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Associations Between the Phosphatidylethanol Alcohol Biomarker and Self‐Reported Alcohol Use in a Sample of HIV‐Infected Outpatient Drinkers in Western Kenya
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Rebecca K. Papas Benson N. Gakinya Michael M. Mwaniki Alfred K. Keter Hana Lee Michelle P. Loxley Debra A. Klein John E. Sidle Steve Martino Joyce B. Baliddawa Kathryn L. Schlaudt Stephen A. Maisto 《Alcoholism, clinical and experimental research》2016,40(8):1779-1787
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Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge,Implications, and Future Directions
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Emily C. Williams Judith A. Hahn Richard Saitz Kendall Bryant Marlene C. Lira Jeffrey H. Samet 《Alcoholism, clinical and experimental research》2016,40(10):2056-2072
Alcohol use is common among people living with human immunodeficiency virus (HIV). In this narrative review, we describe literature regarding alcohol's impact on transmission, care, coinfections, and comorbidities that are common among people living with HIV (PLWH), as well as literature regarding interventions to address alcohol use and its influences among PLWH. This narrative review identifies alcohol use as a risk factor for HIV transmission, as well as a factor impacting the clinical manifestations and management of HIV. Alcohol use appears to have additive and potentially synergistic effects on common HIV‐related comorbidities. We find that interventions to modify drinking and improve HIV‐related risks and outcomes have had limited success to date, and we recommend research in several areas. Consistent with Office of AIDS Research/National Institutes of Health priorities, we suggest research to better understand how and at what levels alcohol influences comorbid conditions among PLWH, to elucidate the mechanisms by which alcohol use is impacting comorbidities, and to understand whether decreases in alcohol use improve HIV‐relevant outcomes. This should include studies regarding whether state‐of‐the‐art medications used to treat common coinfections are safe for PLWH who drink alcohol. We recommend that future research among PLWH include validated self‐report measures of alcohol use and/or biological measurements, ideally both. Additionally, subgroup variation in associations should be identified to ensure that the risks of particularly vulnerable populations are understood. This body of research should serve as a foundation for a next generation of intervention studies to address alcohol use from transmission to treatment of HIV. Intervention studies should inform implementation efforts to improve provision of alcohol‐related interventions and treatments for PLWH in healthcare settings. By making further progress on understanding how alcohol use affects PLWH in the era of HIV as a chronic condition, this research should inform how we can mitigate transmission, achieve viral suppression, and avoid exacerbating common comorbidities of HIV and alcohol use and make progress toward the 90‐90‐90 goals for engagement in the HIV treatment cascade. 相似文献
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P. Pradat M.‐A. Le Pogam J.‐B. Okon P. Trolliet P. Miailhes C. Brochier M. Maynard F. Bailly F. Zoulim L. Cotte 《Journal of viral hepatitis》2013,20(9):650-657
We aimed to compare the evolution of estimated glomerular filtration rate (eGFR) in HIV‐, HIV–HBV‐ and HBV‐infected patients treated with tenofovir disoproxil fumarate (TDF). Three groups of patients receiving TDF > 12 months were recruited: 194 HIV‐infected patients, 85 HIV–HBV‐coinfected patients and 50 HBV‐infected patients. eGFR was estimated using the Modification of the Diet in Renal Disease (MDRD) equation. Multivariate regression models were constructed to estimate factors associated with eGFR decrease from baseline. A total of 329 patients were studied. Median follow‐up was 2.7 years. Median eGFR decrease was ?4.9 (?16.6 to +7.2) mL/min/1.73 m2. After multivariate stepwise regression analysis, age (P = 0.0002), non‐African origin (P < 0.0001), baseline eGFR (P < 0.0001) and TDF duration (P = 0.02) were associated with eGFR decrease in the whole population, while hypertension, diabetes and type of infection were not. Age (P < 0.0001), non‐African origin (P = 0.0004), baseline eGFR (P < 0.0001) and TDF duration (P = 0.007) remained associated with eGFR decline in HIV and HIV–HBV‐infected patients, while other variables including HIV risk factor, CDC stage, CD4 and HIV‐RNA levels were not. Age (P = 0.03), non‐African origin (P = 0.004), baseline eGFR (P < 0.0001) and baseline HBV–DNA > 2000 IU/mL (P = 0.04) were associated with eGFR decline in HBV and HIV–HBV‐infected patients, while other variables including HBV risk factor and fibrosis stage were not. Estimated glomerular filtration rate decline under TDF therapy appears mainly associated with older age, non‐African origin, higher baseline eGFR and longer TDF administration but not with the type of viral infection. Regular follow‐up of renal function, especially tubular function is recommended during TDF therapy. 相似文献
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Interventions to significantly improve service uptake and retention of HIV‐positive pregnant women and HIV‐exposed infants along the prevention of mother‐to‐child transmission continuum of care: systematic review
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Alexandra C. Vrazo Jacqueline Firth Anouk Amzel Rebecca Sedillo Julia Ryan B. Ryan Phelps 《Tropical medicine & international health : TM & IH》2018,23(2):136-148
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Neighborhood‐Level Drinking Norms and Alcohol Intervention Outcomes in HIV Patients Who Are Heavy Drinkers
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Jennifer C. Elliott Erin Delker Melanie M. Wall Tianshu Feng Efrat Aharonovich Melissa Tracy Sandro Galea Jennifer Ahern Aaron L. Sarvet Deborah S. Hasin 《Alcoholism, clinical and experimental research》2016,40(10):2240-2246
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Comparison of Traditional and Novel Self‐Report Measures to an Alcohol Biomarker for Quantifying Alcohol Consumption Among HIV‐Infected Adults in Sub‐Saharan Africa
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Stephen B. Asiimwe Robin Fatch Nneka I. Emenyonu Winnie R. Muyindike Allen Kekibiina Glenn‐Milo Santos Thomas K. Greenfield Judith A. Hahn 《Alcoholism, clinical and experimental research》2015,39(8):1518-1527