooled odds ratio (95% confidence interval, P‐value) regarding IL‐1B?31 CC plus TT versus CT was 0.73 (0.60–0.89, P = 0.002) for intestinal type gastric carcinoma. Genotyping methods and publication time could constitute the sources of heterogeneity across studies. Publication biases were not found. Conclusion: IL‐1B ?511 T allele and IL‐1 RN *2 VNTR are significantly associated with an increased risk of developing gastric carcinoma and even more significantly with non‐cardia gastric carcinoma or with intestinal‐type gastric carcinoma. Both are significantly associated with an increased risk of developing gastric carcinoma among Caucasians, but not among Asians or Hispanics.     

消化性溃疡和胃癌病人血清可溶性IL－2受体和纤维结合素的观察

用多克隆单克隆夹心ＥＬＩＳＡ法和单向扩散法测定溃疡病和胃癌患者血清可溶性白细胞介素２受体（ｓｏｌｕｂｌｅＩＬ－２ｒｅｃｅｐｔｏｒｓ，ＳＩＬ－２Ｒ）和纤维结合素（ｆｉｂｒｏｎｅｃｔｉｎ，ＦＮ）。结果显示溃疡病血清ＳＩＬ－２Ｒ和ＦＮ分别为２１２．９２±１２２．２７Ｕ／ｍｌ和２９８．０９±３３．４６ｎｇ／ｍｌ，胃癌分别为５５９．２７±２３４．０１Ｕ／ｍｌ和３３６．６５±３９．２１ｎｇ／ｍｌ。与正常人２４０．０±９７．０７Ｕ／ｍｌ和３２３．６４±２８．２１ｎｇ／ｍｌ比较，胃癌患者ＳＩＬ－２Ｒ水平明显升高（Ｐ＜０．００１），其中肿瘤有转移者低于无转移者（Ｐ＜０．０５）。这表明血清ＳＩＬ－２Ｒ和ＦＮ检测可做为胃癌病人病情监测和判断预后的指标，亦可用以签别良性和恶性溃疡。     

COX-2在胃溃疡与胃癌的表达及其与幽门螺杆菌的关系

[目的]探讨COX-2在幽门螺杆菌(Hp)感染和非感染胃溃疡与胃癌的表达。[方法]选择胃病患者共285例,分为胃溃疡患者(胃溃疡组)200例(病理分型:肠上皮化生96例和异型增生104例),胃癌患者(胃癌组)85例;以正常胃黏膜者50例为对照组。根据胃镜检查和组织病理学检查受试者胃黏膜中COX-2蛋白的表达,并比较各病理分型及Hp感染与非感染者COX-2蛋白表达的差异。[结果]COX-2蛋白在胃溃疡组的肠上皮化生、异型增生中及胃癌组癌细胞中均有表达,在正常胃黏膜组织中不表达。胃溃疡组和胃癌组的COX-2阳性表达均强于对照组,差异有统计学意义(P0.05);胃癌组的COX-2阳性表达强于胃溃疡组,差异有统计学意义(P0.05);胃溃疡组异型增生者COX-2阳性表达强于肠上皮化生者,差异有统计学意义(P0.05);胃癌组Hp阳性COX-2阳性表达强于胃溃疡组Hp阳性者,差异有统计学意义(P0.05);胃癌组Hp阴性者COX-2阳性表达强于胃溃疡组Hp阴性者,差异有统计学意义(P0.05);胃溃疡组和胃癌组中Hp阳性者COX-2阳性表达均强于Hp阴性者,差异有统计学意义(P0.05)。[结论]Hp感染会促进胃溃疡COX-2的表达,Hp感染和COX-2过度表达会使胃溃疡患者癌变的概率大大增加。     

Peptic ulcer of the gastric tube after esophagectomy for cancer: clinical implications

The use of the stomach as an esophageal substitute has become a well-established treatment procedure after esophagectomy for cancer. During the procedure, a bilateral truncal vagotomy is performed, which should prevent the occurrence of acid-related diseases in the gastric tube and in the remaining esophagus. We report the case of a man who presented a plugged perforated peptic ulcer that subsequently decompensated following endoscopic examination 1 year after a transthoracic esophagectomy with neoadjuvant chemo-radiation for a middle third squamous cell carcinoma. Resection of the ulcer and suture with a pleural patch was performed. There was no evidence of recurrent malignancy at time of surgery. The pathophysiology of gastric tube ulcer is multifactorial. Long-term treatment with an anti-secretory proton pump inhibitor may decrease esophageal complications of duodeno-gastric-esophageal reflux and could prevent the recurrence of gastric tube ulcers.     

Circulating interleukin-27 levels in Helicobacter pylori-infected patients with gastric or duodenal ulcers, independent of the bacterial cytotoxin-associated gene A virulence factor

OBJECTIVE: The aim was to evaluate the interleukin (IL)‐27 levels in Helicobacter pylori (H. pylori)‐infected patients with gastric ulcer (GU) or duodenal ulcer (DU) and to determine its association with H. pylori virulence factor cytotoxin‐associated gene A (CagA). METHODS: In all, 127 H. pylori infected patients (including 96 DU patients, of whom 61 were anti‐CagA⁺ and 35 were anti‐CagA^‐) and 31 GU patients (of whom 15 were anti‐CagA⁺ and 16 were anti‐CagA^‐), 60 asymptomatic (AS) carriers (of whom 30 were anti‐CagA⁺ and 30 were anti‐CagA^‐) and 30 healthy H. pylori‐negative participants (as a control) were enrolled in the study. Serum concentrations of IL‐27 were measured by the enzyme‐linked immunosorbent assay method. RESULTS: The mean levels of IL‐27 in the GU (44.26 ± 7.12 pg/mL) and DU patients (40.84 ± 3.90 pg/mL) was significantly higher than those observed in the AS carriers (22.06 ± 1.90 pg/mL, P < 0.001) and the control group (18.12 ± 1.68 pg/mL, P < 0.001 and P < 0.002, respectively). In the GU, DU and AS groups the levels of IL‐27 in anti‐CagA⁺ participants were not significantly differ from that in the anti‐CagA^‐ participants. CONCLUSIONS: These results showed that the mean concentration of IL‐27 in H. pylori‐infected peptic ulcer (PU) patients was higher than in AS carriers and the healthy control group. The serum concentrations of IL‐27 were not affected by the CagA factor.     

Ulcer in the gastric tube for esophageal replacement: a comparison of 12 esophageal cancer patients with or without postoperative radiotherapy

BACKGROUND AND AIMS: Ulcer in the gastric tube for esophageal replacement, which was caused by peptic factors or postoperative radiotherapy (Rx), are occasionally reported. The aim of this study was to clarify the clinicopathologic features of the ulcers in the gastric tube. METHODS: In 62 patients with a reconstructed gastric tube, after esophagectomy for esophageal cancer, esophagogastroduodenoscopy was performed. Ulcers of the gastric tube were detected in 12 patients: six with postoperative Rx and six without Rx. The 12 patients with gastric tube ulcers (GU-group) were reviewed and compared to the remaining 50 patients without ulcers of the gastric tube (Control-group). Clinicopathologic features of gastric tube ulcers were compared between the patients with and without Rx. RESULTS: There was no difference in any parameter between the patients of the GU- and Control-groups. Comparing the patients of the GU-group with and without Rx, the ulcers of the gastric tube in the patients without Rx were frequently located in the lower part of the gastric tube (P = 0.067), detected in a later period after surgery (P = 0.055), associated with cervical esophagitis (P = 0.03), and less associated with gastritis (P = 0.03). In three patients of the GU-group without Rx, Helicobacter pylori was detected in the gastric tube. Two of the three patients had a history of peptic ulcers before surgery, and had recurrence of the gastric tube ulcers. CONCLUSIONS: Gastric tube ulcers without postoperative Rx may have different characteristics compared to those induced by Rx.     

Novel interleukin-4 and interleukin-1 receptor antagonist gene variations associated with non-cardia gastric cancer in Japan: comprehensive analysis of 207 polymorphisms of 11 cytokine genes

BACKGROUND AND AIM: Helicobacter pylori (H. pylori)-induced chronic atrophic gastritis is a high-risk factor for gastric cancer. Immune responses to H. pylori are involved in gastric mucosal inflammation, and might affect clinical outcome, including the development of gastric cancer. The present study examines the significance of gene polymorphisms of various cytokines in the development of gastric cancer following H. pylori infection. METHODS: One hundred Japanese non-cardia gastric cancer patients and 93 dyspeptic patients as controls were enrolled in the study (age range 50-75 years). All patients were positive for H. pylori. Genomic DNA was extracted from peripheral whole blood leukocytes, and we comprehensively analyzed 207 single nucleotide polymorphisms (SNP) in 11 cytokine genes; interleukin (IL)-1alpha, IL-1beta, IL-1 receptor antagonist (RN), IL-4, IL-4R, IL-8, IL-10, IL-12, TNF-alpha, TNF-beta, and IFN-gamma, using either invader assay (163 SNP), direct sequencing (22 SNP), or PCR-restriction fragment length polymorphism (22 SNP). RESULTS: Among the 207 SNP examined, the IL-4 gene diplotypes (984 and 2983 AA/GA) had a significant negative association with gastric cancer development (odds ratio =0.3, 95% confidence interval =0.1-0.9). When we adopted the dyspeptic patients over 66 years of age as the controls, the IL-1RN gene diplotypes (-1102 and 6110 CG/GA) also had a significant negative association (odds ratio =0.2, 95% confidence interval =0.1-0.7). CONCLUSION: A comprehensive analysis of 207 SNP of 11 cytokine genes revealed that variations in IL-4 and IL-1RN genes are negatively associated with the risk of developing gastric cancer following H. pylori infection. Distinct host cytokine responses in the gastric mucosa might have a role in H. pylori-induced carcinogenesis.     

A double-blind, randomized, parallel group study of omeprazole and ranitidine in Korean patients with gastric ulcer

Abstract The efficacy of the proton pump inhibitor omeprazole, 20 mg every morning, was compared with that of the H₂-receptor antagonist ranitidine, 150 mg every morning and at bedtime, in a double-blind randomized parallel group study in 250 patients with gastric or prepyloric uicers. At both 4 and 8 weeks, significantly more patients had healed ulcers in the omeprazole group than the ranitidine group, whether the results were analysed on a per-protocol or an intention-to-treat basis. At 4 weeks, 74% of patients in the omeprazole group were healed compared with 51% in the ranitidine group ( P = 0.001), and at 8 weeks the corresponding values were 99 and 82% ( P = 0.001, per-protocol cohort). Omeprazole treatment and small ulcer size significantly increased the probability of healing, but smoking had no significant effect. Patients in the omeprazole group had significantly fewer occurrences of daytime epigastric pain during the first 4 weeks than the ranitidine group ( P = 0.0037), as shown by their diary cards. Both treatments were well tolerated.     

白细胞介素1基因多态性与北京地区胃癌的关系

目的　了解白细胞介素 (IL) 1β 31、IL 1β 5 11和IL 1受体拮抗因子基因 (IL 1RN)多态性在北京地区胃癌患者及慢性胃炎患者中的分布情况 ,探讨IL 1基因多态性与北京地区胃癌的关系。方法　收集北京地区 5 7例胃癌患者和 12 0例慢性胃炎患者的外周血标本 ,提取DNA ,用聚合酶链反应 限制性片段长度多态性法 (PCR RFLP)检测入选患者的IL 1基因多态性情况 ,并比较这些基因多态性在胃癌组和慢性胃炎组的分布差异。结果　IL 1β 31C等位基因在慢性胃炎组和胃癌组中的分布频率分别为 4 9.2 %和 6 1.4 % ,胃癌组明显高于慢性胃炎组 (P <0 .0 5 ) ,携带IL 1β 31C等位基因增加胃癌的风险性 ,IL 1β 31C/C纯合子型的胃癌风险OR值为 2 .4 (95 %CI =1.0～ 5 .9)。IL 1β 5 11T等位基因在慢性胃炎组和胃癌组中的分布频率分别为 4 7.9%和 6 5 .8% ,胃癌组明显高于慢性胃炎组 (P <0 .0 1) ,携带IL 1β 5 11T等位基因增加胃癌的风险性 ,IL 1β 5 11T/T纯合子型的胃癌风险OR值为 3.8(95 %CI =1.5～ 9.7)。IL 1RN 2等位基因在慢性胃炎组和胃癌组中的分布频率分别为 3.8%和 11.4 % ,胃癌组明显高于慢性胃炎组 (P <0 .0 1) ,携带IL 1RN 2等位基因增加胃癌的风险性 ,L/ 2杂合子型的胃癌风险OR值为 3.5 (95 %CI =1.4～ 8.9     

Synchronous gastric cancer in primary sporadic colorectal cancer patients in Korea

Background and aims Colorectal cancer has been reported to be the malignancy most frequently associated with gastric cancer in Korea. The aim of this study was to define the frequency and clinical characteristics of synchronous gastric cancer detected at preoperative esophagogastroduodenoscopy (EGD) in colorectal cancer patients. Materials and methods This prospective study analyzed the EGD results from 1,542 consecutive colorectal cancer patients who underwent surgery from January 2003 to December 2005 at the Center for Colorectal Cancer, National Cancer Center, Korea. Results Of the 1,542 cases, 1,155 (74.9%) underwent EGD at our center and 387 underwent EGD at other hospitals within 6 months before surgery. Of the 1,542 cases, synchronous gastric cancers were detected in 31 cases (2.0%). Of these 31 cases, 26 had early gastric cancer (EGC; 83.9%) and 5 had advanced gastric cancer. Ten (38.5%) of the 26 EGC cases were managed using endoscopic mucosal resection. Compared to colorectal cancer patients without synchronous gastric cancer, the group of patients with synchronous gastric cancer was older (65.5 ± 9.6 vs 58.4 ± 11.3 years, p = 0.001) and had a greater proportion of males (77.4 vs 59.4%, p = 0.043). Conclusion This study found that 2% of Korean sporadic colorectal cancer patients had synchronous gastric cancer. A preoperative EGD for colorectal cancer patients is likely to greatly assist in the diagnosis of synchronous gastric cancer at an early stage and the implementation of appropriate minimally invasive treatment. Presented at the Tenth Congress of Asian Federation of Coloproctology, Singapore, March 24–26, 2005.     

Influential factors in procedure time of endoscopic submucosal dissection for gastric cancer with fibrotic change

Background: Factors correlating with the technical difficulty of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) are still unclear. EGC coexisting with fibrosis inside lesions has been a common therapeutic indication for ESD. The aim of this study was to clarify the most important factor related to difficult ESD for EGC. Patients and Methods: Fifty‐six patients (49 male and seven female, median age 66 years) who received ESD at a single institute for EGC with fibrosis in the resected lesion were selected. Various clinicopathological factors, including the histological findings of fibrotic changes within the cancer area in the resected specimen, were evaluated statistically for correlation with ESD procedure time. Results: Univariate linear regression analysis with logarithmic ESD procedure time revealed the upper‐third portion of lesion in the stomach (P = 0.02), histological classification of dense fibrosis (ulcer/ulcer scar‐III/IV) within EGC (P < 0.001), and presence of peptic ulcer other than EGC (P = 0.04). Areas of the resected specimen (P < 0.001) and fibrosis (P < 0.001) were significant factors related to prolonged operation times. Multivariate analysis demonstrated that the upper‐third portion of lesion (P = 0.007), ulcer/ulcer scar‐III/IV findings (P = 0.006), and area of resected specimen (P = 0.006) were significant independent factors influencing ESD procedure time. Conclusion: Histological findings of fibrotic changes coexisting with EGC are closely related to technical difficulty in ESD as well as the location of tumors. Preoperative precise evaluation of fibrotic changes within EGC may be helpful to predict a technical difficulty in ESD.     

Analysis of CYP2E1 polymorphism for the determination of genetic susceptibility to gastric cancer in Koreans

BACKGROUND: Interindividual genetic differences in susceptibility to chemical carcinogens are among the most important host factors in human cancer. The present study was undertaken to reveal the association between the polymorphism of CYP2E1 (CYP2E1/PstI and CYP2E1/DraI) with genetic susceptibility to gastric cancer development in Koreans. METHODS: In the present study, 120 gastric cancer patients and 145 controls with no history of tumors were analyzed. CYP2E1 was determined by polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP), or PCR and direct gel electrophoresis. RESULTS: The overall genotype distribution of CYP2E1 was not significantly different from that of controls. However, the genotype distribution of the patient subgroups with a history of heavy cigarette smoking (>30 pack/year) in the CYP2E1/PstI and CYP2E1/DraI polymorphisms were significantly different from those of non-smoking patients (P = 0.0122 and P = 0.0029, respectively). The difference was also noticeable in the younger patient subgroup (aged 相似文献   

胃癌及良性胃病患者血和胃粘膜细胞内维生素的变化

目的 进一步评价维生素在胃癌发生中的变化,为维生素防治胃癌提供理论依据。 方法 以微量生化法检测胃癌、萎缩性胃炎、胃溃疡外周静脉血,供癌或溃疡灶动静脉血,手术切除胃癌标本各部位粘膜细胞内,内镜下活检粘膜组织细胞内维生素A,C,E及β-胡萝卜素的含量。 结果 胃癌与胃溃疡外周血清4种维生素含量均低于常人(P<0.01),供癌灶动静脉血中β-胡萝卜素含量之差明显大于供良性溃疡灶者(P<0.01),胃癌者静脉血中维生素C含量高于动脉血。而良性溃疡则相反;胃癌手术标本粘膜细胞内4种维生素的含量基本上按癌区→癌旁→外周正常区顺序递增,萎缩性胃炎活检胃粘膜细胞内4种维生素含量高于大体标本中类似病理改变的粘膜细胞。 结论 胃癌的发生发展中4种抗氧化维生素,尤其是β-胡萝卜素有代谢异常。     

Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer

AIM: To evaluate the association between of the interleukin-10 (IL-10) promoter polymorphisms and survival of advanced gastric cancer (GC) patients. METHODS: The IL-10 (-1082, rs1800896; -819, rs1800871; and-592, rs1800896) genotypes in 234 patients with advanced gastric cancer and in 243 healthy controls were determined by polymerase chain reaction-restriction fragment length polymorphism assay. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by unconditional logistic regression for the ...     

Helicobacter pylori epidemiology in relation to peptic ulcer and gastric cancer in South and North China

Abstract Peptic ulcer disease is twice as common in people living in South China when compared with those in North China. However, the gastric cancer rate in North China is three times that of South China. The overall Helicobacter pylori prevalence rate is similar in North and South China populations and it is higher than Caucasians living in Western societies. However, there is a significantly higher prevalence of H. pylori seropositivity among those who live in the high gastric cancer areas of China. On the other hand, there is no significant difference in the H. pylori positive rate in the peptic ulcer disease patients between the two regions of China. Other permissive/associated co-factors in the development of peptic ulcer disease or gastric cancer remain unknown at this stage.     

肺癌患者白介素1受体拮抗剂基因多态性的研究

目的 对肺癌患者和健康人的白介素1受体拮抗剂基因(interleukin-1 receptor antagonist gene,IL-1RN)多态性进行研究,探讨IL-1RN与肺癌易感性的关系.方法 采用聚合酶链式反应技术对148例肺癌患者和150名健康对照者的IL-1RN基因多态性进行分析.结果 Ⅱ类等位基因(IL-...     

Association between interleukin-1 gene polymorphisms and Helicobacter pylori infection in gastric carcinogenesis in a Chinese population

BACKGROUND AND AIM: Helicobacter pylori is a major cause of chronic gastritis and peptic ulcer disease and a definite carcinogen for gastric adenocarcinoma. However, the underlying pathogenic mechanisms are not fully understood. Interleukin-1 (IL-1) is a key cytokine involved in H. pylori-induced gastric inflammation. The present study aimed to determine polymorphisms of IL-1B and IL-1 receptor antagonist (IL-1RN) genes and their association with H. pylori infection and gastroduodenal diseases in Chinese patients. METHODS: Three hundred and ninety-nine patients with gastroduodenal diseases (129 chronic gastritis, 127 duodenal ulcer and 143 non-cardiac gastric cancer) and 264 healthy controls were genotyped for IL-1B-511 and IL-1RN gene polymorphisms by the PCR-RFLP method. H. pylori infection status was determined by a validated serological test. RESULTS: The frequency of IL-1B-511 T allele was significantly higher in H. pylori positive patients with non-cardiac gastric cancer than in both H. pylori negative patients with non-cardiac gastric cancer (60%vs 46%, P = 0.0342, OR = 1.666, 95% confidence interval [CI]: 1.045-2.656) and in healthy controls (60%vs 48%, P = 0.0071, OR = 1.665, 95%CI: 1.149-2.412). However, the polymorphism was not associated with chronic gastritis and duodenal ulcer. Multivariate logistic regression analyses identified that IL-1B-511 T/T carrier status was an independent risk factor for non-cardiac gastric cancer in the presence of H. pylori infection (adjusted OR = 3.01, 95%CI: 1.27-7.11, P = 0.01), and the frequency of IL-1B-511 T allele was an increased risk factor for developing gastric cancer (P = 0.03, adjusted OR = 2.29, 95%CI: 1.08-4.86). There was no association between IL-1RN gene polymorphisms and H. pylori infection and other gastroduodenal diseases. CONCLUSION: IL-1B-511 T allele is associated with H. pylori infection in non-cardiac gastric cancer in a Chinese population. The IL-1B-511 gene polymorphism appears to play an important role in gastric carcinogenesis in Chinese patients with H. pylori infection.