Angiolymphoid Hyperplasia with Eosinophilia

Angiolymphoid hyperplasia has become a well-recognized entity in adults. Kimura's disease is a similar and possibly identical disease occurring in Oriental children. This is a case report of angiolymphoid hyperplasia with eosinophilia occurring in a 12-year-old Caucasian boy with elevated levels of serum IgE. The condition responded to intralesional triamcinolone. A brief review of the literature is presented and various modes of therapy are discussed.     

耳血管淋巴组织增生伴嗜酸细胞浸润3例

3例耳部及耳周围血管淋巴组织增生伴嗜酸细胞浸润患者,女2例,男1例,分别以左耳后、右耳后丘疹、结节,左耳屏及外耳道结节就诊。经病理学检查均诊断为:血管淋巴组织增生伴嗜酸细胞浸润。     

血管淋巴样增生伴嗜酸性粒细胞增多症1例

患者女,左侧耳廓周围出现丘疹结节伴瘙痒1年余,擦伤后破溃出血不止。病理活检示:表皮角化过度及棘层肥厚,真皮层上部有较多扩张的毛细血管,内皮细胞肿胀肥大突向管腔,血管周围见大量淋巴细胞、组织细胞及嗜酸粒细胞浸润,真皮中下部可见多处具有生发中心的淋巴样滤泡。诊断:血管淋巴样增生伴嗜酸粒细胞增多症。     

A Case of Angiolymphoid Hyperplasia with Eosinophilia of the Lower Eyelid

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a subcutaneous angioproliferating tumor with a characteristic inflammatory infiltrate that consists mainly of lymphocytes and eosinophils. A 24-year-old man presented with a firm single asymptomatic erythematous papule on the lower eyelid. Histopathological findings showed a proliferation of blood vessels lined with epithelioid cells and perivascular infiltration of lymphocytes and eosinophils. We report a case of ALHE occurring on an unusual site.     

妊娠后发生血管淋巴样组织增生伴嗜酸粒细胞增多1例

患者女,22岁。患者怀孕8周时右上肢出现多发性红色丘疹、结节。皮疹组织病理示:真皮内血管增生,内皮细胞肿胀,血管周围较多淋巴细胞、嗜酸粒细胞等浸润。诊断:血管淋巴样组织增生伴嗜酸粒细胞增多。     

男性乳头嗜酸性粒细胞增多性血管淋巴样增生1例

患者男,42岁。右侧乳头出现红色结节伴瘙痒3个月,无明显症状。皮损组织病理示:表皮大致正常,真皮内见大量增生的毛细血管,管腔不规则,毛细血管内皮细胞增生、肿胀,并向腔内突起,血管周围大量嗜酸性粒细胞及淋巴细胞浸润。诊断:嗜酸性粒细胞增多性血管淋巴样增生。     

Angiolymphoid Hyperplasia with Eosinophilia That Was Possibly Induced by Vaccination in a Child

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign vasoproliferative disease of an unknown cause involving the skin or subcutaneous tissue of the head and neck, and particularly around the ear. It predominantly affects Caucasian adults during the third and fourth decades and it very rarely occurs in children. We experienced a case of ALHE in a 2-year-old Korean boy who had a firm, pruritic, skin-colored, subcutaneous nodule on his right upper arm. The histopathological findings were compatible with ALHE and they showed prominent vascular changes with epitheloid or histiocytoid endothelial cells surrounded by inflammatory cells, including a large proportion of eosinophils. This unusual distribution of the lesion and the young age of the patient may be associated with vaccination.     

嗜酸性粒细胞增多性血管淋巴样增生

<正>患者,男,37岁。主诉:面部、耳垂、下颌出现丘疹、结节,偶伴痒6年。现病史:患者诉6年前无明显诱因面部、耳垂出现丘疹、结节,当地医院诊断为过敏性皮炎,予口服及外用药(具体不详)治疗,未见明显好转。随后下颌陆续出现数个斑块、结节,偶伴有瘙痒。为求进一步诊治来我院门诊就诊。患者起病以来,精神、胃纳、睡眠可,大、小便正常,体重无明显改变。既往史:无特殊,否认家族中有类似病史。     

木村病1例

患者男,58岁。右侧耳前部肿块10年。组织病理检查显示:真皮内血管及淋巴组织增生,可见淋巴滤泡样结构,并见大量嗜酸性粒细胞。诊断:木村病。     

Angiolymphoid hyperplasia with eosinophilia affecting the nail bed and underlying bone

A 69-year-old Japanese woman had a dark red, 1-cm nodule located in the nail bed of the middle toe of her right foot. An X-ray examination revealed an osteolytic lesion of the distal phalanx of the right middle toe. Histopathology showed a proliferation of blood vessels surrounded by epithelioid cells and an infiltration of many eosinophils and some inflammatory cells. There has been no recurrence after surgical excision of the skin lesion and the distal phalanx of the right middle toe.     

Angiolymphoid Hyperplasia with Eosinophilia Mimicking Multiple Cylindromas: A Rare Case Report

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare and idiopathic vascular disorder. It is characterized by red to brown papules and nodules, typically localized on the head and neck, particularly around the ear as singular or multiple lesions. Although ALHE is a benign disease, lesions are often persistent and difficult to eradicate. Young to middle age women are more commonly affected. The histological examination corresponds to a florid vascular proliferation with atypical endothelial cells surrounded by a lymphocytic and eosinophilic infiltrate. We describe an elderly male with multiple nodular lesions over the scalp mimicking cylindromas; the histological examination was consistent with ALHE.     

血管淋巴样增生伴嗜酸细胞增多1例

患者女, 34岁,右侧头皮起疹、轻痒 2年来诊。右侧头皮可见一约 3cm×6cm大小水肿性斑块,正常肤色,上有 5~6个孤立存在的黄豆大小结节,互不融合,无压痛。组织病理示:表皮角化不全,棘层肥厚,真皮血管扩张、充血,血管周围较多淋巴细胞、组织细胞及嗜酸性粒细胞浸润。诊断:血管淋巴样增生伴嗜酸细胞增多。予以复方倍他米松注射液局部封闭, 2月后皮损有所缩小。     

血管淋巴样增生伴嗜酸细胞增多1例

患者女,26岁,耳后头皮出现皮疹,无明显自觉症状6年。病理显示真皮内大量血管增生,周围淋巴及嗜酸性粒细胞浸润。     

Hiperplasia angiolinfoide con eosinofilia. Estudio clínico patológico de 9 casos

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare disease characterized by single or multiple angiomatous lesions typically located on the scalp and the face. We present a retrospective analysis of 9 cases of ALHE. The lesions appeared largely as multiple grouped papules or, in some cases, subcutaneous nodules, located mainly on the scalp, particularly around the ear. We also observed lesions in atypical locations, such as areas of the head other than the scalp, and the shoulder, neck, and forearm. At these sites the lesions had an atypical clinical appearance that made diagnosis difficult; this should be borne in mind in patients with single, well-delimited lesions with a vascular appearance and superficial ulceration or crusting. Surgery was the most common treatment in our series, and even though ALHE is considered a benign condition, recurrence was common.     

误诊为血管瘤的嗜酸性粒细胞增多性血管淋巴样增生

报告1例误诊为血管瘤的嗜酸性粒细胞增多性血管淋巴样增生。患者男,40岁。左耳廓及左耳后多发结节伴瘙痒8个月。皮肤科检查:左耳廓及耳后散在多个黄豆至蚕豆大暗红色结节,表面光滑,质硬,孤立不融合,可推动,无压痛,部分皮损表面结痂。皮损组织病理检查:真皮内血管增生,内皮细胞肿胀,向管腔突出,血管周围及胶原纤维间淋巴组织细胞和嗜酸性粒细胞浸润。诊断:嗜酸性粒细胞增多性血管淋巴样增生。     

Angiolymphoid hyperplasia with eosinophilia showing characteristics of Kimura's disease

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign condition affecting principally the head and neck region of young females. We describe a 42-year-old female patient of ALHE showing the typical changes of endothelial cells and features similar to Kimura's disease in histologic and immunohistochemical findings.