皮肤弹性过度1例

患儿男,5岁。皮肤弹性过度,脆性增加,关节伸展过度4年。皮损组织病理示真皮胶原纤维疏松、紊乱。弹性纤维染色示真皮上、中部弹性纤维数量增加。诊断:皮肤弹性过度。     

皮肤弹性过度综合征一例

摘 要：报告1例皮肤弹性过度综合征。患儿女,7岁。双下肢易受外伤,伤口不易愈合4年。皮损组织病理检查示：表皮无异常。真皮胶原纤维纤细、断裂,着色浅淡,排列疏松。弹力纤维染色：弹力纤维明显增多。病理诊断：皮肤弹力过度性皮肤。诊断：皮肤弹性过度综合征。     

皮肤弹性过度伴免疫学检查异常1例

报告皮肤弹性过度伴细胞免疫缺陷1例。患儿女，13岁。出生后即有皮肤弹性过度，脓疱疮反复发作4年。实验室检查发现有缺铁性贫血，皮损组织病理检查无特异性，脓液细菌培养出金黄色葡萄球菌，淋巴细胞亚群检查CD3 32%，CD427%，CD8 20%，CD4/CD8 1.35。先后给予免疫调节剂，系统及外月抗生素，抗贫血药等治疗。患儿细胞免疫缺陷得到纠正，深脓疱疮及缺铁性贫血治愈。     

皮肤弹性过度1例

患者女,22岁.因皮肤弹性过度,关节伸展过度,血管脆性增加20年于2011年8月11日来我院就诊.患者系足月顺产,出身时全身皮肤、关节正常.患者自出身后不久即有全身皮肤弹性过度,表现为皮肤柔软,摸之有绒样感,在皱褶处拉起皮肤然后放松时皮肤可恢复其原来位置,幼儿期出现全身关节伸展过度,初期仅限于双手指间关节,后渐累及四肢大关节,1岁学走路时步态困难,易摔跤,双手及双膝关节在轻度外力作用下即可引起半脱臼.患者皮肤和血管的脆性亦增加,轻微外伤即可造成较大的伤口,且愈合过程非常慢,皮肤轻度碰伤后可出现明显紫癜及血肿.患者因出生时就表现为眼距增宽,2年前曾做眼距缩小手术,术后伤口恢复慢,且留有瘢痕.患者平日身体较差,易患"感冒",走远路会出现乏力、胸闷等不适.父母体健,非近亲结婚,家族成员中无遗传病及类似疾病史.     

皮肤弹性过度1例

临床资料患者男，16岁。因皮肤弹性过度10年余就诊。患者5个月左右父母发现其跌倒或轻微碰撞后皮肤易引起破损撕裂，但易愈合，留下一较大的萎缩性瘢痕。并发现其皮肤弹性过度、拉起皮肤放松时，即弹向原处。手指关节活动伸展过度。无心肺异常、无胃肠道出血现象。患者足月顺产，父母非近亲结婚，家族亲系三代否认有类似病史。     

皮肤弹性过度1例报告

皮肤弹性过度是一种少见的具有遗传倾向的疾病。现将我们发现的1例报告如下。     

日光对皮肤弹性的影响

目的观察日光和年龄对皮肤弹性的影响。方法问卷调查受试者（郊县组94例，市区组105例）的日光曝晒情况，并应用皮肤弹性测量仪测量外眦部、鼻唇沟及眶下皮肤弹性参数，包括：弹性，黏弹性，可扩展性和张力参数。比较不同年龄组间、市区与郊县组间各弹性参数间的差异。结果市区和郊县各弹性参数均与年龄有较好的相关性，随年龄增长，皮肤各弹性参数均下降。郊县组与市区组比较，弹性和黏弹性参数差异较小，而可扩展性和张力参数差异较大。结论弹性和黏弹性参数可能与内在老化有关，而可扩展性和张力参数可能与光老化有关。     

Ehlers-Danlos综合征1例

 报告1例Ehlers-Danlos综合征。患者女,31岁。因“全身皮肤弹性过大30余年”就诊。皮肤科情况：皮肤外观正常,全身皮肤弹性过度,触之柔软如天鹅绒,四肢、手足关节可过度拉伸。临床诊断：Ehlers-Danlos综合征。     

Cutis hyperelastica circumscripta. A case report with a morphologic study

This is a report on a 20-year-old female patient with localized cutis hyperelastica. Light and electron microscopy revealed an increase of elastic fibers compared to collagen tissue.     

Solitary Milialike Idiopathic Calcinosis Cutis: A Case Unassociated with Down Syndrome

We report a unique case of solitary milialike idiopathic calcinosis cutis (MICC) in a healthy Korean woman, which is not associated with Down syndrome. This case of MICC would be a form of idiopathic calcinosis cutis, which can be solitary or multiple, sporadic or associated with Down syndrome.     

臀部疣状皮肤结核误诊1例

患儿女,10岁,右臀部环状斑块8余年,曾多次误诊为股癣。皮损组织病理示:表皮角化不全,毛囊角栓,表皮假上皮瘤样增生;真皮浅中层弥漫炎细胞浸润,以淋巴细胞为主;真皮内可见上皮样细胞结节,浸润的细胞有淋巴细胞、多核巨细胞及组织细胞等。抗酸染色(-),PPD试验(3+)。诊断:疣状皮肤结核。     

A Case of Congenital Leukemia Cutis

Congenital leukemia is a rare condition diagnosed at birth to 6 weeks of life with an estimated incidence of 4.7 per million live births. In a review, about 25~30% of cases were well documented as leukemia cutis. We report a case of a 3-month-old infant presented with asymptomatic multiple erythematous to bluish patches and nodules, which had developed about two months ago. Biopsy of the cutaneous lesions revealed immature cells which are overall monotonous with large kidney shaped nucleus, prominent nucleoli and moderate cytoplasm. These atypical cells stained positive for leukocyte common antigen, lysozyme and CD68. With this result, a congenital leukemia cutis was diagnosed. Six months later, she underwent cord blood stem cell transplantation. Seven months after the cord blood stem cell transplantation, the bone marrow examination revealed a normal result. Leukemia can be presented in the skin, the eruption may be nonspecific and it may precede systemic involvement. The recognition is important because early diagnosis can lead to appropriate treatment, followed by better prognosis.     

A Case of Congenital Leukemia Cutis

Congenital leukemia is a rare disease that develops from birth to 6 weeks of life. Leukemia cutis involves cutaneous infiltration by leukemic cells and is an unusual manifestation of leukemia, and has been documented in 25~30% of patients with congenital leukemia. The authors report a case of congenital leukemia cutis. A newborn male presented with widespread firm dusky red papules and nodules on almost his entire body surface. Skin biopsy specimens confirmed the presence of leukemic infiltrations, and bone marrow cytology was consistent with acute myeloid leukemia of the FAB M5 type.     

皮肤痘疮样斑状萎缩1例

男性患，22岁，以躯干、四肢小片状皮肤萎缩12年就诊。皮肤损害表现为圆形或卵圆形的皮肤萎缩斑，触之有松弛感。皮肤组织病理显示表皮萎缩及真皮浅层弹力纤维消失。     

A Case of Tuberculosis Cutis Orificialis with Perianal Involvement

Tuberculosis cutis orificialis (TCO) is a rare manifestation of cutaneous tuberculosis that is caused by auto-inoculation of mycobacteria in patients with advanced internal tuberculosis. TCO occurs in oral, perianal, or genital mucosa and adjacent skin. The tongue is the most frequently affected site, but the perianal area can also be affected. A 39-year-old male presented with a 4-month history of painful ulcers on the perianal area. The histopathologic findings revealed granulomatous infiltrates composed of epithelioid cells and Langhans-type giant cells in the dermis, and a few acid-fast bacilli noted on Ziehl-Neelsen staining. The polymerase chain reaction (PCR) was positive for Mycobacterium tuberculosis and the chest X-ray showed findings consistent with active pulmonary tuberculosis in both upper lung zones. The skin lesion showed complete resolution 2 months after the start of treatment with antituberculosis agents. We report a case of TCO with perianal involvement in a patient with underlying active pulmonary tuberculosis.