彩色多普勒技术研究视网膜中央静脉阻塞眼血流动力学

目的 研究视网膜中央静脉阻塞患者眼动脉、睫状后短动脉、视网膜中央动脉和视网膜中央静脉血流动力学变化及其意义。方法 采用美国Acuson公司Sequoia512型彩色电脑超声诊断仪,检测视网膜中央静脉阻塞患者患侧17眼,健侧17跟及正常对照64眼眼动脉、睫状后短动脉、 视网膜中央动脉收缩期峰值流速,舒张末期流速、搏动指数、阻力指数和视网膜中央静脉的最大血流速度。结果 视网膜中央静脉阻塞患者侧眼动脉、睫状后短动脉、视网膜中央动脉的收缩期峰值流速、舒张末期流速明显低于正常对照组,而搏动指数、阻力指数明显高于正常对照眼;视网膜中央静脉阻塞患者眼视网膜中央静脉的最大血流速度明显低于健眼,健眼睫状后短动脉、视网膜中央动脉的收缩期峰值流速、舒张末期流速明显低于正常对照组。结论 视网膜中央静脉阻塞患者血流动力学明显异常,彩色多普勒技术可作为研究其血流动力学指标的重要方法。     

彩色多普勒成像技术检测视网膜静脉阻塞眼血流动力学的变化

目的探讨视网膜静脉阻塞(retinal vein occlusion,RVO)患者视网膜中央动脉(central retinal artery,CRA)和视网膜中央静脉(central retinal vein,CRV)血流动力学特征及其意义。方法使用ATL-HDI3000彩色多普勒诊断仪，检测RVO患者患眼48只、对侧临床健康眼39只及正常对照眼40只的CRA收缩期峰值血流速度(peak systolic velocity,PSV)、舒张末期血流速度(end diastolic velocity,EDV)和血管搏动指数(pulsatility index,PI)，CRV最大血流速度(maximun velocity，Vmax)。结果RVO患眼、对侧临床健康眼CRA的PSV和EDV均显著低于正常对照眼，RVO患眼PI显著高于正常对照眼；RVO患眼CRA的PSV显著低于RVO对侧临床健康眼，RVO患眼PI显著高于RVO对侧临床健康眼；RVO患眼、对侧临床健康眼CRV的Vmax均显著低于正常对照眼。结论RVO患眼和对侧临床健康眼血流动力学异常。彩色多普勒成像技术可作为其早期诊断的重要手段。(中华眼底病杂志,1998,14:111-113)     

彩色多普勒成像技术检测视网膜静脉阻塞眼血流动力学的变化

目的探讨视网膜静脉阻塞（ｒｅｔｉｎａｌｖｅｉｎｏｃｃｌｕｓｉｏｎ，ＲＶＯ）患者视网膜中央动脉（ｃｅｎｔｒａｌｒｅｔｉ－ｎａｌａｒｔｅｒｙ，ＣＲＡ）和视网膜中央静脉（ｃｅｎｔｒａｌｒｅｔｉｎａｌｖｅｉｎ，ＣＲＶ）血流动力学特征及其意义。方法使用ＡＴＬ－ＨＤＩ３０００彩色多普勒诊断仪，检测ＲＶＯ患者患眼４８只、对侧临床健康眼３９只及正常对照眼４０只的ＣＲＡ收缩期峰值血流速度（ｐｅａｋｓｙｓｔｏｌｉｃｖｅｌｏｃｉｔｙ，ＰＳＶ）、舒张末期血流速度（ｅｎｄ－ｄｉａｓｔｏｌｉｃｖｅｌｏｃｉｔｙ，ＥＤＶ）和血管搏动指数（ｐｕｌｓａｔｉｌｉｔｙｉｎｄｅｘ，ＰＩ），ＣＲＶ最大血流速度（ｍａｘｉｍｕｎｖｅｌｏｃｉｔｙ，Ｖｍａｘ）。结果ＲＶＯ患眼、对侧临床健康眼ＣＲＡ的ＰＳＶ和ＥＤＶ均显著低于正常对照眼，ＲＶＯ患眼ＰＩ显著高于正常对照眼；ＲＶＯ患眼ＣＲＡ的ＰＳＶ显著低于ＲＶＯ对侧临床健康眼，ＲＶＯ患眼ＰＩ显著高于ＲＶＯ对侧临床健康眼；ＲＶＯ患眼、对侧临床健康眼ＣＲＶ的Ｖｍａｘ均显著低于正常对照眼。结论ＲＶＯ患眼和对侧临床健康眼血流动力学异常。彩色多普勒成像技术可作为其早期诊断的重要手段     

视网膜中央静脉阻塞患者球后血流动力学变化的研究

视网膜中央静脉阻塞患者球后血流动力学变化的研究王大军臧企视网膜中央静脉阻塞（ｃｅｎｔｒａｌｒｅｔｉｎａｌｖｅｉｎｏｃｃｌｕｓｉｏｎ，ＣＲＶＯ）为常见致盲眼病。视网膜中央静脉（ｃｅｎｔｒａｌｒｅｔｉｎａｌｖｅｉｎ，ＣＲＶ）及视网膜中央动脉（ｃｅｎｔｒａ...     

难治性视网膜静脉阻塞继发黄斑水肿的血流动力学分析

目的 分析难治性视网膜静脉阻塞继发黄斑水肿的血流动力学特征,以期为临床诊治提供参考。方法 描述性病例研究。纳入2019年1月至2021年12月在安徽医科大学附属巢湖医院眼科确诊的难治性视网膜静脉阻塞继发黄斑水肿的46例(46只眼)患者作为病例组,其中男性26例(26只眼),女性20例(20只眼),年龄(63.6±1.3)岁,对照组选取40例(40眼)非难治性视网膜静脉阻塞继发黄斑水肿的患者,男性17例,女性23例,年龄(64.9±1.5)岁,收集两组患者的平均动脉压、心率、红细胞、血小板,凝血酶时间,并记录视网膜静脉收缩期峰值流速(peak systolic velocity,PSV)、舒张末期流速(enddiastolicvelocity, EDV)、阻力指数(esistanceindex,RI)、及臂视网膜时间(arm-retinal time,ART),眼压值。结果 46例难治性RVO继发黄斑水肿的患者中,合并高血压25例(54.3%),吸烟12例(26.1%),平均动脉压(93,112.3)mmHg、心率(76.5±7.7)次/分、红细胞(4.02,4.66)×10^9...     

视网膜静脉阻塞眼底血流超声初步研究

目的：观察视网膜静脉阻塞患者视网膜中央血管系统的微循环变化。方法：运用超声多普勒技术对视网膜静脉阻塞患者47眼作视网膜中央动脉（CRA）和视网膜中央静脉（CRV）血流速度的检测。结果：患者CRA,CRV的血流速度下降明显（P＜0.01）,与眼别、年龄、性别无明显差别;舒张末期血流速度（EDV）、收缩期血流加速度（A）反应灵敏,早期 即有变化（P＜0.01）;收缩期峰值血流速度（PSV）下降则相对滞后;阻力指数（RI）变化不大。部分静脉郁滞性视网膜病变（VSR）患者的各测值以后均回升,而出血性网膜病变（HR）者却不变。早期综合治疗对部分VSR患者的预后有利。结论：血流速度超声检测指数敏感地反映了视网膜微循环情况,可作为病情、预后及疗效观察的参考依据。     

葛根素治疗视网膜中央静脉阻塞前后彩色超声多普勒成像技术检测

视网膜中央静脉阻塞(CRVO)发生率高、预后欠佳。我们应用葛根素治疗,并利用彩色超声多普勒成像技术(CDI)测量患者应用葛根素前后视网膜中央动静脉血流频谱有关参数,以评价葛根素对CRVO的疗效。     

视网膜中央静脉阻塞的彩色超声多普勒检查

采用彩色超声多普勒成象技术对１０例视网膜中央静脉阻塞患者进行视多膜中央动、静脉的血流测定，并选择１０例性别、年龄相当的正常健康人进行对照。结果显示：患眼的视网中央动脉收缩期峰值血流速度（ＰＳＶ）和加速度（Ａ），平均视网膜中央静脉以速（ＣＲＶ）较对侧健肯和正常对照明显降低，而且ＣＲＶ较ＰＳＶ降低明显，提示ＣＲＶ的测量可能在鉴别缺血型与非缺血型视网膜中央静脉阻塞以及预测新生血管并发症的产生方面有一定意     

彩色多普勒成像对巩膜扣带术球后眼血流动力学的研究

目的:观察一定范围环扎带缩短率的孔源性视网膜脱离巩膜扣带术术前、术后眼血流动力学的改变。方法:采用彩色多普勒成像(CDI)对28例单眼视网膜脱离患者术前、术后的视网膜中央动脉(CRA)的收缩期峰值流速(Vmax)、舒张期末流速(Vmin)、平均血流速度(V),阻力指数(RI)、搏动指数(PI)进行测量,以对侧正常眼作对照。结果:术前患眼与对照眼的CRA各项指标比较,差异无统计学意义。术后14d视网膜脱离眼CRA的Vmax,Vmin均升高,RI,PI亦增高,与对照眼以及术前指标差异无统计学意义。结论:一定范围环扎带缩短率的环扎加压术术后短期内视网膜血供受无影响,彩色多普勒超声是检测眼部血流变化的较理想方法。     

Arterial blood flow characteristics in central retinal vein occlusion and effects of panretinal photocoagulation treatment: an investigation by colour Doppler imaging

AIMS: To determine whether an increase in vascular resistance in the central retinal and ophthalmic arterial circulations contributes to the development of central retinal vein occlusion (CRVO), or haemodynamic alterations in central retinal and ophthalmic arteries occur secondary to the vein occlusion as increased intravascular pressure is transferred through the capillary bed to the arterial side and the effect of panretinal photocoagulation treatment on these circulations in ischaemic cases. METHODS: The ophthalmic and central retinal arteries of the affected and non-affected eyes of 20 patients with non-ischaemic CRVO, 13 patients with ischaemic CRVO, and 22 control subjects were investigated by colour Doppler imaging. Panretinal photocoagulation (PRP) treatment was applied to the eyes with ischaemic CRVO. Maximum and minimum blood flow velocities, and resistivity indexes were calculated in the affected and healthy eyes of patients and in the control eyes. RESULTS: Average blood flow velocity in the central retinal and ophthalmic arteries of patients with non-ischaemic CRVO did not differ from their fellow eyes, but a significantly lower average blood flow velocity was found in the ophthalmic and central retinal arteries of the patients with ischaemic CRVO compared with their fellow eyes. Patients with ischaemic CRVO had significantly lower blood flow velocities in their ophthalmic and central retinal arteries than non-ischaemic cases that were further reduced following PRP treatment. CONCLUSION: This study suggests that impaired arterial blood flow observed in patients with CRVO may be partly related to secondary changes in the retrobulbar arterial circulation as a result of enhanced arterial resistance following CRVO. These data also demonstrate that PRP treatment decreases retinal and ophthalmic blood flow velocities in patients with ischaemic CRVO.     

Ischemic retinal vein occlusion: characterizing the more severe spectrum of retinal vein occlusion

Retinal vein occlusion (RVO)-including central RVO, branch RVO, and hemicentral and hemispheric RVO—is the second most common vascular cause of visual loss, surpassed only by diabetic retinopathy. The presence and extent of retinal ischemia in RVO is associated with a worse prognosis. On this basis, most previously conducted studies considered ischemic retinal vein occlusion (iRVO) and non-iRVO as separate entities based on set thresholds of existing retinal ischemia as determined by fundus fluorescein angiography. Other diagnostic technologies have been used specifically in the differentiation of ischemic central retinal vein occlusion and nonischemic central retinal vein occlusion. To date, there is no fully accepted definition for iRVO. Some clinicians and researchers may favor establishing a clear differentiation between these forms of RVO; others may prefer not to consider iRVO as a separate entity. Whatever the case, retinal ischemia in RVO confers a higher risk of visual loss and neovascular complications; thus, it should be determined as accurately as possible in patients with this disease and be considered in clinical and experimental studies. Most recently conducted clinical trials evaluating new treatments for macular edema secondary to RVO included none or only few patients with iRVO based on previous definitions (i.e., few patients with sizeable areas of retinal ischemia were recruited in these trials), and thus it is unclear whether the results observed in recruited patients could be extrapolated to those with retinal ischemia. There has been scant research aiming at developing and/or testing treatments for retinal ischemia, as well as to prevent new vessel formation as a result of RVO. We provide a detailed review of the knowledge gathered over the years on iRVO, from controversies on its definition and diagnosis to the understanding of its epidemiology, risk factors and pathogenesis, the structural and functional effects of this disease in the eye and its complications, natural history, and outcomes after treatment. In each section, the definition of iRVO used is given so, independently of whether iRVO is considered a separate clinical entity or a more severe end of the spectrum of RVO, the information will be useful to clinicians to determine patient's risk, guide therapeutic decisions, and counsel patients and for researchers to design future studies.     

視網膜中央静脈阻塞與球后血流動力學及血液流變學相關性研究

目的探討視網膜中央静脈阻塞(CRVO)患者的視網膜中央動脈(CRA),眼動脈(OA)的血液動力學、血液流變學改變及其相互關系.方法采用美國AcusoN-128XP/10彩色多普勒成像(CDI)技術檢測23例CRCO患者和23例正常人CRA.OA血液動力學及血液流變學改變.結果 CRVO患者CRA收縮期最大血流速度(Vmax)比對側眼(P＜0.05)及對照眼(P＜0.01)下降,舒張末期最小血流速度(Vmin)比對側眼及對照組顯著性增高(P＜0.05),阻力指數(RI)比對側眼(P＜0.05)及對照組(P＜0.01)增高.低切率全血比粘度較對照組顯著性增高(P＜0.01),并與CRAO患者Vmax(r=-0.641 P＜0.01)、Vmin(r=-0.538 P＜0.01)成負相關.結論 CRVO患眼CRA的CDI參數异常,表明動脈血流速度的下降與CRVO發病相關,CRA供血减少是引起視網膜損害的主要原因之一.低切率全血比粘度增高是導致CRVO患眼CRA血流下降因素之一.     

视网膜静脉阻塞的危险因素分析

目的 分析视网膜中央静脉阻塞(central retinal vein occlusion,CRVO)和视网膜分支静脉阻塞(branch retinal vein occlusion,BRVO)的危险因素;并对CRVO和BRVO危险因素进行直接比较.方法 对46例CRVO(CRVO组)、33例BRVO(BRVO组)与79例老年性白内障或屈光不正患者(对照组)行危险因素和血脂谱分析,并对比观察.结果 多元线性回归分析结果显示:高同型半胱氨酸血症(P＜0.000 1)、高总胆固醇(P=0.003 0)、高脂蛋白a(P =0.027 0)、高血压(P =0.022 0)、短眼轴(P ＜0.000 1)与CRVO显著相关;而高同型半胱氨酸血症(P＜0.0001)、高总胆固醇(P =0.008 0)、高血压(P=0.002 0)、高体质量指数(P=0.004 0)、短眼轴(P=0.001 0)与BRVO相关.一元线性回归分析示CRVO和BRVO上述危险因素比较没有明显差别.结论 CRVO、BRVO危险因素包括系统(高血脂、高血压、高同型半胱氨酸)和眼部(短眼轴)的多种因素,但是这些危险因素在CRVO和BRVO之间没有显著差异.     

彩色多普勒超声技术对糖尿病视网膜病变患者视网膜血流动力学的分析研究

目的：通过彩色多普勒超声技术观察糖尿病性视网膜病变(diabeticretinitis,DR)患者血流动力学的变化。

方法：选取2014-06/2017-05于我院就诊的糖尿病(diabetes mellitus,DM)患者96例96眼,根据眼底检查结果分为A、B、C三组,A组为单纯DM患者32例32眼; B组为糖尿病合并单纯性视网膜病变(NPDR)患者32例32眼; C组为糖尿病合并增殖性视网膜病变(PDR)患者32例32眼。同时选取健康志愿者30例30眼作为对照组。采用彩色多普勒超声技术检测患者眼部CRA(视网膜中央动脉)、PCA(睫状后动脉)、OA(眼动脉)血流动力学改变情况,并探讨糖尿病患者视网膜病变程度与糖化血红蛋白(HbA1c)、空腹血糖(FBG)、糖尿病病程的关系。

结果：各组CRA、PCA、OA血流动力学指标差异均有统计学意义(P<0.05)。A组与对照组CRA、PCA、OA的PSV比较,差异均无统计学意(P>0.05); C组CRA、PCA、OA的PSV与EDV最低、RI最高,与A、B组比较差异均有统计学意义(P<0.05)。各组HbA1c、FBG比较,差异均有统计学意义(P<0.05)。病程仅A组与C组间比较,差异有统计学意义(P<0.05)。

结论：彩色多普勒超声监测DM患者CRA、PCA、OA血流动力学改变,可了解患者视网膜的血流变化,对DM患者视网膜病变的预防和治疗有重要价值。