Reliability and validity of dermatology life quality index： assess- ment of quality of life in human immunodeficiency virus/acquired immunodeficiency syndrome patients with pruritic papular erup- tion

OBJECTIVE： To test the reliability and validity of dermatology life quality index（DLQI） in simplified Chinese language by assessing the quality of life（QoL） in HIV（human immunodeficiency virus）/AIDS（Acquired immunodeficiency syndrome） patients with pruritic papular eruption（PPE）. METHODS： A study of simplified-Chinese-versiond from10 questions with the principal component analysis and the contribution rate of the 3 common factors was 59.95%. CONCLUSION： The simplified-Chinese-version DIQL is an acceptable and valid scale for HIV/AIDS patients with PPE. It can be used to evaluate the QoL of HIV/AIDS patients with PPE in China.     

Efficacy and safety of Traditional Chinese Medicine for the treatment of acquired immunodeficiency syndrome: a systematic review

Objective

To systematically review the efficacy and safety of Traditional Chinese Medicine (TCM) interventions, compared with control interventions (placebo or conventional Western medical therapy), in the treatment of acquired immunodeficiency syndrome (AIDS).

Methods

Electronic databases including PubMed, the Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang Data were searched to identify relevant randomized controlled trials (RCTs) published as of May 2012. Studies were selected according to the specified inclusion and exclusion criteria and then subjected to methodological quality assessment, data extraction, and meta-analysis according to the Cochrane Handbook for Systematic Reviews of Interventions.

Results

Twelve RCTs involving 881 patients with AIDS were included. Methodological quality assessment showed that two were high-quality, two were moderate-quality, and eight were low-quality. Meta-analysis showed that TCM interventions were associated with significantly reduced plasma viral load compared with placebo [odds ratio OR=2.46, 95% confidence interval CI (1.02, 5.94); P=0.04]. However, the reductions in plasma viral load significantly favored conventional Western medical therapy alone over integrated traditional Chinese and Western medical therapy [OR=0.16, 95% CI (0.05, 0.55); P=0.004]. Patients receiving TCM interventions had significantly higher CD4 + T lymphocyte counts compared with those on placebo [OR=2.54, 95% CI (1.40, 4.60); P=0.002]. In addition, TCM interventions were significantly more likely to have improved clinical symptoms [OR=2.82, 95% CI (1.85, 4.31); P < 0.00001]. TCM interventions conferred a similar risk of adverse events (AEs) compared with control interventions [OR=1.87, 95% CI (0.58, 6.01); P=0.29].

Conclusion

Current evidence suggests that TCM interventions are significantly more effective than placebo in reducing plasma viral load and increasing CD4+ T lymphocyte count in patients with AIDS. When compared with conventional Western medical therapy, TCM interventions were significantly less effective in reducing plasma viral load, although they were associated with a higher percentage of patients with improved symptoms. Patients receiving TCM interventions did not seem to be at an increased risk of AEs.     

Traditional Chinese Medicine etiology and pathogenesis of acquired immune deficiency syndrome in simian immunodeficiency virus-infected Chinese rhesus macaques

Objective

To investigate the traditional Chinese Medicine (TCM) etiology and pathogenesis of acquired immune deficiency syndrome (AIDS) by 18-month observation of Chinese rhesus macaques infected with simian immunodeficiency virus (SIV) mac₂₃₉.

Methods

Thirty-five healthy Chinese rhesus macaques were divided into a model group (n=30) and a control group (n=5). The model was established by inoculating monkeys intravenously with SIVmac₂₃₉. Changes in TCM symptoms after SIV infection within 18 months were then observed and recorded. Routine blood tests, SIV viral load, T-lymphocyte subsets, plasma triiodothyronine (T₃), tetraiodothyronine (T₄), adrenocorticotropic hormone (ACTH) and Cortisol (Cor) were tested periodically during the experiment.

Results

During the acute infection period of SIV, model monkeys temporarily showed clinical symptoms such as diarrhea, dysphoria and slight weight loss. Decrease percentages of CD4⁺ T-lymphocytes were observed but levels of T₃, T₄, Cor, and ACTH were relatively unchanged. Monkeys in the model group during the early and middle periods of infection showed no obvious symptoms, except few monkeys exhibited transient diarrhea and reduced food intake. All variables at this stage showed normal fluctuations. In the middle period model group monkeys showed chronic and persistent diarrhea, weight loss, reduced food intake and low levels of T₃ and Cor. In the late period, symptoms including emaciation, weight loss, listlessness, crouching in corners and low levels of T₃ appeared.

Conclusion

The results suggest that the rhesus monkey SIV/SAIDS model can be applied to research on TCM etiology and pathogenesis of AIDS. According to this model, the etiology of disease is the SIV virus. The pathogenesis manifests as the invasion of SIV virus, incubation of the virus, balance between virus and healthy “Qi”, damage to spleen and kidney as the disease progressed, exhaustion of vitality and finally the failure of five zang and six fu organs.     

病毒性心肌炎患者生活质量量表的信度与效度研究

目的:对条目筛选后形成的病毒性心肌炎患者生活质量量表的信度、效度进行考评。方法:使用病毒性心肌炎患者生活质量量表对100例临床诊断为病毒性心肌炎的患者和100名健康志愿者分别进行调查,以t检验、相关分析、Cronbach,sα系数、因子分析、多元逐步回归分析等方法考评量表的信度与效度。结果:本量表具有较好的重测信度、分半信度、同质性信度,提示量表具有较好的稳定性和精确性,量表条目的内部一致性可。同时量表具有较好的内容效度和区分效度,总体结构效度与研究者对量表构想结构基本相符,提示量表具有较高的准确性和有效性。结论:本量表具有较好的信度、效度,可作为病毒性心肌炎患者生活质量的评价工具,并可以补充用于中西医结合治疗病毒性心肌炎的疗效评价体系。     

类风湿关节炎患者生活质量调查分析

目的:评价贵阳市区就诊类风湿关节炎(RA)患者生活质量。方法:以本院就诊的门诊和住院RA患者为研究对象,采用生活质量表进行问卷调查。结果:258例RA患者中,生活质量总积分值最高值111分,最低分41分,平均(75.93±15.28)分,生活质量比较差占45.59%,生活质量很差者占6.82%。生活质量总积分在不同的性别、年龄及病程RA患者间无统计学意义。结论:贵阳地区就诊RA患者生活质量普遍较差,生理功能受损最严重。     

升阳益胃汤加减对腹泻型肠易激综合征患者疗效及生活质量的影响

目的 观察升阳益胃汤加减对腹泻型肠易激综合征(IBS-D)患者临床疗效及生活质量的影响.方法 选择IBS-D患者80例随机分为两组,治疗组给予升阳益胃汤加减治疗,对照组用西药常规治疗,疗程均为4周.观察患者治疗后临床疗效,并采用国际通用SF-36生存量表对患者治疗前后的生活质量进行评估.结果 治疗组总有效率为85.0％,对照组总有效率为65.0％;治疗组在SF-36量表中躯体疼痛、总体健康、社会功能、精神健康方面的积分均有明显提高(P＜0.05),并且优于对照组(P＜0.05).结论 升阳益胃汤加减不仅能够改善IBS-D患者症状,并且可提高患者的生活质量.     

病毒性心肌炎患者生活质量量表的反应度测评

目的:评价病毒性心肌炎患者生活质量量表的反应度。方法:使用病毒性心肌炎患者生活质量量表对50例临床诊断为病毒性心肌炎的患者分别进行治疗前后的调查,从患者治疗前后生活质量量表得分变化和效应尺度两方面考察量表的反应度。结果:患者生活质量量表的生理维度、心理维度、社会维度得分和总分在治疗后均较治疗前提高,且差异有统计学意义(P0.01)。生理维度、社会维度和总量表的效应尺度在0.52-0.65之间,心理维度的效应尺度为0.37。结论:病毒性心肌炎患者生活质量量表具有较好的反应度,可以利用该量表进行病毒性心肌炎的疗效评价。     

益气养阴方对晚期恶性肿瘤化疗患者生活质量的影响

目的：评价中药益气养阴方对改善晚期恶性肿瘤化疗患者生活质量的影响。方法：将60例晚期恶性肿瘤化疗患者按照随机对照的方式分为两组,对照组和观察组各30例。对照组予常规化疗,观察组在常规化疗的基础上予中药益气养阴方煎服,1剂/日,2周为1个疗程。比较观察组在服用中药8周后与对照组在生活质量改善效果及EORTC QLQ-C30生活质量评分等方面的差异。结果：治疗后两组生活质量改善效果比较差异有统计学意义（P〈0.05）,且治疗后在EORTC QLQ-C30生活质量评分方面观察组均较对照组有统计学差异（P〈0.05）。结论：中药益气养阴方能显著提高患者EORTC QLQ-C30生活质量评分,从而起到改善晚期恶性肿瘤化疗患者生活质量的作用。     

Correlation between lower gastrointestinal tract symptoms and quality of life in patients with stable chronic obstructive pulmonary disease

OBJECTIVE： To explore correlations between the symptoms of constipation and abdominal distention and severity of chronic obstructive pulmonary disease（COPD） in patients with stable disease.METHODS： We studied 191 patients with stable COPD（according to defined criteria） in this cross-sectional study from four three-level class A Chinese medicine hospitals in China. We built an Epidata 3.0 database and performed statistical analysis with SPSS, version 17.0. We analyzed correlations between the frequency of lower gastrointestinal tract symptoms（constipation and abdominal distention） and scores for major pulmonary symptoms（cough, sputum and wheezing） based on the St. George＇s Respiratory Questionnaire（SGRQ）,6-minute walking distance（6MWD） and frequency of acute exacerbations of COPD（AECOPD）.RESULTS： In addition to their pulmonary symptoms, 39.79% and 40.31% of study patients withstable COPD reported constipation and abdominal distention, respectively. Scores for major pulmonary symptoms（cough, sputum and wheezing）, AECOPD and SGRQ values in patients with constipation and abdominal distention were significantly greater, and the 6MWD markedly shorter, than in those without them. According to Pearson＇s correlation analysis, there were strong correlations between these lower gastrointestinal tract symptoms and scores for pulmonary symptoms, SGRQ, 6MWD and AECOPD.CONCLUSION： Lower gastrointestinal tract symptoms such as constipation and abdominal distention can adversely affect pulmonary symptoms, frequency of acute exacerbations and quality of life in patients with stable COPD.     

脊髓损伤致截瘫病人生存质量与家庭支持的相关性研究

目的：探讨脊髓损伤致截瘫病人生存质量与家庭支持的相关性。方法采用MOS—SF36、SSRS量表对25例脊髓损伤致截瘫病人进行调查。结果：生存质量与家庭支持的关系总分及各因子评分呈正相关系,差异有显著性（rT=0．227、rI=0．109、rS=0．226、rU=0．194;P〈0．05）。配偶健在的患者家庭支持总分高于离婚或丧偶者（F=21．202,〈0．01）。患者文化程度越高获得的家庭支持总分也越高（F=2．786,〈0．01）。结论：脊髓损伤致截瘫病人的家庭支持可提高其生存质量。     

脊髓损伤致截瘫病人生存质量与家庭支持的相关性研究

目的探讨脊髓损伤致截瘫病人生存质量与家庭支持的相关性。方法采用MOS—SF36、SSRS量表对25例脊髓损伤致截瘫病人进行调查。结果生存质量与家庭支持的关系总分及各因子评分呈正相关系,差异有显著性（rT=0．227、rI=0．109、rS=0．226、rU=0．194;P〈0．05）。配偶健在的患者家庭支持总分高于离婚或丧偶者（r=21．202,〈0．01）。患者文化程度越高获得的家庭支持总分也越高（F=2．786,〈0．01）。结论脊髓损伤致截瘫病人的家庭支持可提高其生存质量。     

针灸结合康复训练对中风偏瘫后遗症患者康复效果和生活质量影响研究

目的:研究针灸结合康复训练对中风偏瘫后遗症患者康复效果和生活质量的影响。方法:研究对象选取我院2017年10月-2018年10月间收治的中风偏瘫后遗症患者88例,采用随机数字法将其分为对照组和观察组,每组各44例。对照组给予常规治疗,观察组在常规治疗的基础上进行针灸结合康复训练,每周5次,治疗4周。比较两组患者的康复效果、生活质量和患者下肢的表面肌电值(iEMG)。结果:治疗后,观察组的神经功能缺损评分(Neurological Deficit Scale,NDS)明显低于对照组(P<0.05),观察组的功能综合评分(Functional Comprehensive Assessment,FCA)、四肢简化Fugl-Meyer评分及日常生活活动能力评分(Activity of Daily Living,ADL)均明显高于对照组(P<0.05)。治疗后观察组患者的iEMG值均显著高于对照组(P<0.05)。结论:针灸结合康复训练治疗中风偏瘫后遗症的临床疗效显著,能提高患者的康复效果和生活质量,值得在临床推广。     

综合护理干预对慢性肺源性心脏病患者不良心理及生活质量的影响

目的观察综合护理干预对慢性肺源性心脏病（以下简称慢性肺心病）患者不良心理及生活质量的影响。方法将72例慢性肺心病患者随机分为2组,对照组36例接受常规护理,干预组36例接受综合护理干预。采用汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）检测患者的不良心理情况,采用生活质量量表评定患者的生活质量。结果对照组和干预组均能降低HAMD、HAMA得分,改善患者的日常生活能力和社会活动能力（P〈0．01,P〈0．05）,干预组优于对照组（P〈0．01）。结论综合护理干预可显著改善慢性肺心病患者的不良心理并提高患者的生活质量。     

Correlation between lower gastrointestinal tract symptoms and quality of life in patients with stable chronic obstructive pulmonary disease

Objective

To explore correlations between the symptoms of constipation and abdominal distention and severity of chronic obstructive pulmonary disease (COPD) in patients with stable disease.

Methods

We studied 191 patients with stable COPD (according to defined criteria) in this cross-sectional study from four three-level class A Chinese medicine hospitals in China. We built an Epidata 3.0 database and performed statistical analysis with SPSS, version 17.0. We analyzed correlations between the frequency of lower gastrointestinal tract symptoms (constipation and abdominal distention) and scores for major pulmonary symptoms (cough, sputum and wheezing) based on the St. George's Respiratory Questionnaire (SGRQ), 6-minute walking distance (6MWD) and frequency of acute exacerbations of COPD (AECOPD).

Results

In addition to their pulmonary symptoms, 39.79% and 40.31% of study patients with stable COPD reported constipation and abdominal distention, respectively. Scores for major pulmonary symptoms (cough, sputum and wheezing), AE-COPD and SGRQ values in patients with constipation and abdominal distention were significantly greater, and the 6MWD markedly shorter, than in those without them. According to Pearson's correlation analysis, there were strong correlations between these lower gastrointestinal tract symptoms and scores for pulmonary symptoms, SGRQ, 6MWD and AECOPD.

Conclusion

Lower gastrointestinal tract symptoms such as constipation and abdominal distention can adversely affect pulmonary symptoms, frequency of acute exacerbations and quality of life in patients with stable COPD.     

温阳复元方对缺血性脑卒中患者运动功能及生存质量影响研究

目的: 探讨温阳复元方对缺血性脑卒中患者的疗效及对运动功能、生存质量影响。方法:选取缺血性脑卒中患者88例,采用随机数字表法分为对照组和观察组,各44例。对照组采取卒中病常规用药治疗,观察组在对照组基础上给予温阳复元方治疗。比较两组临床疗效,治疗前、治疗1个及两个疗程后中医证候积分、神经功能、运动功能、生活自理能力、脑血流动力及生存质量情况。结果:观察组1个疗程、两个疗程后中医证候积分、FMA评分、Barthel指数、QOL-BREF评分均高于对照组、NIHSS评分均低于对照组(P<0.05); 两个疗程后,观察组R水平低于对照组,DR及Vmin均高于对照组(P<0.05); 观察组总有效率93.18%高于对照组72.73%(P<0.05)。两组患者治疗期间均未发生明显的药物不良反应情况(P>0.05)。结论:温阳复元方可显著改善缺血性脑卒中患者运动功能和生活活动能力,提高生存质量,临床疗效确切,未见明显不良反应。     

全面护理干预对甲状腺功能亢进患者心理情绪及生活质量的影响分析

目的:分析全面护理干预对甲状腺功能亢进患者心理情绪及生活质量的影响。方法:选取2018年1月-2018年12月莒南县中医医院诊治的108例甲状腺功能亢进患者资料,随机分两组,对照组54例行常规护理,研究组54例行全面干预护理,比较两组护理前后的焦虑自评量表(Self-Rating Anxiety Scale,SAS)评分和抑郁自评量表(Self-Rating Depression Scale,SDS)评分,以及生活质量、满意度。结果:护理后,研究组SAS(42.21±4.29)分和SDS(39.18±3.06)分低于对照组;研究组社会功能(24.88±1.39)分、躯体功能(23.05±1.93)分等生活质量优于对照组,比较差异明显具统计学意义(P <0.05);且研究组满意度94.44%(51/54)高于对照组74.07%(40/54),比较差异明显具统计学意义(P <0.05)。结论:甲状腺功能亢进患者采取全面护理干预措施,可缓解患者不良情绪,提高患者满意度,为患者打造较高的生活质量。     

探讨氨磺必利与氯氮平对以阴性症状为主的精神分裂症的疗效及对生活质量的影响

目的:探讨氨磺必利与氯氮平对以阴性症状为主的精神分裂症的疗效及对生活质量的影响。方法:将2018年1月-2019年1月在清远市第三人民医院精神科治疗的65例以阴性症状为主的精神分裂症患者随机分为两组,对照组采用氯氮平治疗,观察组采用氨磺必利治疗,比较两组患者的临床疗效、阴性症状量表(SANS)评分变化。结果:观察组治疗总有效率为85.71%(30/35),明显高于对照组的66.67%(20/30)(P<0.05);观察组治疗12周后思维贫乏、意志缺乏、情感淡漠、注意障碍、兴趣社交缺乏等SANS评分明显低于对照组(P<0.05)。结论:氨磺必利对以阴性症状为主的精神分裂症的疗效更佳,能有效改善精神症状,提高生活质量,且不良反应发生率较低,具有积极的临床意义。     

胃食管反流病患者生存质量与反流相关症状、中医肝胃不和证症状相关性分析

目的 分析胃食管反流病患者生存质量与反流相关症状、中医肝胃不和证症状的相关性.方法 对确诊为胃食管反流病的患者分别测评其反流相关症状、中医肝胃不和证症状及患者生存质量,并采用直线相关的方法分析生存质量与反流相关症状、中医肝胃不和证症状的相关性.结果 胃食管反流病患者生存质量在生理职能、身体疼痛、社会功能、精神健康四个维...