共查询到20条相似文献，搜索用时 15 毫秒
1.
Shin-ichi Tokushige Shun-ichi Matsuda Genko Oyama Yasushi Shimo Atsushi Umemura Takuya Sasaki Satomi Inomata-Terada Akihiro Yugeta Masashi Hamada Yoshikazu Ugawa Shoji Tsuji Nobutaka Hattori Yasuo Terao 《Clinical neurophysiology》2018,129(11):2421-2432
Objective
Deep brain stimulation (DBS) can provide insights into the workings of the basal ganglia (BG) by interfering with their function. In patients with Parkinson's disease (PD) treated with DBS of the subthalamic nucleus, we studied the effect of DBS on scanning eye movements.Methods
In the visual memory task, subjects viewed images of various complexities for later recall. In visual search tasks, subjects looked for and fixated one odd target ring, embedded among 48 Landolt rings, which either stood out or not from the distractors. We compared the parameters of scanning saccades when DBS was on and off.Results
In the visual memory task, DBS increased the amplitude of saccades scanning simple but not complex drawings. In the visual search tasks, DBS showed no effect on saccade amplitude or frequency.Conclusions
Saccades when viewing simple images were affected by DBS since they are internally guided saccades, for which the involvement of BG is large. In contrast, saccades when viewing complex images or during visual search, made with the help of visual cues in the images (externally guided saccades) and less dependent on BG, were resistant to the effect of DBS.Significance
DBS affects saccades differentially depending on the task. 相似文献2.
L. Bonetti N.T. Haumann P. Vuust M. Kliuchko E. Brattico 《Clinical neurophysiology》2017,128(10):1923-1936
Objective
Depression is a state of aversion to activity and low mood that affects behaviour, thoughts, feelings and sense of well-being. Moreover, the individual depression trait is associated with altered auditory cortex activation and appraisal of the affective content of sounds.Methods
Mismatch negativity responses (MMNs) to acoustic feature changes (pitch, timbre, location, intensity, slide and rhythm) inserted in a musical sequence played in major or minor mode were recorded using magnetoencephalography (MEG) in 88 subclinical participants with depression risk.Results
We found correlations between MMNs to slide and pitch and the level of depression risk reported by participants, indicating that higher MMNs correspond to higher risk of depression. Furthermore we found significantly higher MMN amplitudes to mistuned pitches within a major context compared to MMNs to pitch changes in a minor context.Conclusions
The brains of individuals with depression risk are more responsive to mistuned and fast pitch stimulus changes, even at a pre-attentive level.Significance
Considering the altered appraisal of affective contents of sounds in depression and the relevance of spectral pitch features for those contents in music and speech, we propose that individuals with subclinical depression risk are more tuned to tracking sudden pitch changes. 相似文献3.
Ana Catarina Franco Olympia Kremmyda Jan Rémi Soheyl Noachtar 《Clinical neurophysiology》2018,129(5):952-955
Objective
Positive interictal epileptiform discharges (IEDs) are rarely recorded from surface EEG, due to the orientation of the cortex and its neurons. Their frequency and significance in adults is unknown, and has only been studied as a phenomenon of the neonatal period and childhood. We aimed to evaluate the frequency and characteristics of positive epileptiform discharges in a large cohort of patients.Methods
We retrospectively reviewed 24,178 reports from 18,060 patients of non-invasively recorded EEGs for various indications.Results
Positive IEDs were recorded in six patients (eight EEGs – 0.033%), all of which had epileptic seizures. Brain surgery was the most common reason for recording positive and not negative IEDs. Cortical malformation was the most probable etiology in the remaining patients.Conclusions
Positive IEDs seem to be of lower frequency in adults than in children and are highly associated with epilepsy. They appear more often, but not exclusively, in adult patients with skull defects.Significance
This is the first adult series reported. Positive IEDs must be identified for the correct diagnosis and clearly differentiated from normal variants. 相似文献4.
Shabbir Hussain Merchant Sheng-Han Kuo Yu Qiping Linda Winfield Guy McKhann Sameer Sheth Seth L. Pullman Blair Ford 《Clinical neurophysiology》2018,129(8):1628-1633
Objective
To identify pre-operative clinical and computerized spiral analysis characteristics that may help ascertain which patients with Essential Tremor (ET) will exhibit ‘early tolerance’ to ventral intermediate nucleus of thalamus (Vim) deep brain stimulation (DBS).Methods
Identification of comparative characteristics of defined cases of ‘early tolerance’ versus patients with sustained satisfactory response treated with Vim DBS surgery for medically-refractory ET, based on retrospective chart review by a clinician blinded to the findings of computerized spiral analysis.Results
Statistically significant differences in two spiral analysis indices, SWVI and DoS, were found in the dominant upper limbs of patients who developed ‘early tolerance’, whereas the clinical characteristics were not significantly different.Conclusion
Objective measurements of upper limb kinematics using graphonomic tests like spiral analysis should be considered in the pre-operative evaluation for DBS, especially in the setting of moderate-severe predominantly action and proximal postural tremors.Significance
Ours is the first investigation looking into the pre-operative clinical and objective physiologic characteristics of the patients who develop ‘early tolerance’ to Vim DBS for the treatment of essential tremor. The study has significant implications for pre-operative evaluation and potential surgical target selection for the treatment of tremors. 相似文献5.
Sarah Schnitzler Christian Johannes Hartmann Stefan Jun Groiss Lars Wojtecki Alfons Schnitzler Jan Vesper Jan Hirschmann 《Clinical neurophysiology》2018,129(5):959-966
Objective
To assess whether high frequency oscillations (HFOs, >150?Hz), known to occur in basal ganglia nuclei, can be observed in the thalamus.Methods
We recorded intraoperative local field potentials from the ventral intermediate nucleus (VIM) of the thalamus in patients with Essential Tremor (N?=?16), Parkinsonian Tremor (3), Holmes Tremor (2) and Dystonic Tremor (1) during implantation of electrodes for deep brain stimulation. Recordings were performed with up to five micro/macro-electrodes that were simultaneously advanced to the stereotactic target.Results
Thalamic HFOs occurred in all investigated tremor syndromes. A detailed analysis of the Essential Tremor subgroup revealed that medial channels recorded HFOs more frequently than other channels. The highest peaks were observed 4?mm above target. Macro- but not microelectrode recordings were dominated by peaks in the slow HFO band (150–300?Hz), which were stable across several depths and channels.Conclusion
HFOs occur in the thalamus and are not specific to any of the tremors investigated. Their spatial distribution is not homogeneous, and their appearance depends on the type of electrode used for recording.Significance
The occurrence of HFOs in the thalamus of tremor patients indicates that HFOs are not part of basal ganglia pathophysiology. 相似文献6.
Objective
Emotional dysregulation has emerged as a core symptom domain in adults with Attention-Deficit/Hyperactivity Disorder (ADHD). However, the pathophysiological underpinnings remain poorly understood. This study investigated attentional biases to positive and negative emotional words as possible contributing mechanisms.Methods
Event-related potentials (ERPSs) and behavioral attention bias indices were recorded from 39 adult patients with ADHD and 41 healthy controls during a verbal dot-probe task with positive-neutral, negative-neutral, and neutral-neutral word pairs.Results
Cue-locked N2pc amplitudes indicated a significant attentional bias towards emotional words in patients with ADHD and healthy controls. In healthy controls, the bias was only significant in positive trials. In patients, the bias was associated with ADHD severity and self-reported poor emotion regulation skills. ADHD patients also exhibited reduced target-locked P1 amplitudes and inferior behavioral performance compared with healthy controls.Conclusions
Our findings provide evidence of an attention bias to positive and negative emotional stimuli in adult patients with ADHD and adverse effects of emotional stimuli on task performance.Significance
An attentional bias to emotional stimuli might contribute to emotional reactivity and dysregulation in adult patients with ADHD. 相似文献7.
Yuto Suzuki Rei Enatsu Aya Kanno Satoko Ochi Nobuhiro Mikuni 《Clinical neurophysiology》2018,129(10):2132-2136
Objective
This study investigated the function and networks of the auditory cortices in the posterior lateral superior temporal area (PLST) using a combination of electrical cortical stimulation and diffusion tensor imaging (DTI).Methods
Seven patients with intractable focal epilepsy in which the PLST auditory cortices were identified during the electrical cortical stimulation were enrolled in this study (left side: four patients, right side: three patients). Electrical stimulation at 50?Hz was applied to the chronically implanted subdural electrodes to identify the PLST auditory cortices. DTI was used to identify the subcortical fibers originating from the PLST auditory cortices found by electrical stimulation.Results
Electrical stimulation of the right PLST auditory cortices induced hearing impairment in three patients and left side stimulation elicited hearing illusory sounds in four patients. DTI detected the middle longitudinal fasciculus (MLF) in all patients, the superior longitudinal fasciculus (SLF) in six patients and the inferior fronto-occipital fasciculus (IFOF) in three patients, originating from the PLST auditory cortices.Conclusion
This study suggests different functional roles between the right and left PLST auditory cortices, and the networks originating from these areas.Significance
MLF, SLF and IFOF might be associated with the auditory processing. 相似文献8.
Motomu Suga Yuki Kawakubo Yukika Nishimura Kenji Hashimoto Masato Yumoto Kiyoto Kasai 《Clinical neurophysiology》2018,129(7):1444-1448
Objective
Uncovering molecular bases for auditory language processing in the human brain is a fundamental scientific challenge. The power and latency of the magnetic mismatch field (MMF) elicited by phoneme change, which are magnetoencephalographic indices of language function in its early stage of information processing, are theoretically thought to be modulated by N-methyl-d-aspartate-type glutamate receptor (NMDAR) function, but no study has yet assessed this possibility. We have thus sought to demonstrate an association between phonetic MMF power/latency and levels of plasma d-serine, an intrinsic co-agonist of glycine binding sites on NMDAR, in adults.Methods
The MMF response to phoneme changes was recorded using 204-channel magnetoencephalography in 61 healthy, right-handed, Japanese adults. Plasma levels of d- and l-serine were measured for each participant.Results
We did not find a significant correlation between MMF power/latency and plasma serine levels.Conclusions
Despite a sufficient sample size, we failed to find an association between the physiological markers of the early stage of information processing of language in the auditory cortex and biomarkers indexing glutamatergic function.Significance
Our study did not indicate that a molecular index of glutamatergic function could be a surrogate marker for the early stage of information processing of language in humans. 相似文献9.
Georg Kägi Diane Ruge Florian Brugger Petra Katschnig Rafael Sauter Mirta Fiorio Michele Tinazzi John Rothwell Kailash P. Bhatia 《Clinical neurophysiology》2017,128(7):1142-1147
Objective
Idiopathic adult onset cervical dystonia (IAOCD) is considered to be a partially penetrant autosomal dominant genetic condition. Dystonia may result from genetic and environmental factors. In this view, part of the physiology should be an endophenotype stemming from the genetic background. We assessed the most discriminative test to separate patients with IAOCD and healthy controls for further endophenotyping in non-affected 1st degree relatives.Methods
We included patients with IAOCD, their 1st degree relatives and healthy controls. Tests performed: (1) Sensory temporal discrimination (visual, tactile, visuo-tactile), (2) Paired pulse paradigms using transcranial magnetic stimulation (TMS), (3) Mental rotation paradigms.Results
45 patients with IAOCD, 23 healthy controls and 14 non-affected 1st degree relatives were recruited. Visuo-tactile temporal discrimination separated best between controls and patients as well as between controls and 1st degree relatives. 36% of the latter had an abnormal visuo-tactile temporal discrimination. No difference between patients and healthy controls was found for the other paradigms.Conclusions
Visuo-tactile temporal discrimination separates controls from patients with IAOCD and its 1st degree relatives. 36% of the latter had abnormal visuo-tactile thresholds supporting the role of visuo-tactile temporal discrimination as an endophenotype for IAOCD.Significance
Even though the study was of exploratory design, our findings expand the understanding of endophenotypes in IAOCD. 相似文献10.
Xinyi Geng Xin Xu Andreas Horn Ningfei Li Zhipei Ling Peter Brown Shouyan Wang 《Clinical neurophysiology》2018,129(5):1001-1010
Objective
This study aims to use the activities recorded directly from the deep brain stimulation (DBS) electrode to address the focality and distinct nature of the local field potential (LFP) activities of different frequency.Methods
Pre-operative and intra-operative magnetic resonance imaging (MRI) were acquired from patients with Parkinson’s disease (PD) who underwent DBS in the subthalamic nucleus and intra-operative LFP recording at rest and during cued movements. Images were reconstructed and 3-D visualized using Lead-DBS® toolbox to determine the coordinates of contact. The resting spectral power and movement-related power modulation of LFP oscillations were estimated.Results
Both subthalamic LFP activity recorded at rest and its modulation by movement had focal maxima in the alpha, beta and gamma bands. The spatial distribution of alpha band activity and its modulation was significantly different to that in the beta band. Moreover, there were significant differences in the scale and timing of movement related modulation across the frequency bands.Conclusion
Subthalamic LFP activities within specific frequency bands can be distinguished by spatial topography and pattern of movement related modulation.Significance
Assessment of the frequency, focality and pattern of movement related modulation of subthalamic LFPs reveals a heterogeneity of neural population activity in this region. This could potentially be leveraged to finesse intra-operative targeting and post-operative contact selection. 相似文献11.
Stuart W. Mackenzie Richard Irving Peter Monksfield Raghu Kumar Attila Dezso Raymond F. Reynolds 《Clinical neurophysiology》2018,129(11):2350-2360
Objectives
We determined if eye movements evoked by Electrical Vestibular Stimulation (EVS) can be used to detect vestibular dysfunction in patients with unilateral vestibular schwannoma (VS).Methods
Ocular torsion responses to monaural sinusoidal EVS currents (±2?mA, 2?Hz) were measured in 25 patients with tumours ranging in size from Koos grade 1–3. For comparative purposes we also measured postural sway response to EVS, and additionally assessed vestibular function with the lateral Head Impulse Test (HIT). Patient responses were compared to age-matched healthy control subjects.Results
Patients exhibited smaller ocular responses to ipsilesional versus contralesional EVS, and showed a larger asymmetry ratio (AR) than control subjects (19.4 vs. 3.3%, p?<?0.05). EVS-evoked sway responses were also smaller in ipsilesional ear, but exhibited slightly more variability than the eye movement response, along with marginally lower discriminatory power (patients vs. controls: AR?=?16.6 vs 2.6%, p?<?0.05). The HIT test exhibited no significant difference between groups.Conclusions
These results demonstrate significant deficits in the ocular torsion response to EVS in VS patients.Significance
The fast, convenient and non-invasive nature of the test are well suited to clinical use. 相似文献12.
Fernanda Emanuelle Almeida Castro Amorim Alinne Martiniano Sahdo Lydia Maria Pereira Giuliano Denise Spinola Pinheiro Nadia Iandoli de Oliveira Braga Gilberto Mastrocola Manzano 《Clinical neurophysiology》2017,128(1):262-269
Objective
The study aimed to examine the effect of the stimulus phase of air-conducted sound on ocular vestibular evoked myogenic potentials (oVEMPs).Methods
oVEMPs were recorded after air-conducted sounds (500 Hz, 4 ms duration), presented with initial condensation (positive), rarefaction (negative), and alternant polarities from 12 healthy subjects.Results
Most responses showed a bifid n10 peak separated by ～1.9 ms. The most prominent sub-peak after condensation was shorter than the most prominent sub-peak after rarefaction; however, the first sub-peak was shorter after the rarefaction stimuli. When a third sub-peak appeared, it occurred before the most prominent sub-peak after condensation and after the most prominent sub-peak after rarefaction. The latency difference between this third sub-peak and the closest sub-peak was shorter than the difference among the others sub-peaks, in both cases; the oVEMPs after alternating stimuli was an amalgam of the responses to the different stimuli.Conclusions
The findings suggest that the negative to positive change of the stimulus was the main event responsible for the stimulation, and that when a third sub-peak appeared it was related to the initiation or the end of the stimulus.Significance
These findings suggested that the oVEMP response, obtained by air conducted sound, was secondary to stimulation of the same type of afferent vestibular unit, independent of the stimulus polarity. 相似文献13.
Chih-Ming Chang Yi-Ho Young Fu-Shan Jaw Chi-Te Wang Po-Wen Cheng 《Clinical neurophysiology》2017,128(9):1617-1624
Objective
The staging system of Meniere’s disease utilizes audiograms to probe cochlear dysfunction. We explored the addition of galvanic vestibular-evoked myogenic potentials (VEMP) to further explore vestibular function.Methods
Seventy patients with unilateral Meniere’s disease were enrolled in this study. Within 2 weeks of diagnosis, all subjects underwent pure tone audiometry, cervical and ocular VEMP, and caloric test. The prevalence of abnormal tests and the VEMP characteristic parameters such as latencies and amplitudes were analyzed.Results
In affected ears, the abnormal rate of acoustic cVEMPs, galvanic cVEMPs, vibratory oVEMPs and galvanic oVEMPs was 37%, 17%, 20%, and 9%, respectively. No significant differences existed in VEMP latencies and amplitudes between affected ears and unaffected ears.Conclusions
The impairment of otolithic organs was found to be more than that of vestibular afferents. The deterioration of the saccule was more than that of the utricle, whereas retrolabyrinthine degeneration of sacculo-collic reflex and vestibulo-ocular reflex was similar.Significance
This study is the first to use an electrophysiological test to evaluate the retrolabyrinthine function of patients with unilateral Meniere’s disease. 相似文献14.
Luis Velázquez-Pérez Roberto Rodríguez-Labrada Reidenis Torres-Vega Ricardo Ortega-Sánchez Jacqueline Medrano-Montero Rigoberto González-Piña Yaimeé Vázquez-Mojena Georg Auburger Ulf Ziemann 《Clinical neurophysiology》2018,129(5):895-900
Objective
Corticospinal tract (CST) dysfunction is common in the pre-ataxic stage of spinocerebellar ataxia type 2 (SCA2) but quantitative assessment of its progression over time has not been explored. The aim of this study was to quantify the progression of CST dysfunction in pre-ataxic SCA2 using transcranial magnetic stimulation (TMS).Methods
Thirty-three pre-ataxic SCA2 mutation carriers and a 33 age- and gender-matched healthy controls were tested at baseline and 2-years follow-up by standardized clinical exams, validated clinical scales, and TMS.Results
Pre-ataxic SCA2 mutation carriers showed a significant increase of resting motor thresholds (RMT) to abductor pollicis brevis (APB) and tibialis anterior (TA) muscles, and of central motor conduction time (CMCT) to TA at 2-years follow-up, over and above changes in healthy controls. The changes in the pre-ataxic SCA2 mutation carriers were independent of the presence of clinical signs of CST dysfunction at baseline, and independent of conversion to clinically definite SCA2 at 2-years follow-up.Conclusions
TMS markers of CST dysfunction progress significantly during the pre-ataxic stage of SCA2.Significance
TMS measures of CST dysfunction may provide biomarkers of disease progression prior to clinical disease expression that have potential utility for monitoring neuroprotective therapies in future clinical trials. 相似文献15.
Viateur Tuyisenge Lena Trebaul Manik Bhattacharjee Blandine Chanteloup-Forêt Carole Saubat-Guigui Ioana Mîndruţă Sylvain Rheims Louis Maillard Philippe Kahane Delphine Taussig Olivier David 《Clinical neurophysiology》2018,129(3):548-554
Objective
Intracranial electroencephalographic (iEEG) recordings contain “bad channels”, which show non-neuronal signals. Here, we developed a new method that automatically detects iEEG bad channels using machine learning of seven signal features.Methods
The features quantified signals’ variance, spatial–temporal correlation and nonlinear properties. Because the number of bad channels is usually much lower than the number of good channels, we implemented an ensemble bagging classifier known to be optimal in terms of stability and predictive accuracy for datasets with imbalanced class distributions. This method was applied on stereo-electroencephalographic (SEEG) signals recording during low frequency stimulations performed in 206 patients from 5 clinical centers.Results
We found that the classification accuracy was extremely good: It increased with the number of subjects used to train the classifier and reached a plateau at 99.77% for 110 subjects. The classification performance was thus not impacted by the multicentric nature of data.Conclusions
The proposed method to automatically detect bad channels demonstrated convincing results and can be envisaged to be used on larger datasets for automatic quality control of iEEG data.Significance
This is the first method proposed to classify bad channels in iEEG and should allow to improve the data selection when reviewing iEEG signals. 相似文献16.
Louis-David Beaulieu Hugo Massé-Alarie Edith Ribot-Ciscar Cyril Schneider 《Clinical neurophysiology》2017,128(7):1290-1298
Objective
To investigate the ability of transcranial magnetic stimulation (TMS) outcomes in the chronic stroke population to (i) track individual plastic changes and (ii) detect differences between individuals. To this end, intrarater “test-retest” reliability (relative and absolute) was tested for the ipsilesional and contralesional hemispheres.Methods
Thirteen participants with a unilateral stroke (≥6 months ago) and sensorimotor impairments were enrolled. Single and paired-pulse TMS outcomes were obtained from the primary motor cortex (M1) representation of the tibialis anterior muscle in both hemispheres and at two sessions separated by one week. The standard error of the measurement (SEMeas), minimal detectable change (MDC) and intraclass correlation coefficient (ICC) were studied.Results
Active motor threshold and latency of motor evoked potentials provided the lowest SEMeas and highest ICCs for both ipsi- and contralesional hemispheres. However, MDC were generally large, thus questioning the use of TMS outcomes to track individual plastic changes of M1.Conclusions
Our study provided supporting evidence of good to excellent intrarater reliability for a few TMS outcomes and proposed recommendations on the interpretation and the use of that knowledge in future work.Significance
Psychometric properties of TMS measures should be further addressed in order to better understand how to refine their use in clinical settings. 相似文献17.
Ana R. Gonçalves Carina Fernandes Rita Pasion Fernando Ferreira-Santos Fernando Barbosa João Marques-Teixeira 《Clinical neurophysiology》2018,129(5):1020-1029
Objective
Aging is known to alter the processing of facial expressions of emotion (FEE), however the impact of this alteration is less clear. Additionally, there is little information about the temporal dynamics of the neural processing of facial affect.Methods
We examined behavioral and neural age-related changes in the identification of FEE using event-related potentials. Furthermore, we analyze the relationship between behavioral/neural responses and neuropsychological functioning. To this purpose, 30 younger adults, 29 middle-aged adults and 26 older adults identified FEE.Results
The behavioral results showed a similar performance between groups. The neural results showed no significant differences between groups for the P100 component and an increased N170 amplitude in the older group. Furthermore, a pattern of asymmetric activation was evident in the N170 component. Results also suggest deficits in facial feature decoding abilities, reflected by a reduced N250 amplitude in older adults. Neuropsychological functioning predicts P100 modulation, but does not seem to influence emotion identification ability.Conclusions
The findings suggest the existence of a compensatory function that would explain the age-equivalent performance in emotion identification.Significance
The study may help future research addressing behavioral and neural processes involved on processing of FEE in neurodegenerative conditions. 相似文献18.
Tomofumi Yamaguchi Tue Hvass Petersen Henrik Kirk Christian Forman Christian Svane Mathilde Kofoed-Hansen Finn Boesen Jakob Lorentzen 《Clinical neurophysiology》2018,129(9):2010-2021
Objective
The present study evaluated ankle stiffness in adults with and without neurological disorders and investigated the accuracy and reproducibility of a clinically applicable method using a dynamometer.Methods
Measurements were obtained from 8 healthy subjects (age 39.3), 9 subjects with spastic cerebral palsy (CP) (age 39.8) and 8 subjects with multiple sclerosis (MS) (age 49.9). Slow and fast dorsiflexion stretches of the ankle joint were performed to evaluate passive muscle-tendon-joint stiffness, reflex mediated stiffness and range of movement (ROM), respectively. Intra/inter-rater reliability for passive and reflex mediated ankle muscle stiffness was assessed for all groups.Results
Subjects with CP and MS showed significantly larger values of passive stiffness in the triceps surae muscle tendon complex and smaller ROM compared to healthy individuals, while no significant difference in reflex mediated stiffness. Measurements of passive muscle-tendon-joint stiffness and reflex mediated stiffness showed good to excellent inter- and intra-rater reliability (ICC: 0.62–0.91) in all groups.Conclusion
Increased stiffness was found in subjects with CP and MS with a clinically applicable method that provides valid and reproducible measurement of passive ankle muscle-tendon-joint stiffness and reflex mediated stiffness.Significance
The present technique may provide important supplementary information for the clinician. 相似文献19.
Yu-ichi Noto Neil G. Simon Alexis Selby Nidhi Garg Kazumoto Shibuya Nortina Shahrizaila William Huynh José M. Matamala Thanuja Dharmadasa Susanna B. Park Steve Vucic Matthew C. Kiernan 《Clinical neurophysiology》2018,129(5):974-980
Objective
To elucidate differences in the distribution and firing frequency of fasciculations between peripheral nerve hyperexcitability syndromes and amyotrophic lateral sclerosis (ALS) and to explore the generator site of fasciculations.Methods
Ultrasound of 14 preselected muscles was performed in patients with peripheral hyperexcitability and ALS. The distribution and firing frequency of fasciculations were calculated. Cortical excitability assessment was also done by threshold tracking transcranial magnetic stimulation.Results
In total, 518 muscles from 37 peripheral hyperexcitability patients and 756 muscles from 54 ALS patients were examined. Regarding the detection rate, 74% of muscles in ALS patients demonstrated fasciculations, compared with 34% of muscles in peripheral hyperexcitability patients (P?<?0.001). The number of unique repeating focal muscle fasciculation movements per muscle and firing frequency of individual fasciculations in ALS were both significantly higher than those in peripheral hyperexcitability (P?<?0.001). Furthermore, cortical silent period duration negatively correlated with the number and firing frequency of fasciculations in ALS (P?<?0.05). A similar relationship was not evident in peripheral hyperexcitability.Conclusions
In ALS patients, fasciculations were more widespread, greater in number and higher in firing frequency than in peripheral hyperexcitability patients.Significance
A significant proportion of fasciculations in ALS may be influenced by changes in central excitability. 相似文献20.
Peter Poortvliet Billie Hsieh Andrew Cresswell Jacky Au Marcus Meinzer 《Clinical neurophysiology》2018,129(1):33-41