硬皮病用中西医结合治疗前后甲皱微循环检查分析

硬皮病属于结缔组织疾病 ,是以局限性或弥漫性皮肤及内脏器官结缔组织纤维化或硬化 ,以及小血管痉挛最后发生萎缩为特征的疾病。本病中医学归属“皮痹疽范畴”。活血化瘀是相应的治疗方法。近几年来 ,临床及实验研究证实 ,血瘀患者可有全身或局部微循环障碍。本文以硬皮病患者为对象 ,观察其甲皱循环指标变化结果如下。1　临床资料一般情况　本组 40例硬皮病患者 ,年龄 8～ 5 6岁 ,其中 8～ 18岁 10例 ,19～48岁 2 2例 ,49～ 5 6岁 8例。系统性硬皮病 8例 ,局限性硬皮病 32例 ,男 9例 ,女31例 ,男女之比为 1:3.4。发病年龄 ,局限性硬皮病多…     

寻常型银屑病皮肤及甲襞微循环变化分析

目的：研究寻常型银屑病患者皮损、非皮损、甲襞微循环血流灌注变化情况。方法：利用激光多普勒散斑血流仪检测88例寻常型银屑病患者胫前皮损、非皮损与100名对照胫前正中及两组指尖血流灌注绝对值。结果：患者皮损、非皮损与正常对照皮肤微循环灌注绝对值分别为（319.96±124.65）BPU,（100.87±19.74）BPU和（60.10±13.90） BPU,三组比较差异有统计学意义（均P＜0.05）。甲银屑病指尖微循环灌注值为（406.31±64.01BPU）,高于无甲受累患者的（270.13±69.41） BPU和对照组的（361.15±113.70） BPU,差异有统计学意义（P＜0.05）;皮损微循环灌注绝对值与PASI评分之间呈正相关（r=0.744）。结论：寻常型银屑病患者皮肤及甲襞微循环血流灌注异常,皮损部位灌注值与病情严重程度相关。     

黄芪维胺酯联合应用对银屑病甲襞微循环的影响

我们于１９９５年７月以来应用黄芪，维胺酯治疗银屑病３４例，观察了对甲襞微循环的影响，现报告如下。临床资料观察组３４例，平均年龄３３．４７±３．１８岁，平均病程６２．５０±１４．５６月。对照组３０例，平均年龄３１．７６±４．４６岁，平均病程５７．００±...     

系统性红斑狼疮患者甲皱微循环观察

在系统性红斑狼疮患者的甲皱中可见到非常明显的异常，表现为视野模糊，管袢减少，弯曲，呈螺旋状并分枝，排列紊乱，管经扩张，血流缓慢，袢顶部淤血，袢周有渗出及出血等。     

银屑病患者的甲皱襞微循环观察

本文对65例银屑病患者及45例正常人甲皱襞微循环进行了对照观察,结果前者甲皱襞微循环图象在视野色泽、血管袢数目、形态长度和及宽度等方面较正常人有明显的差别,而进行期患者较静止期患者改变更为明显。     

寻常型银屑病患者丹参治疗前后甲皱微循环变化比较分析

我院于 1995～ 1998年对 5 0例住院寻常型银屑病患者采用丹参液静脉滴注及加服活血化瘀中药。于治疗前后进行甲皱微循环观察 ,现将疗效及观察情况报告如下 :1　临床资料　本组患者 5 0例 ,男性 ,47例 ,女性 3例。年龄 18～ 6 5岁 ,平均 32 6岁。病程最长 2 6年 ,最短 3月 ,平均 4年。其中点滴状 2 6例 ,钱币状 18例 ,地图状 6例 ,进行期 33例 ,静止期 17例 ,反复发作 2 0例 ,初发 15例。全部病例均在入院时行甲皱微循环检测 ,出院前复测。本组病例治疗前半月均未采取任何特殊治疗。临床表现确诊为寻常型银屑病者 (红皮病型、关节病型、脓疱…     

丹参对斑秃患者甲皱微循环的影响

斑秃是皮肤科的常见病之一，其病因和发病机制尚不完全清楚。国内外有研究表明斑秃患者存在不同程度的微循环障碍，临床治疗效果不甚满意，笔者利用丹参治疗69例斑秃病人，观察丹参对甲皱微循环的影响。     

硬皮病和硬肿病甲皱微循环以及内脏受损的分析

本文报导了系统性、局限性硬皮病及硬肿病135例甲皱微循环改变及在诊断分型中的意义.认为微循环障碍在系统性硬皮病发病学中是中心环节.提出各自微循环改变特点似乎不取决于雷诺氏现象有无、硬化总面积大小及手指硬化与否,而与型别有关.详细描述了管袢脱落及其后的演变过程并提出管拌脱落是管袢数目减少的重要机制和形成出血点的机制之一.     

Clinical study of nail changes in leprosy and comparison with nail changes in diabetic patients

Background Nail changes in leprotic patients are not specific to leprosy, and may be observed in other peripheral neuropathies. Diabetes is one of the diseases that present with nail dystrophy secondary to peripheral neuropathy, vasculopathy, trauma and infections. Therefore, nail changes in diabetic neuropathy are expected to be very similar to that of leprosy. Objectives To evaluate the frequency and pattern of nail changes in Egyptian leprotic patients with the different spectrums of the disease, and to compare nail changes in leprosy with those seen in patients with diabetic neuropathy. Methods The study included 115 leprosy patients and 60 patients with diabetic peripheral neuropathy. Nail examination was thoroughly carried out and various nail changes were recorded including the location of the involved nails (fingers, toes). Results Our study detected similar incidence of nail changes in both multibacillary (MB) (86%) and paucibacillary (PB) patients (86%). Flag sign (alternating horizontal bands of whitish and pinkish discoloration of the nail) observed in our study was not reported before. It was more commonly seen in MB patients (21%) than in PB patients (14%). Our results also revealed that the nail changes were more commonly seen in leprosy patients (86%) than in diabetic patients (68%). Conclusion Nail changes in leprosy are multifactorial, and could be related to one or more of the following: neuropathy, endarteritis, trauma, drugs or superimposed infections. Nail changes in leprosy may be used as an additional clue that helps in the diagnosis.     

麻风患者甲皱微循环的研究

应用自制的毛细血管镜,对瘤型、界线类和结核样型麻风共56例,进行甲皱微循环观察.发现麻风患者除临床上有皮肤和神经病变外,约80%的病例有毛细血管拌形态上的异常.血液流态亦有较明显的改变.这些变化主要见于瘤型麻风,界线类和结核样型麻风依次减轻.而瘤型麻风晚期又比早期为重.经分析.作者认为甲皱微循环的异常主要取决于麻风的病型和病期.而与爪手畸形的关系不大.     

Early stage onychomadesis presenting as painful swellings of proximal nail folds

Two Korean men complained of painful erythematous swellings of the proximal nail folds. When we removed the overlying nail plates, we observed new ones growing under the old ones. These painful swellings disappeared after the affected nails were extracted. We found typical onychomadesis in another finger during the follow-up, suggesting that the initial condition marked the onset of onychomadesis. Because both patients had plaster casts removed recently and histories of trauma, it was hypothesized that trauma might be responsible for this peculiar condition.     

Congenital hypertrophy of the lateral nail folds of the hallux.

A case of a 7-month-old boy with bilateral symmetrical congenital hypertrophy of the lateral nail folds of the hallux is described. The body showed no other skin symptoms. The types of ingrowing nails in infancy are discussed. A partial remission of the disease after 1 year was observed.     

手足口病甲损害临床分析

分析门诊收治的480例手足口病的患儿,记录全身和指（趾）皮损分布情况,所有患儿随诊半年。480例患儿中共有58例（12.1%）出现了甲损害,共累及445个指（趾）,其中手指261个,足趾184个。445个指（趾）甲损害表现为甲脱落397个（89.2%),米斯线25个（5.6%）,甲横沟23个(5.2%)。     

Clofazimine induced nail changes

Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis. These nail changes gradually disappeared when the dose of clofazimine was reduced.