痛泻要方抑木组分缓解IBS-D高敏中医机理探讨及研究进展

正1 IBS-D发病机制肠易激综合征(Irritable Bowel Syndrome,IBS)是一种胃肠功能紊乱而引发的疾病,具体表现为持续存在或间歇发作的腹痛、腹泻、排便习惯改变及大便性状(腹泻、便秘、腹泻便秘交替)异常,没有明显形态学或生化异常改变的症候群。根据不同症状,临床上将IBS分为腹泻型肠易激综合征(Irritable Bowel Syndrome with Diarrhea,IBS-D)、便秘型肠易     

马来酸曲美布汀联合双歧四联活菌治疗腹泻型肠易激综合征20例

肠易激综合征(IBS)指的是一组包括腹痛、腹胀、排便习惯和大便性状异常,持续存在或间歇发作,而又缺乏明显的形态学和生化学异常改变可以解释的症候群,是一种发病率较高的慢性功能性疾病。根据临床症状,IBS可分为腹泻型、便秘型和腹泻便秘交替型3型,其中以腹泻型最为多见。自200     

健脾疏肝汤治疗腹泻型IBS临床观察

<正>肠易激综合征(IBS)是一种以腹痛或腹部不适伴排便习惯改变和(或)大便性状异常的功能性肠病[1]。在我国,IBS患者在消化专科门诊中就诊的比例达20%～50%[2],属于常见病多发病。本病可分为便秘型、腹泻型、便秘腹泻交替型,其中腹泻型是临床较常见病症。本病病因尚不十分清楚,     

肠易激综合征病因研究进展

肠易激综合征（irritable bowel syndrome．IBS）是临床上最常见的一种胃肠道功能紊乱性疾惠．是一组包括腹痛、腹胀、以大便习惯改变为主要特征，并伴大便性状异常．持续存在或间歇发作。而又缺乏形态学及生物化学异常改变等可用器质性疾病解释的临床症状．大致可分为腹泻型、便秘型、混合型及未分型。据报道不论是西方发达国家还是发展中国家IBS的患病率均非常高，我国人群患病率估计在20％，也有报道在西方国家IBS患者占胃肠门诊病人的25％～50％，在我国约占40％。本文就近年IBS的病因研究进展作一综述。     

马来酸替加色罗治疗便秘型肠易激综合征92例效果观察

肠易激综合征(irritable bowel syndrome,IBS)是一组包括腹痛、腹胀、排便习惯改变和大便性状异常、黏液便等表现的临床综合征,但必须经检查排除引起这些症状的器质性疾病,是最常见的一种功能性肠道疾病。根据IBS的临床特点可分为腹泻型、便秘型和腹泻便秘交替型。治疗药物有平滑肌松弛剂、肠容积性药物、促动力药物和影响精神药物,但疗效不够理想。我院消化科2002年6月~2005年6月应用马来酸替加色罗片(重庆药友制药有限责任公司生产,规格:6 mg×6片×1盒)治疗便秘型IBS(C-IBS)92例,取得良好效果,现报告如下。1对象和方法1·1研究对象…     

中医外治法治疗肠易激综合征的研究概况

正肠易激综合征(Irritable Bowel Syndrome,IBS)是一种发病机制尚未明确的慢性功能性肠道病变,临床主要表现以腹痛、腹部不适、大便性状及排便习惯改变、精神状态异常等为特征。临床上大致分为腹泻性(IBS-D)、便秘型(IBS-C)、混合型(IBS-M)、不定型(IBS-U)4种类型[1]。本病临床表现个体差异较大,治疗上目前尚无一种药物能对所有IBS病人     

替加色罗治疗便秘型肠易激综合征的临床疗效观察

肠易激综合征（Irritable Bowel Syndrome，IBS）是一种以腹痛或腹部不适伴排便习惯改变和（或）大便性状异常的功能性肠病，特征是没有感染或炎症的存在，常呈间歇性反复发作，多见于中青年女性。IBS可分为腹泻为主型（IBS—D）、便秘为主型（IBS—C）和腹泻便秘交替型（IBs—A）。作者自2003年5月至2006年3月用替加色罗治疗便秘型肠易激综合征（irritable bower syndrome，constipation—predominant，便秘型IBS）患者27例，并与安慰剂对照组比较，现报道如下。     

5-HT、IL-8等炎性因子在肠易激综合征中的研究进展

<正>肠易激综合征(IBS)是一种常见的功能性胃肠病,是一组包括腹胀、腹痛、大便性状和排便习惯异常,持续存在或者间歇性发作的,缺乏明显可以解释的生化学和形态学异常的症候群,其明确的病因和发病机制目前还在研究中。肠易激综合症大致可以分为三类,腹泻型(D-IBS)、便秘型(C-IBS)和腹泻便秘交替型(A-IBS)。在20世纪90年代,Weston等[1]就认为IBS的发病可能与肠道低度炎症反应以及     

黛力新治疗肠易激综合征40例疗效观察

肠易激综合征（Irritable bowel syndrome，IBS）是一组以腹痛、腹胀、排便习惯和大便性状异常，黏液便持续存在或间歇发作，而又缺乏形态学和生化学异常改变可解释的症候群。近年来，IBS发病率逐年增高，占胃肠门诊的25％-50％。其特点是女多于男，年轻人多于老年人，知识分子干部多于工人农民。根据临床症状，IBS可分为腹泻型、便秘型和腹泻便秘交替型3型。目前认为IBS的发病与内脏感觉过敏、脑肠轴的改变、胃肠动力学异常、精神行为异常、肠道感染后菌群失调等多种因素有关。IBS的药物治疗主要从调节内脏敏感性和胃肠运动功能，调整脑-肠轴稳态，消除患者精神障碍等多角度入手，常用的有钙通道阻滞药、促胃肠动力药、肠容积性泻药、调节精神药物及对症治疗。近年来我们应用黛立新治疗了40例肠易激综合征患者，获得了较好的疗效。现分析如下：     

腹泻型肠易激综合征的中医临床研究进展

肠易激综合征(IBS)是指一组包括有排便习惯改变、粪便性状异常、排便感觉异常、腹痛及腹胀等临床表现的功能性疾病,症状持续存在或间歇发作。其属中医“泄泻”、“腹痛”、“便秘”等范畴。国内调查研究显示,IBS患者占消化科门诊量的30%~50%,北京地区符合罗马Ⅱ标准和man-ning标准的检出率分别是0.82%与7.01%,男女之比约为1∶1.5〔1〕,多见于18~30岁的青少年〔2~3〕。IBS可分为腹泻型、便秘型、腹泻(或便秘)交替型以及腹痛型,其中腹泻型最多见。〔4〕中医学对腹泻型IBS的诊治有独道的见解,亦取得了良好的临床效果。现综述如下。辨证分…     

Interaction of peptidoglycans with anti-IgGs and with complement.

This report describes the interaction of peptidoglycan (Streptococcus group A, Staphylococcus epidermidis and Micrococcus lysodeikticus) with 2 serum mediator systems, namely with the anti-IgG system and with complement. The observation that the majority of rabbits hyperimmunized with A-variant streptococcal vaccine produced anti-group carbohydrate antisera containing anti-IgGs and antibodies directed to peptidoglycan suggested that the production of these 2 latter antibodies was related. This view was supported by the finding of a monoclonal 7S anti-IgG with antibody specificity for the pentapeptide of peptidoglycan as evidenced by inhibition of the coprecipitation of 7S anti-IgG with antigen-antibody complexes by the pentapeptide. Inhibition of the anti-idiotype reaction by the pentapeptide provided further evidence for the antibody specificity of 7S anti-IgG for peptidoglycan. When added to normal human sera all peptidoglycan preparations inhibited the hemolytic activity of the sera. Consumption of C3 in C2 deficient serum and consumption of C2 in normal serum indicated the activation of both known complement pathways. Activation of the classical pathway of complement was more efficient since 50 mug of peptidoglycan consumed approximately 70% of C2 per ml normal serum whereas more than 2 mg of the same preparations was required to inactivate 17-24% of C3 in C2 deficient sera. Each of the different peptidoglycan preparations consumed similar amounts of complement in all 20 sera tested. This finding suggested that activation of the classical complement pathway by peptidoglycan was not mediated by anti-peptidoglycan antibodies present in only 20-40% of normal human sera.     

异病酚静脉全麻下复合氯胺酮或曲马多行纳屈酮快速阿片脱毒的效果比较

Toreleasetheseverewithdrawalsymptomsoftheheroinad-dicts,weinjecttheNaloxineinthegeneralanesthesia.160volun-teersreceivedRODwereperformedunderthecombinedanesthesiawithpropofol,midazolamandketamine.1Subjectsandmethods1.1Subjects160volunteerswhoaccordingwiththediagnosticstandardoftheICD-10abouttheopiate-addiction,male:145,fe-male15.Age:(30±6),theeldestwas45yearsold.Themeanbodyweightwasabout(58±8)kg.Educationalbackground:pri-maryschool118cases,juniorhighschool:24casesandseniorhighschool/seco…     

The comparison of effects of rapid opiate detoxification with ketamine complex and with tramadol and naltrexone under general anesthesia with propofol

Objective To release the heroin addicts‘ sufferings,we made rapid opiate detoxification by injecting naloxine under the general anesthesia.Method 160 volunteers were divided at randon into two groups:Group A were performed under the combined anesthesia with propofol,midazolam and kelamine.Group B were performed under the combined anesthesia with propofol with midazolam and tramadol.The vital signs were recorded and the withdrawal syndrome of the volunteers were assessed during the whole process.Result All of the withdrawal symptoms scores 24 hours after ROD in group B were lower than its pre-treatment;The symptoms of the thirs,tsleeping disturbance,nausea and vomiting,skeletal muscular pains and anorexia scores in group A were also lower than its pre-treatment;and no too much differeence belween group A and group B.But tearing,anxiety and diarrhea scores in group A were almost the same as the pre-treatment and higher than group B.Both groups received of the naloxone treatment smoothly,and remained in the hospital for about 3 days.Conclusion The effect of rapid opiate detoxification of naltrexone with the ketamine or tramadol under anesthesia is obvious.The tramadol is better than others.     

替吉奥联合亚叶酸钙及奥沙利铂治疗晚期结直肠癌病人的观察与护理

[目的]总结替吉奥联合亚叶酸钙及奥沙利铂治疗晚期结直肠癌病人的观察与护理。[方法]对25例无法手术切除的晚期结直肠癌病人采用替吉奥胶囊联合亚叶酸钙、奥沙利铂方案进行治疗,同时加强心理护理、毒副反应的观察与护理等。[结果]治疗过程中出现Ⅰ级和Ⅱ级神经毒性8例,恶心、呕吐、食欲下降12例,骨髓抑制5例,变态反应1例,经处理后均好转;1例病人死亡,其余病人均顺利进行治疗。[结论]加强替吉奥联合亚叶酸钙及奥沙利铂治疗晚期结直肠癌病人的护理,可保证治疗的顺利进行。     

缩腺液治疗扁桃体炎的疗效观察及其护理

扁桃体炎是儿童常见病、多发病,传统药物治疗可暂缓症状,但不能根治;手术治疗痛苦大、出血多、费用高,常合并有并发症。我科运用缩腺液治疗扁桃体炎3 0例收到了良好的效果。现报告如下。1　对象与方法1.1　对象　本科于2 0 0 2年—2 0 0 3年共收治扁桃体炎病人5 0例,年龄为7岁～2 0岁,分两组进行。缩腺液治疗组3 0例,男13例,女17例;其中重度12例,中度9例,轻度9例;对照组2 0例,男9例,女11例;其中重度8例,中度7例,轻度5例。两组病人年龄、性别、病情严重程度基本一致,差异无统计学意义(P >0 .0 5 )。1.2　方法　对照组采用药物治疗,静脉输注…     

艾滋病合并结核病及马尔尼菲青霉病患者的护理

目的 通过分析艾滋病合并结核病及马尔尼菲青霉病患者的临床资料,提高对三病并存的护理认识.方法 分析并总结26例艾滋病合并结核病及马尔尼菲青霉病住院患者的临床特点、治疗及护理方法.结果 本组患者治愈5例,好转13例,死亡8例.存活患者随访6～30个月均未复发.结论 三病并存时临床表现复杂,无特异性,护理难度大,应仔细观察病情,及早诊治,精心护理,对改善预后有重要意义.     

艾滋病合并结核病及马尔尼菲青霉病患者的护理

目的通过分析艾滋病合并结核病及马尔尼菲青霉病患者的临床资料,提高对三病并存的护理认识。方法分析并总结26例艾滋病合并结核病及马尔尼菲青霉病住院患者的临床特点、治疗及护理方法。结果本组患者治愈5例,好转13例,死亡8例。存活患者随访6～30个月均未复发。结论三病并存时临床表现复杂,无特异性,护理难度大,应仔细观察病情,及早诊治,精心护理,对改善预后有重要意义。     

Coping and compensation strategies of patients with disseminated encephalomyelitis and of patients with schizophrenic psychoses]

In ten patients with schizophrenic psychosis and ten patients with multiple sclerosis, the coping and compensation strategies were examined by means of semistructured interviewing. The following categories were considered: 1. avoidance; 2. habituation and/or adaptation to the disease; 3. efforts to compensate the deficits by will-power; 4. efforts to train certain types of behaviour; 5. self-treatment; 6. disease awareness and insight. Examples for these categories are given for both groups of patients. There is a surprising similarity in the statements made by the schizophrenic patients and those with multiple sclerosis. All of the patients with multiple sclerosis had developed coping strategies against psychological symptoms. It is suggested that the neuropsychological deficits in multiple sclerosis resemble the symptoms of reduced energetic potential observed in schizophrenia. In both groups efforts should be made to activate the compensation strategies by adequate training procedures.     

Experience with the treatment of atrial fibrillation with cordarone and digoxin

Paraxysmal and recent cardiac fibrillations have been treated in 42 patients with cordaron combined with digoxin. The arrest of fibrillation was achieved for 5 days in 29 patients (69%) suggesting high efficacy of the combination.