复方酮康唑霜治疗头皮脂溢性皮炎和头皮银屑病的疗效观察

目的　观察复方酮康唑霜治疗头皮脂溢性皮炎和头皮银屑病的效果。方法　对 140例头皮脂溢性皮炎、5 4例头皮银屑病随机分为治疗组和对照组 ,治疗后检查糠秕孢子菌。结果　经 1- 2个疗程治疗 ,头皮脂溢性皮炎和头皮银屑病的痊愈率分别为 94.36 %、6 .9% ,有效率 10 0 %、79.32 % ;对照组痊愈率分别为 15 .94%、0 ,有效率为 73.91%、6 0 % ,两组疗效相比有显著差异。结论　复方酮康唑霜治疗头皮脂溢性皮炎、头皮银屑病是一种见效快、疗效好的药物 ,优于传统药物。     

伊曲康唑联合酮康唑治疗头皮脂溢性皮炎疗效分析

目的观察伊曲康唑联合酮康唑治疗头皮脂溢性皮炎临床疗效及安全性。方法选择96例头皮脂溢性皮炎患者为研究对象,随机分为两组,各48例。治疗组给予伊曲康唑胶囊（200mg／d）口服联合2％酮康唑洗剂（2次／周）头皮局部外用;对照组仅给予2％酮康唑洗剂（2次／周）头皮局部外用。对比观察两组患者治疗后临床疗效及复发率。结果①治疗组总显效率87．50％,明显高于对照组的64．58％（P〈0．01）;②治疗组患者6个月内复发率10．42％,明显低于对照组的43．75％（P〈0．01）。结论伊曲康唑联合酮康唑治疗头皮脂溢性皮炎临床疗效显著,复发率低。     

2%酮康唑洗剂治疗头皮脂溢性皮炎30例分析

目的：观察２％酮康唑洗剂对头皮脂溢性皮炎的疗效。方法：选择头皮脂溢性皮炎６０例,随机等分两组：２％酮康唑洗剂组和头皮洗剂组,进行疗效比较。结果：两组有效率及头屑、油性脂溢、瘙痒三项症状的疗效差异均无差异性（Ｐ〉０．０５）。潮红症状的疗效,２％酮康唑洗剂组优于头皮洗剂治疗组（Ｐ〈０．０５）。结痂症状的疗效,头皮洗剂组优于２％酮康唑洗剂组（Ｐ＝０．０５）。结论：两种药物对头皮脂溢性皮炎均有较好疗效,可     

2％酮康唑洗剂治疗头皮糠疹和头皮脂溢性皮炎50例疗效观察

头皮糠疹和头皮脂溢性皮炎是皮肤科常见病、多发病，酮康唑具有抗卵圆形糠秕孢子菌的活性。头皮糠疹病和头皮脂溢性皮炎，以红斑、鳞屑为主要临床表现。伴有不同程度的瘙痒，成人多见，被认为是局部卵圆形糠秕孢子菌过度繁殖所致。我科2003年10月～2005年6月使用2％酮康唑洗剂（商品名采乐洗剂，西安扬森制药有限公司生产），治疗头皮糠疹和头皮脂溢性皮炎50例，取得较好的疗效，现将治疗情况总结如下。     

肤舒止痒膏治疗头皮脂溢性皮炎疗效观察

目的:观察肤舒止痒膏治疗头皮脂溢性皮炎的临床效果。方法:将66例头皮脂溢性皮炎患者随机分为2组,采用肤舒止痒膏治疗的36例患者一组,采用康王治疗的30例患者一组,两组治疗疗程均为4周。结果:两组有效率(痊愈+显效)近期治疗结果比较无显著差异(χ2=0.01,P>0.05),4周疗程结束后肤舒止痒膏组复发率明显低于康王组,差异有显著统计学意义(χ2=4.70,P<0.05)。结论:肤舒止痒膏治疗头皮脂溢性皮炎效果良好,疗效持久,值得临床进一步推广应用。     

2%酮康唑洗剂治疗头皮糠疹和头皮脂溢性皮炎50例疗效观察

头皮糠疹和头皮脂溢性皮炎是皮肤科常见病、多发病,酮康唑具有抗卵圆形糠秕孢子菌的活性。头皮糠疹病和头皮脂溢性皮炎,以红斑、鳞屑为主要临床表现,伴有不同程度的瘙痒,成人多见,被认为是局部卵圆形糠秕孢子菌过度繁殖所致。我科2003年10月~2005年6月使用2%酮康唑洗剂(商品名采乐洗剂,西安扬森制药有限公司生产),治疗头皮糠疹和头皮脂溢性皮炎50例,取得较好的疗效,现将治疗情况总结如下。     

复方卡力孜然酊治疗头皮脂溢性皮炎临床疗效观察

目的探讨复方卡力孜然酊治疗头皮脂溢性皮炎的临床疗效及安全性。方法将66例患者随机分成2组,治疗组(36例)外用复方卡力孜然酊,对照组(30例)外用2%酮康唑洗剂。疗程8w,治疗2、4、8w后各复诊1次,观察疗效及不良反应。结果治疗2w后,治疗组和对照组有效率分别为27.78%和56.67%;治疗4w后,治疗组和对照组有效率分别为63.89%和66.67%;治疗8w后,两组有效率分别为75.00%、83.33%。两组均未见明显不良反应。结论复方卡力孜然酊治疗头皮脂溢性皮炎安全有效。     

水杨酸去屑护发露治疗头皮脂溢性皮炎临床疗效研究

目的：观察水杨酸去屑护发露治疗头皮脂溢性皮炎的临床疗效及安全性。方法：选取2020年4月-2020年10月于笔者科室就诊的头皮脂溢性皮炎患者15例,以自身治疗前后为对照,外用去屑护发露,每日或隔日1次。对比治疗前后皮损局部皮肤镜检查、鳞屑评分、头皮皮脂分泌情况、瘙痒情况、不良反应率等评估疗效。结果：患者在使用水杨酸去屑护发露后头屑明显减少,ASFS评分降低;皮脂分泌率和瘙痒程度与基线相比明显下降。2例患者在初次使用去屑护发露头皮出现轻微刺痛感,未予特殊处理,自行缓解,继续使用后无不适且未影响治疗。结论:水杨酸去屑护发露在治疗头皮脂溢性皮炎时,可减轻头皮屑、瘙痒、头皮油脂分泌,而且无明显刺激反应。     

中药头皮脂溢搽剂的动物实验研究

目的：研究中药头皮脂溢搽剂对皮肤的急性毒性、过敏性及刺激性。方法：日本大耳白兔35只，雌雄各半，体重2．5-3．0kg；急性毒性试验用15只，刺激性试验用20只，两者均随机分组。将动物背部用去毛剂脱毛，敷药后观察大耳白兔全身中毒、局部表现以及死亡情况，判断中药头皮脂溢搽剂对皮肤的急性毒性和刺激性。豚鼠30只，雌雄兼用，随机分组；动物背部用去毛剂脱毛，致敏接触受试药观察豚鼠机体免疫系统在皮肤上的反应，评分、计算致敏率，评估中药头皮脂溢搽剂的过敏性。结果：用药各组大耳白兔全身及敷药区皮肤未见红斑和水肿，以及采食、体重、眼结膜和口腔黏膜，呼吸、循环、中枢神经系统、四肢活动等均未见明显异常，证实中药头皮脂溢搽剂对实验动物皮肤急性毒性很小，无刺激性；豚鼠敷药区皮肤未见红斑和水肿，表明中药头皮脂溢搽剂对实验动物免疫系统影响很小，无过敏性。结论：中药头皮脂溢搽剂对皮肤的急性毒性很小、无过敏性及刺激性，提示临床用药安全。     

2%酮康唑洗剂治疗头皮脂溢性皮炎30例临床观察

临床上治疗头皮脂溢性皮炎的有效药物不多 ,笔者于1997年以来 ,通过对 30例头皮脂溢性皮炎应用 2 %采乐洗剂(2 %酮康唑洗剂 ,比利时杨森制药公司生产 )治疗效果的观察 ,疗效较佳 ,报告如下。1　临床资料1.1　一般资料　 5 2例头皮脂溢性皮炎患者随机分为观察组30例 ,年龄 17～ 5 8岁 ,平均为 30 .5岁 ,其中男 12例 ,女 18例 ;对照组 2 2组 ,年龄为 2 1～ 5 2岁 ,平均年龄 33.2岁 ,其中男 8例 ,女 14例。1.2　治疗方法　观察组治疗方法为 :先用清水湿润头皮 ,再用 2 %采乐洗剂约 5 ml揉擦 5 min左右 ,然后用清水洗净 ,每周 2次 ,连用 4周 ;对…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.