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1.
Shazia Anjum Manish Bathla Saminder Panchal Gurvinder Pal Singh Manpreet Singh 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(2):135-140
Introduction
Research in the last decade tried to focus on natural and unnatural causes of death in schizophrenic patients, but recent few years has focussed on emerging cardio-metabolic risk factors, as a cause of mortality in such patients.Aim of the study
To assess the determinant of metabolic syndrome in drug naïve schizophrenic patients.Methodology
It was a cross sectional study; 30 indoor patients with diagnosis of schizophrenia were included. Height, weight, waist circumference and Blood pressure assessment was done by using standard protocol. Fasting Blood Glucose (FBG), Triglyceride (TGs), High Density Lipoprotein (HDL) cholesterol, Low Density Lipoprotein (LDL) total cholesterol were measured. International Diabetes Federation (IDF) criteria was considered for establishing metabolic syndrome. Statistical analysis was done by using chi square and ANOVA.Results
Majority of the patients were females; hailing from rural area; unskilled professional; educated up to below primary level; were single and Hindu by religion. Most common metabolic abnormality was low HDL in 76.6%; High TGs in 26.6%; High SBP ≥130 mm Hg in 16.67%; DBP>85 mm Hg in 13.33%; High FBS 10% of the patients.In risk assessment strongest risk factors for metabolic syndrome were high waist circumference, FBS and TGs. BMI, total cholesterol, LDL and VLDL were also observed as a risk factors in drug naïve schizophrenic patients.Conclusion
HDL, FBS, TGs, waist circumference and BMI are all the strong risk factors for development of metabolic syndrome in drug naïve schizophrenia patients. 相似文献2.
Garland Castaneda Taft Bhuket Benny Liu Robert J. Wong 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(1):5-8
Aims
Better understanding risk factors for metabolic syndrome (MetS) will allow early targeted intervention to mitigate long term risk. We aim to determine the disparate impact of each individual MetS component on overall risk of developing MetS, stratified by sex, race/ethnicity, and age.Methods
Using data from the 2003–2014 National Health and Nutrition Examination Survey (NHANES), MetS prevalence among adults (age ≥18) was stratified by sex, race/ethnicity, age, and by individual MetS components (e.g. hypertension (HTN), diabetes mellitus (DM), waist circumference, serum high density lipoprotein (HDL), serum triglycerides (TG). Mutlivariate logistic regression models were used to evaluate the disparate impact of each risk factor on MetS risk.Results
Overall MetS prevalence was 33.3%, with the highest prevalence among older individuals, among women, and among Hispanics. When stratified by each individual component of MetS, low serum HDL was the strongest predictor of MetS risk overall and among both men and women, among all race/ethnic groups, and among all age groups (overall: OR 20.1, 95% CI 18.6–21.7). While presence of DM also increased an individual’s risk of MetS, DM was the weakest predictor of MetS.Conclusions
Among U.S. adults, low serum HDL carries the strongest risk in predicting development of MetS. This effect was seen among men and women, among all race/ethnic groups, and among all age groups, highlighting the importance of low serum HDL as a marker of MetS risk. 相似文献3.
Masoud Mirzaei Mohammad Khajeh 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(5):677-682
Background and objectives
The purpose of this study was to determine the best anthropometric index and calculate the cut-off point for each anthropometric index in predicting the risk of type II diabetes in the population of Yazd city in Iran.Materials and methods
The present analytical cross-sectional study was performed using the data from Yazd Health Study (YaHS) with a sample size of 9293. All required data including anthropometric indices BMI, WC, WHR, and WHtR were extracted from the YAHS questionnaire. The ROC curve was employed to compare the predictive power of each anthropometric index in the risk of developing the type II diabetes.Results
WHtR in both genders had better predictive power for the risk of type II diabetes (AUC?=?0.692 for males and AUC?=?0.708 for females), and BMI showed a weaker predictive power (AUC?=?0.603 for males and AUC?=?0.632 for females), WC and WHR also revealed similar predictive power in the risk of type II diabetes. The cut-off point of BMI for predicting the risk of diabetes was almost identical in both genders (26.2 in males and 25.9 in females), the cut-off point of WC (91?cm), and WHtR (0.56) in males was lower than in the females (96?cm for WC and 0.605 for WHtR). The cut-off point of WHR in males (0.939) was higher than in females (0.892).Conclusion
The WHtR showed the best predictor of diabetes risk compared to other indices, and the BMI was the weakest predictor of the risk for diabetes. 相似文献4.
Sarah Aparecida Vieira Poliana Cristina de Almeida Fonseca Cristiana Santos Andreoli Patrícia Feliciano Pereira Helen Hermana Miranda Hermsdorff Andréia Queiroz Ribeiro Silvia Eloiza Priore Sylvia do Carmo Castro Franceschini 《Revista portuguesa de cardiologia》2018,37(5):425-432
Introduction and Objective
Studies in adults have shown an association between increased adiposity and hypertension, but few studies have analyzed this association in childhood. The aim of this study was to investigate the association between blood pressure (BP) and body adiposity indicators in children, controlling for the variables of birth conditions, sociodemographics, lifestyle and diet.Methods
In this cross‐sectional study of 399 children aged 4 to 7 years, the dependent variable was BP, measured according to the protocol established by the 7th Brazilian Guidelines on Hypertension. The explanatory variables of the study were waist‐to‐height ratio (WHtR) and body mass index (BMI). Multiple linear regression was used to assess the independent association between adiposity and BP indicators adjusted for the variables of birth conditions, sociodemographics, lifestyle and diet. Statistical significance was set as α=5%.Results
BMI for age and WHtR correlated positively with systolic (SBP) and diastolic blood pressure (DBP). After multivariate analysis, higher values of BMI (model 1) and WHtR (model 2) were associated with increased SBP and DBP.Conclusion
Increased body adiposity, as assessed by BMI and WHtR, was associated with increased SBP and DBP among the children studied. Thus, we suggest the use of BMI and WHtR in the nutritional assessment of children to detect changes in BP and other cardiometabolic risk factors in this population. 相似文献5.
Tohid Jafari-Koshki Shahram Arsang-Jang Ashraf Aminorroaya Marjan Mansourian Masoud Amini 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):563-567
Aims
This study aimed to introduce and apply modern statistical techniques for assessing association and predictive value of risk factors in first-degree relatives (FDR) of patients with diabetes from repeatedly measured diabetes data.Methods
We used data from 1319 FDR’s of patients with diabetes followed for 8 years. Association and predictive performance of weight (Wt), body mass index (BMI), waist and hip circumferences (WC and HC) and their ratio (WHR), waist-height ratio (WHtR) and a body shape index (ABSI) in relation to future diabetes were evaluated by using Cox regression and joint longitudinal-survival modeling.Results
According to Cox regression, in total sample, WC, HC, Wt, WHtR and BMI had significant direct association with diabetes (all p?<?0.01) with the best predictive ability for WHtR (concordance probability estimate?=?0.575). Joint modeling suggested direct associations between diabetes and WC, WHR, Wt, WHtR and BMI in total sample (all p?<?0.05). According to LPML criterion, WHtR was the best predictor in both total sample and females with LPML of ?2666.27 and ?2185.67, respectively. However, according to AUC criteria, BMI had the best predictive performance with AUC-JM?=?0.7629 and dAUC-JM?=?0.5883 in total sample. In females, both AUC criteria indicated that WC was the best predictor followed by WHtR.Conclusion
WC, WHR, Wt, WHtR and BMI are among candidate anthropometric measures to be monitored in diabetes prevention programs. Larger multi-ethnic and multivariate research are warranted to assess interactions and identify the best predictors in subgroups. 相似文献6.
Mahmoud Abdallah El-Husseiny Ashraf Abdel-Hameed Abdel-Moneim Mohammed Arafat Abdel-Maksoud Kamel Suliman Hammad 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):491-495
Objective
The study was performed to evaluate the technique of laproscopic minigastric bypass for metabolic syndrome patients.Study design
The patients were enrolled in a combined prospective study and had a retrospectively gathered outcome analysis.Patient and methods
The study includes thirty patients; 24 females and 6 males suffering from metabolic syndrome with a mean age of 33.15?±?10.17?years (range, 20–59), who fulfilled the criteria for bariatric surgery with BMI >35 with associated co-morbidities, all patients underwent laparoscopic mini-gastric bypass.Results
BMI and WC were significantly reduced post-operatively; also co-morbidities as DM, hypertension and dyslipidemia were resolved or controlled. The mean operative time was 90?±?12.6?min (range, 80–120). No mortality was reported within 30?days of surgery.Conclusion
Laparoscopic mini gastric bypass is an effective procedure for the treatment of obesity, HTN, type 2 DM and dyslipidemia, technically feasible, safe operation with a low rate of major postoperative complications. 相似文献7.
Tarek Mohamed Ali Ahmad El Askary 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1045-1050
Background
Inconsistent results have been described regarding the part of fetuin-A and testosterone in arterial stiffness in type 2 diabetes mellitus (T2DM).Aim
To look into the links of serum fetuin-A and testosterone levels with brachial-Ankle pulse wave velocity (baPWV), a marker of arteriosclerosis and common carotid intima media thickness (ccIMT), a marker of early atherosclerosis, in diabetic Saudi men patients.Subjects and methods
One hundred and fifty adult male patients with T2DM and 60 non-diabetic control subjects were enrolled from different Saudi Arabia Taif hospitals. Biochemical analysis, anthropometric measurements, blood pressure, baPWV and ccIMT were investigated.Results
Stepwise regression in diabetic patients revealed that the most important predictor of ba-PWV was serum fetuin-A followed by serum glucose and the most important predictor of ccIMT was serum fetuin-A followed by serum HDL then serum triglycerides.Conclusions
Only fetuin-A levels not testosterone are negatively associated with early markers of atherosclerosis. 相似文献8.
K. Hajian-Tilaki B. Heidari 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):991-997
Background
Several abdominal obesity measures have been used for prediction of 10-year cardiovascular disease (CVD) risk but the superiority of these measures remains controversial. The objective of this study was to assess the predictive ability of abdominal obesity measures for risk of CVD events in an Iranian adult population.Methods
We analyzed the data of population based cross-section study of 567 representative samples of adult population aged 40–70 years in Babol, the north of Iran. The demographic data, the anthropometric measures, lipid profile and cardiometabolic risk factors were measured with standard methods. Waist to hip ratio (WHR), waist to height ratio (WHtR), conicity index(CI), abdominal volume index (AVI) and body mass index(BMI)were calculated. The individual 10-year CVD risk was estimated based on ACC/AHA model. ROC analysis was performed to assess the diagnostic ability of different abdominal obesity measures and body mass index (BMI) in predicting of high risk of CVD events.Results
About 42.5% of men and 15% of women had at least 10% risk of 10-year cardiovascular events and 21.1% of men and 3.0% of women had ≥20% risk. Except WHR for men, all abdominal obesity measures significant predictors for ≥10% risk CVD risk in both sexes but not BMI. The greater ability of CVD risk prediction was observed by WHtR and CI in both sexes with higher AUC in females compared with men for ≥10% risk.Conclusion
WHtR and CI are superior indexes in predicting of high risk of CVD events in both sexes. 相似文献9.
Maaz Ozair Saba Noor Alok Raghav Sheelu Shafiq Siddiqi Anjum Mirza Chugtai Jamal Ahmad 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):301-304
Background
Type 2 diabetes mellitus (T2DM) is a major health burden worldwide with many patients encountering thyroid dysfunction later in their life. Various studies have found that diabetes and thyroid disorders mutually influence each other and both disorders tend to coexists. However, the prevalence of thyroid dysfunction and associated clinical variables in these patients has not been investigated.Objectives
The study aimed at determining the incidence and prevalence of thyroid dysfunction in patients with T2DM in relation to age, sex, metabolic syndrome and other co-morbid conditions.Research designs & methods
In this cross-sectional study, 250 Type 2 DM patients were enrolled aged between 40 and 75 years. All the patients were evaluated for thyroid dysfunction by testing thyroid profile (T3, T4 and TSH. These subjects were also investigated for fasting blood sugar (FBS), post prandial glucose (PPG) glycosylated hemoglobin (HbA1c), serum cholesterol, serum triglycerides, high density lipoprotein (HDL), low density lipoprotein(LDL), very low density lipoprotein(VLDL), blood urea, serum creatinine and presence of other co-morbid conditions. The observations and interpretations were recorded and results obtained were statistically analyzed.Results
A high prevalence of thyroid dysfunction (28%) was observed in type 2 diabetic patients with subclinical hypothyroidism (18.8%) as the commonest thyroid disorder. Thyroid dysfunction was more prevalent in females, with presence of dyslipidemia, retinopathy, poor glycemic state (HbA1c ≥7) and longer duration of diabetes as significant contributing factors associated.Conclusions
In addition to glycemic status, screening of thyroid disorder should be routinely done in type 2 diabetic subjects along with other comorbid conditions. 相似文献10.
Maryam Abbasian Mehri Delvarianzadeh Hossein Ebrahimi Farideh Khosravi Pirasteh Nourozi 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):497-500
Aims
This study aimed to investigate the relationship between the total antioxidant capacity (TAC) and Malondialdehyde (MDA) with number of metabolic syndrome (Mets) components on the personnel working in Shahroud University of Medical Sciences.Methods
This cross-sectional study was conducted on 167 personnel aged 30–60 years old. ATP III criteria were used to diagnose patients with MetS. Oxidative stress indicators were measured. The data was analyzed via one-way ANOVA, and Pearson and Spearman correlation coefficients.Results
The result showed that TAC had a significant positive correlation with HDL and a significant negative correlation with abdominal obesity. In addition, there was a significant positive association between the level of MDA and age, BMI, abdominal obesity, diastolic blood pressure, triglycerides, and LDL; however, it had a negative significant correlation with HDL.Conclusions
The measurement of TAC and MDA biomarkers can increase the early diagnosis of patients at risk of developing Mets. 相似文献11.
Mansour Agahi Negar Akasheh Afshin Ahmadvand Hossein Akbari Fatemeh Izadpanah 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(1):9-15
Introduction
The use of second-generation atypical antipsychotics has an increasing role in the development of metabolic syndrome. However, these medications due to metabolic disorders can lead to an increased risk of cardiovascular disease and subsequently mortality as well as reduced adherence to treatment. The main objective of current study was to determine the ability of melatonin to reduce the metabolic effects of second-generation antipsychotics.Methods
This double blind controlled clinical trial was conducted on 100 patients aged 18–64 years old were treated with the second-generation antipsychotics for the first time. The patients were divided randomly into two groups of 50. The case group received slow-release melatonin at a dose of 3 mg and the control group was given oral placebo at 8 p.m.Results
The findings in melatonin group indicated significantly increase of HDL and decreased fasting blood sugar and systolic blood pressure, as well as had statistically significant increase in waist circumference, weight and BMI compared with placebo group.Conclusion
According to the findings, it can be claimed that the addition of melatonin to atypical antipsychotics has led to a reduction in some of the metabolic effects of these drugs. In this study, HDL level was increased, and the mean systolic blood pressure and FBS were decreased in the melatonin group. Considering that these factors are contributing to cardiovascular disease as a leading cause of mortality in psychiatric patients, so the use of melatonin can reduce some of the medical effects of long-term treatment of atypical antipsychotics. 相似文献12.
Sara Araújo Ana Rouxinol-Dias José Mesquita-Bastos José Silva Loide Barbosa Jorge Polónia 《Revista portuguesa de cardiologia》2018,37(4):319-327
Objective
To assess ambulatory blood pressure monitoring (ABPM) circadian patterns and their determinants in a large sample of normotensive and hypertensive patients.Methods
A total of 26 170 individual ABPM recordings from 1995 to 2015 were analyzed. Mean office blood pressure (OBP), 24-hour blood pressure (BP), daytime BP and nocturnal BP were measured. Circadian patterns were classified by nocturnal systolic BP fall as extreme dipper (ED, ≥20%), dipper (D, 10%-19.9%), non-dipper (ND, 0%-9.9%), and reverse dipper (RD, <0%).Results
The population were 52% female, aged 58±15 years, mean body mass index (BMI) 27±5 kg/m2. Using ABPM criteria of normalcy, 22.8% were normotensives (NT), 19.1% were untreated hypertensives, 29.7% were controlled hypertensives and 28.4% were treated but uncontrolled hypertensives. Among NT, 60.7% were white-coat hypertensive. In controlled hypertensives 62.4% had OBP ≥140/90 mmHg. In treated but uncontrolled hypertensives 8.2% had masked uncontrolled hypertension. ABPM values were lower than OBP in all cases. In all subgroups the most common pattern was D (42-50%), followed by ND (35-41%), ED (7-11%) and RD (4-11%). Age and BMI were determinants of attenuation of nocturnal BP fall and ND+RD. The proportion of ND+RD was higher in patients with BMI >30 kg/m2 vs. others (46.5 vs. 42.9%, p<0.01) and in those aged ≥65 vs. <65 years (54.9. vs. 33.1%, p<0.00). Nocturnal BP fall was greater in NT than in hypertensives (11.3±6.7 vs. 9.9±7.9%, p<0.000).Conclusions
There was a marked discrepancy between office and ABPM values. The rates of control on ABPM were more than double those on OBP. Non-dipping occurred in >43%, including in NT. Age and BMI predicted non-dipping. 相似文献13.
Kamna Singh Ritu Singh Sudhir Chandra Sanjay Tyagi 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):275-278
Objectives
The present study aims to evaluate the levels of HDL and Paraoxonase-1 (PON1) and their correlation in atherosclerotic patients with and without diabetic mellitus (DM) as well as in control subjects in Northern Indian population.Materials and methods
We analyzed lipid profiles and Serum PON1 levels by automated analyzer and ELISA, respectively. Study subjects (N?=?150) were divided in three groups; Group I: Atherosclerotic patients without DM (N?=?50), Group II: Atherosclerotic patients with DM (N?=?50); Group III: Controls (N?=?50).Results
We found a significantly (p?<?0.0001) low levels of HDL-C in Group I (32.2?±?7.3) and Group II (36.9?±?11.5) as compared to Group III (41.0?±?7.1). PON-1 levels were also significantly lower in Group I (60.1?±?10.5) and Group II (50.0?±?13.9) when compared to Group III (95.0?±?12.0). We observed a significant correlation (r?=?0.59, p?<?0.001) between the levels of PON1 and HDL-C in study subjects.Conclusions
The reduced levels of HDL and PON-1 and their significant correlation in CAD patients may be associated with the pathogenesis of this disease. Considering HDL as a dependent variable, Paraoxonase-1 is the most important parameter contributing to the total variation in HDL in CAD. 相似文献14.
Mohd Wamique Wahid Ali D. Himanshu Reddy Preeti Vishwakarma Mohd Waseem 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):843-847
Aim
To evaluate the serum paraoxonase 1 activity and determine its association with duration in type 2 Diabetes mellitus patients.Methods
A total of 80 cases from type 2 diabetes mellitus and healthy controls were enrolled in the present case control study. Human serum PON1 concentration was measured by ELISA and western blotting and it activity was determined spectrophotometrically using 4-nitrophenyle acetate. Diagnostic accuracy of serum PON1 to identify type 2 Diabetes mellitus was calculated with ROC analysis.Result
Serum concentration of LDL, VLDL, TG, A1C, FBS and TC levels showed significantly higher levels in type 2 diabetes patients as compared to healthy controls, however there were no significant differences found in the level of HDL. Serum PON1 concentration and activity monitored in patients with >1?year diabetes showed higher level (75.1?±?6.8?ng/mL) as compared to patients with >3?years diabetes (65.24?±?1.6?ng/mL), its level was further decreased in patients with >5 (53.8?±?2.6?ng/mL) and >7?years (48.1?±?2.7?ng/mL) of diabetes. PON1 concentration decreased as the duration of diabetes increased. PON1 level was further decreased due to habits like smoking and alcohol consumption.Conclusion
Serum PON1 levels decrease in states of high oxidative stress like metabolic syndrome, obesity, uncontrolled diabetes, and dyslipidemia. It can be used as diagnostic marker for diabetes mellitus along with increased TG, LDL, VLDL and FBG. 相似文献15.
Ramzi Shawahna Yousef Shanti Hamzeh Al Zabadi Mutassem Sharabati Ammar Alawneh Rakan Shaqu Ibrahim Taha Adnan Bustami 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(5):693-704
Aims
The current study was carried out to examine prevalence of complications related to diabetes mellitus (DM) and to investigate association between clinical variables and biochemical factors with complications of DM in patients treated in primary healthcare settings in the West Bank of Palestine.Materials and methods
Sociodemographic, clinical, and biochemical variables were collected from 385 patients visiting 17 primary healthcare settings in the West Bank. Patients provided blood and urine samples, responded to a questionnaire interview, and were subjected to ophthalmic examination.Results
HbA1c levels were predicted by duration of DM (p?<?0.001), HDL (p?=?0.011), alkaline phosphatase (p?=?0.001), blood urea (p?=?0.006), and LDL (p?=?0.008). Triglycerides levels were predicted by blood urea (p?=?0.002), HDL (p?<?0.001), and total cholesterol (p?<?0.001). GOT levels were predicted by LDL (p?=?0.002) and GPT (p?<?0.001). GPT levels were predicted by HDL (p?=?0.003) and blood urea (p?=?0.025). Urine albumin were predicted by total cholesterol (p?=?0.001), LDL (p?=?0.005), and blood urea (p?=?0.036). CD ratio was predicted by the IOP and the IOP was predicted by the CD ratio (p?=?0.001).Conclusions
Prevalence of complications related to DM was high among patients with DM treated in primary healthcare practice. These complications and risk factors were predicted by certain clinical characteristics and biochemical factors. Policies and programs are needed to manage these modifiable risk factors. 相似文献16.
Rafael Garcia-Carretero Luis Vigil-Medina Inmaculada Mora-Jimenez Cristina Soguero-Ruiz Rebeca Goya-Esteban Javier Ramos-Lopez Oscar Barquero-Perez 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(5):625-629
Background
The aim of our study was to determine whether prediabetes increases cardiovascular (CV) risk compared to the non-prediabetic patients in our hypertensive population. Once this was achieved, the objective was to identify relevant CV prognostic features among prediabetic individuals.Methods
We included hypertensive 1652 patients. The primary outcome was a composite of incident CV events: cardiovascular death, stroke, heart failure and myocardial infarction. We performed a Cox proportional hazard regression to assess the CV risk of prediabetic patients compared to non-prediabetic and to produce a survival model in the prediabetic cohort.Results
The risk of developing a CV event was higher in the prediabetic cohort than in the non-prediabetic cohort, with a hazard ratio (HR)?=?1.61, 95% CI 1.01–2.54, p?=?0.04. Our Cox proportional hazard model selected age (HR?=?1.04, 95% CI 1.02–1.07, p?<?0.001) and cystatin C (HR?=?2.4, 95% CI 1.26–4.22, p?=?0.01) as the most relevant prognostic features in our prediabetic patients.Conclusions
Prediabetes was associated with an increased risk of CV events, when compared with the non-prediabetic patients. Age and cystatin C were found as significant risk factors for CV events in the prediabetic cohort. 相似文献17.
Heitham Awadalla Sufian K. Noor Wadie M. Elmadhoun Sarra O. Bushara Ahmed O. Almobarak Amel Abdalrhim Sulaiman Mohamed H. Ahmed 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):961-964
Background
Diabetes mellitus (DM) is a major health problem in Sudan and is a leading cause of morbidity and mortality. Dyslipidemia is a major complication of diabetes and an important risk factor for cardiovascular disease (CVD). The objective of this study was to determine the prevalence of dyslipidemia and its co-relation with the glycemic control in individuals with diabetes in River Nile State, Sudan.Methods
Individuals with diabetes attended, Naserudin Karamalla Diabetic (NKDM) Centre, in Atbara teaching hospital during study period, who volunteered to participate were included. Only those on treatment for DM for at least one year were included. Venous samples were collected for cholesterol, triglycerides, HDL, LDL, blood glucose and Glycosylated hemoglobin. Participants were interviewed using standardized pretested questionnaire to record medical history and sociodemographic characteristics. Blood pressure, body mass index (BMI) and waist circumference were measured.Results
A total of 188 individuals were included. The mean age was 49.5?+?13.9 and (128) 68.1% were females. Most patients were having DM for at least 3–5 years 69 (36.7%). Poor diabetes control (HbA1c >7) was recorded in 87.2%, hypercholesterolemia, hypertriglyceridemia and high LDL were identified in 36.6%, 27.7% and 26.6% respectively. In addition, HDL was low in 61.2% of patients.Conclusion
Low HDL is a prominent feature in two thirds of individuals with diabetes, while high cholesterol and high triglyceride were seen in over one quarter. 相似文献18.
F. Javier Sangrós Jesús Torrecilla Carolina Giráldez-García Lourdes Carrillo José Mancera Teresa Mur Josep Franch Javier Díez Albert Goday Rosario Serrano F. Javier García-Soidán Gabriel Cuatrecasas Dimas Igual Ana Moreno J. Manuel Millaruelo Francisco Carramiñana Manuel Antonio Ruiz Francisco Carlos Pérez Enrique Regidor 《Revista espa?ola de cardiología》2018,71(3):170-177
Introduction and objectives
Some anthropometric measurements show a greater capacity than others to identify the presence of cardiovascular risk factors. This study estimated the magnitude of the association of different anthropometric indicators of obesity with hypertension, dyslipidemia, and prediabetes (altered fasting plasma glucose and/or glycosylated hemoglobin).Methods
Cross-sectional analysis of information collected from 2022 participants in the PREDAPS study (baseline phase). General obesity was defined as body mass index ≥ 30 kg/m2 and abdominal obesity was defined with 2 criteria: a) waist circumference (WC) ≥ 102 cm in men/WC ≥ 88 cm in women, and b) waist-height ratio (WHtR) ≥ 0.55. The magnitude of the association was estimated by logistic regression.Results
Hypertension showed the strongest association with general obesity in women (OR, 3.01; 95%CI, 2.24-4.04) and with abdominal obesity based on the WHtR criterion in men (OR, 3.65; 95%CI, 2.66-5.01). Hypertriglyceridemia and low levels of high-density lipoprotein cholesterol showed the strongest association with abdominal obesity based on the WHtR criterion in women (OR, 2.49; 95%CI, 1.68-3.67 and OR, 2.70; 95%CI, 1.89-3.86) and with general obesity in men (OR, 2.06; 95%CI, 1.56-2.73 and OR, 1.68; 95%CI, 1.21-2.33). Prediabetes showed the strongest association with abdominal obesity based on the WHtR criterion in women (OR, 2.48; 95%CI, 1.85-3.33) and with abdominal obesity based on the WC criterion in men (OR, 2.33; 95%CI, 1.75-3.08).Conclusions
Abdominal obesity indicators showed the strongest association with the presence of prediabetes. The association of anthropometric indicators with hypertension and dyslipidemia showed heterogeneous results.Full English text available from:www.revespcardiol.org/en 相似文献19.