周边型牙源性纤维瘤21例临床病理回顾

目的 回顾周边型牙源性纤维瘤的临床病理特点.方法 按WHO(2017)牙源性肿瘤分类标准对21例周边型牙源性纤维瘤的临床病理资料进行回顾性分析.结果 在21病例中,男性7例,女性14例;平均年龄27岁;上颌牙龈8例,下颌牙龈13例.肿块为局部软组织突出表现.X线片和手术中见3例牙槽骨有吸收改变.5例术后复发.组织学上,...     

周边型牙源性纤维瘤35例临床病理研究

目的：总结周边型牙源性纤维瘤的临床病理特点。方法：按ＷＨＯ（１９９２）牙源笥肿瘤分类标准对３５例周边型牙源性纤维瘤的临床病理资料进行回顾性分析。结果;３５例中,男性１４例,女性２１例;平均年龄３１岁;上颌牙龈１４例,下颌牙龈２０例。肿块为局部软组织突出表现。Ｘ线片和手术中五例牙槽骨有吸怍改变。     

44例牙源性纤维瘤临床病理分析

目的 研究牙源性纤维瘤的临床病理特点。方法 按世界卫生组织（WHO）1992年牙源性肿瘤分类标准对44例牙源性纤维瘤的临床病理特点及生物学行为进行回顾性研究。结果 本组44例中,女31例,男13例。发病年龄2－70岁,平均29岁。中心型5例,周边型39例。上颌19例,下颌25例。X线及手术中见4例牙槽骨明显破坏。术后有4例复发。组织学上表现为WHO型39例、单纯型4例和牙源性颗粒细胞瘤1例。肿瘤无明显包膜,边界尚清。结论 牙源性纤维瘤不是单一性肿瘤,组织学上表现为WHO型、单纯型和牙源性颗粒细胞瘤。诊断时应与增殖性牙滤泡、粘液瘤等相鉴别。     

外周型牙源性纤维瘤伴牙齿吸收1例

本文报告罕见的牙龈增生伴牙齿吸收的病例 ,其临床特点为牙龈外生性肿块 ,其病理检查表现以增生活跃的纤维结缔组织中有散在的牙源性上皮为特点 ,诊断为外周型牙源性纤维瘤。本刊审校编委认为 :本病例不是一种新类型的牙龈病 ,而是“牙本质—骨化纤维瘤”。因病例罕见 ,本刊特予发表并附组织学照片 ,供有兴趣的专家、读者讨论     

下颌骨中心性牙源性纤维瘤1例

<正>牙源性纤维瘤是一类来源于牙源性间叶组织的良性肿瘤,临床上极为少见,组织病理上牙源性纤维瘤由大量的胶原纤维构成,牙源性上皮细胞构成的上皮岛和上皮条索分布其间,组织内可能含有类似于发育异常的牙本质、发育不良的牙骨质及骨样物质所构成的钙化物。中心性牙源性纤维瘤是一种发生于颌骨中心性的良性肿瘤,我科曾收治1例发生于下颌骨的中心性牙源性纤维瘤,现报告如下。     

中心性牙源性纤维瘤1例报告

中心性牙源性纤维瘤是一类非常少见的良性肿瘤,主要来自于形成上皮的间叶组织,由大量的胶原纤维构成,牙源性上皮细胞构成的上皮岛和上皮条索分布其间,组织内可能含有类似于发育异常的牙本质,发育不良的牙骨质及骨样物质所构成的钙化物。     

外周性牙源性纤维瘤和外周性骨化性纤维瘤的临床病理研究

本文对外周性牙源性纤维瘤(POF—WHO型)和外周性骨化性纤维瘤(POF)的临床表现和组织形态特点进行比较研究,发现两者尽管均为发生于牙龈的局限性肿块,但POF的溃疡发生率和复发率均显著高于POF—WHO型。POF—WHO型纤维母细胞主质中散在多少不一的牙源性上皮团和发育不良牙本质等多种钙化物,属外周性牙源性肿瘤。而POF的纤维结缔组织中硬组织则以骨和牙骨质样物质多见,无牙源性上皮,但其纤维母细胞与邻近牙齿的牙周韧带主纤维束相移行,因而认为是一种与牙周膜有关的反应性,增生性瘤样病变。     

骨外型牙源性钙化上皮瘤

骨外型牙源性钙化上皮瘤极为罕见,通过复习1966～2011年英文MEDLINE与1994～2011年中文CHKD中收录的文献,仅有37例骨外型牙源性钙化上皮瘤的个案报告。根据上述资料分析,发现该瘤具有以下临床特点,就诊年龄3～71岁,平均35.8岁;男13例,女19例,男女比例为1∶1.46;肿块直径0.5～4 cm,平均1.76 cm;好发部位主要是牙龈,累及下颌与上颌牙龈的比例为1∶1;组织学特征表现与骨内型牙源性钙化上皮瘤基本相同;复发率为5.4%。因该瘤具有浅表骨侵蚀能力,应行完整的肿瘤切除结合骨面刮治术。     

成釉细胞纤维瘤的临床特点和病理分析

成釉细胞纤维瘤由类似牙板和成釉器的牙源性上皮条索和类似牙乳头的牙源性外胚间充质组成,但没有成牙本质细胞,不含牙釉质和牙本质等牙齿硬组织,是一种真性、混合性牙源性良性肿瘤.     

Peripheral Odontogenic Myxoma: A Review of the Literature and Report of Two Cases

Two cases of peripheral odontogenic myxoma with a verifiable location in gingival soft tissue and without bone involvement were compared with those reported in the literature. This study showed that they form a distinct albeit rare clinical entity with a potential to grow into large disfiguring lesions. The probability that small peripheral odontogenic myxomas are interpreted as edematous irritation fibromas may contribute to the small number of peripheral odontogenic myxomas recorded in the literature. The differential diagnosis of soft tissue myxoid proliferations is discussed.     

Small Central Odontogenic Fibroma Mimicking Hyperplastic Dental Follicle and Dentigerous Cyst

Central odontogenic fibroma has been defined as a benign odontogenic tumor, representing the intraosseous counterpart of a peripheral odontogenic fibroma. The odontogenic fibroma is a rare tumor. Differential diagnosis of radiolucent lesions in the molar-premolar region of mandible which involve impacted tooth may include central odontogenic fibroma, hyperplastic dental follicle, dentigerous cyst, unicystic ameloblastoma, and keratocystic odontogenic tumor. We describe an example of a small central odontogenic fibroma mimicking hyperplastic dental follicle and dentigerous cyst, resulting in uneruption of a primary tooth.     

牙骨质-骨化纤维瘤X线分析

目的 总结牙骨质—骨化纤维瘤的X线表现特点。方法 对1977—2002年华西口腔医学院收治的21例牙骨质—骨化纤维瘤病例的X线片进行回顾性分析。结果 牙骨质—骨化纤维瘤的X线表现特点为①多发于下颌骨前磨牙及磨牙区。②形态较为规则，边界清楚，部分周缘可有致密骨壁线。③病变区密度不均匀，为放射透光区与阻射区混杂存在。④病变区膨胀及相关牙受压移位明显，而牙根吸收不明显，病变区内可含牙。⑤发生于下颌的单囊性病变：位于牙根下方，呈圆或类圆形，根尖下方有不规则的致密团块影，病变周围有致密骨壁线。结论 通过对牙骨质—骨化纤维瘤X线表现的分析可以为其临床诊断及手术方式的选择提供一定的依据。     

牙源性始基瘤1例

牙源性始基瘤是颌面部罕见的良性牙源性肿瘤。本文报道1例牙源性始基瘤,并结合文献探讨其临床病理特征及治疗原则。     

成釉细胞纤维瘤与成釉细胞纤维肉瘤

目的:观察成釉细胞纤维瘤(ameloblastic fibroma, AF)及成釉细胞纤维肉瘤(ameloblastic fibrosarcoma, AFS)的间质成份,探讨其与临床生物学行为的关系。方法:14例肿物(AF 11例,AFS 3例)切片经HE染色,光镜下观察,5例新鲜标本(AF 3例,AFS 2例)取材后电镜观察。结果:11例AF中有3例复发,复发率为2713%,复发时间分别是术后半年、1年、10年。3例AFS中1例为原发,2例为AF恶变而来。组织病理学显示AF中成釉细胞上皮成分散布于富含纤维粘液样结缔组织中,间质成分主要为成纤维细胞,此外,可见组织样细胞和纤维组织样细胞及少量未分化间叶细胞。AFS中间质成纤维细胞密集增生,胞核浓染,核浆比例失调有明显异型性,其中2例成釉细胞上皮成份明显减少或缺如。结论:AF间质细胞具有一定的增殖活性,经各种刺激可恶变为AFS。AFS中的上皮减少和缺如可与间质细胞的过度增生恶变有关。AFS间质的细胞具有明显的恶性特征。     

Odontogenic fibroma like lesions: Clinico-pathological considerations

Radiographically enlarged dental follicle is observed in many cases associated with delayed tooth eruption. Pericoronal radiolucencies are seen in neoplasms (odontogenic fibroma), developmental anomalies (regional odontodysplasia), hamartomatous lesions (odontogenic epithelial hamartoma), opercula of third molars, in follicles associated with unerupted third molars, regional odontodysplasia, in dental follicles around impacted teeth of enamel dysplasia with hypodontia syndrome and amelogenesis imperfecta cases with multiple impactions. Interestingly, operculum and the follicle of these lesions histopathologically are identical to odontogenic fibroma (WHO) type. However, the lack of universally accepted clinic-pathological features for such lesions may hinder their recognition. We report a case of regional odontodysplasia wherein (in which) the impacted canine is surrounded by radiolucency measuring about 1.5–2 cm, histopathologic examination of the excised opercula revealed features reminiscent of central odontogenic fibroma (WHO type) with an abundance of odontogenic epithelium and calcifications. The aim of this paper is to discuss various lesions exhibiting histopathological features similar to odontogenic fibroma, as awareness of the clinicopathological features of such lesions is very important to plan proper treatment.     

A Case Report of Cemento-Ossifying Fibroma

The concept of ‘fibro-osseous lesions’ of bone evolved over the last several decades to include two major entities: fibrous dysplasia and ossifying fibroma as well as the other less common lesions such as florid osseous dysplasia, periapical dysplasia, focal sclerosing osteomyelitis, proliferative periostitis of garrie and ostitis deformans. The cemento-ossifying fibroma is a central neoplasm of bone as well as periodontium which has caused considerable controversy because of confusion of terminology and criteria of diagnosis. The cemento-ossifying fibroma is odontogenic in origin where as ossifying fibroma of bony origin. This article reports a case of an 11-year-old male who came to us with the history of swelling at the maxillary anterior region causing difficulty in closing of mouth as well as mastication.     

牙源性角化囊肿的手术治疗：保守性或根治性方法

牙源性角化囊肿（odontogenic keratocyst，OKC）因其侵袭性行为、组织学和遗传学方面的新发现，在WHO的分类中已命名为牙源性角化囊性瘤（keratocystic odontogenic tumour，KCOT）。本文复习了这种病变的生物学特点，并结合笔者的研究经验和相关文献资料分别介绍保守性和根治性治疗策略。