麝香保心丸治疗急性心肌梗死180例

目的：观察在治疗急性心肌梗死药物基础上加用麝香保心丸的临床疗效。方法2007年5月-2012年6月我院收治急性心肌梗死患者360例，随机分为对照组180例，给予低分子肝素钙、β受体阻滞剂、阿司匹林、氯吡格雷、硝酸酯类药物、他汀类药物、血管紧张素转换酶抑制剂/血管紧张素Ⅱ受体拮抗剂，符合条件的患者给予溶栓疗法；治疗组（180例）在上述基础上联用麝香保心丸。疗程结束后对2组结果进行比较。结果治疗组治疗效果优于对照组。结论麝香保心丸对急性心肌梗死的疗效肯定。     

无导管室医院的急性ST段抬高心肌梗死患者的住院治疗状况分析

近年来,大量循证医学研究成果表明,急性ST段抬高心肌梗死(STEMI)患者应得到及时的再灌注治疗,而在实施再灌注治疗的基础上早期应用低分子肝素、β受体阻滞剂、血管紧张素转换酶抑制剂(ACEI)、他汀类调脂药、阿司匹林、氯吡格雷等药物可提高患者生存率,而且我国及ACC/AHA急性心肌梗死(AMI)治疗指南中均强调了这些治疗的必要性。本     

急性心肌梗死治疗现状分析

目的: 了解急性心肌梗死(AMI)患者住院期间治疗现状及与指南差距。方法: 选自2002年12月~2005年11月AMI住院患者92例,统计分析接受药物阿司匹林、低分子肝素、硝酸脂类、β-受体阻滞剂、血管紧张素转换酶抑制剂(ACEI)、他汀类调脂药及静脉溶栓、经皮冠状动脉介入治疗(PCI)临床应用情况。结果: 患者住院期间不同年度阿司匹林使用率90.32%~93.10%,低分子肝素70.97%~82.76%,硝酸脂类78.13%~80.65%,β-受体阻滞剂62.50%~65.52%,ACEI46.88%~58.62%,他汀类调脂药6.25%~68.97%;再灌注治疗中,静脉溶栓31.25%~41.38%,PCI3.13%~17.24%。结论: 经循证医学证实有效治疗措施大部分在二级甲等医院已得到较好的应用,部分措施已达三甲医院水平,PCI应用差距最大,且短期内难以改善,静脉溶栓仍是早期再灌注主要途径。     

急性冠状动脉综合征并消化道出血34例临床治疗分析

目的:对34例急性冠状动脉综合征并消化道出血患者的临床治疗效果进行分析。方法:患者消化道出血后停用低分子肝素和阿司匹林,并配合血管紧张素Ⅰ转化酶抑制剂、他汀类、β-受体阻滞剂、硝酸脂类药物进行强化治疗,后经质子泵抑制剂静脉治疗,其中黑便患者停用氯吡格雷,至大便转黄后恢复其原有药物的治疗,待大便潜血消失后口服质子泵抑制剂并加用阿司匹林。结果:患者1～3周后病情得以好转,其中黑便患者5 d后大便转黄,患者大便潜血均转为阴性后通过质子泵抑制剂和阿司匹林维持治疗。随访1年,未有患者出现活动性出血现象。结论:合理的通过氯吡格雷康栓治疗急性冠状动脉综合征并消化道出血,可取的满意疗效。     

重庆市1010例急性心肌梗死住院治疗状况分析

目的 调查分析重庆地区急性心肌梗死(AMI)一般情况和临床治疗状况.方法 回顾分析重庆市1010例AMI住院病历,记录其一般情况、病史特征、诊断、治疗方式及药物使用情况.结果 行经皮冠状动脉介入治疗(PCI)325例,占32.2%,直接PCI 91例,占9.0%,药物溶栓治疗122例,占12.1%;药物使用:肝素/低分子肝素86.6%,他汀类80.8%,硝酸酯类76.7%,阿司匹林90.1%,阿司匹林联用氯吡格雷74.7%,ACEI/ARB 74.2%,β受体阻滞剂55.1%;逐年比较,他汀类、阿司匹林、阿司匹林联用氯吡格雷及肝素/低分子肝素使用率有提高,ACEI/ARB和β受体阻滞剂的实际/适宜使用率呈增加趋势.结论 重庆地区AMI早期再灌注治疗及药物治疗距<急性心肌梗死诊断和治疗指南>要求尚有差距.     

尿激酶联合氯吡格雷治疗急性心肌梗死48例的临床疗效观察

目的观察尿激酶溶栓联合氯吡格雷治疗急性心肌梗死的临床疗效。方法静脉溶栓的96例患者被随机分为对照组和治疗组,溶栓前均给予阿司匹林0．3gpo,治疗组于入院后即口服氯吡格雷300rag,次日改为75mg,qd,po。观察两组溶栓厉的血管再通率及心血管不良事件情况。结果治疗组梗死后的血管再通率明显提高（P〈0．05）,梗死后心绞痛、心律失常、再发梗死明显低于对照组（P〈0．05）。结论尿激酶溶栓联合氯吡格雷治疗急性心肌梗死安全有效。     

氯吡格雷联合阿司匹林和尿激酶治疗急性ST段抬高型心肌梗死的临床疗效研究

目的 评价氯吡格雷联合阿司匹林、尿激酶溶栓治疗急性ST段抬高型心肌梗死(STEMI)的有效性和安全性.方法 选取STEMI患者96例,按是否加用氯吡格雷分为两组:对照组48例,采用肠溶阿司匹林片口服,尿激酶静脉溶栓治疗,溶栓12 h后皮下注射低分子肝素;氯吡格雷组48例,在对照组治疗基础上加用氯吡格雷负荷量300 mg,以后75 mg/d.临床观察指标为梗死相关动脉心肌梗死溶栓试验(TIMI)Ⅲ级血流、冠脉内血栓、出血并发症、住院期间心血管事件.结果 氯吡格雷组患者梗死相关动脉TIMIⅢ级血流者的比例较对照组显著升高(P＜0.05),冠脉内血栓发生率较对照组显著降低(P＜0.05).两组患者在出血并发症、再梗死、心源性死亡、总死亡方面差异无统计学意义(P＞0.05).结论 氯吡格雷联合阿司匹林、尿激酶溶栓治疗STEMI能改善梗死血管畅通率,并不增加出血并发症.     

氯吡格雷治疗急性心肌梗死的临床观察

目的：探讨氯吡格雷治疗急性心肌梗死（AMI）的有效性和安全性。方法：选择符合溶栓治疗适应证、无溶栓治疗禁忌证发病12 h以内的急性心肌梗死患者107例,将其分为观察组和对照组。对照组44例,给予肠溶阿司匹林片口服,尿激酶静脉溶栓治疗,溶栓12 h后皮下注射低分子肝素钙;观察组63例,在对照组治疗基础上加用氯吡格雷负荷量300 mg,以后75 mg/d。对两组间血管再通率、冠状动脉内血栓形成率和治疗后心肌梗死再发率、出血率、病死率及梗死后心绞痛发生率等进行比较分析。结果：患者经治疗后心绞痛发生率、再发心肌梗死率、血管再通率、冠脉内血栓形成率观察组显著低于对照组,差异有统计学意义（P〈0.05）,心力衰竭率、出血率、脑梗死发生率、死亡率观察组与对照组相比差异无统计学意义（P〉0.05）。结论：氯吡格雷治疗急性心肌梗死是安全有效的。     

社区医院急性心肌梗死治疗分析

目的: 了解近年来社区医院急性心肌梗死(AMI)患者的住院治疗状况。方法: 调查亳州市人民医院2000~2003年出院诊断为AMI、住院时间>24 h患者的病史资料及各种治疗措施的使用情况。结果: 共调查168例患者,接受溶栓30例(17.86%),适宜溶栓率30.00%,其中动态观察心电图和心肌酶学者10例(5.95%)。β受体阻滞剂(BB)与血管紧张素转换酶抑制剂(ACEI)使用率为50.60%与57.74%;低分子肝素、阿司匹林、硝酸酯类使用率较高,分别为60.12%、85.71%、89.28%;普通肝素使用率为23.21%;他汀类药物和其他调脂药物使用率分别为4.17%和8.33%。所有患者接受中药治疗。结论: 社区医院AMI治疗情况与2000年国际ECC和CPR治疗指南的要求差距明显,中药应用普及。     

氯吡格雷对急性心肌梗死溶栓治疗效果的影响

静脉溶栓治疗能使50％～60％ST段抬高型急性心肌梗死患者发生再灌注，明显降低的病死率，然而，有20％以上经溶栓发生再通的病例发生梗死相关冠脉再闭塞，溶栓药物能增加血小板激活．降低溶栓疗效，增加再闭塞危险。ISIS-2研究证明，溶栓治疗同时应用阿司匹林能显著降低病死率。动物实验发现．氯吡格雷比阿司匹林更有效。本研究目的是评价氯吡格霄对急性心肌梗死患者溶栓治疗效果和安全性的影响。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.