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目的 观察舌下含服尘螨滴剂对变应性鼻炎患者行免疫治疗的效果,评价舌下含服尘螨滴剂的有效性及安全性。方法 54例变应性鼻炎患者舌下含服尘螨滴剂,统计治疗前后患者症状评分的变化及不良反应的发生。结果患者治疗前后的症状评分差异有统计学意义(P<0.01),无不良反应发生。结论 舌下含服尘螨滴剂对变应性鼻炎患者有明显的治疗作用,且安全方便。 相似文献
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Bernhard Olzowy Gregor von Gleichenstein Martin Canis Nikolaus Plesnila Klaus Mees 《European archives of oto-rhino-laryngology》2008,265(11):1329-1333
It is controversially discussed inasmuch acute hearing disorders might originate from impaired cochlear circulation. Hypoxia-specific
alterations of inner ear parameters measurable in patients with acute sensorineural hearing loss would therefore be of great
interest. Aim of this study was to characterize hypoxia-related alterations of the 2f
1−f
2 distortion product. Nine guinea pigs were anaesthetized by i.m. administration of Midazolam, Medetomidin and Fentanyl. For
introduction of hypoxia, the spontaneously breathing animals were offered a gas mixture of N2O and O2 containing either 21 or 12–13% O2. Distortion product otoacoustic emissions (DPOAEs) were continuously monitored at f
2 = 16 kHz; f
2/f
1 = 1, 2; DP-definition = 2f
1−f
2; L
1 = 65 dB and L
2 = 55 dB, while inhaled oxygen was switched from 21 to 12–13% and back. Oxygen saturation (SaO2) was continuously monitored. Data from an hypoxic interval were only used for further data processing if DPOAE levels were
stable before and after hypoxia. Six hypoxic intervals in five animals fulfilled the stability criterion. During the hypoxic
interval with the highest measured SaO2 (75%), no alterations of DPOAE levels were observed. During the remaining five hypoxic intervals, when SaO2 ranged between 57 and 70%, DPOAE levels were on average lower with an increased standard deviation compared to mean pre-hypoxic
levels. Mean decrease correlated with the decrease of SaO2 (r = 0.90, P = 0.014). Alterations followed a characteristic time course—when hypoxia was started, DPOAE levels exhibited a short increase
before they decreased and remarkably destabilized. After re-oxygenation DPOAE levels showed a pronounced level decrease, while
SaO2 already had recovered to pre-hypoxic values. After reaching a minimum, DPOAE levels slowly recovered to pre-hypoxic values.
The decrease of DPOAE levels during hypoxia and the post-hypoxic level alterations have similarly been described by other
authors before, while the distinct destabilization and transiently increased DPOAE levels have not been explicitly mentioned.
A micromechanical mechanism that might explain a transient level increase and the post-hypoxic DPOAE level changes is discussed. 相似文献