Active infection with Helicobacter pylori in healthy couples

The mode of spread of Helicobacter pylori infection is subject to ongoing debate. Recent studies among patients with gastrointestinal disorders suggest a potential role of conjugal transmission. In this study, the clustering of H. pylori infection was assessed among 110 employees of a health insurance company and their partners. Active infection with H. pylori was measured by the 13C-urea breath test. Information on potential confounders was collected by a standardized questionnaire. Overall, 16 employees (14.5%) and 24 partners (21.8%) were infected. While only 7% (6/86) of employees with an uninfected partner were infected, this applied to 42% (10/24) of employees with an infected partner. A very strong relation between partners' infection status persisted after control for age and other potential confounders (adjusted odds ratio, 7.0; 95% confidence interval, 1.8-26.7). Furthermore, the risk of infection increased with the number of years lived with an infected partner. These results support the hypothesis of a major role of spouse-to-spouse transmission of H. pylori infection.     

健康体检人群幽门螺杆菌感染与白蛋白尿的相关性CSCD

Objective To investigate the correlation between Helicobacter pylori (H.pylori) infection and albuminuria inphysical examination population. Methods It was a cross‑sectional study. All the adults who received physical examination and underwent 13C‑urea breath test at the Physical Examination Center in Tongji Hospital in 2021 were selected as the study subjects. General data (such as demographic information and past medical history) were documented. The physical measurement and blood biochemical indicators were checked too. Multivariate analysis was used to analyze the relationship between H. pylori infection and albuminuria. Results A total of 30 311 subjects were included in this analysis. There were 17 123 males and 13 188 females with an age of (44.51±12.17) years. The positive rate of H. pylori infection was 27.3%. The incidence of albuminuria in subjects with H. pylori infection was 6.7%, and it was 6.1% in the subjects without H. pylori infection (P=0.031). After adjusting for the confounding factors such as gender, age, diabetes and hypertension, H. pylori infection was independently associated with the risk of albuminuria (odds ratio (OR)=1.133, 95%CI: 1.018-1.261, P=0.022). Conclusion H. pylori infection is positively correlated with the occurrence of albuminuria in the physical examination population. © 2021 Chinese Medical Journals Publishing House Co.Ltd.     

部队人群幽门螺杆菌的血清流行病学研究

目的 调查幽门螺杆菌(H.pylori)在部队人群中的流行状况.方法 应用免疫印迹法测定血清H.pylori CagA、VacA和Ureas抗体.结果 部队人群H.pylori总感染率、Ⅰ型和Ⅱ型感染率分别为44.07％、31.61％和12.46％.男、女感染率分别为43.85％和46.43％.H.pylori感染率随...     

Correlation between oral hygiene and Helicobacter pylori infection

As introduced by different studies, dental plaque is known as a reservoir of Helicobacter Pylori (HP) and a potential source for gastric re-infection. Also, it has been demonstrated that individuals with gastric HP infection manifest a greater plaque index and a higher incidence rate for gingivitis. The goal of the present research was survey of severity and prevalence of periodontal diseases associated with gastric HP infection among patients having referred to the endoscopy wards of Imam Khomeini and Milad hospitals. In this research, 122 patients with gastric HP infection were investigated for determining 4 indices: plaque index (PI), gingival index (GI), clinical attachment loss (CAL) and pocket depth (PD), for all existing teeth, using RUT (rapid urease test). The results indicated that about 86.9% of patients had developed gingivitis of various degrees and 100% of them were afflicted with periodontitis of different degrees, and about 64.8% of patients showed a weak PI, and 61.5% had a low level of education. This low-level education seen in majority of the studied subjects, addresses a high degree of importance and influence of the oral hygiene in gastric HP infections. Hence, gastroentrologists are required to refer patients to dentists in line of preserving oral and dental health.     

幽门螺杆菌感染与桥本甲状腺炎的关系

目的研究幽门螺杆菌感染对于桥本甲状腺炎的影响,探讨桥本甲状腺炎与幽门螺杆菌感染的治疗方法和效果。方法从2012年1月-12月入院治疗桥本甲状腺炎的患者中随机选取150例,对应选取150名健康人员作为对照组;对这两组研究对象进行幽门螺杆菌检查,将检测出阳性者进行对比;经检查后发现150例桥本甲状腺炎患者中有96例幽门螺杆菌检测阳性,将其随机平分为对照组和观察组;观察组采取合理的方法进行抗菌感染的治疗,而对照组则未进行任何治疗,4个月后检测甲状腺过氧化酶抗体和甲状腺球蛋白抗体的滴度这两个指标值,研究比较检测值。结果 150例桥本甲状腺炎患者中有96例幽门螺杆菌感染,感染率64.0%;150名健康人员中幽门螺杆菌感染65例,感染率43.3%,桥本甲状腺炎患者的幽门螺杆菌感染率高于健康人群;幽门螺杆菌检测阳性的桥本甲状腺炎患者治疗4个月后观察组患者甲状腺过氧化酶抗体和甲状腺球蛋白抗体的滴度均比治疗前有大幅度的下降,对照组的两项指标无明显的变化。结论发生幽门螺杆菌感染时患者更易患桥本甲状腺炎,一旦对该类患者进行抗幽门螺杆菌感染的治疗,桥本甲状腺炎易治愈,加快其治愈的过程。     

幽门螺杆菌感染与反流性食管炎的相关性分析

目的分析幽门螺杆菌感染与反流性食管炎之间的关系,为临床治疗提供科学依据。方法选择2009年1月-2012年12月胃镜室行胃镜检查的明确诊断为反流性食管炎患者1 281例,根据2000年中华医学会消化病学分会提出的Tygatat分级标准,将所有反流性食管炎患者分为Ⅰ^Ⅴ级,比较不同分级反流性食管炎患者幽门螺杆菌感染率及感染程度。结果幽门螺杆菌感染率反流性食管炎患者为63.00%;在不同分级反流性食管炎患者中,感染率Ⅰ级为67.84%、Ⅱ级为67.68%、Ⅲ级为54.64%、Ⅳ级为47.50%、Ⅴ级为33.33%,随着反流性食管炎疾病程度的加重,幽门螺杆菌感染率降低,两者呈反比关系;患者反流性食管炎病情越轻,幽门螺杆菌感染程度越重,幽门螺杆菌感染程度与反流性食管炎疾病严重程度呈反比关系。结论幽门螺杆菌对反流性食管炎具有一定的保护作用,反流性食管炎严重程度随幽门螺杆菌感染率及感染程度的增加而降低,两者呈负相关,反流性食管炎患者在行幽门螺杆菌根除治疗时,应选择恰当的时机,以免使原有疾病加重。     

胃幽门螺杆菌感染与牙周炎的相关性分析

目的分析胃幽门螺杆菌感染(Hp)与牙周炎的相关性,为临床诊治工作提供客观依据。方法选取2015年1月-2016年12月的慢性牙周炎患者100例作为病例组,牙周健康的体检者100例作为对照组,检测及分析所有病例组患者的牙周袋深度、牙周退缩、平均牙周袋深度、平均牙周退缩等牙周损害相关指标,分析两组研究对象的胃内Hp感染情况。结果病例组患者的胃内Hp阳性率及DOB水平均显著高于对照组,两组比较差异有统计学意义(P<0.05);重度慢性牙周炎患者的DOB值及胃内Hp阳性率均高于中度慢性牙周炎患者,中度慢性牙周炎患者的DOB值及胃内Hp阳性率均高于轻度慢性牙周炎患者,差异均有统计学意义(P<0.05);直线相关分析结果显示,慢性牙周炎患者的DOB值与平均牙周袋深度呈正相关(P<0.05),Spearman等级相关分析结果显示,慢性牙周炎患者的DOB值与病情等级呈正相关(P<0.05);Logistic多元回归分析结果显示,重度慢性牙周炎的发生与病程、DOB值、Hp阳性、平均牙周袋深度具有相关性(P<0.05)。结论胃内Hp感染与牙周炎的发生和进展具有密切的关系,其感染程度与牙周炎患者的牙周组织损害程度和疾病严重程度具有相关性,可能在促进牙周炎病情进展方面发挥着重要的作用。     

Seroepidemiology of Helicobacter pylori infection in a population of Egyptian children

BACKGROUND: To describe the seroepidemiology of Helicobacter pylori infection in a population of Egyptian children under 3 years. METHODS: A cohort of children under 36 months, residing in Abu Homos, Egypt, were visited at home twice weekly. Information regarding the child's breastfeeding status was obtained, and periodic anthropometric and household hygiene surveys were performed. In June 1997, a serosurvey was conducted on 187 study participants over 6 months old. The serosurvey was repeated in October 1997. All sera were tested for IgG antibodies to H. pylori. RESULTS: The June prevalence of H. pylori infection was 10%, and the incidence from June to October was 15%. Between June and October, 8 (42%) of 19 children that were positive for H. pylori infection seroreverted to negative. All seroreversions occurred in children 6-17 months. Other than age, no sociodemographic or environmental factor was significantly associated with incident H. pylori infection. There was no significant differences in the weight-for-age, weight-for-height, and height-for-age z-scores between children with and without prevalent H. pylori infection. CONCLUSIONS: Infection with H. pylori is common in Egyptian children under 3 years old and is not associated with malnutrition. No predictors for H. pylori infection were found. Our preliminary evidence for transient H. pylori infections in young children needs to be confirmed in a prospective cohort study, and predictors for persistent infection should be sought, since only these may be relevant to the known sequellae of infection.     

上海地区职业体检人群幽门螺杆菌感染与生活 方式的关系及危险因素研究

目的 调查上海地区职业体检人群中幽门螺杆菌（ Helicobacter pylori ,HP）感染现状,评价个人生活方式与HP感染的关系并对HP感染的可能危险因素进行探讨。为制定上海地区职业人群预防幽门螺杆菌感染策略提供参考依据。方法 采用整群抽样的方法选取2020年5月—2020年10月在华东疗养院进行HP检测的上海地区职业体检人群为研究对象,根据HP检测结果分为阳性组（1 045例）和阴性组（3 203例）,比较两组间体格检查、实验室检查及生活方式间的差异,并使用logistic回归探讨HP感染的危险因素。结果 本研究4 248例职业体检人群中,HP阳性检出率为24.6%,其中60~65岁年龄组HP感染率最低,仅为16.3%,各年龄组感染率不同（〖XC小五号.EPS;P〗=4.757, P ＜0.05）。有吸烟史（〖XC小五号.EPS;P〗=32.819 ,P ＜0.001）、饮酒史（〖XC小五号.EPS;P〗=8.499 ,P ＜0.05））的职业体检人群HP感染率显著高于未吸烟饮酒人群。HP感染阳性组中体质指数（BMI）( t =3.610, P ＜0.001)、收缩压( t =3.254, P ＜0.05)、舒张压( t =4.113, P ＜0.001)、空腹血糖( t =2.648, P ＜0.05)、胆固醇( t =2.112, P ＜0.05)等指标均高于阴性组。logistic回归显示,工作中的体力强度（ OR =1.206,95% CI :1.034~1.406）、经常请客应酬（ OR =1.161,95% CI :1.015~1.329）、吸烟史（ OR =1.236,95% CI :1.124~1.359）、体质指数（BMI）（ OR =1.026,95% CI :1.003~1.050）、空腹血糖（ OR =1.084,95% CI :1.012~1.161）是HP感染的危险因素,60~65岁年龄组（ OR =0.520,95% CI :0.332~0.814）、常吃水果（ OR =0.902,95% CI :0.818~0.994）是HP感染的保护因素。结论 上海职业体检人群HP阳性率24.6%明显低于我国平均水平;HP感染与生活方式存在密切联系。     

幽门螺杆菌感染与复发性口腔溃疡的相关性研究

目的研究幽门螺杆菌(Hp)感染与复发性口腔溃疡(RAU)的相关性,探寻复发性口腔溃疡的发病机制。方法选择2012年1月-2013年1月136例RAU患者作为RAU组,同时选择同期136名健康体检者作为健康组,均采用C-尿素呼气试验(C-UBT)及胃镜进行口腔及胃Hp检测;将RAU组消化道Hp阳性患者根据治疗方法分为观察组与对照组,所有患者均常规抗炎治疗,观察组在常规治疗的基础上给予阿莫西林+雷尼替丁+甲硝唑三联治疗,对两组治疗效果进行比较。结果 RAU组口腔Hp阳性61例、消化道Hp阳性46例,阳性率分别为44.85%、33.82%,健康组口腔Hp阳性20名、消化道Hp阳性19名,阳性率分别为14.71%、13.97%,两组比较差异有统计学意义(P<0.05);两组消化道Hp阳性患者,消化道溃疡发生率分别为78.26%与63.16%,差异无统计学意义;RAU组46例消化道Hp阳性患者中观察组23例治疗总有效率82.61%,对照组23例治疗总有效率56.52%,两组比较差异有统计学意义(P<0.05)。结论 Hp感染与复发性口腔溃疡有一定的相关性,复发性口腔溃疡患者Hp阳性率高于口腔健康者,抗Hp三联治疗后对口腔溃疡的愈合具有一定影响。     

体检人群幽门螺杆菌感染状况及影响因素分析

目的 探讨体检人群幽门螺杆菌（Hp）感染状况,分析其影响因素,为制定Hp感染防护措施提供依据。方法 采用简单随机抽样方法对2018年6月至2019年5月期间在北京市某医院体检中心进行健康体检人群进行抽样,对抽中的人群进行问卷调查、尿素[¹³C]散剂呼气试验和血生化指标检测。采用描述流行病学分析方法对该人群Hp感染情况进行分析,并采用单、多因素分析方法对Hp感染影响因素进行分析。结果 本研究共对 1 058名体检人群进行调查,调查人群中男女性别比为1∶0.9,年龄以30~59岁为主,占45.94%,文化程度以高中/中专为主,占38.00%。检出Hp阳性者338例,阳性率为31.95%。多因素Logistic回归分析结果显示,年龄越大（OR=3.097）、同型半胱氨酸（Hcy）异常（OR=3.662）、有饮酒习惯（OR=4.484）者Hp阳性风险越大,Hp知识认知水平高者（OR=0.163）Hp阳性检出风险越小。结论 该体检人群Hp阳性检出率较高,年龄、饮酒行为、Hp知识水平、Hcy异常等与Hp感染有关,应根据人群感染特征制定相应防护措施,降低Hp感染风险。     

Relationship between lifetime alcohol consumption and Helicobacter pylori infection

PURPOSE: Several studies have demonstrated an inverse relationship between current moderate alcohol consumption and Helicobacter pylori (H. pylori) infection suggesting that alcohol consumption may facilitate elimination of this chronic infection. The aim of this study was to further explore this hypothesis by taking lifetime alcohol consumption, which may be a better marker of the relevant exposure than current alcohol consumption, into account. METHODS: A total of 1206 patients between 30 and 70 years of age who underwent in-patient rehabilitation due to coronary heart disease were included in a cross sectional study carried out between January 1999 and April 2000. Participants provided information on average amount of alcohol consumed during past 12 months as well as during lifetime. H. pylori infection status was measured by serum immunoglobulin G antibodies. RESULTS: There was an inverse non-linear relation between amount of current alcohol consumption and H. pylori seroprevalence. By contrast, we found an inverse dose-response relationship between lifetime alcohol consumption and H. pylori seroprevalence with the strongest risk reduction among subjects who had consumed more than 500,000 g of alcohol during life (adjusted odds ratio, 0.65; 95% confidence interval, 0.42-1.00). CONCLUSION: Our analysis supports the hypothesis that alcohol consumption may facilitate elimination of H. pylori infection among adults.     

Helicobacter pylori seroepidemiology in risk groups

Helicobacter pylori is associated with peptic ulcer and chronic active gastritis. The response to infection can be determined by measuring serum titers of anti-H.pylori antibodies. We compared antibody liters in 612 serum samples from 570 individuals considered at risk forH. pylori infection, 170 of them are control sera from 110 adults and 60 children with no gastric alterations. The study groups were 93 institutionalized mentally handicapped children, 40 heterosexual couples, 101 HIV-sero-positive patients, 86 patients with chronic renal failure and 40 individuals (20 adults and 20 children) with symptoms associated with gastritis or gastro duodenal ulcer disease. In the adult and child control groups, 33.5% and 11.6% of the individuals had circulating anti-H.pylori antibodies. Significantly more adults (80%) and children (75%) with gastric symptoms had detectable circulating antibody titers. Elevated titers were also found in institutionalized children and in adults with renal failure.     

Seroprevalence, correlates and trends of Helicobacter pylori infection in the Israeli population

We examined the prevalence, correlates and trends of H. pylori infection in Israel using residual sera obtained in 2007-2008 from 1466 Jewish subjects aged 0-77 years and 897 Arabs aged 0-19 years, and in 2000-2001 from 627 Jewish and 575 Arab subjects aged 0-19 years. H. pylori IgG antibodies were measured by ELISA. The age-adjusted H. pylori seroprevalence was 45.2% in Jewish participants. Seropositivity increased with age, reaching 60% at age ≥ 50 years and ranged from 24.3% in subjects originating from North America/Western Europe/Australia, to 63.2% in those from Asia/Africa/South America. Among Arabs, H. pylori seroprevalence was 42.1% and reached 65% in adolescents. There was no significant change in seroprevalence between 2000-2001 and 2007-2008. High prevalence of H. pylori was found in Arabs, and in Jews originating from countries of high H. pylori endemicity. These findings are characteristic of countries of diverse ethnic structure and recent immigration.     

Blood lead level and Helicobacter pylori infection in a healthy population: A cross-sectional study

Abstract

The aim of this study was to investigate whether elevated blood lead level (BLL) is a risk factor for Helicobacter pylori infection. Upper gastrointestinal endoscopy was performed on 2,625 subjects who visited a university hospital for general health examination. H. pylori infection was detected using histologic examination with Giemsa staining, and BLLs were measured. The mean BLL was 2.83?±?1.31?μg/dL. The prevalence of H. pylori infection was 27.8%. The BLL was significantly higher in the H. pylori infection-positive group compared to the non-infected group (2.96?±?1.33?μg/dL vs. 2.78?±?1.30?μg/dL, p?<?0.001), which remained significant after adjusting for other confounders. H. pylori infection significantly increased as the BLL increased (OR: 1.143, 95% CI 1.068–1.223). We found a relationship between BLL elevation and H. pylori infection rate.     

性别间和家庭聚集的幽门螺杆菌感染的Meta分析

目的：综合分析并探讨幽门螺杆菌感染情况，方法：运用Meta分析方法对幽门螺杆菌性别间和家庭聚集的研究进行综合定量分析，结果：性别间幽门螺杆菌感染率有细微差别（95％CI：0．0579－0．0963）；父母均阳性子女幽门螺杆菌感染率较父母均阴性者为高（95％CI：0．3378－0．5042）。结论：幽门螺杆菌感染率存在性别差异和家庭聚集现象，幽门螺杆菌流行病学研究涉及很多方面，但均缺乏足够调查和证据。尚需进一步研究。     

幽门螺杆菌感染与特发性血小板减少性紫癜的相关性

目的探讨特发性血小板减少性紫癜(ITP)发病与幽门螺杆菌(Hp)感染的关系及寻求难治性ITP的有效治疗途径。方法回顾性分析156例ITP患者的临床及实验室资料,将137例慢性ITP(CITP)中Hp阳性的患者随机分为两组:A组应用糖皮质激素治疗,B组激素联合根除Hp治疗;19例难治性ITP单纯应用根除Hp治疗。结果156例患者Hp总感染率为70.5%,其中CITP为69.3%,难治性ITP为78.9%。A、B两组有效率分别为57.8%和74.0%,差异有统计学意义(P<0.05);单纯抗Hp治疗难治性ITP有效率为42.0%。结论ITP患者Hp感染率较高,激素联合抗Hp治疗疗效较好且持久,缓解后复发率低;难治性ITP根除Hp治疗有效,为其探索出一条有益的治疗途径。     

Relationship between Helicobacter pylori infection and chronic obstructive pulmonary disease

There is some evidence indicating the role of Helicobacter pylori infection in pathogenesis of extragastrointestinal diseases including skin, vascular, and autoimmune disorders, as well as some respiratory diseases. The aim of this study was to investigate the association between H. pylori and chronic obstructive pulmonary disease (COPD). In a case-control study, 90 patients with COPD and 90 age- and sex- matched control subjects were included. Serum samples were tested for anti-H. pylori and anti-CagA IgG by ELISA. A physician completed a questionnaire including demographic characteristics, habitual history, and spirometric findings for each patient. Of 90 patients with COPD 66 (51%) had mild, 31 (34.4%) moderate, and 13 (14.4%) sever disease. There was no significant association between H. pylori IgG seropositivity and COPD. Serum levels of anti-CagA IgG were significantly higher in patients with COPD than in the control subjects (P < 0.001). No association was observed between H. pylori infection and severity of COPD. The results suggest that there is an association between CagA-positive H. pylori infections and COPD. Further studies should be planned to investigate the potential pathogenic mechanisms that might underlie these associations.     

Children Helicobacter pylori infection: antibiogram results

Helicobacter pylori infection is frequent in children. The eradication rate is variable, it is influenced by resistance of the bacteria to the antibiotics used. The aim of this study was to determine the resistance rate of the most commonly used antibiotics among helicobacter pylori (Hp) strains isolated in infected children. PATIENTS AND METHODS: 60 children (26 males, 34 females), with mean age of 8 years 8 months (3 years and 2 month (2.5-13.5 years) underwent an oesogastroscopy. Forty six of them had helicobacter infection assessed by the presence of Hp on the gastric biopsy and or positivity of urease test. The infected children were treated with three medication; Omeprazole. Clarythromycin, and Amoxicillin. The eradication of Hp was confirmed in 13 patients by the absence of Hp on the gastric biopsy and/or negativation of the urease test; RESULTS: Culture was positive in 13 infected children susceptibility to anti microbial drugs was done in ten children. Nine children had primary metronidazole resistance, three had both clarythromycin and Metronidazole resistance, three had Clarythromycin primary resistance. No case of Amoxicillin primary resistance was detected. Children eradication was achieved in four children among 13 children. This study shows the difficulty of Hp culture. It confirms the absence of Hp resistance to Amoxicilline. the high level of Hp resistance to Metronidazole and the mild level of Clarythromycin resistance. The authors stress the importance of Antibiotic susceptibility assay in helicobacter pylori infections.     

幽门螺杆菌感染基因型与胃肠疾病的关系

目的 探讨幽门螺杆菌(Hp)感染基因型与胃肠疾病的关系。方法 选取2017年6月-2020年6月新乡市中心医院258例胃肠疾病患者,其中慢性胃炎患者112例(慢性胃炎组)、消化性溃疡患者98例(消化性溃疡组)、胃癌患者48例(胃癌组),聚合酶链式反应(PCR)检测Hp基因型并分析其在胃肠疾病中的分布情况,分析Hp感染基因型与胃肠疾病患者预后关系。结果 消化性溃疡组胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、胃泌素-17(G-17)、降钙素原(PCT)、C-反应蛋白(CRP)、中性粒细胞百分比、淋巴细胞百分比、单核细胞百分比均高于慢性胃炎组(P<0.05),胃癌组PGⅠ、PGⅡ和中性粒细胞百分比水平均低于慢性胃炎组(P<0.05),胃癌组G-17高于慢性胃炎组(P<0.05);胃癌组PGⅠ、PGⅡ、CRP水平和中性粒细胞百分比、淋巴细胞百分比、单核细胞百分比均低于消化性溃疡组(P<0.05),而G-17水平高于消化性溃疡组(P<0.05);消化性溃疡组Hp感染基因型cagA、iceA、baba2占比低于慢性胃炎组(P<0.05),而vacA占比高于慢性胃炎组(P<0.05);胃癌组vacA占比高于慢性胃炎组(P<0.05),而iceA占比低于慢性胃炎组和消化性溃疡组(P<0.05);胃癌预后差患者中vacA基因亚型m2占比高于慢性胃炎组和消化性溃疡组(P<0.05)。结论 Hp感染基因型可能影响胃肠疾病病变程度,其中Hp感染基因型vacA亚型m2可能与胃癌不良预后存在关系。