家庭性粘液水肿性苔藓一例

先证者女,７１岁,因颈部两侧丘疹,不痛、不痒１３年,于１９９６年９月来我科就诊。１３年前发现项部靠近发际处有小米粒大小正常肤色的丘疹,皮损数目逐渐增多,面积扩大并融合成片。因无自觉症状及家中有同样病史,一直未予重视。有高血压２０年,白内障７年,否认有肝炎、糖尿病及甲状腺疾病史。家族史:先证者的母亲有同样病史数１０年,已死于肝硬化,姐弟３人,妹妹有同样病史,弟弟无此病,追问外祖父母和祖父母病史不清。体检:一般情况良好,血压２３／１５ｋＰａ,各系统检查无异常。皮肤科检查:颈部两侧、项部,见许多小米粒大小淡黄色、扁平带有…     

粘液水肿性苔藓1例

粘液水肿性苔藓１例陈昭渭，刘迎江，付江洲，何丽阳福建省福州市皮肤病防治院皮肤科（邮政编码３５０００１）患者女，６４岁。右下肢小腿胫前部密集米粒状丘疹月余，逐渐扩大伴有肿痛。既往患支气管炎二十余年，无肝炎结核史，无甲亢及内分泌紊乱史，家族中无类似病史。...     

粘液水肿性苔藓1例

粘液水肿性苔藓（ｌｉｃｈｅｎｍｙｘｅｄｅｍａｔｏｓｕｓ,ＬＭ）是一种少见的以皮肤中纤维母细胞增殖、酸性粘多糖过度沉积,临床以限局性或全身性苔藓样丘疹为特征的皮肤病,最近作者见到１例,现报告如下。患者男,３６岁,干部。因肩、腰、背及上肢伸侧皮肤斑块半年...     

粘液水肿性苔藓1例

粘液水肿性苔藓１例姜海燕，丁连英，金非，赵桂兰粘液水肿性苔藓是一种以皮肤内纤维母细胞增生、酸性粘多糖过多沉积、胶原破碎为特征的少见病。我们见到１例，现报告如下。患者，女，３８岁。１８年前发现额、面、颈部皮肤起粟粒大淡红色扁平丘疹，逐渐融合成片、增厚，...     

粘液水肿性苔藓伴转移性肿瘤一例

患者女 ,68岁,因左侧肩颈胸部黄色、淡黄色斑块,瘙痒 1月余于 1998年 5月 8日初诊。 1个月前,左侧肩颈部出现数个淡黄色丘疹、结节,皮疹初起时无明显瘙痒,后渐增大,部分融合成斑块,皮疹波及左侧锁骨及胸前区。颈背部略有瘙痒。 15年前行胃大部切除手术,术后病理切片确诊为胃癌。 体检：一般情况好,心、肺、肝、脾检查均正常。颈部左侧、锁骨上扪及多个花生至核桃大小淋巴结,质中等,部分与周围组织粘连,活动差,按压有疼痛。皮肤科情况：左侧肩、颈、胸部、项背部见较多黄豆至蚕豆大小的淡黄色至黄红色半球状丘疹、结节,部分融…     

粘液水肿性苔藓死亡1例

粘液水肿性苔藓死亡１例黄利军１刘飞２周毅成２马淑文３戚基萍４患者女，４５岁，农民。１９９０年４月初诊。患者１年前无诱因，前臂出现数个米粒大丘疹，相继于颜面、四肢、躯干等皮肤变硬厚黑，其上多数米粒大丘疹，全身胀满感，面部重，不发热，食欲正常，既往健康。...     

粘液水肿性苔藓伴肝功能和免疫球蛋白异常一例报告

患者女,60岁.于1934年7月中旬始发烧伴咳喘.开始3天体温39℃,继以不规则低热.8月1日来本院内科门诊,按慢性支气管炎处理.     

粘液水肿性苔藓3例临床病理分析

粘液水肿性苔藓是一种罕见的先天性皮肤粘蛋白增多症,本科收治3例患者。男2例,女1例。临床表现主要为淡红色或近皮色粟粒大小丘疹,表面有蜡样光泽,以躯干和四肢伸侧为主。组织病理检查真皮内可见大量粘蛋白沉积。3例患者用维甲酸联合激素治疗,疗效不显著。     

苯丁酸氮芥治疗粘液水肿性苔藓

报告1例应用盐酸苯丁酸氮芥(chlorambucil)治疗弥漫性苔藓样丘疹型粘液水肿性苔藓取得良好效果。 1例40岁的黑人妇女,病程2个月面、肩和臂部出现痒性斑疹,逐渐发展成小丘疹,之后两侧手和腕的灵活性受限。体检见面部、耳后、躯干前后、四肢近端有很多2～3mm大小、肉色、坚实、表面光滑的丘疹。耳后乒疹活组织检查,显示成纤维细胞增多真皮浅、中层稀疏的胶原纤维间的间隙增大,胶质铁染色粘蛋白阳性。实验室检查血象、生化指标和甲状腺功能皆正常。血清蛋白电泳显示γ区有κ-亚型单克隆免疫球     

Lichen myxedematosus: histochemical study

The case is reported of a diabetic female aged 32 years with lichen myxedematosus. Skin biopsy showed enormous amounts of mast cells (59,000/mm3) and heavy deposition of acid mucopolysaccharides.     

黏液水肿性苔藓1例

报告1例黏液水肿性苔藓或硬化性黏液水肿。患者男，45岁。面部皮肤弥漫性肿胀、硬化并有多发隆起性斑块，鼻根部斑块隆起明显，形成一纵行皮嵴，颈部、躯干、双上肢近端泛发苔藓样丘疹。常规实验室检查无异常。皮肤组织病理示真皮内胶原纤维及成纤维细胞增多，胶原束间黏蛋白沉积。     

Lichen myxedematosus associated with chronic hepatitis C

A 55‐year‐old woman presented with a 4‐month history of sclerotic and thickened lichen myxedematosus (LM) cutaneous lesions on her face and trunk. She suffered from chronic hepatitis and had been seen by a physician for 8 months. Examination revealed an asymptomatic hard nodular lesion on her nose, multiple flesh‐colored papules grouped on her nape, upper back, and chest, and painful swollen lesions on both of her hands ( Fig. 1 ).

Figure 1 Open in figure viewer PowerPoint Cutaneous lesions of the patient. Multiple flesh‐colored hard papules are grouped on the upper back, nape, and scalp     

黏液水肿性苔藓2例

报告2例黏液水肿性苔藓。例1.女,16岁。全身起丘疹、结节2个月,以手部结节损害为特征。例2．女,40岁。四肢、躯干丘疹3年,伴面部斑块1年,以眉间隆起的纵向斑块为特征。此2例患者的丘疹、结节组织病理检查均示真皮胶原纤维疏松,成纤维细胞增生,胶原纤维束间阿新蓝染色阳性。     

Lichen myxedematosus: a rare group of cutaneous mucinosis

Cutaneous mucinoses are a heterogeneous group of dermatoses in which excess deposition of mucin in the dermis gives the skin a waxy appearance, with papules and plaques that can vary from self-healing mucinosis to even disrupting the normal shape of a patient’s face, conferring a leonine facies, or be part of life threatening diseases like scleromyxedema. This review will describe the most recent classification on lichen myxedematosus in the generalized (scleromyxedema) and the localized forms, as well as the different organ systems involved in scleromyxedema, diagnostic workup, current management, and prognosis.     

Lichen myxedematosus and multiple myeloma type IgG/kappa

Lichen myxedematosus and scleromyxedema are rare disorders with cutaneous deposition of mucin, without any disturbance of the thyroid function. They are regularly associated with the presence of abnormal proteins in the serum. These proteins have been now identified as paraproteins and are one of the main symptoms of these diseases. The association of a papular mucinosis with a classical plasmacytoma is exceptional. We report a patient in whom lichen myxedematosus is associated with a multiple myeloma of the type IgG/kappa. Cultured skin fibroblasts show a marked decrease of arylsulfatase A activity. An antineoplastic-steroid therapy has brought a remission of both plasmacytoma and skin lesions.