移居外地1年后地震灾区儿童与当地儿童行为和情绪问题的对照研究

目的 了解震后1年汶川地震灾区移居日照安康家园儿童的行为与情绪状况,并和当地儿童的行为与情绪比较.方法 对汶川地震后移居日照安康家园1年的513名儿童进行调查,得有效问卷487份,以在同校就读的日照本地儿童475名作为对照,采用儿童行为评定量表(CBCL)、儿童焦虑性情绪障碍筛查表(SCARED)、儿童抑郁障碍自评量表(DSRSC)评定儿童行为和焦虑抑郁情绪.结果 安康家园组和对照组在CBCL量表的行为总分[(26.73±6.28)分,(20.26±5.76)分,t=16.64,P＜0.01]及退缩[(3.23±1.68)分,(2.02±1.43)分,t=12.91,P＜0.01]、躯体主诉[(2.79±1.34)分,(1.67±1.22)分,t=13.55,P＜0.01]、焦虑抑郁[(3.38±1.79)分,(1.95±1.21)分,t=14.48,P＜0.01]、社交问题、注意问题、攻击行为、内向性行为、社交分、学校分等因子方而差异有显著性,两组在SCARED和DSRSC量表中的焦虑、抑郁总分及躯体化、广泛性焦虑、分离性焦虑和社交恐怖等因子方而差异有显著性.结论 与非灾区儿童比较,移居外地1年后地震灾区儿童仍有较多的行为问题和焦虑抑郁情绪.     

长期无病生存白血病儿童情绪、自我意识及个性特征的对照研究

目的 探讨长期无病生存白血病儿童的情绪、自我意识及个性特征.方法 选用儿童焦虑性情绪障碍筛查表、儿童抑郁障碍自评量表、Piers-Harris儿童自我意识量表和儿童版艾森克个性问卷分别对19例长期无病生存白血病、20例初发白血病和40例正常对照儿童进行评定.结果 长期无病生存组患儿在焦虑总分以及躯体化/惊恐、广泛性焦虑和社交恐怖分量表评分[分别为(25.72±14.72)分,(6.11±4.36)分,(5.72±4.56)分和(7.67±4.19)分]高于对照组[分别为(16.11±11.81)分,(3.82±1.69)分,(2.84±1.92)分和(3.95±2.85)分],差异具有显著性(均P＜0.01或P＜0.05).2组白血病患儿自我意识总分[分别为(60.06±8.07)分和(58.25±6.54)分]均低于正常对照组(均P＜0.01或P＜0.05),其中长期无病生存组在焦虑和合群分量表得分明显低于正常对照组(均P＜0.01或P＜0.05),而初发白血病组患儿在行为、智力与学校情况、焦虑分量表得分显著低于正常对照组(均P＜0.01或P＜0.05).长期无病生存组与初发白血病组患儿及正常对照组比较,性格普遍偏于内向.结论 长期无病生存白血病儿童较正常儿童有更多的焦虑情绪、较低的自我意识和内向性格特征.     

脑瘫儿童对父母情绪的影响

目的:了解脑瘫儿童对父母情绪的影响。方法:采用医院焦虑抑郁量表(HAD),对脑瘫儿童的父母以及非脑瘫儿童的父母的抑郁和焦虑情绪进行调查和比较,其中将36例脑瘫儿童的父亲和(或)母亲作为脑瘫儿童的父母组,将52例非脑瘫儿童的父亲和(或)母亲作为非脑瘫儿童的父母组,即对照组。结果:脑瘫儿童的父母组在焦虑[A分值,(10.03±2.67)分]、抑郁[D分值,(10.81±2.57)分]和总分[T分值,(20.56±3.72)分]均显著高于非脑瘫儿童的父母组得分[(8.13±2.46)、(7.77±2.22)、(15.90±3.50)分,P0.01]。结论:脑瘫儿童父母与非脑瘫儿童父母相比较有更多的抑郁和焦虑情绪。因此,有必要对脑瘫儿童的家长进行社会心理干预。     

初中学生焦虑抑郁状况与家庭功能缺陷调查

目的：初步了解初中青少年焦虑抑郁的患病现况，探讨青少年焦虑抑郁的家庭功能特征。方法：采用焦虑性情绪障碍筛查表（SCARED）、儿童抑郁自评量表（DSRSC）和家庭环境量表中文版（FES-CV）调查深圳市某中学初二年级的150名初中生。结果：焦虑性情绪障碍筛查表（SCARED）筛查阳性的36名，占总人数的24．00％；儿童抑郁自评量表（DSRSC）总分大于和等于划界分的有40名，占总人数的33．33％；焦虑和抑郁组均显示在亲密度、矛盾性、独立性、娱乐性因子得分与中国常模比较有显著性差异。结论：在初中青少年中存在焦虑抑郁和家庭功能缺陷。     

心理干预对腹膜透析患者焦虑、抑郁情绪和生活质量的影响

目的 探讨心理干预对腹膜透析患者焦虑、抑郁情绪和生活质量的影响.方法 采用健康状况问卷(SF-36)评估 164 例腹膜透析患者的生活质量;分别用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA) 评估患者的抑郁、焦虑症状,根据评分并将其分为抑郁、焦虑组与非抑郁、焦虑组,比较2组间生活质量及腹膜透析质量的差异.将抑郁、焦虑组患者以就诊先后顺序分为心理干预组和非心理干预组,比较2组间生活质量及腹膜透析质量的差异.结果 腹膜透析患者抑郁、焦虑情绪的发生率分别为21.95%和41.46%.抑郁、焦虑症状评分与生活质量8项指标中7项呈负相关;尤其在躯体疼痛、情感问题所导致的角色限制和情感健康中差异有显著性(r分别为-0.310,-0.367,-0.409;均P<0.01),抑郁、焦虑组SF-36总分[(46.23±16.25) 分,(73.69±19.17)分, P=0.000]、主观综合营养评估[(19.84±4.41)分,(57.34±6.14)分,P<0.01]、尿素清除指数[(2.00±0.43)分,(3.76±0.35)分,P＜0.01]明显低于非抑郁、焦虑组.心理干预治疗后心理干预组SF-36总分、主观综合营养评估、尿素清除指数明显高于非心理干预组.结论 腹膜透析患者抑郁、焦虑症状发生率较高,且与患者生活质量密切相关. 心理干预对腹膜透析患者焦虑、抑郁情绪和生活质量的影响     

外来务工人员子女儿童行为和情绪问题的对照研究

目的 了解外来务工人员子女行为与情绪问题特征.方法 随机分层整群抽取佛山市外来务工子女642名与本地儿童585名进行对照研究,采用儿童行为评定量表(CBCL)、儿童焦虑性情绪障碍筛查表、儿童抑郁障碍自评量表评定儿童行为和焦虑抑郁情绪.结果 外来务工子女组和对照组在CBCL量表的行为总分[(25.49±5.16)分,(21.93±4.96)分]及退缩[(2.58±1.73)分,(1.89±1.32)分]、焦虑抑郁[(3.07±1.87)分,(1.93±1.15)分]、社交问题、攻击行为、内向性行为、社交分、学校分等因子方面差异有显著性,2组在焦虑、抑郁总分及广泛性焦虑、社交恐怖和学校恐怖等因子方面差异有显著性.结论 外来务工子女有较多的行为问题和焦虑抑郁情绪,有必要对他们进行心理行为干预.     

团体心理治疗对乳腺癌改良根治术后患者焦虑抑郁情绪及生命质量的影响

目的 探讨团体心理治疗对乳腺癌改良根治术后患者情绪状态和生命质量的干预效果.方法 将70例乳腺癌改良根治术后的患者采用随机数字表法分为试验组和对照组.对照组接受常规化疗,试验组除接受化疗外同时参加每周1次,共8次的团体心理治疗.比较2组患者治疗前后抑郁、焦虑水平和生命质量有无差异.结果 1.经过团体心理治疗后,试验组患者抑郁、焦虑和食欲丧失评分[分别为(45.08±7.25)分,(42.23±4.72)分,(26.88±20.04)分],低于对照组[分别为(50.15±5.82)分,(49.00±7.07)分,(42.39±29.30)分],差异具有显著性(P＜0.01);疲倦评分显著低于对照组[分别为(41.75±19.65)分,(48.31±23.62)分](P＜0.05);社会功能、总健康状况和形体领域评分[分别为(65.59±23.93)分,(54.30±33.05)分,(64.78±21.91)分],高于对照组[分别为(57.47±29.66)分,(48.38±29.30)分,(43.28±21.91)分],差异具有显著性(P＜0.01).2.试验组患者团体治疗前后抑郁、焦虑评分比较,差异具有显著性(P＜0.01).结论 团体心理治疗可以缓解乳腺癌改良根治术后化疗患者的焦虑和抑郁情绪,提高整体生命质量.     

综合心理干预对乳腺癌患者生存质量的影响

目的 探讨综合性心理干预对乳腺癌患者化疗期间生存质量的影响.方法 将83例化疗期乳腺癌患者随机分为干预组和对照组,干预组除接受常规化疗及护理外还进行为期8周的综合性心理干预,对照组仅接受常规化疗及护理,以乳腺癌患者生命质量测定量表(FACT-B),焦虑自评量表(SAS),抑郁自评量表(SDS )为指标,评价心理干预对乳腺癌患者生存质量的影响.结果 综合性心理干预后干预组总的生存质量以及功能领域和情感领域[分别为(89.49±10.64)分,(15.73±5.50)分,(19.48±5.05)分]明显高于对照组[(分别为(79.68±16.75)分,(12.01±5.81)分,(14.38±4.13)分](P＜0.05),干预后乳腺癌患者的恶心及睡眠状况得到改善(P＜0.05),疼痛程度干预前后变化不明显(P＞0.05);干预后干预组的SAS、SDS评分[分别为(29.03±4.79)分,(30.67±6.12)分]与对照组[分别为(36.15±5.73)分, (42.88±9.45)分]差异具有显著性(P＜0.05).结论 综合性的心理干预能够改善乳腺癌患者的情绪状态,提高其生存质量.     

心理干预对乳腺癌患者希望水平和生活质量的影响

目的 探讨心理干预对乳腺癌患者化疗期间希望水平和生活质量的影响.方法 将95例乳腺癌患者随机分为干预组和对照组,对照组接受常规的治疗和护理,干预组在此基础上接受为期8周的心理干预,以Herth希望量表(HHI)和欧洲肿瘤患者生存质量核心问卷(QLQ-C30)为指标,评价心理干预对乳腺癌患者希望水平和生活质量的影响.结果 心理干预后干预组希望总分及其3因子分[分别为(40.43±4.25)分,(13.28±1.61)分,(13.62±1.70)分,(13.53±1.52)分]高于对照组[分别为(37.82±4.49)分,(12.29±1.89)分,(12.90±1.67)分,(12.63±1.51)分],差异具有显著性(P＜0.05),干预组的整体生活质量、躯体功能和角色功能[分别为(82.27±15.11)分,(75.89±12.24)分,(72.34±22.86)分]高于对照组[分别为(65.82±14.16)分,(68.30±16.42)分,(53.06±27.36)分],差异具有显著性(P＜0.05),干预组的疲乏、疼痛、失眠和食欲丧失[分别为(39.48±14.62)分,(25.18±16.98)分,(29.79±24.31)分,(18.44±21.77)分]低于对照组[分别为(49.43±17.58)分,(36.74±19.54)分,(46.26±28.72)分,(40.82±22.84)分],差异具有显著性(P＜0.01).结论 心理干预可以提高乳腺癌患者的希望水平和牛活质量.     

肠易激综合征患者心理状态、家庭因素及患病危险因素分析

目的 探讨肠易激综合征(Irritable Bowel Syndrome,IBS)患者情绪、人格特质、述情特点、疾病观念与求医行为及家庭情况等因素及相关的危险因素.方法 2010年7月至2012年1月在云南省第二人民医院消化科门诊及病房,通过方便取样对126例符合罗马Ⅲ标准的IBS患者,进行腹部症状及严重程度调查,同时进行焦虑自评量表(SAS)、抑郁自评量表(SDS)、家庭环境量表(FES)、系统家庭动力学自评量表(SSFD)、艾森克人格问卷(EPQA)、多伦多述情障碍量表(TAS)、疾病观念与求医行为量表(ICHSB)等问卷调查,并将调查结果与126例健康志愿者进行比较.结果 1.IBS组抑郁、焦虑、家庭环境因子V、艾森克因子N和因子总分、多伦多述情障碍因子Ⅱ[分别为(40.23±6.96)分,(38.73±7.49)分,(6.78±1.57)分,(13.67±5.37)分,(43.11±7.12)分,(23.12±4.42)分],高于对照组[分别为(36.43±7.25)分,(32.08 ±7.25)分,(5.72±2.01)分,(11.22±5.43)分,(39.38±6.75)分,(20.92±3.95)分];多伦多述情障碍因子Ⅲ(14.73±4.13)分低于对照组(15.11±3.48)分,差异具有显著性(P＜0.05).2.腹部症状与抑郁、焦虑、系统家庭动力学因子Ⅲ和因子总分、疾病观念与求医行为因子Ⅱ呈正相关,与家庭环境因子Ⅰ和因子Ⅸ呈负相关.3.焦虑、成功性、年龄、缺乏识别情感和躯体感受的能力为危险因素,受教育年限为保护因素.结论 IBS患者易伴有抑郁、焦虑情绪,家庭成员支持少、家庭规则不明确者症状重;焦虑、竞争性活动、缺乏识别情感和躯体感受的能力为危险因素.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.