共查询到20条相似文献,搜索用时 78 毫秒
1.
2.
米非司酮联合甲基睾丸素治疗子宫肌瘤180例疗效观察 总被引:2,自引:0,他引:2
目的观察米非司酮联合甲基睾丸素治疗子宫肌瘤的临床效果。方法 180例子宫肌瘤患者每月月经第1~3天每晚睡前服用米非司酮12.5mg;甲基睾丸素5mg/次,每天1次,连服3个月。对比用药前后彩色B型超声下子宫及肌瘤大小变化情况,对比用药前后促卵泡生成激素(FSH)、黄体生成素(LH)、孕酮(P)、雌激素(E2)、雄激素(T)、催乳激素(PRL)等血清激素变化情况,并记录不良反应。结果 165例患者子宫及肌瘤体积均明显减小,与用药前比较差异有统计学意义(P〈0.05或P〈0.01);15例患者无明显改变,改为手术治疗。FSH、LH、E2、P水平均较用药前明显降低(P〈0.05),且肝肾功能无明显变化,不良反应轻微。结论 米非司酮联合甲基睾丸素可明显减轻子宫肌瘤患者症状,且无明显不良反应,值得临床推广应用。 相似文献
3.
去氢罗默碱的电合成1)伍家泉(彼迪药业有限公司,广洲开平529331)陈虹2)陈琪瑞3)庞开圻3)(武警医学院,天津300162)关键词电解还原;去氢罗默碱;阿朴菲阿朴菲类生物碱存在于某些植物中,其中许多具有抗癌、抗菌、抗帕金森氏综合征等生理作用〔1... 相似文献
4.
甲基睾丸素用于药物流产的临床研究 总被引:1,自引:0,他引:1
目的 探讨甲基睾丸素用于药物流产的临床效果。方法 将300例观察对象随机分为两组;每日早晚各服米非司酮25mg,连服3d,观察组同时加服甲基睾丸素10mg,每日3次,连服3d,两组于第4d早晨空腹服米索前列醇0.6mg。结果 观察组完全流产率96%,姐90%,具有显著差异;阴道流血量观察组比对照明显减少,两组有极显著差异;阴道流血时间观察组比对照组明显缩短,两组有极显著差异。结论药物流产同时加服甲 相似文献
5.
6.
报道了蛋白同化激素坦波龙的一种新合成方法,即采用国内易得的19-羟基-雄甾-4-烯-3,17-二酮为原料,经七步反应合成坦波龙,并对氧化、缩合和水解等反应条件进行了研究。 相似文献
7.
去氢骆驼蓬碱衍生物的合成和抗肿瘤活性研究 总被引:1,自引:0,他引:1
目的 合成去氢骆驼蓬碱衍生物并研究其抗肿瘤活性。方法 以去氢骆驼蓬碱为原料,在NaH催化下先用卤代烷烃对9位氮原子进行烷基化,然后用溴化苄将2位氮原子进行季铵化,得到一系列去氢骆驼蓬碱衍生物,用 MTT 法考察其对肿瘤细胞的抑制作用。结果 合成了6个新的去氢骆驼蓬碱衍生物,结构经1H-NMR、MS和红外光谱确证。与去氢骆驼蓬碱相比,所合成的化合物均有明显的抗肿瘤活性。结论 初步药理实验结果表明去氢骆驼蓬碱9-苯丙基取代能够明显提高抗肿瘤效果。 相似文献
8.
近年来米非司酮及米索前列醇联合应用终止早期妊娠因其痛苦小,损伤少,使用方便而广泛应用于临床。在获得满意的流产率同时,有相当部分患者在流产后有长时间的阴道淋漓出血,个别病人即使在诊刮后仍不能有效的止血。为提高药物流产成功率,解决药物流产后出血量多,持续时间长的问题。我院于1999年3月至12月给门诊自愿药物流产者早孕妇女50例服用甲基睾丸素,并与对照组50例对比,效果满意,现报道如下: 相似文献
9.
甲基睾丸素及其它甾体的HPLC测定 总被引:2,自引:0,他引:2
王伟民 《中国医药工业杂志》1995,26(6):258-261
以HPLC法测定甲基睾丸素及其它甾体,采用Shim-Pack ODS柱,甲醇-水(72:28)为流动相,炔诺酮为内标,检测波长为241或254nm。与TLC、UV法相比,本法简便、准确、可靠、重现性好。 相似文献
10.
11.
JAN IZDEBSKI DONALD YAMASHIRO CHOH HAO LI GIOVANNI VITI 《Chemical biology & drug design》1982,20(1):87-92
The synthesis of human γ-lipotropin by the solid-phase method is described. The synthetic product was characterized by Rf in partition chromatography on Sephadex G-50, paper electrophoresis, polyacrylamide gel electrophoresis, thin-layer chromatography, HPLC, end group determination, peptide mapping of a tryptic digest, and amino acid analyses of acid and enzymic digests. The synthetic material is identical to natural human γ-lipotropin when assayed against natural human β-lipotropin for lipolytic activity. 相似文献
12.
Abstract: In the present study, the effect of ethanol on central monoamine synthesis in developing and adult male rats was studied by measuring the accumulation of DOPA and 5–hydrotryptophan after inhibition of aromatic amino acid decarboxylase. Before adolescence, ethanol caused a decrease of DOPA accumulation in the whole rat brain, while after adolescence ethanol increased the DOPA synthesis. Ethanol had no effect on the serotonin synthesis at any of the ages studied. It is suggested that hormonal events occuring during puberty may be of importance for the stimulatory properties of ethanol observed at adult age 相似文献
13.
Oxygen-17 isotope was introduced into the α-carboxyl group of glycine, 1-phenylalanine, 1-leucine and 1-tyrosine by acid catalyzed exchange of 17O from H217O or by acid hydrolysis of respective amino acid methyl esters in H217O. Quantitative enrichment of glycine was achieved by acid hydrolysis of amino acetonitrile in H217O. For α-amino protection in amino acids t-butoxycarbonyl (Boc) group was employed for 17O labeled enkephalin synthesis. Five analogues of Leu-enkephalins (I–V) labeled with 17O at different amino acid residues were synthesized by solid phase method. 17O n.m.r. spectra were measured at 24.4 and 67.8 MHz for Leu-enkephalins 17O labeled at Gly2 and Phe4 positions. A downfield shift was observed for 17O labeled Gly2 Leu-enkephalin upon heating. This shift is indicative of the rupture of intramolecular hydrogen bonds. The preliminary results confirm the hypothesis that an intramolecular hydrogen bond exists between the carbonyl group of Gly2 and NH group of Leu5. 相似文献
14.
Background: Substances developed for therapeutic use are also known to be misused by athletes as doping agents and, outside of regulated sport, for image-enhancement. This has generated a market for counterfeit doping substances. Counterfeit doping agents may be of poor pharmaceutical quality and therefore constitute health risks to consumers. Objectives: This study aims to investigate the pharmaceutical quality of 1,190 doping products seized at the Swiss border. Methods: Swiss customs authorities seize incoming shipments potentially containing doping agents. Qualitative and semiquantitative analyses were performed in order to test for prohibited doping substances. The main analytical methods utilized for characterizing confiscated compounds were liquid chromatography-high resolution mass spectrometry, polyacrylamide gel electrophoresis with subsequent in-gel tryptic digestion and identification of peptidic compounds using nanoliquid chromatography-tandem mass spectrometry, and electrochemiluminescence immuno assay. Results: For 889 (75%) of the analyzed products, the label suggested the content of anabolic agents, for 146 samples (12%) peptide hormones or growth factors, and for 113 items (9%) antiestrogens, aromatase inhibitors or other metabolic modulators. For the majority of the investigated products, the pharmaceutical quality was an unsatisfactory standard: nonapproved substances were detected and less than 20% of the products contained the claimed substance in the respective amount. Conclusion: A comprehensive sample of confiscated doping products was analyzed, allowing for monitoring of developments regarding the use of doping substances in Switzerland and for anticipating future trends and challenges in sports drug testing. An alarming number of tested products was of substandard pharmaceutical quality. 相似文献
15.
16.
17.
18.
目的:以羟基黄体酮和一氯化碘为原料,合成17α-羟基-21-碘黄体酮。方法:设计正交试验考察溶剂体系、反应温度及原料配比对反应结果的影响,得到优化反应条件。结果:通过新的合成方法合成了目标产物。结论:最佳反应条件为:反应溶剂为水、反应温度为0~5℃、羟基黄体酮与一氯化碘摩尔比为1.0:1.0,粗品精制后收率98%以上。 相似文献
19.
M F Nesterin V M Budik R V Narodetskaia G I Solov'eva V G Stoianova 《Farmakologiia i toksikologiia》1980,43(5):597-601
The action of different doses and time of metandrostenolone administration on liver morphology and activity of the enzymes of blood serum, liver and pancreatic tissue was studied in experiments on male rats. It was established that metandrostenolone regardless of its dose and time of administration produces changes in enzymatic activity and in morphological characteristics, manifesting in hypertrophy of hepatocytes in modification of the cell size of the reticuloendothelium as well as in the magnitude and amount of nucleoli in the nucleus. The changes also involve impaired rhythmicity of RNA and glycogen synthesis by the liver. 相似文献