共查询到20条相似文献，搜索用时 31 毫秒
1.
T.-T. Li A.-P. Wang J.-X. Lu M.-Y. Chen C.-C. Zhao Z.-H. Tang L.-X. Li W.-P. Jia 《Diabetes & metabolism》2018,44(5):437-443
Aim
As the prevalence and clinical characteristics of non-alcoholic fatty liver disease (NAFLD) are still unknown in ketosis-onset diabetes, the present study compared the characteristics of NAFLD in type 1 diabetes (T1D), ketosis-onset and non-ketotic type 2 diabetes (T2D) patients.Methods
This cross-sectional study was performed with newly diagnosed Chinese patients with diabetes, including 39 T1D, 165 ketosis-onset and 173 non-ketotic T2D, with 30 non-diabetics included as controls. NAFLD was determined by hepatic ultrasonography, then its clinical features were analyzed and its associated risk factors evaluated.Results
NAFLD prevalence in patients with ketosis-onset diabetes (61.8%) was significantly higher than in controls (23.3%; P = 0.003) and in T1D patients (15.4%; P < 0.001). However, there was no difference in prevalence between ketosis-onset and non-ketotic T2D patients (52.6%; P = 0.229), although BMI and alanine aminotransferase (ALT) proved to be independent risk factors for the presence of NAFLD in both these groups whereas, in T1D patients, serum uric acid levels were independent risk factors.Conclusion
NAFLD prevalence and risk factors in ketosis-onset diabetes were similar to those in non-ketotic T2D, but different from those in T1D. These data provide further evidence that ketosis-onset diabetes should be classified as a subtype of T2D rather than idiopathic T1D. 相似文献2.
Nicolas Roberto Robles Juan Lucio Ramos Edgar Chavez Boris Gonzalez Candia Miguel Angel Bayo Antonio Cidoncha Juan Lopez Gomez Juan Jose Cubero 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):933-937
Backgrounds
Iron deficiency has been studied extensively in patients with chronic kidney disease on hemodialysis therapy. However, few studies looked at iron treatment in the non-dialysis chronic kidney disease population.Methods
Five hundred and eighty patients were studied (247 were diabetic persons). Patients were divided into 4 groups: non-diabetic subjects without CKD, non-diabetic ones with GFR?<?60?mL/min, diabetic persons without CKD and diabetic ones with GFR?<?60?mL/min). Iron deficiency was diagnosed when serum ferritin level was <100?mg/dl. It was defined as diminished iron availability when ferritin was above 100?mg/dl and serum transferrin saturation (TSAT) was <20%.Results
Anemia was more frequent in the diabetic CKD patients group (52.4%, p?<?0.001). Anemia prevalence was also higher in all CKD patients as well as in diabetic patients compared with non-diabetic ones. Iron deficiency was more frequent in diabetic patients. Among CKD diabetic patients the prevalence of iron deficiency was higher than in non-diabetic CKD ones. Diminished iron availability prevalence was higher in non-diabetic patients. Logistic regression analysis showed that only sex and diabetes mellitus were independently associated with iron deficiency.Conclusions
Anemia was more common in diabetic CKD patients. Diabetes mellitus was independently associated with iron deficiency. Surprisingly, diminished iron availability was not more frequent in diabetic patients. The physio-pathological mechanisms that could explain these findings remain to be elucidated. 相似文献3.
Deepak Gahlan Rajesh Rajput Pratibha Gehlawat Rajiv Gupta 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):333-336
Background
Patients of diabetes mellitus experience psychological difficulties associated with their disease which remains unrecognized involving several states related to coping with diabetes. Diabetes distress is a distinct condition which is often mistaken for depression and is related to adverse disease outcomes.Aims and objective
To study the prevalence and predictors of diabetes distress in patients of Type 2 Diabetes mellitus (T2DM) in a tertiary care centre.Materials and methods
This cross-sectional study was conducted over a period of one year at Endocrine OPD of Pt. B.D. Sharma PGIMS, Rohtak, a tertiary care centre in northern India. 410 consecutive patients having T2DM attending the endocrine OPD were screened for psychiatric disorders and 189 diabetic patients with no underlying psychiatric disorders were included in the study. Their socio-demographic and relevant clinical variables were recorded. Diabetes Distress Scale (DDS) was used to measure distress due to the disease in these patients.Results
It was found that the prevalence of diabetes distress was 18.0%; among them 16.1% had emotion related distress, 5.6% regimen related distress, 1.5% interpersonal related distress and 1.2% physician related diabetes distress. The major predictors for high diabetes distress scores among diabetic cases were low education level, retinopathy, neuropathy and hypertension.Conclusion
The present study suggests that emotion related diabetes distress was more prevalent among diabetic patients. Lower education level and the presence of diabetic complications contribute as risk factors for high diabetes distress. 相似文献4.
Ali Abdulmajid Dyab Allawi 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(2):91-97
Background
Inflammation and malnutrition play an important role in endothelial dysfunction, atherosclerosis and excessive cardiovascular morbidity and mortality in ESRD patientsAim of the study
The primary objective is to determine the prevalence of inflammation, malnutrition and atherosclerosis in patients on maintenance haemodialysis. Secondary objective was to determine the association for atherosclerosis with inflammation and malnutrition.Patient and methods
One hundred and one adult patients with end stage renal disease on maintenance haemodialysis who are met with the exclusion criteria were enrolled in this cross sectional study from haemodialysis unit of Baghdad teaching hospital over the period of July/2015 ? June 2016. All patients were thoroughly examined and many variables were evaluated (age, gender, blood pressure, diabetes mellitus, serum lipid profile, smoking habits, serum albumin, CRP, calcium, Phosphate, Parathyroid hormone and haemoglobin measurements). All patients underwent a carotid Doppler ultrasound study.Results
Atherosclerosis was present in 65.3%: 58.4% of patients had malnutrition and 43.6% had inflammation. The association for atherosclerosis and high CRP and low serum albumin is strong and independent of other atherosclerosis risk factors. There is significant inverse and independent correlation between CRP and albumin.Conclusion
Inflammation (high serum CRP) and malnutrition (low serum albumin) in patients on haemodialysis are significantly associated with carotid atherosclerosis. Inflammation was more prevalent in the malnourished patients than in those with normal nutritional status. 相似文献5.
Tarek Mohamed Ali Ahmad El Askary 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1045-1050
Background
Inconsistent results have been described regarding the part of fetuin-A and testosterone in arterial stiffness in type 2 diabetes mellitus (T2DM).Aim
To look into the links of serum fetuin-A and testosterone levels with brachial-Ankle pulse wave velocity (baPWV), a marker of arteriosclerosis and common carotid intima media thickness (ccIMT), a marker of early atherosclerosis, in diabetic Saudi men patients.Subjects and methods
One hundred and fifty adult male patients with T2DM and 60 non-diabetic control subjects were enrolled from different Saudi Arabia Taif hospitals. Biochemical analysis, anthropometric measurements, blood pressure, baPWV and ccIMT were investigated.Results
Stepwise regression in diabetic patients revealed that the most important predictor of ba-PWV was serum fetuin-A followed by serum glucose and the most important predictor of ccIMT was serum fetuin-A followed by serum HDL then serum triglycerides.Conclusions
Only fetuin-A levels not testosterone are negatively associated with early markers of atherosclerosis. 相似文献6.
Soorampally Vijay Abdoul Hamide Gandhipuram Periyasamy Senthilkumar Vadivelan Mehalingam 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(5):649-652
Introduction
Renal tubulo-interstitial damage has an important role in the pathogenesis of early diabetic nephropathy. Urinary biomarkers can help in the detection of early nephropathy in type 2 diabetic patients. The aim of this study was to estimate the levels of urinary neutrophil gelatinase associated lipocalin (NGAL) and cystatin-C in type 2 diabetic patients with early diabetic nephropathy & to compare them with diabetic patients without nephropathy and to correlate urinary NGAL and cystatin-C levels with microalbuminuria in them.Study design
Cross-sectional comparative study.Material and methods
The study was conducted on 126 patients with type 2 diabetes along with 30 control subjects attending the outpatient care department of a tertiary care teaching hospital. There were 3 study groups-diabetic patients with microalbuminuria, diabetic patients without albuminuria and control subjects who were non-diabetic without any renal disease. Details on duration of diabetes and glycemic status were obtained from the patients. Urine examination was done for subjects in all the groups to look for microalbuminuria along with estimation of NGAL and cystatin-C levels. Samples were stored at ?20?°C in the deep freezer.Results
Urinary NGAL and cystatin-C levels were significantly elevated in patients with microalbuminuria (228.18 & 3.23?ng/ml) as compared to those without albuminuria (146.12 & 2.61?ng/ml) and in control subjects (26.56 & 0.30?ng/ml). Urinary NGAL and cystatin-C levels showed a linear correlation with microalbuminuria in diabetic patients.Conclusion
Urinary NGAL and cystatin-C levels were increased in type 2 diabetic patients with early diabetic nephropathy as compared to patients without nephropathy. Urine NGAL and cystatin-C levels also showed a positive correlation with microalbuminuria (urine albumin-creatinine ratio) in patients with type 2 diabetes mellitus. 相似文献7.
Abdul Hakeem Alrawahi Patricia Lee 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):387-391
Aim
The first cardiovascular risk prediction model in the Arab world was recently developed for Omanis with type 2 diabetes mellitus. This study aims to validate the newly developed model.Materials and methods
A retrospective cohort study design was applied in this study. The model was validated in two samples; the model derivation sample and a separate validation sample, consisting of 1314 and 405 diabetics respectively. All patients were free of cardiovascular disease at the baseline (2009–2010) and were followed up until: the first cardiovascular event occurred; the patient died; or up to December 2015. All data were retrieved from the patients’ medical records in a primary care setting.Results
In both the derivation and validation samples, the model showed good discrimination, with an area under the receiver operating curve of 0.73 (95% CI; 0.69–0.77) and 0.70 (95% CI: 0.59–0.75) respectively. Calibration of the model was satisfactory and the actual difference between the mean predicted and observed risk in different risk groups ranged from 0.7%–3.1% and 0.1%–4.2% in the derivation and validation samples respectively.Conclusion
The recently developed cardiovascular disease risk assessment model for Omanis with type 2 diabetes achieved adequate overall validity. The model showed good discrimination and acceptable calibration; it therefore has the potential to be used in local clinical settings. However, further validation and comparison studies are needed to judge the generalizability and superiority of the model over other tools currently used in Oman. 相似文献8.
Aladeen Alloubani Abdulmoneam Saleh Ibrahim Abdelhafiz 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):577-584
Background
Stroke is becoming a major challenge in healthcare systems, and this has necessitated the study of the various risk factors. As the number of people with hypertension, diabetes mellitus and obesity increases, the problem is expected to worsen. This review paper evaluates what can be done to eliminate or reduce the risk of stroke.Objective
The aim of the research is to evaluate the risk factors for stroke. The paper also aims to understand how these risks can be handled to avoid incidences of stroke.Method
Published clinical trials of stroke risk factors studies were recognised by a search of EMBASE and MEDLINE databases with keywords hypertension, blood pressure, diabetes mellitus, stroke or cardiovascular disease, or prospective study, and meta-analysis.Results
The findings of this review are that the prevention of stroke starts with identifying risk factors for stroke, most of the patients diagnosed with stroke have various risk factors. Consequently, it is a very significant to identify all the risk factors for stroke as well as to teach the patient how to dominate them.Conclusion
after summarising all the studies mentioned in the paper, it can be established that hypertension and diabetes mellitus are a stroke risk factors and correlated in patients with atherosclerosis. 相似文献9.
Mohammad Hossein Dabbaghmanesh Farideh Danafar Ahad Eshraghian Gholamhossein Ranjbar Omrani 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):513-517
Background
Low serum vitamin D has been associated with metabolic syndrome and Non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate the impact of vitamin D supplementation in treatment of patients with NAFLD.Methods
In a double blind, randomized, placebo controlled trial patients with NAFLD were randomized to receive one weekly pearl of placebo, 50,000?U vitamin D3 (cholecalciferol) pearl per week and 0.25?mg calcitriol (1,25 dihydroxycholecalciferol) pearl per day for 3 months.Results
106 NAFLD patients were randomized to receive calcitriol, vitamin D3 and placebo pearls for 12 weeks and data for 91 patients were analyzed. After 12 weeks of treatment, serum alkaline phosphatase levels was significantly decreased from baseline levels in vitamin D and calcitriol treated groups (P?<?0.05). Serum and gamma glutamyl transferase (GGT) level was also significantly decreased compared to the baseline levels after 12 weeks of treatment with vitamin D. There was no statistically significant difference between placebo, calcitriol, vitamin D groups in terms of serum aminotransferase, alkaline phosphatase, serum GGT and lipid profile (P?>?0.05).Conclusion
While significant reduction of serum alkaline phosphatase and GGT were seen with vitamin D and calcitriol supplementation from baseline levels, no beneficial effects was seen when comparing vitamin D, calcitriol and placebo groups at the end of trial. 相似文献10.
Vimal Upreti Vijay Maitri Pawan Dhull Ajay Handa M.S. Prakash Anil Behl 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):509-512
Context
Vitamin D supplementation in type 2 diabetes mellitus patients may lead to improved glycemic control by improving insulin secretion and decreasing insulin resistance.Aims
To investigate effect of oral vitamin D supplementation on glycemic control, in patients with type 2 diabetes mellitus and coexisting hypovitaminosis D.Settings and design
Randomized, Parallel Group, Placebo Controlled Trial carried out in a tertiary care hospital of Indian Armed Forces.Methods and material
Sixty patients with coexisting type 2 diabetes mellitus and hypovitaminosis D were randomized into cases and controls and were supplemented with oral Vitamin D and microcrystalline cellulose respectively for six months. Subjects' HbA1c and vitamin D levels were monitored at the beginning and end of the study, fasting plasma glucose (FPG) & post prandial plasma glucose (PPPG) during monthly OPD visits.Statistical analysis used
Intra-group comparison was made by paired t test & unpaired t test was used for inter-group (A v/s B) comparisons. Repeated measures ANOVA was undertaken to compare values over time.Results
The two groups were comparable for all parameters at baseline. Case group showed significant decrease in mean HbA1c levels (7.29% to 7.02%; P?=?0.01), mean FPG levels (131.4 to 102.6?mg/dl; P?=?0.04) and mean PPPG levels (196.2 to 135.0?mg/dl; P?<?0.001). Incidentally, significant improvement in systolic as well as diastolic blood pressure and total cholesterol was also noted in the cases, while for LDL cholesterol improvement tended towards significance (p?=?0.05).Conclusions
We found that oral vitamin D supplementation was associated with improved glycemic control and other metabolic parameters in patients with type 2 diabetes mellitus. Supplementation to achieve normal levels of vitamin D can be a promising adjuvant therapy for T2DM patients & coexisting hypovitaminosis D. 相似文献11.
Salwa S. Hosny Meram M. Bekhet Hayam A. Hebah Nagwa R. Mohamed 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1019-1024
Background
Diabetes mellitus is the leading cause of end stage renal disease worldwide. Early identification of diabetic nephropathy even before appearance of microalbuminuria is a challenge for early prevention of occurrence and progression of this complication. Neutrophil gelatinase-associated lipocalin is a small protein that belongs to the lipocalin protein. Urinary neutrophil gelatinase-associated lipocalin is a promising early marker in different renal problems.Aim of the work
To measure urinary neutrophil gelatinase-associated lipocalin in type 2 diabetic patients and to assess its role as an early marker for diagnosis of diabetic nephropathy and diabetic retinopathy.Patient and methods
The current study included 60 subjects with type 2 diabetes and 20 healthy control subjects. Diabetic subjects were divided into 3 groups according to urinary albumin creatinine ratio; 20 normoalbuminuric patients, 20 micro-albuminuric patients and 20 macroalbuminuric patients. They were subjected to history taking, full clinical examination, fundus examination, anthropometric measurement, urinary neutrophil gelatinase-associated lipocalin and urinary albumin creatinine ratio.Results
Urinary neutrophil gelatinase-associated lipocalin was higher in all diabetic groups than in the control group, with no difference in between diabetic groups. The difference was of great value when comparing normoalbuminuric group with control as albumin creatinine ratio was not different while the urinary neutrophil gelatinase-associated lipocalin was statistically significant (5.94?±?1.85?ng/dl vs 1.96?±?0.65, p?<?0.001). No correlation was found with retinopathy.Conclusion
Urinary neutrophil gelatinase-associated lipocalin is a sensitive marker for early detection of diabetic nephropathy even in normoalbuminuric patients denoting early tubular damage before microalbuminuria. It is not correlated with retinopathy. 相似文献12.
Farbod Ebadifard Azar Mahnaz Solhi Fatemeh Darabi Alireza Rohban Mitra Abolfathi Nazila Nejhaddadgar 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1075-1078
Aims
Diabetes mellitus is a chronic and progressive disease which requires ongoing medical care as well as patient’s self-care skills to prevent acute complications. The purpose of this study is to determine the effect of the PRECEDE-PROCEED model combined with self-management theory on self-care behaviors in type 2 diabetic patients.Methods
In this semi-experimental study, 86 type 2 diabetic patients referred to the diabetes clinic of Ardabil were randomly selected and divided into two groups (n?=?43). Patients in group 1 received educations based on PRECEDE-PROCEED model combined with self-management theory while patients in group 2 received only educations based on PRECEDE-PROCEED model. The self-made questionnaire was used to measure demographic information and PRECEDE-PROCEED model variables at baseline and one month after the intervention.Results
The mean scores of knowledge, attitude, self-efficacy (p?=?0.001), self-care (p?=?0.001), enabling factors, and reinforcing factors had significant differences in both groups before and after the intervention (p?<?0.05). In addition, one month after the intervention, the mean scores of attitude, self-efficacy, self-care, and reinforcing factors were significantly higher in group 1 compared to group 2.Conclusion
The results indicate the effectiveness of an educational intervention based on PRECEDE-PROCEED model combined with self-management theory to improve self-care behaviors in patients with type 2 diabetes. 相似文献13.
Muhammad Bilal Abdul Haseeb Abdur Rehman 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):375-380
Background
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. The two main documented pathogenic mechanisms are hyperinsulinemia and hyperandrogenemia but there is growing evidence for increased predisposition to cardiovascular disease, dyslipidemia, and type 2 diabetes mellitus. Our study aims to analyze the association of PCOS with cardiovascular risk factors.Methods
This is a prospective study which targeted 100 PCOS patients from Civil Hospital Karachi over a period of one year (July 2016 to July 2017). An equal number of age-matched healthy control participants were also included in the study. The student’s t-test was used to assess the significance of differences using SPSS version (19). The statistical significance was set at a p-value of <.05.Results
The most frequently presented feature associated with PCOS was primary infertility seen in 72% of the patients. Mean arterial pressure, fasting glucose and insulin levels and insulin resistance was found to be significantly different in PCOS patients as compared to their controls. A classic atherosclerotic lipid profile demonstrating elevated total cholesterol and low-density lipoprotein-C (LDL-C) levels and decreased serum high density lipoprotein-C(HDL-C) was observed in our study.Conclusion
This study established a significant yet independent association of PCOS with major cardiovascular risk factors. This association can effectively progress into CVD outcomes which necessitates early intervention programs and preventative strategies to reduce mortality from cardiovascular events. This study lays out the framework for conducting further researches on the PCOS women while exploring novel cardiovascular risk factors. 相似文献14.
T. Mahévas D. Gobert M. Gatfossé A. Mekinian O. Fain 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2017,38(3):201-203
Introduction
Hepatic glycogenosis is a rare syndrome, which includes poorly controlled diabetes mellitus, hepatomegaly, delayed puberty, and growth delay. Insulin edema is sometimes associated.Case report
An 18-year-old woman presented with diffuse edema, hepatomegaly, amenorrhea, uncontrolled diabetes, and elevated transaminases and cholestasis. Hepatic ultrasonography and abdominal computed tomographic scan confirmed the hepatomegaly. The liver biopsy showed a massive glycogenosis and the diagnosis of hepatic glycogenosis was confirmed. Too large doses of insulin were responsible of diffuse edema. Diabetes equilibration and diminution of insulin intakes allow correction of this disorder.Conclusion
Excess of insulin can lead to excessive hepatic glycogen storage by activation of glycogenosis enzymes. Biological manifestations consist on elevated liver enzymes and hyperlactatemia. There is a link between administration of high dose of insulin and edema. Hepatic glycogenosis should be suspected when diabetes is uncontrolled and be considered as a differential diagnosis of steatosis. It may be associated and revealed by insulin edema directly related to excessive insulin intakes. 相似文献15.
Deldar Morad Abdulah Alan Bapeer Hassan Farsat Saeed Saadi Ary Habeeb Mohammed 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):969-975
Objectives
Dietary and physical activity advice have been considered to be seminal ingredients in prevention and management of type 2 diabetes mellitus. In this regard, the impacts of a three-month self-management intervention on glycemic control in patients with type 2 diabetes were examined in the present study.Study design
A Double-arm post-test intervention study.Methods
In the current post-test intervention study, three two-hour educational sessions on dietary habits and physical activity designed according to Health Belief Model were presented to 16 non-complicated type 2 diabetic patients and their dietary, physical activities, and biochemical outcomes were compared to a 23 patient-control arm in Iraq in 2017. The level of physical activity was measured through International Physical Activity Questionnaire (IPAQ), dietary habits through UK Diabetes and Diet Questionnaire (UKDDQ), and biochemical indicators including HbA1c were measured after three months of program completion.Results
The study showed that walking, taking vegetable, fruit, and bread were higher and taking full-fat cheese and full-fat spread was lower among experimental group significantly compared to control arm. In addition, the experimental group had a substantial higher albumin and lower urea, ALP-Phosphatase, and glucose levels in comparison with control patients. No substantial change was seen in HbA1C and no change in milk and fish products.Conclusions
The substantial positive changes in physical activity, dietary habits, and some biochemical indicators were seen following intervention completion in the experimental arm. 相似文献16.
Ehimen Phyllis Odum Ekenechukwu Esther Young 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(2):141-145
Background
Elevated cardiac troponin I, Creatine kinase (CK-MB) and Myoglobin levels are observed in the setting of acute myocardial damage. However sub-clinical elevations occur in patients with diabetes mellitus. This study was carried out to determine the relationship between the presence of multiple cardiovascular risk factors and the metabolic syndrome and elevations in cardiac markers in patients with type2 diabetes mellitus.Subjects and methods
Consecutive stable out-patients with type2 diabetes mellitus at the University of Port Harcourt Teaching Hospital, Nigeria were recruited. Non-diabetic individuals such as hospital staff and the general public acted as controls. Baseline demographic data collection was done and waist circumference, weight, height and blood pressure were measured. Venous samples were assayed for CTnI, CK-MB and Myoglobin levels using ELISA. Data was analysed using SPSS v 20.Results
There were 188 DM patients, who were older than the 200 control subjects (56.1?±?13.1?years and 42.7?±?5.7?years, p?<?0.001). Mean duration of diabetes was 7.1(5.7)?years. Hypertension was present in 59%, 84.6% had dyslipidaemia, while 76.1% had metabolic syndrome. All the cardiac markers were significantly higher in DM patients than controls. The presence of hypertension or dyslipidaemia was not significantly associated with the cardiac markers (p?>?0.05 for all), however the DM patients with metabolic syndrome had higher levels of CK-MB and myoglobin but not CTnI than those without.Conclusion
Diabetes mellitus is associated with chronic sub-clinical elevation of cardiac markers and this is more in those with multiple cardiovascular risk factors and/or the metabolic syndrome. 相似文献17.
Yen Ping Ng Ramadan Ahmed Guat See Ooi Chia Ying Lau Ganesh Pandian Balasubramanian Cheng Hoon Yap 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1025-1030
Introduction
In Malaysia, 61% of dialysis cases are secondary to diabetes. To date, we are still lacking of data on the rate of progression of type 2 diabetes mellitus (T2DM) to end stage renal disease (ESRD) in Malaysia.Materials and methods
This was a retrospective study conducted at nephrology unit of a tertiary hospital in Kedah. All diabetic ESRD patients who fulfilled the inclusion criteria were identified and recruited for analysis.Results
The mean duration of DM to ESRD was found to be 14.37?±?4.42 years. Mean duration for the onset of diabetic nephropathy was 8.73?±?3.37 years. There was a relative short duration from diabetic nephropathy to ESRD noted, which was 5.63?±?2.06 years. The mean duration of DM to ESRD for patients receiving RAAS blocker was found to be 18.23?±?2.38 years as compared to 11.41?±?2.94 years for those who did not (95% CI: -0.64 to -2.46). For different type of RAAS blockers, namely ACE inhibitor and angiotensin receptor blocker (ARB), there was no significant difference observed pertaining to mean duration of DM to ESRD; 17.89?±?1.97 years for ACEi and 19.00?±?4.16 years for ARB (95% CI: -4.74 to 2.52).Discussion
Time frame from diabetic nephropathy to ESRF among Malaysian population was shorter as compared to findings from other countries with an average period of 15 to 25 years. RAAS blockers should be initiated early in diabetic patients. 相似文献18.
Anthony P. Sunjaya Angela F. Sunjaya 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1031-1037
Aims
To compare the clinical and glycemic profile as well as pregnancy complications and infant mortality among diabetic mothers in Indonesia.Materials and Methods
Data was obtained from medical records of Internal-Medicine Clinic in Hermina Podomoro General Hospital during the period January-December 2015. Subjects were grouped into good and poor outcome groups based on infant mortality.Results
Forty-five subjects were obtained with an average age of 31 years, 41 had gestational diabetes mellitus while 4 had pregestational diabetes. Twenty-one patients had high-risk pregnancies (age >30 years or <20 years). No maternal mortalities were reported, only 6 pregnancies were complicated with infant death. Comorbidities mainly found were preeclampsia, anemia and urinary tract infection. Most patients delivered through caesarian section. Almost all of them were treated with insulin. Comparison between both groups showed that those with poor outcomes have a significantly higher body mass index prior to pregnancy, higher body weight prior and after pregnancy as well as worse glycemic profile.Conclusion
Diabetes in pregnancy has been found to increase rates of infant mortality. This study showed that patients with poor glycemic control are at a greater risk of infant mortality. Therefore increased monitoring and prenatal care as well as optimal glycemic control for patients with diabetes in pregnancy is recommended. Optimal glycemic control will lead to diabetic mothers with pregnancies of equal risk and similar outcomes to those of normal patients. 相似文献19.
Zahra Karimi Farima Kahe Adeel Jamil Jolanta Marszalek Asiye Ghanbari Mohsen Afarideh Elias Khajeh Sina Noshad Alireza Esteghamati Gerald Chi 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):365-368
Background
Nephropathy is a major complication of type 2 diabetes mellitus (T2DM) and is heralded by the insidious development of microalbuminuria (MA). It is suggested that the serum levels of Intercellular Adhesion Molecule-1 (ICAM-1) is correlated with diabetic nephropathy. In this cross-sectional study, we evaluated serum ICAM-1 level in diabetic patients with and without MA.Methods
A total of 187 participants were enrolled and were classified into three groups including 40 healthy controls and 2 diabetic groups with (n?=?59) or without MA (n?=?88). Serum levels of ICAM-1, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, very low density lipoprotein cholesterol and C-reactive protein (CRP) were measured in all three groups. Statistical analyses were performed using the SPSS software. A P-value less than 0.05 was considered statistically significant.Results
Serum levels of ICAM-1 were significantly higher in diabetic patients irrespective of MA. Moreover, ICAM-1 levels in patients with MA were significantly higher than patients without MA. Patients with MA had significantly higher age and blood pressure compared to those without MA (P?=?0.001). Serum levels of ICAM-1 were significantly correlated with age and HbA1c.Conclusions
Overall, serum ICAM-1 levels were significantly higher in T2DM patients with MA and it may be associated with the severity of diabetic kidney disease. 相似文献20.
Alessandra M. Mantovani Cristina E.P.T. Fregonesi Mariana R. Palma Fernanda E. Ribeiro Rômulo A. Fernandes Diego G.D. Christofaro 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2017,11(1):47-50
Individuals with diabetes develop lower extremity amputation for several reasons. Investigations into pathways to the development of complications are important both for treatment and prevention.