Phenacetin-induced hemolytic anemia

The hematological features of phenacetin-induced hemolytic anemia are presented in order to make the physician aware of the abnormalities which suggest the use of an oxidant drug. The presence of “bitten out” red cells is the commonest initial clue to the existence of drug-induced hemolytic anemia. The diagnosis is confirmed by the demonstration of Heinz bodies and sulfhemoglobinemia. Early recognition of this form of drug-abuse may avert the development or progression of analgesic nephropathy.     

Surgical treatment of hemolytic anemia

The therapeutic effect of splenectomy in 70 cases of hemolytic anemia are reported. The diagnosis and therapeutic effects were analysed. It was evident that the effects were related to different types of hemolytic anemia. The HS type had the best result. Gallstones were detected in 6 cases of this series. Splenectomy and cholecystectomy were performed together in 5 cases. The median incision of upper abdomen was selected. The authors believe that the causes of infection after splenectomy are complicated and they cannot be explained by Igs alone.