Benefit of combined cardiac rehabilitation on exercise capacity and cardiovascular parameters in patients with type 2 diabetes

Favorable effects of exercise training on cardiovascular prognosis have been reported repeatedly in patients with diabetes mellitus type 2 (DM2). However, little is known about the cardiovascular rehabilitation effects in diabetic patients with coronary artery disease (CAD). This study has evaluated the benefits of combined aerobic-resistance training in two groups of patients--diabetics and non-diabetics--after percutaneous coronary intervention (PCI). Changes in exercise capacity parameters, resting cardiovascular and anthropometrical parameters were evaluated in 77 patients who completed 12-weeks of combined aerobic-resistance training: 32 patients with DM2 (DM) and 45 patients without DM2 (NDM). Significant improvements in exercise capacity (total peak workload [W(peak)], peak workload per kg of body weight [W(peak)/kg], total peak oxygen uptake [VO(2peak)], peak oxygen uptake per kg of body weight [VO(2peak)/kg]) were found in both DM and NDM (p < 0.01 and p < 0.001, respectively). The decrease in resting heart rate (HR(rest)), resting systolic (SBP(rest)) resting diastolic (DBP(rest)) blood pressures, body weight (BW) and BMI in the DM group was not statistically significant. However, there was a statistically significant decrease in SBP(rest), BW and BMI in the NDM group. In conclusion, this study demonstrated similar beneficial effects of combined cardiovascular training on exercise capacity in patients with or without type 2 diabetes mellitus. Our results suggest that the combined cardiac training is well tolerated and useful in secondary prevention in patients with DM2 and CAD.     

Association between height-corrected appendicular and regional skeletal muscle mass and insulin resistance in patients with type 2 diabetes

[Purpose] The effect of height-corrected skeletal muscle masses on insulin resistance has not been fully investigated in patients with type 2 diabetes. In this study, we aimed to investigate the association between height-corrected appendicular and regional skeletal muscle masses and insulin resistance in patients with type 2 diabetes. [Participants and Methods] We included 136 male and 100 female patients with type 2 diabetes (average age, male 55.7 ± 12.3 years old, female 60.7 ± 11.3 years old, and average height, male 1.67 ± 0.06 m, female 1.54 ± 0.06 m) in this study. Bioelectrical impedance analysis was used to evaluate skeletal muscle mass. We calculated the appendicular skeletal muscle mass index by dividing the appendicular skeletal muscle mass by the square of the patient’s height. The upper limb muscle mass, lower limb muscle mass, and trunk muscle mass figures were also divided by the square of the patient’s height. We used the homeostasis model assessment of insulin resistance as a marker of insulin resistance. [Results] In multiple regression analysis, the homeostasis model assessment of insulin resistance was inversely associated with appendicular skeletal muscle mass index and lower limb muscle mass/height² in male patients with type 2 diabetes when adjusted for age and body mass index. Similarly, the homeostasis model assessment of insulin resistance was inversely associated with appendicular skeletal muscle mass index and lower limb muscle mass/height² in non-obese female patients with type 2 diabetes. [Conclusion] We have confirmed that there is an association between appendicular skeletal muscle mass index and lower limb muscle mass/height² with insulin resistance in male and female patients with type 2 diabetes, except in females with obesity.     

Effects of yoga exercise on maximum oxygen uptake,cortisol level,and creatine kinase myocardial bond activity in female patients with skeletal muscle pain syndrome

[Purpose] This study analyzed the effects of yoga exercise on maximum oxygen uptake, cortisol level, and creatine kinase myocardial bond activity in female patients with skeletal muscle pain syndrome. [Subjects] The subjects were 24 female patients with skeletal muscle pain syndrome. [Methods] The subjects were divided into 2 groups: a yoga exercise group (n = 12) and a non-exercise control group (n = 12). Body composition, maximum oxygen uptake, cortisol level, and creatine kinase myocardial bond activity were measured before and after a 12-week yoga exercise program. [Results] After the 12-week yoga exercise program, the exercise group exhibited slightly higher maximum oxygen uptake and creatine kinase myocardial bond activity than the control group, but the differences were not statistically significant. In addition, the exercise group exhibited a significant decrease in cortisol level. [Conclusion] Regular and continuous aerobic exercise such as yoga improves body composition, maximum oxygen uptake, cortisol level, and creatine kinase myocardial bond activity in female patients with skeletal muscle pain syndrome.Key words: VO₂max, Cortisol, Creatine kinase myocardial bond     

Effects of regular exercise on obesity and type 2 diabete mellitus in Korean children: improvements glycemic control and serum adipokines level

[Purpose] The aim of the study was to clarify the effects of regular exercise on lipid profiles and serum adipokines in Korean children. [Subjects and Methods] Subjects were divided into controls (n=10), children who were obese (n=10), and children with type 2 diabetes mellitus (n=10). Maximal oxygen uptake (VO₂max), body composition, lipid profiles, glucagon, insulin and adipokines (leptin, resistin, visfatin and retinol binding protein 4) were measured before to and after a 12-week exercise program. [Results] Body weight, body mass index, and percentage body fat were significantly higher in the obese and diabetes groups compared with the control group. Total cholesterol, triglycerides, low-density lipoprotein cholesterol and glycemic control levels were significantly decreased after the exercise program in the obese and diabetes groups, while high-density lipoprotein cholesterol levels were significantly increased. Adipokines were higher in the obese and diabetes groups compared with the control group prior to the exercise program, and were significantly lower following completion. [Conclusion] These results suggest that regular exercise has positive effects on obesity and type 2 diabetes mellitus in Korean children by improving glycemic control and reducing body weight, thereby lowering cardiovascular risk factors and adipokine levels.Key words: Leptin, Resistin, Visfatin     

Effect of resistance exercise on insulin sensitivity of skeletal muscle

Insulin resistance (IR) is the common pathophysiological basis of many metabolic diseases. IR is characterized by decreased glucose uptake in skeletal muscle and adipose tissue, especially in skeletal muscle. Skeletal muscle is the main target tissue of glucose uptake under insulin stimulation. Glucose uptake by skeletal muscle is complex, and it is controlled by many pathways. The PI3K/AKt/GSK-1 signaling pathway is not only the main pathway for insulin signal transduction but also an important mechanism for regulating blood glucose. From the binding of insulin to its receptors on the surface of target cells to the transportation of glucose from extracellular fluid to skeletal muscle, a series of signal transduction processes is completed, any of which potentially affects the physiological effects of insulin and leads to IR. Resistance exercise (RT) can reduce skeletal muscle IR and effectively improve blood glucose control and glycosylated hemoglobin level in patients with type 2 diabetes mellitus (T2DM). However, the exact mechanism by which RT improves skeletal muscle IR remains unclear. Therefore, this paper discusses the above problems by tracking the progress of the literature to deepen the correlation between RT and skeletal muscle insulin sensitivity and provide further evidence for the application of exercise therapy in IR. In conclusion, RT mainly improves insulin sensitivity of skeletal muscle by increasing muscle mass, microvascular blood flow, and glucose transporter-4 expression in skeletal muscle, as well as by reducing lipid accumulation and inflammation in skeletal muscle. Thus, it is potentially useful in the prevention and treatment of T2DM.     

Basal and exercise-induced skeletal muscle blood flow is augmented in type I diabetes mellitus

Hyperaemia occurs early in the renal and retinal microcirculation of patients with type I (insulin-dependent) diabetes mellitus, and may be critical in the development of nephropathy and retinopathy. We therefore sought to determine whether resting and exercise-induced hyperaemia was also apparent in the skeletal muscle circulation of young subjects with type I diabetes. Blood flow was assessed by venous occlusion plethysmography in 18 diabetic (DM) subjects and 20 matched controls. Exercise entailed 2 min of isotonic exercise against no load. Endothelium-dependent and -independent vasodilator function was assessed following intra-arterial infusion of acetylcholine and sodium nitroprusside respectively. Forearm blood flow (FBF) was higher in DM subjects than in controls (3.3+/-0.3 and 2.2+/-0.2 ml x min(-1) x 100 ml(-1) forearm respectively; P<0.005). This was not due to differences in forearm or body size, blood pressure, heart rate, lipid status or glycaemic control. Peripheral insulin levels were higher in DM subjects than in controls (48.5+/-8 and 15.5+/-1.5 micro-units/ml respectively; P<0.005). Resting FBF was closely correlated with insulin levels (r(2)=0.4; P<0.005). Parameters of exercise-induced hyperaemia [including peak flow (16.4+/-1.4 and 12.0+/-0.7 ml x min(-1) x 100 ml(-1) forearm in DM and control subjects respectively; P<0.01) and the volume repaid to the forearm at 5 min post-exercise (32.1+/-3.1 and 23.1+/-1.4 ml x 100 ml(-1) forearm respectively; P<0.05)] were also significantly greater in DM subjects, even when differences in resting FBF were taken into account. Peak hyperaemic blood flow and the volume repaid at 5 min were also related to insulin levels (r(2)=0.16; P<0.05 and r(2)=0.27; P<0.005 respectively). The vasodilator response to acetylcholine was reduced in DM subjects (P<0.05; analysis of variance), and the slope of this dose-flow relationship was inversely related to insulin levels (r(2)=0.2; P<0.05). These data show that both resting and exercise-induced skeletal muscle blood flow are augmented in young patients with type I diabetes, possibly due to the vasodilatory effect of increased insulin levels. Diminished vasodilator responses to acetylcholine may also, in part, be a consequence of insulin-augmented resting muscle blood flow.     

Relationships of Pulmonary Oxygen Uptake Kinetics with Skeletal Muscle Fatigue Resistance and Peak Oxygen Uptake in Healthy Young Adults

[Purpose] The objective of this study was to determine the validity of pulmonary oxygen uptake kinetics in assessment of the ability of skeletal muscles to utilize oxygen. [Subjects] We evaluated 12 young, healthy males. [Methods] The subjects completed a series of tests to determine their peak oxygen uptake, pulmonary oxygen uptake kinetics at the onset of moderate-intensity treadmill exercise, and the rate of decline in electromyographic (EMG) mean power frequency (MPF) (EMG MPF_rate) during one continuous, fatiguing, isometric muscle action of the plantar flexors until exhaustion at approximately 60% maximum voluntary contraction. We discussed the relationships between pulmonary oxygen uptake kinetics and EMG MPF_rate reflecting the ability of skeletal muscles to utilize oxygen and between pulmonary oxygen uptake kinetics and peak oxygen uptake reflecting the ability to deliver oxygen to skeletal muscles. We hypothesized that pulmonary oxygen uptake kinetics may be more highly correlated with EMG MPF_rate than peak oxygen uptake. [Results] Pulmonary oxygen uptake kinetics (33.9 ± 5.9 s) were more significantly correlated with peak oxygen uptake (50.6 ± 5.5 mL/kg/min) than EMG MPF_rate (−14.7 ± 8.7%/s). [Conclusion] Pulmonary oxygen uptake kinetics is a noninvasive index that is mainly usable for evaluation of the ability of cardiovascular system to deliver oxygen to skeletal muscles in healthy young adults with slower pulmonary oxygen uptake kinetics (>20 s).Key words: Pulmonary oxygen uptake kinetics, Oxygen utilization capacity, Oxygen delivery capacity     

Effects of exercise on glycemic control in type 2 diabetes mellitus in Koreans: the fifth Korea National Health and Nutrition Examination Survey (KNHANES V)

[Purpose] The aim of this study was to investigate the effect of exercise on glycemic control using data from fifth Korea National Health and Nutrition Examination Survey and to provide appropriate exercise guidelines for patients with type 2 diabetes mellitus in Korea. [Subjects and Methods] We selected 1,328 patients from the fifth Korea National Health and Nutrition Examination Survey database who had type 2 diabetes and ranged in age from 30 to 90 years. Statistical analyses included χ² tests, multiple linear regression, and logistic regression. [Results] Factors found to be significantly related to glycemic control included income level, physical activity based on intensity of aerobic exercise, use of diabetes medicine, presence of hypertension, duration of diabetes, and waist circumference. In addition, engaging in combined low- and moderate-intensity aerobic exercise when adjusted for resistance exercise was found to lower the risk of glycemic control failure. [Conclusion] Patients with type 2 diabetes mellitus in Korea should engage in combined low- and moderate-intensity aerobic exercise such as walking for 30 minutes or more five times a week. Physical activity is likely to improve glycemic control and thus prevent the acute and chronic complications of diabetes mellitus.Key words: Exercise, Glycemic control, Type 2 diabetes mellitus     

2型糖尿病左室舒张功能及颈动脉损害的相关研究

[目的]探讨2型糖尿病(T2DM)对左室舒张功能及颈动脉损害的影响.[方法]随机选取T2DM患者136例(T2DM组),健康对照组90例,均采用标准方法检测血压、测量身高(m)、体重(kg);检测血糖、血脂等生化指标.采用标准方法测定E峰与A峰比值(E/A),并测量颈动脉内膜中层厚度(IMT).[结果]T2DM组E峰值...     

Vasodilator prostanoids, but not nitric oxide, may account for skeletal muscle hyperaemia in Type I diabetes mellitus

We and others have previously documented increased resting and exercise-induced skeletal muscle blood flow in young subjects with Type I (insulin-dependent) diabetes mellitus compared with healthy controls. Both NO and prostanoids are important regulators of vascular tone and may therefore contribute to this hyperaemia. The aim of the present study was to determine the contribution of NO and vasodilator prostanoids to this skeletal muscle hyperaemia in diabetes. We assessed the effects of infusion into the intrabrachial artery of the cyclo-oxygenase inhibitor acetylsalicylic acid (ASA; aspirin) and of the L-arginine analogue N(G)-monomethyl-L-arginine (L-NMMA) on skeLetal muscle blood flow in subjects with Type I diabetes mellitus (DM subjects) and control subjects. Blood flow was measured by venous occlusion plethysmography. Isotonic forearm exercise involved 2 min of wrist flexion and extension. Resting flow (forearm blood flow; FBF) was augmented in DM subjects, as was peak exercise-related blood flow (PFBF) and the volume repaid to the forearm 5 min after exercise (AUC 5, where AUC is area under the flow-time curve) (P<0.05), even when accounting for differences in basal flow. Infusion of L-NMMA reduced resting flow by 48% in controls (P<0.005) and by 12% in DM subjects (not significant). L-NMMA reduced PFBF and AUC 5 by 29% (P<0.05) and 39% (P<0.0005) respectively in controls, but had no significant effect on these parameters in DM subjects. Infusion of ASA reduced FBF, PFBF and AUC 5 in both DM (P<0.05) and control (P<0.05) subjects, but the magnitude of this reduction was greater in DM than in control subjects (ANOVA, P<0.05), even when differences in resting FBF were accounted for. Indeed, ASA eliminated the differences in FBF, PFBF and AUC 5 between DM and control subjects. Thus increased release of vasodilator prostanoids, rather than of NO, appears to account for skeletal muscle hyperaemia in Type I diabetes.     

Exercise Training Improves Cardiac Autonomic Nervous System Activity in Type 1 Diabetic Children

[Purpose] We investigated the effect exercise training has on cardiac autonomic nervous system (ANS) and cardiovascular risk profiles in children with type 1 diabetes mellitus (DM). [Subjects] Fifteen type 1 DM children (all boys; 13.0±1.0 years of age) were enrolled in the study. [Methods] The subjects received exercise training three times a week in a 12-week program. Each child was asked to walk on a treadmill to achieve an exercise intensity of VO₂max 60%. ANS activity was measured by power spectral analysis of the electrocardiogram (ECG). Blood samples were obtained for serum lipid profiles. To evaluate Doppler-shifted Fourier pulsatility index (PI) analysis, a 5-MHz continuous wave Doppler (VASCULAB D10) set was used to measure forward blood flow velocity (FLOW) in the radial artery. [Results] Total and low-frequency (LF) power of heart rate variability increased significantly after exercise intervention. Total cholesterol (TC) levels were significant lower after exercise intervention. Total and high-frequency (HF) power were significantly correlated with higher TC levels, but diastolic blood pressure and HF was significantly correlated with lower TC levels. [Conclusion] Regular exercise intervention should be prescribed for children with type 1 DM.Key words: Autonomic nervous system, Exercise, Diabetes mellitus     

Aerobic training during hemodialysis improves body composition,muscle function,physical performance,and quality of life in chronic kidney disease patients

[Purpose] We assessed the influences of individualized aerobic training on body composition, knee joint muscle function, physical performance, and quality of life in chronic kidney disease patients. [Subjects] Ten chronic kidney disease patients undergoing dialysis. [Methods] Overall physical function and quality of life before and after 12 weeks of aerobic training were evaluated by body composition, the six-minute walk test, cardiopulmonary exercise tests, and Short Form 36-item questionnaire. [Results] The six-minute walk test distance increased significantly after 12 weeks aerobic training. Resting metabolic rate, lactate threshold, maximum oxygen uptake, and quality of life tended to increase after training. Post-training weight, muscle mass, body fat mass, fat percentage, body mass index, and peak torque of right and left knee extension and flexion did not change significantly. [Conclusion] Intra-dialytic training can a safe approach to maintain or improve physical performance and quality of life of chronic kidney disease patients undergoing hemodialysis without adverse events or negative cardiovascular responses. Aerobic training may prevent a decline in body composition and knee joint muscle function due to inactivity in chronic kidney disease patients. Clinically, aerobic training may initially be adapted to maintain overall physical function or improve quality of life in chronic kidney disease patients undergoing hemodialysis.Key words: Aerobic training, Physical performance, Hemodialysis     

强化糖尿病健康教育对胰岛素治疗的初诊糖尿病患者效果的影响

[目的]了解强化糖尿病(DM)教育对胰岛素治疗的初诊2 型糖尿病(T2DM)患者效果的影响.[方法]将100例初诊T2DM患者随机分成两组各50例,均予胰岛素降糖治疗,对照组予以常规糖尿病宣教,干预组同时给予强化DM健康教育,比较治疗前后及两组治疗后抑郁自评量表(SDS)评分,糖尿病相关知识得分及血糖等相关指标的变化....     

2型糖尿病患者血糖、血脂与轻度认知功能损害的关系

【目的】探讨2型糖尿病（T2DM）患者轻度认知功能损害（MCI）的相关因素。【方法】采用蒙特利尔认知评估（MoCA）北京版量表作为认知功能的主要测评工具,选取T2DM合并MCI患者58例为研究对象,T2DM无MCI患者60例为对照。空腹静脉采血。测定入选病例的糖化血红蛋白（HbAlc）、血脂、肝肾功能。【结果】与对照组比较,MCI组非高密度脂蛋白胆固醇（NHDL—C）、胆固醇（TC）、甘油三酯（TG）、HbAIc水平明显升高（P〈0．01）,高密度脂蛋白胆固醇（HDL-C）水平降低（P〈0．01）,低密度脂蛋白胆固醇（LDL—C）、丙氨酸转氨酶（ALT）、肌酐（Cr）差异无统计学意义。两组糖尿病（DM）病程、体重指数（BMI）差异具有统计学意义（均P〈0．05）。【结论】NHDL—C是DM并发MCI危险性评估的一项有用的指标。T2DM患者血糖控制不良、血脂紊乱等因素与认知功能损害相关。     

Health related quality of life in patients with long-standing insulin dependent (type 1) diabetes mellitus: benefits of regular physical training

BACKGROUND AND AIMS: Regular exercise is recommended to diabetic patients in addition to dietary restrictions and drug therapy. We have studied whether health related quality of life (HRQOL) can be improved by a regular physical training program. METHODS: 23 otherwise healthy patients with history of type 1 diabetes for 20 +/- 10 years were included. 15 patients (age: 41 +/- 2 years) participated in an aerobic physical training program over 4 months and 8 patients (33 +/- 11 years) served as a control group. HRQOL was assessed by a validated questionnaire (MOS SF-36). Tests were carried out at baseline and after 4 months. RESULTS: Physical training increased peak oxygen uptake (VO2max) by 27 +/- 13% after 4 months (p = 0.04) in the training group. There was no significant change in hand or leg isometric muscle strength. All HRQOL scales improved in the training group with significantly higher (p < 0.04) Social Functioning and Vitality scores, respectively. Moreover, insulin requirements decreased during physical training program (p < 0.05). CONCLUSIONS: Our data indicate that physical exercise training in patients with type I diabetes mellitus improves metabolic control and various aspects of HRQOL. Besides enhanced cardiorespiratory capacity, this is an important subjective benefit in patients with longstanding insulin dependent (type 1) diabetes mellitus.     

老年2型糖尿病与非酒精性脂肪性肝病相关性研究

[目的]探讨老年2型糖尿病（T2DM）合并非酒精性脂肪肝的临床相关因素.[方法]对老年T2DM合并非酒精性脂肪性肝病（NAFLD）或无NAFLD患者及健康对照志愿者进行血脂水平、空腹血糖（FBG）及空腹胰岛素（FINS）的测定,并计算体质量指数（BMI）,腰臀比值（WHR）及胰岛素敏感指数（HOMA-IR）,并进行分析.[结果]与对照组（n=35）、不合并NAFLD组比较（n=40）,合并NAFLD的T2DM患者（n=42）的BMI、WHR、血甘油三酯（TG）、收缩压（SBP）、HOMA-IR显著增高,HOMA-β降低（P〈0.05或P〈0.01）.[结论]T2DM患者合并NAFLD,与肥胖（主要是腹型肥胖）、血脂紊乱、血压增高相关;导致糖尿病合并NAFLD的最主要原因为胰岛素抵抗及其所包含的脂代谢紊乱.     

The Effects of 12 Weeks Regular Aerobic Exercise on Brain-derived Neurotrophic Factor and Inflammatory Factors in Juvenile Obesity and Type 2 Diabetes Mellitus

[Purpose] The purpose of this study was to investigate the effects of 12 weeks regular aerobic exercise on brain-derived neurotrophic factor (BDNF) and inflammatory factors in juvenile obesity and type 2 diabetes mellitus (T2DM). Obesity and T2DM, typically common among adults, have recently become more prevalent in the Korean juvenile population, affecting not only their lipid profiles and oxidant stress levels, but also their BDNF and inflammatory factor levels. [Subjects] This study enrolled 26 juveniles (boys = 15, girls = 9) who were assigned to a control group (CG, n = 11), obesity group (OG, n = 8), or T2DM group (TG, n = 7). [Methods] The outcome of a 40–60-minute aerobic exercise session that took place three times per week for 12 weeks at a maximum oxygen intake (VO_2max) of 50~60% was investigated. [Results] The exercise resulted in a significant reduction in the resting serum BDNF and TrkB levels (baseline) among juveniles in the OG and TG as compared to those in the CG. Additionally, the 12 weeks of regular aerobic exercise led to significant reductions in body weight, body fat percentage, and body mass index in the OG and a significant increase of VO_2max in the OG and TG. However, no significant differences in serum NGF or inflammatory factors were found among the three groups. There was a significant increase in resting serum BDNF levels following the 12 weeks regular exercise only in the OG. [Conclusion] While 12 weeks of regular aerobic exercise had a positive effect on body composition, and increased BDNF levels of juveniles in the OG, it did not affect the inflammatory factor levels and had no effect on the TG.Key words: Obesity, T2DM, BDNF     

2型糖尿病合并冠心病患者超敏C反应蛋白、白细胞介素6水平及临床意义分析

目的探讨2型糖尿病合并冠心病患者超敏C反应蛋白（hs-CRP）、白细胞介素6（IL-6）水平及临床意义。方法检测并比较糖尿病（DM）组、冠心病（CHD）组、糖尿病合并冠心病（DM合并CHD）组及健康对照组hs-CRP、IL-6、空腹血糖（FPG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）、甘油三脂（TG）。结果DM合并CHD患者血清TG、LDL-C均明显高于健康对照组和DM、CHD组,HDL-C水平低于健康对照组,4组之间比较差异均有统计学意义（P〈0．05）。4组hs—CRP、IL-6水平经比较差异有统计学意义（P〈0．05）。健康对照组hs—CRP、IL-6低于其他3组,DM合并CHD组hs-CRP、IL-6高于单纯DM组及CHD组,且CHD组hs-CRP、IL-6高于DM组,差异有统计学意义（P〈0．05）。结论2型糖尿病合并冠心病常伴有脂代谢异常,2型糖尿病合并冠心病患者的血清hs—CRP、IL-6水平明显升高,联合检测hsCRP、IL-6水平对早期发现2型糖尿病合并冠心病有一定意义。     

Comparison of Two-point Discrimination Perception in Stroke Patients with and without Diabetes Mellitus

[Purpose] The aim of this study was to compare two-point discrimination (TPD) perception in stroke patients with diabetes mellitus (DM) and without diabetes mellitus (non-DM). [Subjects] The subjects were 53 poststroke hemiparetic patients (21 stroke patients with DM; 32 stroke patients without DM). [Methods] TPD was measured on the tips of the first through fifth fingers on both the affected and unaffected sides. [Result] Comparison of TPD between fingers on the unaffected side and affected side fingers showed significantly poorer responses in all five fingers on the affected side. TPD was also significantly poorer in the DM group compared with the non-DM group in all five fingers on the affected side, but no differences were observed for the unaffected side. [Conclusion] These findings suggest that TPD was significantly poorer in the fingers on the affected side vs. the unaffected side in poststroke hemiparetic patients. DM caused a significantly poorer TPD in the fingers on the affected side in poststroke patients but had no significant effect on the fingers on the unaffected side.Key words: Stroke, Two-point discrimination, Diabetes mellitus