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1.
Tarek Mohamed Ali Ahmad El Askary 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1045-1050
Background
Inconsistent results have been described regarding the part of fetuin-A and testosterone in arterial stiffness in type 2 diabetes mellitus (T2DM).Aim
To look into the links of serum fetuin-A and testosterone levels with brachial-Ankle pulse wave velocity (baPWV), a marker of arteriosclerosis and common carotid intima media thickness (ccIMT), a marker of early atherosclerosis, in diabetic Saudi men patients.Subjects and methods
One hundred and fifty adult male patients with T2DM and 60 non-diabetic control subjects were enrolled from different Saudi Arabia Taif hospitals. Biochemical analysis, anthropometric measurements, blood pressure, baPWV and ccIMT were investigated.Results
Stepwise regression in diabetic patients revealed that the most important predictor of ba-PWV was serum fetuin-A followed by serum glucose and the most important predictor of ccIMT was serum fetuin-A followed by serum HDL then serum triglycerides.Conclusions
Only fetuin-A levels not testosterone are negatively associated with early markers of atherosclerosis. 相似文献2.
Nicolas Roberto Robles Juan Lucio Ramos Edgar Chavez Boris Gonzalez Candia Miguel Angel Bayo Antonio Cidoncha Juan Lopez Gomez Juan Jose Cubero 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):933-937
Backgrounds
Iron deficiency has been studied extensively in patients with chronic kidney disease on hemodialysis therapy. However, few studies looked at iron treatment in the non-dialysis chronic kidney disease population.Methods
Five hundred and eighty patients were studied (247 were diabetic persons). Patients were divided into 4 groups: non-diabetic subjects without CKD, non-diabetic ones with GFR?<?60?mL/min, diabetic persons without CKD and diabetic ones with GFR?<?60?mL/min). Iron deficiency was diagnosed when serum ferritin level was <100?mg/dl. It was defined as diminished iron availability when ferritin was above 100?mg/dl and serum transferrin saturation (TSAT) was <20%.Results
Anemia was more frequent in the diabetic CKD patients group (52.4%, p?<?0.001). Anemia prevalence was also higher in all CKD patients as well as in diabetic patients compared with non-diabetic ones. Iron deficiency was more frequent in diabetic patients. Among CKD diabetic patients the prevalence of iron deficiency was higher than in non-diabetic CKD ones. Diminished iron availability prevalence was higher in non-diabetic patients. Logistic regression analysis showed that only sex and diabetes mellitus were independently associated with iron deficiency.Conclusions
Anemia was more common in diabetic CKD patients. Diabetes mellitus was independently associated with iron deficiency. Surprisingly, diminished iron availability was not more frequent in diabetic patients. The physio-pathological mechanisms that could explain these findings remain to be elucidated. 相似文献3.
Mohammed Hadi Al-Osami Ekhlas Khalid Hameed 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):939-942
Background
Diabetes Mellitus (DM) is a major health burden worldwide. Patients with type 2 DM has various complications, including impaired bone health. Adiponectin is novel adipocytokine that could influence bone metabolism.Objective
We investigated the relationships between serum adiponectin versus lumbar bone mineral density (BMD) in type 2 diabetic osteoporotic postmenopausal women.Subjects and methods
This study is a case control study included 90 postmenopausal women; divided as (group A) composed of 30 type 2 diabetic osteoporotic postmenapausal,(group B) composed of 30 non diabetic osteoporotic postmenopausal and 30 apparently healthy non osteoporotic postmenopausal women as a control group. All participants underwent Dual Energy X-ray Absorptiometry to measure the lumbar Bone Mineral Density (BMD).Serum adiponectin was measured by ELISA Kits. SPSS was used to analyze the data.Results
Among the studied subjects, group B showed a significant negative correlation between serum adiponectin and lumbar BMD. The diabetic osteoporotic postmenapausal group (group B) showed the lowest concentration of serum adiponectin (μg/mL): 5.14 compared with 11.02 and 8.63 in group A, and the control, respectively. Lumbar BMD of group B was significantly higher than that of group A.Conclusions
Serum adiponectin is associated with lumber BMD in diabetic osteoporotic postmenopausal women. These findings suggest that serum adiponectin was involved in bone metabolism in this group. 相似文献4.
Lobna F. El Toony Dina Ali Hamad Omar Mohammed Omar 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(5):761-767
Background
Ramadan fasting is associated with the risk of acute complications including hypoglycaemia. Therefore, patients' education before Ramadan and follow up during Ramadan is essential for safe fasting.Objectives
To evaluate the effect of pre-Ramadan education program on biochemical parameters and the risk of hypoglycaemia in patients with type 2 diabetes mellitus.Methods
A prospective interventional controlled design was carried out on 320 Muslim patients with type 2 diabetes. They were divided into 2 groups; the control group (n?=?200) who received standard diabetic care and the intervention group (n?=?120) who received focused individualized diabetic education sessions before Ramadan. The study was carried out on 3 phases (before, during and after Ramadan). Post-education change of hypoglycaemia risk and biochemical parameters during Ramadan fasting were the primary outcomes.Results
Fasting blood glucose decreased significantly during, and after Ramadan in both groups (P?<?0.001). Hypoglycaemia during fasting occurred in 4.1% of patients in the intervention group vs. 19.5% in the control group. Post Ramadan reduction of HbA1c?<?7% increased statistically significantly in the intervention group (from 20.8% of patients before Ramadan to 55.8% after Ramadan). Low-density lipoprotein cholesterol decreased in the intervention group (P?=?0.024). The body weight of the patients did not significantly change in both groups.Conclusion
There was a significant impact of pre-Ramadan educational program on reduction of hypoglycaemic risk and other acute complications, reduction of low-density lipoprotein cholesterol and improvement of high-density lipoprotein cholesterol. Therefore, it is recommended for the fasting patients especially those with high and very high risk during Ramadan. 相似文献5.
Seyed Alireza Ebadi Parichehr Darvish Ali Jamshidi Fard Behnam Safarpour Lima Omid Gharoei Ahangar 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):893-896
Aims
Hypoglycemia can be considered the most common complication of Diabetes Mellitus treatment. So far, controversial studies have been carried out to examine the impacts of hypoglycemia on the cognitive function.Methods
This study was conducted as case-control. The case group was 35 patients with Diabetes Mellitus Types I or II hospitalized in Imam Hussein Hospital, Tehran, Iran, who have experienced hypoglycemic attacks (glucose level below 70?mg/dl). The control group consisted of diabetic patients hospitalized in hospital, but they had no history of hypoglycemia. As the blood glucose level became in normal range and the patients’ Mental status became stable, the brain cognitive function was examined using Mini-Mental State test.Results
The mean age of the subjects in the case and control groups was 56.77, 53.73 years old, respectively. The mean cognitive score in the control and hypoglycemic groups was 29.09 and 25.29, respectively. The mean MMSE cognitive score was significantly diminished in the hypoglycemic group (p?<?0.001).Conclusions
This study indicated that incidence of hypoglycemia in diabetic patients is associated with cognitive disorders. Further, there is a linear association between cognitive disorders and hypoglycemia, age and diabetes mellitus complication. 相似文献6.
Heitham Awadalla Sufian K. Noor Wadie M. Elmadhoun Sarra O. Bushara Ahmed O. Almobarak Amel Abdalrhim Sulaiman Mohamed H. Ahmed 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):961-964
Background
Diabetes mellitus (DM) is a major health problem in Sudan and is a leading cause of morbidity and mortality. Dyslipidemia is a major complication of diabetes and an important risk factor for cardiovascular disease (CVD). The objective of this study was to determine the prevalence of dyslipidemia and its co-relation with the glycemic control in individuals with diabetes in River Nile State, Sudan.Methods
Individuals with diabetes attended, Naserudin Karamalla Diabetic (NKDM) Centre, in Atbara teaching hospital during study period, who volunteered to participate were included. Only those on treatment for DM for at least one year were included. Venous samples were collected for cholesterol, triglycerides, HDL, LDL, blood glucose and Glycosylated hemoglobin. Participants were interviewed using standardized pretested questionnaire to record medical history and sociodemographic characteristics. Blood pressure, body mass index (BMI) and waist circumference were measured.Results
A total of 188 individuals were included. The mean age was 49.5?+?13.9 and (128) 68.1% were females. Most patients were having DM for at least 3–5 years 69 (36.7%). Poor diabetes control (HbA1c >7) was recorded in 87.2%, hypercholesterolemia, hypertriglyceridemia and high LDL were identified in 36.6%, 27.7% and 26.6% respectively. In addition, HDL was low in 61.2% of patients.Conclusion
Low HDL is a prominent feature in two thirds of individuals with diabetes, while high cholesterol and high triglyceride were seen in over one quarter. 相似文献7.
Deldar Morad Abdulah Alan Bapeer Hassan Farsat Saeed Saadi Ary Habeeb Mohammed 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):969-975
Objectives
Dietary and physical activity advice have been considered to be seminal ingredients in prevention and management of type 2 diabetes mellitus. In this regard, the impacts of a three-month self-management intervention on glycemic control in patients with type 2 diabetes were examined in the present study.Study design
A Double-arm post-test intervention study.Methods
In the current post-test intervention study, three two-hour educational sessions on dietary habits and physical activity designed according to Health Belief Model were presented to 16 non-complicated type 2 diabetic patients and their dietary, physical activities, and biochemical outcomes were compared to a 23 patient-control arm in Iraq in 2017. The level of physical activity was measured through International Physical Activity Questionnaire (IPAQ), dietary habits through UK Diabetes and Diet Questionnaire (UKDDQ), and biochemical indicators including HbA1c were measured after three months of program completion.Results
The study showed that walking, taking vegetable, fruit, and bread were higher and taking full-fat cheese and full-fat spread was lower among experimental group significantly compared to control arm. In addition, the experimental group had a substantial higher albumin and lower urea, ALP-Phosphatase, and glucose levels in comparison with control patients. No substantial change was seen in HbA1C and no change in milk and fish products.Conclusions
The substantial positive changes in physical activity, dietary habits, and some biochemical indicators were seen following intervention completion in the experimental arm. 相似文献8.
Salwa S. Hosny Meram M. Bekhet Hayam A. Hebah Nagwa R. Mohamed 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1019-1024
Background
Diabetes mellitus is the leading cause of end stage renal disease worldwide. Early identification of diabetic nephropathy even before appearance of microalbuminuria is a challenge for early prevention of occurrence and progression of this complication. Neutrophil gelatinase-associated lipocalin is a small protein that belongs to the lipocalin protein. Urinary neutrophil gelatinase-associated lipocalin is a promising early marker in different renal problems.Aim of the work
To measure urinary neutrophil gelatinase-associated lipocalin in type 2 diabetic patients and to assess its role as an early marker for diagnosis of diabetic nephropathy and diabetic retinopathy.Patient and methods
The current study included 60 subjects with type 2 diabetes and 20 healthy control subjects. Diabetic subjects were divided into 3 groups according to urinary albumin creatinine ratio; 20 normoalbuminuric patients, 20 micro-albuminuric patients and 20 macroalbuminuric patients. They were subjected to history taking, full clinical examination, fundus examination, anthropometric measurement, urinary neutrophil gelatinase-associated lipocalin and urinary albumin creatinine ratio.Results
Urinary neutrophil gelatinase-associated lipocalin was higher in all diabetic groups than in the control group, with no difference in between diabetic groups. The difference was of great value when comparing normoalbuminuric group with control as albumin creatinine ratio was not different while the urinary neutrophil gelatinase-associated lipocalin was statistically significant (5.94?±?1.85?ng/dl vs 1.96?±?0.65, p?<?0.001). No correlation was found with retinopathy.Conclusion
Urinary neutrophil gelatinase-associated lipocalin is a sensitive marker for early detection of diabetic nephropathy even in normoalbuminuric patients denoting early tubular damage before microalbuminuria. It is not correlated with retinopathy. 相似文献9.
Aladeen Alloubani Abdulmoneam Saleh Ibrahim Abdelhafiz 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):577-584
Background
Stroke is becoming a major challenge in healthcare systems, and this has necessitated the study of the various risk factors. As the number of people with hypertension, diabetes mellitus and obesity increases, the problem is expected to worsen. This review paper evaluates what can be done to eliminate or reduce the risk of stroke.Objective
The aim of the research is to evaluate the risk factors for stroke. The paper also aims to understand how these risks can be handled to avoid incidences of stroke.Method
Published clinical trials of stroke risk factors studies were recognised by a search of EMBASE and MEDLINE databases with keywords hypertension, blood pressure, diabetes mellitus, stroke or cardiovascular disease, or prospective study, and meta-analysis.Results
The findings of this review are that the prevention of stroke starts with identifying risk factors for stroke, most of the patients diagnosed with stroke have various risk factors. Consequently, it is a very significant to identify all the risk factors for stroke as well as to teach the patient how to dominate them.Conclusion
after summarising all the studies mentioned in the paper, it can be established that hypertension and diabetes mellitus are a stroke risk factors and correlated in patients with atherosclerosis. 相似文献10.
Alessandra M. Mantovani Cristina E.P.T. Fregonesi Mariana R. Palma Fernanda E. Ribeiro Rômulo A. Fernandes Diego G.D. Christofaro 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2017,11(1):47-50
Individuals with diabetes develop lower extremity amputation for several reasons. Investigations into pathways to the development of complications are important both for treatment and prevention.
Aim
To evaluate the relationship between amputation and risk factors in people with diabetes mellitus.Materials and method
All participants included in this study (n = 165) were recruited from the Diabetic Foot Program, developed in a Brazilian University, over seven years (2007–2014) and all information for this study was extracted from their clinical records.Results
The prevalence of amputation in patients with diabetes with four risk factors was up to 20% higher when compared to those with only one risk factor. The main predictive risk factors for amputation in this population were the presence of an ulcer and smoking.Conclusion
The risk factors for amputation can be predicted for people with diabetes mellitus and, in the present study, the main factors were the presence of an ulcer and the smoking habit. 相似文献11.
Anthony P. Sunjaya Angela F. Sunjaya 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1031-1037
Aims
To compare the clinical and glycemic profile as well as pregnancy complications and infant mortality among diabetic mothers in Indonesia.Materials and Methods
Data was obtained from medical records of Internal-Medicine Clinic in Hermina Podomoro General Hospital during the period January-December 2015. Subjects were grouped into good and poor outcome groups based on infant mortality.Results
Forty-five subjects were obtained with an average age of 31 years, 41 had gestational diabetes mellitus while 4 had pregestational diabetes. Twenty-one patients had high-risk pregnancies (age >30 years or <20 years). No maternal mortalities were reported, only 6 pregnancies were complicated with infant death. Comorbidities mainly found were preeclampsia, anemia and urinary tract infection. Most patients delivered through caesarian section. Almost all of them were treated with insulin. Comparison between both groups showed that those with poor outcomes have a significantly higher body mass index prior to pregnancy, higher body weight prior and after pregnancy as well as worse glycemic profile.Conclusion
Diabetes in pregnancy has been found to increase rates of infant mortality. This study showed that patients with poor glycemic control are at a greater risk of infant mortality. Therefore increased monitoring and prenatal care as well as optimal glycemic control for patients with diabetes in pregnancy is recommended. Optimal glycemic control will lead to diabetic mothers with pregnancies of equal risk and similar outcomes to those of normal patients. 相似文献12.
Sivabal Vanjiappan Abdoul Hamide Ramesh Ananthakrishnan Senthilkumar Gandhipuram Periyasamy Vadivelan Mehalingam 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):479-482
Introduction
Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of liver disease that ranges from hepatic steatosis to non-alcoholic steatohepatitis. Obesity and diabetes mellitus are the prime risk factors for NAFLD. The aim of this study was to find out the prevalence of NAFLD among patients with type 2 diabetes mellitus and to detect the association of NAFLD with cardiovascular disease in them.Study design
Prospective observational study.Material and methods
The study was conducted on 300 patients with type 2 diabetes mellitus attending the outpatient department of a tertiary care teaching hospital. All patients underwent hepatic ultrasonography to look for hepatic steatosis. Among the 300 patients, 124 were divided into NAFLD and non-NAFLD groups based on the ultrasound findings. These patients were subjected to electrocardiogram, 2D echocardiogram, carotid intima media thickness (CIMT) measurement and ankle brachial pressure index measurement along with measurement of markers of oxidative stress.Results
Hepatic steatosis was present in 61% of diabetic patients in this study. Cardiovascular disease was not found to be significantly associated in diabetic patients with NAFLD. However, cardiovascular risk factors like CIMT, high sensitivity c-reactive protein (hs-CRP) and malondialdehyde (MDA) were elevated in these patients. hs-CRP and MDA levels were found to be significantly associated with the severity of NAFLD.Conclusion
There is a high prevalence of NAFLD in type 2 diabetic patients. No correlation was detected between the presence of NAFLD and cardiovascular disease in them; although there was an association between cardiovascular risk factors and NAFLD. 相似文献13.
14.
Soorampally Vijay Abdoul Hamide Gandhipuram Periyasamy Senthilkumar Vadivelan Mehalingam 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(5):649-652
Introduction
Renal tubulo-interstitial damage has an important role in the pathogenesis of early diabetic nephropathy. Urinary biomarkers can help in the detection of early nephropathy in type 2 diabetic patients. The aim of this study was to estimate the levels of urinary neutrophil gelatinase associated lipocalin (NGAL) and cystatin-C in type 2 diabetic patients with early diabetic nephropathy & to compare them with diabetic patients without nephropathy and to correlate urinary NGAL and cystatin-C levels with microalbuminuria in them.Study design
Cross-sectional comparative study.Material and methods
The study was conducted on 126 patients with type 2 diabetes along with 30 control subjects attending the outpatient care department of a tertiary care teaching hospital. There were 3 study groups-diabetic patients with microalbuminuria, diabetic patients without albuminuria and control subjects who were non-diabetic without any renal disease. Details on duration of diabetes and glycemic status were obtained from the patients. Urine examination was done for subjects in all the groups to look for microalbuminuria along with estimation of NGAL and cystatin-C levels. Samples were stored at ?20?°C in the deep freezer.Results
Urinary NGAL and cystatin-C levels were significantly elevated in patients with microalbuminuria (228.18 & 3.23?ng/ml) as compared to those without albuminuria (146.12 & 2.61?ng/ml) and in control subjects (26.56 & 0.30?ng/ml). Urinary NGAL and cystatin-C levels showed a linear correlation with microalbuminuria in diabetic patients.Conclusion
Urinary NGAL and cystatin-C levels were increased in type 2 diabetic patients with early diabetic nephropathy as compared to patients without nephropathy. Urine NGAL and cystatin-C levels also showed a positive correlation with microalbuminuria (urine albumin-creatinine ratio) in patients with type 2 diabetes mellitus. 相似文献15.
Vimal Upreti Vijay Maitri Pawan Dhull Ajay Handa M.S. Prakash Anil Behl 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):509-512
Context
Vitamin D supplementation in type 2 diabetes mellitus patients may lead to improved glycemic control by improving insulin secretion and decreasing insulin resistance.Aims
To investigate effect of oral vitamin D supplementation on glycemic control, in patients with type 2 diabetes mellitus and coexisting hypovitaminosis D.Settings and design
Randomized, Parallel Group, Placebo Controlled Trial carried out in a tertiary care hospital of Indian Armed Forces.Methods and material
Sixty patients with coexisting type 2 diabetes mellitus and hypovitaminosis D were randomized into cases and controls and were supplemented with oral Vitamin D and microcrystalline cellulose respectively for six months. Subjects' HbA1c and vitamin D levels were monitored at the beginning and end of the study, fasting plasma glucose (FPG) & post prandial plasma glucose (PPPG) during monthly OPD visits.Statistical analysis used
Intra-group comparison was made by paired t test & unpaired t test was used for inter-group (A v/s B) comparisons. Repeated measures ANOVA was undertaken to compare values over time.Results
The two groups were comparable for all parameters at baseline. Case group showed significant decrease in mean HbA1c levels (7.29% to 7.02%; P?=?0.01), mean FPG levels (131.4 to 102.6?mg/dl; P?=?0.04) and mean PPPG levels (196.2 to 135.0?mg/dl; P?<?0.001). Incidentally, significant improvement in systolic as well as diastolic blood pressure and total cholesterol was also noted in the cases, while for LDL cholesterol improvement tended towards significance (p?=?0.05).Conclusions
We found that oral vitamin D supplementation was associated with improved glycemic control and other metabolic parameters in patients with type 2 diabetes mellitus. Supplementation to achieve normal levels of vitamin D can be a promising adjuvant therapy for T2DM patients & coexisting hypovitaminosis D. 相似文献16.
S.V. Madhu G. Sandeep B.K. Mishra M. Aslam 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):923-927
Aim
The burden of diabetes is very high in our country particularly in the urban metros. The present survey was planned to ascertain the current prevalence of diabetes and prediabetes in Delhi since the available prevalence estimates are over a decade old.Methods
The present study was conducted in urban area of east Delhi and followed a multistage random sampling design. The prevalence of known diabetes was ascertained based on self reporting and prevalence of newly detected diabetes and prediabetes was based on oral glucose tolerance test (OGTT).Results
We surveyed 470 households and included 1317 individuals. Prevalence of diabetes was 18.3% (known 10.8% and newly detected 7.5%). Prevalence of prediabetes was 21% as per WHO criteria and 39.5% as per ADA criteria. The ratio of known to unknown diabetes was 1.44:1. Every third household (35.77%) had at least one known case of diabetes. High rates of obesity and central obesity were also observed in the study population.Conclusion
The present study found a strikingly high prevalence of diabetes, prediabetes and obesity in Delhi. This calls for urgent and effective preventive measures to prevent diabetes. 相似文献17.
Ehimen Phyllis Odum Ekenechukwu Esther Young 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(2):141-145
Background
Elevated cardiac troponin I, Creatine kinase (CK-MB) and Myoglobin levels are observed in the setting of acute myocardial damage. However sub-clinical elevations occur in patients with diabetes mellitus. This study was carried out to determine the relationship between the presence of multiple cardiovascular risk factors and the metabolic syndrome and elevations in cardiac markers in patients with type2 diabetes mellitus.Subjects and methods
Consecutive stable out-patients with type2 diabetes mellitus at the University of Port Harcourt Teaching Hospital, Nigeria were recruited. Non-diabetic individuals such as hospital staff and the general public acted as controls. Baseline demographic data collection was done and waist circumference, weight, height and blood pressure were measured. Venous samples were assayed for CTnI, CK-MB and Myoglobin levels using ELISA. Data was analysed using SPSS v 20.Results
There were 188 DM patients, who were older than the 200 control subjects (56.1?±?13.1?years and 42.7?±?5.7?years, p?<?0.001). Mean duration of diabetes was 7.1(5.7)?years. Hypertension was present in 59%, 84.6% had dyslipidaemia, while 76.1% had metabolic syndrome. All the cardiac markers were significantly higher in DM patients than controls. The presence of hypertension or dyslipidaemia was not significantly associated with the cardiac markers (p?>?0.05 for all), however the DM patients with metabolic syndrome had higher levels of CK-MB and myoglobin but not CTnI than those without.Conclusion
Diabetes mellitus is associated with chronic sub-clinical elevation of cardiac markers and this is more in those with multiple cardiovascular risk factors and/or the metabolic syndrome. 相似文献18.
Siyu Chen Xuhong Hou Yu Sun Gang Hu Xiaoyan Zhou Huijuan Xue Peizhu Chen Jingzhu Wu Yuqian Bao Weiping Jia 《Primary Care Diabetes》2018,12(3):231-237
Aims
To assess whether an integrated hospital-community diabetes management program could improve major cardiovascular risk factor control among patients with diabetes in real-world clinical settings.Methods
985 adults with diabetes in the Shanghai Taopu community health service center were enrolled at baseline and 907 subjects completed the follow-up. The follow-up levels of the metabolic profiles were assessed by their averages during the follow up period.Results
After a mean 7-year follow-up period, heamoglobin A1c, systolic and diastolic blood pressure levels decreased by 0.6%, 5.7 mmHg, and 1.5 mmHg, respectively (all P < 0.001). There was a non-significant difference in low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol increased 1.9 mg/dL and triglycerides decreased 28.3 mg/dL, respectively (all P < 0.001). The percentage of patients with diabetes who met any one of three Chinese Diabetes Society goals (heamoglobin A1c <7.0%, blood pressure <140/80 mmHg, and low-density lipoprotein cholesterol <100 mg/dL) increased from 58.2% to 70.1%. The chronic diabetes complication screening rates (diabetic retinopathy, diabetic neuropathy, diabetic nephropathy) have significantly increased, from almost zero to 12–78%.Conclusions
This long-term program has increased the proportions of attaining major cardiovascular risk factors control goals and diabetic chronic complication screening rates among patients with diabetes. 相似文献19.
Leila Yazdanpanah Hajieh Shahbazian Iraj Nazari Saeed Hesam Fatemeh Ahmadi Bahman Cheraghian Hamid Reza Arti Seyed Ehsan Mohammadianinejad 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1039-1043
Aims
This study was done to assess the risk factors associated with diabetic foot ulcer-free survival in patients with diabetes.Materials and Methods
Based on a prospective cohort study, ADFC (Ahvaz Diabetic Foot Cohort) study, carried out in a university hospital, all of the patients with diabetes were followed up for new diabetic foot ulcer (DFU). The time of ulcer development was final outcome during two years in the present study. To analyze the data, the variables were first evaluated by univariate analysis. Subsequently variables with P value <0.2 were tested in multivariate analysis, using backward elimination multiple Cox regression.Results
From among 605 eligible patients of ADFC study, 566 patients without foot ulcer were included for a 2- years follow-up. Thirty subjects (5.3%) developed DFU during the study course none of whom underwent amputation. The DFU-free survival rate was 0.945 over two years of follow-up. In final multivariate Cox regression analysis, the variables which remained in the model and had a statistically significant relationship with time to develop foot ulcer were: dyslipidemia, history of DFU or amputation, nephropathy callus formation in the feet and diabetes duration. Foot deformity and patients' training about self-care of their feet were statistically borderline significant.Conclusions
The DFU-free survival rate was 0.945 over two years of follow-up. In this study, independent risk factors associated with ulcer-free survival in diabetic foot patients were dyslipidemia, prior history of DFU or amputation, diabetic nephropathy, callus formation in the feet and diabetes duration. 相似文献20.
Tora Grauers Willadsen Volkert Siersma Anni Brit Sternhagen Nielsen Rasmus Køster-Rasmussen Ann Dorrit Guassora Dorte Ejg Jarbøl Paolo Eusebi Kirsti Malterud Susanne Reventlow Niels de Fine Olivarius 《Primary Care Diabetes》2018,12(4):354-363