脐血血清铁蛋白测定的价值探讨

目的 :探讨孕妇妊娠晚期、分娩时及新生儿脐带血血清铁蛋白 (SF)含量 ,以了解母体内铁的贮存量以及相互关系。方法 :使用全自动酶标分析仪测定 95例晚期妊娠孕妇的静脉血和脐带血的SF含量值。结果 :正常对照组SF为 83 1± 32 8μg/L ,孕妇分娩时SF为 16 1± 5 5 μg/L ,脐血SF为 96 9± 4 0 8μg/L ;前两者比较有显著差异 (P <0 0 0 1) ,后两者比较亦有显著差异 (P <0 0 0 1) ,对照组与脐带血SF含量比较有差异 (P <0 0 5 )。结论 :孕妇妊娠期SF测定可以动态观察孕妇是否缺铁 ,以便间接了解新生儿铁的贮备 ,并纠正孕妇妊娠晚期的缺铁。     

sTfR和SI对诊断妊娠妇女早期贫血的意义

目的:比较可溶性血清转铁蛋白受体(soluble transferrin receptor,sTfR)和血清铁(serumiron,SI)诊断妊娠期缺铁性贫血的灵敏度和特异度。方法:应用Orion Diagnostica IDeA sTfRIT试剂盒,采用可溶性转铁蛋白受体微粒子增强投射免疫分析法测定其血清可溶性转铁蛋白受体(sTfR)及血清铁值(SI)。结果:50例贫血孕妇的sTfR平均值是(3.011±2.026)mg/L,高于临界值2.3mg/L(P<0.05),属于贫血范围;SI的平均值是(10.704±3.462)μmol/L,属于正常范围。50例正常孕妇的sTfR平均值是(2.047±0.803)mg/L,小于2.3mg/L(P<0.05),属于正常范围;SI的平均值是(18.542±4.835)μmol/L,属于正常范围。贫血孕妇的sTfR水平明显高于正常孕妇(P<0.01),SI水平明显低于正常孕妇(P<0.01)。sTfR及SI测定妊娠妇女缺铁性贫血的灵敏度分别是80%和30%,特异度分别是84%和94%。结论:在诊断孕妇缺铁性贫血中,sTfR和SI的特异度都比较高,但sTfR测定比SI测定灵敏度高且能对孕妇是否缺铁作出正确判断,特别是在亚临床贫血期,sTfR可作为诊断妊娠期早期缺铁性贫血的敏感指标。     

女大学生月经失血量与机体铁营养状况评价

目的定量研究女大学生月经失血量,并对其铁营养状况进行评价。方法用简单随机抽样的方法抽取30名在校女大学生,用调查表收集一般信息。通过称量卫生巾在使用前后的重量,计算收集到卫生巾上的失血量,估计未收集到卫生巾上的失血量,两者相加得月经周期失血量。常规方法测量血中血红蛋白浓度、血清游离原卟啉与血清铁蛋白含量。采用双变量相关分析法分析月经失血量和铁营养状况之间的关系。结果女大学生平均月经周期持续天数为(4.5±1.4)天,平均失血量为(59.3±25.1)g,范围为24～110g。血清铁蛋白、游离原卟啉、血红蛋白的平均含量分别为(25.13±14.33)ng/ml、(0.06±0.01)μg/ml和(131.61±9.76)g/L,22.58%的女大学生处于铁减少期,无临床贫血者。月经失血量与血清铁蛋白含量呈负相关。结论女大学生月经失血量有很大的个体差异,临床上无贫血并不意味着铁营养状况良好,血清铁蛋白是反映机体铁营养状况的敏感指标。     

淀粉铁、蔗糖铁对铁缺乏大鼠的补铁效应

淀粉铁和蔗糖铁是糖和铁的络合物,本实验以相当于5～6mgFe/kg bw/d的淀粉铁或蔗糖铁连续灌胃大鼠24天。并以硫酸亚铁和普通饲料为对照,实验结果表明,淀粉铁组,蔗糖铁组,硫酸亚铁组和普通饲科组的血清铁含量(SIμg/dl)分别为111.08±22.3、118.64±26.80、136.80±54.36、83.44±22.60;血清铁蛋白含量(SFng/ml)分别为12.69±3.19、14.52±1.98、16.91±2.02、7.51±2.09;血红蛋白含量(Hbg/dl)分别为10.71±0.61、10.96±0.45、11.01±0.84、8.46±1.27,淀粉铁、蔗糖铁可被大鼠机体吸收并利用。     

中长跑运动员训练前后血清铁含量的对比分析

目的:检测专业运动员在训练前后血清铁的含量,并对比分析。方法:对23名运动员训练前后血清标本采用电感耦合等离子体发射光谱法(ICP-AES)检测血清铁的含量。结果:23名运动员在训练前血清铁的含量,男:9.78±4.27μmol/L,女:8.33±4.01μmol/L,训练后血清铁含量,男:43.89±17.42μmol/L,女:38.72±19.11μmol/L,P<0.05,两者有明显差异。结论:运动员在训练前后血清铁含量有明显差异。     

血红素铁胶囊改善缺铁性贫血人体试验研究

目的研究血红素铁胶囊对人体缺铁性贫血的改善情况。方法选择男性血红蛋白含量小于130g/L和女性血红蛋白含量小于120g/L的受试者118名,分为试食组和对照组。试食组每人每天6粒服用受试样品,连续30d,对照组按同法给予安慰剂。比较试验前后血红蛋白、血清铁蛋白、红细胞内游离原卟啉含量变化。结果试食组血红蛋白含量平均升高23.6g/L(22.24%),血清铁蛋白含量平均升高34.1μg/ml(75.78%),红细胞内游离原卟啉平均降低0.09μmol/L(10.11%),通过配对t检验及成组t检验比较,差异均有统计学意义(P0.01)。结论在研究剂量范围内可见血红素铁胶囊具有改善人体缺铁性贫血的功能。     

高血压患者血清锌、铜、钙、钴、镉、镁、镍、铬、钛的测定

本文应用直流等离子体原子发射光电直读光谱仪测定了60例正常人,45例高血压患者血清锌、铜、钙、钴、镉、镁、镍、铬、钛含量。结果表明,正常人血清锌19.70±3.75μmol/L(1.2876±0.2457μg/ml),铜17.23±3.48μmol/L(1.0945±0.2213μg/ml),钙2211.09±430.72μmol/L(104.6523±17.2634μg/ml),钴2.87±1.05μmol/L(0.3694±0.0616μg/ml),锅0.44±0.27μmol/L(0.0491±0.0300μg/ml),镁783.71±294.29μmol/L(19.0520±7.1543μg/ml),镍0.42±0.27μmol/L(0.0252±0.0156μg/ml),铬0.28±0.24μmol/L(0.0148±0.0123μg/ml),钛0.82±0.50μmol/L(0.0391±0.0243μg/ml),与文献报道值类似。高血压患者血清锌16.45±2.85μmol/L(1.0754±0.1863μg/ml),钙2308.32±276.29μmol/L(92.5175±11.0738μg/ml),钴2.23±0.62μmol/L(0.1316±0.0368μg/ml)和钛0.61±0.31μmol/L(0.0292±0.0147μg/ml),均低于正常对照组(分别为p<0.001,p<0.05)。镉0.85±0.40μmol/L(0.0951±0.0452μg/ml),镁1022.20±399.91μmol/L (24.8497±9.721 8μg/ml)和镉/锌比值高于正常对照组(P<0.001)。而铜17.58±3.11μmol/L(1.1169±0.1973μg/ml),镍0.39±0.01μmol/L(0.0231±0.0045μg/ml),铬0.31±0.12μmol/L(0.0163±0.0     

晕船对血清钙、磷、镁、铁、铜、锌的影响

目的探讨晕船对血清钙、磷、镁、铁、铜、锌的影响.方法以30名20～22岁男学员为研究对象,用全自动生化分析仪及原子吸收分光光度计测定出航前与晕船发生后的血清钙、磷、镁、铁、铜、锌.结果出航前受试者血清钙、磷、镁、锌、铁的含量依次为(2.17±0.03)、(0.88±0.03)、(0.93±0.01)mmol/L、(10.60±0.33)、(20.48±0.96)μmol/L,航行时,晕船发生后上述血清元素浓度分别为(2.44±0.08)、(1.42±0.05)、(1.13±0.03)mmol/L、(11.98±0.44)、(9.68±0.66)μmol/L,统计学比较差异有显著性;血清铜含量在航行前后分别为(14.29±1.10)和(13.67±0.56)μmol/L,无统计学差异.结论晕船对血清矿物质含量有显著影响,表现为血清钙、磷、镁、锌升高,血清铁下降,血清铜含量变化不显著.     

学龄前与青春前期儿童转铁蛋白受体的比较

目的 比较健康儿童各项铁营养状况评价指标,研究血浆转铁蛋白受体与其它铁营养状况评价指标的相关性.方法 以3-6岁学龄前儿童209名、11-12岁青春前期儿童233名为研究对象,比较两组儿童血浆转铁蛋白受体、铁蛋白浓度,研究转铁蛋白受体与铁蛋白、血红蛋白、总铁结合力及年龄相关性.结果 两组儿童血浆血红蛋白浓度、总铁结合力浓度比较没有差异.血浆铁蛋白浓度随年龄的增长逐渐降低,3-6岁组和11-12岁组分别为60.7±30.5μg/L、48.7±29.5μg/L(t=4.194,P<0.05),血浆转铁蛋白受体浓度随年龄增长逐渐升高,3-6岁组和11-12岁组分别为21.8±6.6 nmol/L、25.2±7.1nmol/L(t=5.217,P<0.05).多元线性回归分析表明,铁蛋白、血红蛋白及年龄对转铁蛋白受体有影响(R2=0.699,F=483.4753,P<0.0001).结论 血浆铁蛋白、血红蛋白及年龄均对转铁蛋白受体有影响,储备铁含量越低铁蛋白对转铁蛋白受体的影响越强.     

铁缺乏儿童血清转铁蛋白受体的变化及对铁干预的反应

目的观察血清转铁蛋白受体(sTfR)在铁状况正常和不同程度缺铁儿童体内的水平和铁干预后的变化,评价sTfR在筛检人群铁缺乏和补铁效果中的价值.方法初筛北京房山区6～14岁儿童1006名,检测其铁生化指标,从中筛选铁正常、贮存铁减少(ID)、红细胞生成缺铁(IDE)和缺铁性贫血(IDA)儿童239名,采用双抗体夹心ELISA法测定sTfR含量,计算sTfR/log血清铁蛋白(SF).对铁缺乏儿童给予口服乙二胺四乙酸钠铁胶囊(60mg元素铁/粒),每次1粒,ID与IDE儿童,每周1次,IDA儿童每周3次,连续9周.补铁后重复测定铁生化指标与sTfR,比较补铁前后sTfR的变化.结果ID、IDE、IDA期儿童sTfR含量分别为(20.03±2.33)nmol/L、(24.52±1.07)nmol/L和(33.28±6.09)nmol/L,sTfR/logSF值分别为18.15±5.31、20.98±8.88和29.08±8.57,均显著高于正常对照组的sTfR(18.74±3.06)nmol/L与sTfR/logSF值9.89±1.74.sTfR与红细胞游离原卟啉(FEP)、血红蛋白(Hb)显著相关.正常儿童sTfR为12.5～23.5nmol/L.补铁后,ID、IDE与IDA期儿童sTfR含量为(16.37±3.10)nmol/L,明显低于补铁前水平,但在IDE与IDA期没有变化;ID期儿童sTfR/logSF值分别为11.42±3.12、16.54±4.70和23.59±9.93,与补铁前相比均显著降低.结论sTfR为鉴定铁缺乏IDE与IDA期的特异指标,sTfR/logSF为观察补铁效果的敏感指标.     

Iron status and dietary intake of Chinese pregnant women with anaemia in the third trimester

Anaemia in pregnancy is a major public health problem in China. Anaemia in pregnant women may be related to dietary intake of nutrients. To examine the relationship between iron status and dietary nutrients, a cross-sectional study in pregnant women was carried out. The intake of foods and food ingredients were surveyed by using 24-h dietary recall. Blood haemoglobin, haematocrit, serum iron, serum ferritin, transferrin and soluble transferrin receptor were measured in 1189 clinically normal pregnant women in the third trimester of pregnancy. The results showed that the average daily intake of rice and wheat was 504.2 g in the anaemia group and 468.6 g in the normal group. Carbohydrates accounted for 63.69% and 63.09% of energy in the anaemia and normal groups, respectively. Intake of fat was very low; 18.38% of energy in anaemia group and 19.23% of energy in normal group. Soybean intake was 109.4 g/day and 63.6 g/day in the anaemia and normal groups, respectively (P < 0.001). There were lower intakes of green vegetables (172.1 g/day) and fruits (154.9 g/day) in the anaemia group than in the normal group (246.2 g/day green vegetables (P < 0.001) and 196.4 g/day fruit (P < 0.001)). Intakes of retinol and ascorbic acid were much lower in the anaemia than in the normal group (P < 0.001). In the anaemia group, vitamin A intake was only 54.76% of the Chinese recommended daily allowance (RDA) and ascorbic acid intake was 53.35% of the Chinese RDA. Intake of total vitamin E was 14.55 mg/day in the anaemia group compared with 17.35 mg/day in the normal group (P < 0.016). Moreover, intake of iron in pregnant women with anaemia was slightly lower than that in the normal group. Comparison of iron status between the anaemia and normal groups found serum iron in women with anaemia at 0.89 microg/L, which was significantly lower than 1.09 microg/L in the normal group (P < 0.001). There were lower average values of ferritin (14.70) microg/L) and transferrin (3.34 g/L) in the anaemia group than in the normal group (20.40 microg/L ferritin (P < 0.001) and 3.44 g/L transferrin (P < 0.001)). Soluble transferrin receptor was significantly higher (32.90 nmol/L) in the anaemia than in the normal group (23.58 nmol/L; P < 0.001). The results of this study indicate that anaemia might be attributed to a low iron intake, a low intake of enhancers of iron absorption and a high intake of inhibitors of iron absorption from a traditional Chinese diet rich in grains.     

The relationship between body iron stores and blood and urine cadmium concentrations in US never-smoking, non-pregnant women aged 20-49 years

Background

Cadmium is a ubiquitous environmental pollutant associated with increased risk of leading causes of mortality and morbidity in women, including breast cancer and osteoporosis. Iron deficiency increases absorption of dietary cadmium, rendering women, who tend to have lower iron stores than men, more susceptible to cadmium uptake. We used body iron, a measure that incorporates both serum ferritin and soluble transferrin receptor, as recommended by the World Health Organization, to evaluate the relationships between iron status and urine and blood cadmium.

Methods

Serum ferritin, soluble transferrin receptor, urine and blood cadmium values in never-smoking, non-pregnant, non-lactating, non-menopausal women aged 20–49 years (n=599) were obtained from the 2003–2008 National Health and Nutrition Examination Surveys. Body iron was calculated from serum ferritin and soluble transferrin receptor, and iron deficiency defined as body iron <0 mg/kg. Robust linear regression was used to evaluate the relationships between body iron and blood and urine cadmium, adjusted for age, race, poverty, body mass index, and parity.

Results

Per incremental (mg/kg) increase in body iron, urine cadmium decreased by 0.003 μg/g creatinine and blood cadmium decreased by 0.014 μg/L. Iron deficiency was associated with 0.044 μg/g creatinine greater urine cadmium (95% CI=0.020, 0.069) and 0.162 μg/L greater blood cadmium (95% CI=0.132, 0.193).

Conclusions

Iron deficiency is a risk factor for increased blood and urine cadmium among never-smoking, pre-menopausal, non-pregnant US women, independent of age, race, poverty, body mass index and parity. Expanding programs to detect and correct iron deficiency among non-pregnant women merits consideration as a potential means to reduce the risk of cadmium associated diseases.     

Comparison of serum levels of iron, zinc and copper in anaemic and non-anaemic pregnant women in China

Zinc and copper deficiency is associated with anaemia or iron deficiency and affects fetus growth and pregnant women during pregnancy. To examine iron, zinc and copper status of Chinese pregnant women with and without anaemia in the third trimester, 1185 subjects were enrolled for measurements of Hb, ferritin, transferrin, soluble transferrin receptor (sTfR), and serum iron, zinc and copper. The results showed that there were lower levels of ferritin (14.1 microg/L) and transferrin (3.33 g/L) in subjects with Hbor=101 g/L. sTfR levels in subjects with Hbor=120 g/L (38.5 nmol/L vs. 25.04 nmol/L, P<0.001). Serum iron was lower in subjects with Hbor=120 g/L (871 microg/L vs. 990 microg/L, P<0.01). Lower levels of serum iron and zinc were also found in anaemic (Hb<110 g/L) as compared with non-anaemic women (Hb>or=110 g/L). Frequencies of marginal deficiencies in serum iron and zinc were 41.58% and 51.05% respectively higher in anaemic than in non-anaemic subjects. Distribution of serum zinc and iron showed a decreasing trend as Hb decreased. Few anaemic as well as non-anaemic subjects had copper deficiency although copper and Hb levels were found inversely correlated and the ratio of copper/iron was higher in anaemic than in non-anaemic group. In conclusion, a lower level of serum zinc in anaemic pregnant women might be related to anaemia and iron deficiency during pregnancy. Therefore, combined zinc and iron supplementation should be recommended to Chinese pregnant women, especially those with anaemia.     

胎儿生长受限孕妇血清及脐血瘦素水平检测的临床意义

目的:检测胎儿生长受限(FGR)患者产前及产后和胎儿脐血的瘦素水平,以探讨瘦素与FGR的关系。方法:采用放射免疫分析法(RIA)测定30例FGR患者和40例正常妊娠妇女产前及产后1周血清和胎儿脐血的瘦素水平以及30例健康未孕妇女瘦素水平,并对结果进行相关性分析。结果:①FGR组产前瘦素水平为(23.23±6.75)μg/L,正常妊娠组产前瘦素水平(24.58±5.69)μg/L,两组比较差异无显著性(P>0.05);两组瘦素水平与脐血瘦素水平均无相关性(r=0.237、r=0.199,P均>0.05);两组瘦素水平与新生儿体重均无相关性(r=0.157、r=0.196,P均>0.05)。②FGR组产后瘦素水平为(7.73±2.96)μg/L,与正常妊娠组产后瘦素水平(7.92±2.54)μg/L比较,无显著性差异(P>0.05),两组分别与健康未孕组瘦素水平(7.44±2.48)μg/L比较,也均无显著性差异(P均>0.05)。③FGR组脐血瘦素水平为(5.84±2.68)μg/L,明显低于正常妊娠组脐血瘦素水平(9.37±3.51)μg/L,两组比较有显著性差异(P<0.01);两组脐血瘦素水平与新生儿体重均呈正相关(r=0.412、r=0.392,P均<0.05)。结论:检测母体血清瘦素水平不能作为预测胎儿出生体重的指标,且母体血清瘦素水平与FGR的发生无关;脐血瘦素水平下降可能与FGR的发生有关,且与新生儿出生体重有关。     

早期反复自然流产患者血浆溶血磷脂酸水平改变的意义

目的:探讨早期反复自然流产患者血浆溶血磷脂酸水平改变的意义。方法:采用薄层比色法测定早期反复自然流产患者30例以及同孕龄正常早孕30例和正常非孕期妇女30例外周血血浆溶血磷脂酸(Lysophosphatid ic ac id,LPA)水平。结果:早期反复自然流产患者血浆溶血磷脂酸水平(3.72±2.39)μmol/L,高于正常早孕(1.99±0.94)μmol/L及正常非孕期妇女(1.70±0.67)μmol/L,差异有统计学意义(P<0.01)。正常早孕和正常非孕期妇女血浆溶血磷脂酸水平相比差异无统计学意义(P>0.05)。结论:血浆溶血磷脂酸水平升高与早期反复自然流产有关。     

广西壮汉族正常足月新生儿血清胆红素的测定研究

目的:确定广西壮汉族正常足月新生儿生后1～7天血清胆红素的动态变化值,为临床诊断奠定基础。方法:①用微量法测定广西地区正常足月新生儿生后第1～7天血清胆红素,分别记录其测定值。②应用生化法与微量法相结合方法,即用静脉生化法与微量法同步测定72例新生儿血清胆红素,用微量法测定值代入生化法与微量法测定值建立的直线回归方程,获取胆红素校正值。结果:①正常足月新生儿1～7天血清胆红素分别为(72.17±14.39)μmol/L、(128.93±28.92)μmol/L、(174.69±33.07)μmol/L、(186.46±34.23)μmol/L、(174.25±37.60)μmol/L、(154.49±42.76)μmol/L、(141.41±44.97)μmol/L,平均峰值(186.46±34.23)μmol/L。②壮族新生儿血清胆红素平均峰值比汉族略高,壮汉两族1～7天血清胆红素的比较差异无统计学意义(P>0.05)。③微量法与静脉生化法胆红素测定值有高度的相关性,两法测定值比较差异无统计学意义(P>0.05);校正后的胆红素值与静脉生化法测定值比较,差异无统计学意义(P>0.05)。结论:广西地区壮汉族足月新生儿生理性黄疸生后1～7天血清胆红素动态变化值,为临床对新生儿黄疸的合理干预提供科学依据。生化法与微量法相结合的方法测定血清胆红素准确、便捷,是一种动态监测新生儿血清胆红素的理想方法。     

北京市孕妇缺铁性贫血的研究

本文通过对100名妊娠早期孕妇的追踪观察发现,孕妇妊娠中、晚期的铁营养状况普遍较差,血红蛋白、红细胞计数、血浆铁蛋白的平均值均明显低于未婚女青年;红细胞游离原卟啉明显高于未婚青年;妊娠晚期的血浆铁水平和运铁蛋白饱和度较妊娠中期明显下降,红细胞游离原卟啉明显升高。膳食调查的结果表明,妊娠早、中、晚期的营养素多摄入不足,唯铁、维生素C、维生素B_1达到供给量标准。本文结合上述资料从孕前铁营养状况、孕期膳食构成和机体铁状况的动态变化等角度重点讨论了北京城区孕妇贫血的性质和原因,并提出了相应的对策。     

Iron and zinc interactions among pregnant Nepali women

Few studies have examined the biologic impact of iron and zinc when given at a ratio of 2:1 during pregnancy. We examined the change in serum zinc after 3 weeks among night blind Nepali pregnant women who were randomly assigned to receive zinc (25 mg) or placebo, stratified by whether they received iron (60 mg) - folate (400 μg) or not. Further, we looked at change in hemoglobin (Hb) and serum ferritin concentrations by whether women had received iron or not, stratified by supplementation group (zinc or placebo). Women who received iron were anemic (Hb < 110 g/L) at baseline. The treatment groups were comparable on serum zinc and ferritin and Hb concentration at baseline. There was a mean increase of ∼1.6 μmol/L (p < 0.05) in the serum zinc concentration in women receiving zinc relative to a decline of ∼0.5 μmol/L in the placebo group, which was similar both in women who received iron or not. Similarly, treatment with iron resulted in significant increases in Hb of 4.8 g/L and 7.8 g/L, and in serum ferritin of 12.2 μg/L and 13.6 μg/L among those in the zinc and placebo groups, respectively. However, there was some evidence that zinc supplementation may adversely effect iron status among women with initial Hb of <85 g/L. This analysis shows an overall lack of a negative iron-zinc interaction when given at a ratio of 2:1.     

Non-anemic iron depletion,oral iron supplementation and indices of copper status in college-aged females

OBJECTIVES: Indices of copper status, specifically serum copper and ceruloplasmin concentrations and erythrocyte superoxide dismutase activity, and iron status, including serum ferritin, transferrin receptors, hemoglobin and hematocrit, were studied in 27 college-aged females with adequate iron versus low iron stores. METHODS: Serum copper and ceruloplasmin concentrations, erythrocyte superoxide dismutase activity, serum ferritin, transferrin receptors, hemoglobin and hematocrit were studied in 15 females with non-anemic iron depletion before and after five weeks of iron supplementation and in 12 healthy iron-adequate females aged 19 to 28 years. RESULTS: Mean hemoglobin, hematocrit and ferritin concentrations of the control group (144 +/- 11 g/L, 43 +/- 3% and 38 +/- 15 micro g/L, respectively) were significantly higher than those of the iron depleted group prior to supplementation (134 +/- 9 g/L, 39 +/- 2% and 11 +/- 6 micro g/L, respectively). The serum transferrin receptor to serum ferritin ratio was significantly greater for the iron depleted group prior to supplementation (890 +/- 753) versus the control group (151 +/- 61). Mean serum copper and ceruloplasmin concentrations and erythrocyte superoxide dismutase activity of the iron-adequate control group (20.0 +/- 5.7 micro mol/L, 463 +/- 142 mg/L and 527 +/- 124 U/mL, respectively) were significantly higher than those of the iron depleted group (12.4 +/- 3.8 micro mol/L, 350 +/- 108 mg/L and 353 +/- 186 U/mL, respectively) prior to supplementation. Following iron supplementation, hematocrit and ferritin concentrations of the iron depleted group significantly increased to 42 +/- 3% and 26 +/- 8 micro g/L, respectively. Mean serum transferrin receptor concentrations and the serum transferrin receptor to ferritin ratios significantly decreased in the iron depleted group following supplementation (6.1 +/- 1.6 mg/L to 4.6 +/- 1.5 mg/L and 890 +/- 753 to 198 +/- 114, respectively). Iron supplementation also significantly increased the mean serum copper concentration to 14.2 +/- 5.4 micro mol/L and, in subjects with serum ferritin concentrations 相似文献   

早孕妇女铁贮存水平缺铁性贫血分析及饮食指导

目的:了解早孕妇女铁贮存水平,预防缺铁性贫血。方法:用塞曼原子吸收光谱仪测定了215例早孕妇女的血清铁、总铁结合力、转铁蛋白饱和度,用以评价铁贮存水平,分析缺铁原因。结果:血清铁平均为12130±4132μmoL/L、TIBC为65111±8118μmoL/L、TS%为18159%±518%。早孕妇女缺铁40例,占18.6%;TIBC低于正常值9例,占412%;TS%低于正常值50例,占2313%。结论:早孕妇女铁贮存不足,缺铁率较高,应尽早补铁,保证胎儿正常发育,避免孕妇缺铁性贫血。