无缝线小切口白内障摘除人工晶体植入术112例报告

目的评价无缝线小切口白内障摘除及人工晶体植入术的疗效.方法对128眼老年性、并发性、先天性、外伤性白内障施行无缝线小切口白内障摘除及人工晶体植入术,对硬核白内障行手法碎核.结果术后1周裸眼或矫正视力≥0.5为80.5%,3个月为95%,术后1周平均散光1.95±1.53D,术后3个月角膜散光为0.93±0.55D.并发症为角膜水肿、后囊膜破裂、暂时性高眼压.结论小切口无缝线白内障摘除及人工晶体植入术术后散光小,手术安全,切口自闭性能好,视力恢复快.     

无缝线小切口白内障摘除术人工晶体植入术112例报告

目的　评价无缝线小切口白内障摘除及人工晶体植入术的疗效。方法　对 12 8眼老年性、并发性、先天性、外伤性白内障施行无缝线小切口白内障摘除及人工晶体植入术 ,对硬核白内障行手法碎核。结果　术后 1周裸眼或矫正视力≥ 0 .5为 80 .5 % ,3个月为 95 % ,术后 1周平均散光 1.95± 1.5 3D ,术后 3个月角膜散光为 0 .93± 0 .5 5D。并发症为角膜水肿、后囊膜破裂、暂时性高眼压。结论　小切口无缝线白内障摘除及人工晶体植入术术后散光小 ,手术安全 ,切口自闭性能好 ,视力恢复快     

小切口无缝线白内障摘除加人工晶体植入术1730例临床疗效观察

目的探讨小切口无缝线白内障囊外摘除加人工晶体植入术治疗非洲黑人白内障的临床疗效。方法对1730例（2207眼）黑人白内障患者行小切口无缝线白内障囊外摘除及人工晶体植入术,评估疗效。结果术后1周视力≥0.5者占63.6%（1403眼）,视力≥1.0者占5.1%（112眼）,散光为（1.96±0.72）D。3个月后视力≥0.5者占94.9%（2094眼）。视力≥1.0（136眼）占6.2%,散光为（0.87±0.54）D。结论小切口无缝线白内障囊外摘除及人工晶体植入术损伤小、术后视力恢复好,在非洲地区有推广运用价值。     

小切口无缝线白内障手术350例分析

目的探讨小切口无缝线白内障摘除及人工晶体植入术的机理、方法及效果。方法回顾性分析350例(388眼)老年性白内障行小切口无缝线白内障摘除及人工晶体植入术的视力、角膜反应及术中并发症等。结果术后3天及1月裸眼视力或矫正视力≥0.5者在小切口无缝线手术中为90.86%,与对照组相比差异无显著性(P>0.05)。结论小切口无缝线白内障摘除及人工晶体植入术效果好,且对Ⅳ和Ⅴ级硬核白内障较安全,较适合基层医院。     

前房内碎核白内障摘除并人工晶体植入的治疗效果

目的 探讨小切口前房内碎核白内障摘除人工晶体植入术的疗效及并发症.方法 白内障病人190例203眼,120眼采用小切口前房内碎核白内障摘除联合人工晶体植入术(简称小切口组);同期83眼采用超声乳化白内障摘除联合人工晶体植入术(简称phaco组).结果 小切口组术后3 d视力≥0.5者74眼(61.7%),phaco组54眼(65.1%),两组比较差异无显著性(χ2=0.24,P>0.05);小切口组术后1月视力≥0.5者98眼(81.7%),phaco组72眼(86.7%),两组比较差异无显著性(χ2=1.48,P>0.05).两组术后散光均较小,小切口组主要并发症为可逆性角膜混浊、术中虹膜脱出、前房出血、前房炎症反应.结论 小切口前房内碎核白内障摘除联合人工晶体植入术治疗白内障创伤小、术中术后并发症少、效果好、技术难度小,适合基层医院推广应用.     

小切口与常规切口白内障摘除人工晶体植入术的比较分析

目的探讨小切口与常规切口对白内障术后视力和角膜散光的影响.方法对196例208眼应用小切口和常规切口行白内障囊外摘除人工晶体植入术,并以术前后的视力和角膜散光结果做比较分析.结果小切口组比常规切口组视力恢复快、散光小,两组相比有显著性差异(P<0.05).结论小切口白内障摘除人工晶体植入术有实用价值.     

基层医院小切口手法碎核人工晶体植入术临床报告

目的 探讨小切口手法碎核对白内障摘除人工晶体植入术临床效果.方法 作直线状5.5mm巩膜隧道切口,采用晶状体手法碎核技术对88例(101眼)白内障摘除,并植入PMMA人工晶体.结果 88例(101眼)中,95眼成功完成手法碎核,未成功者与劈核对力不均造成晶状体核翻转致后囊膜破裂有关.术后1周裸眼或球镜矫正视力≥0.5者占93%,术后1周平均散光为(1.23±0.75)D.结论 本结果 提示直线状巩膜隧道小切口手法碎核人工晶体植入术手术时间短、切口缝线少、手术设备不昂贵,简便易行,可有效地减少术后角膜散光,早期获得良好的视力,降低手术费用,是基层医院治疗白内障最佳方法 .     

小切口白内障摘除术临床分析

目的 探讨小切口白内障摘除并囊袋内人工晶体植入术的手术技巧及临床效果.方法 对138例(196眼)白内障病人采用6mm反眉形巩膜隧道切口完成白内障摘除并囊袋内人工晶体植入术.结果 术后3天矫正视力＜0.3者4眼(占2.04%),0.5以上者138眼(占70.4%);术后1个月视力0.5以上者146眼(占74.5%),术后无严重并发症,角膜散光轻.结论 该术式具有切口小,愈合快,术后散光轻,视力恢复快及操作简单,无需特殊设备等优点.     

基层医院开展小切口白内障手术的体会

目的 探讨小切口白内障囊外摘出术的疗效.方法 白内障108例(116只眼).球后麻醉.巩膜隧道切口加侧切口,行小切口非超声乳化人工晶体植入术治疗白内障.结果 术后1周视力≥0.5者68%,平均散光1.12±0.26D,术后1个月,视力≥0.5者82%,术后3个月,视力≥0.5者85%,平均散光0.25±0.18D.结论 小切口非超声乳化白内障摘除人工晶体植入术,视力恢复快,效果良好.     

巩膜隧道式切口白内障囊外摘出及人工晶体植入术后角膜散光临床分析

目的 :探讨巩膜隧道式切口对人工晶体植入术后角膜散光及视力的影响。方法 :对 33眼采用巩膜隧道式切口行白内障囊外摘出及人工晶体植入术 ,30眼采用角膜缘阶梯状切口行白内障囊外摘出及人工晶体植入术 ,比较术后角膜散光及视力的变化。结果 :巩膜隧道式切口术后 5 d平均角膜散光 ( 3.1 5± 1 .5 4 ) D,术后 3个月 ( 1 .1 9± 0 .4 8) D;对照组为 ( 5 .1 2± 2 .1 3) D和 ( 3.2 5± 1 .5 8) D,两组比较有显著性差异 ( P<0 .0 5 )。术后 5 d裸眼视力≥ 0 .5者 2 6眼 ,占 78.8% ;对照组 1 0眼 ,占 33.3% ,两组比较有显著性差异 ( P<0 .0 5 )。结论 :巩膜隧道式切口白内障囊外摘出及人工晶体植入术术后视力好、散光小 ,是一种经济、有效的白内障复明手术。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.