子宫动脉栓塞与子宫肌瘤剔除术治疗子宫肌瘤疗效对比分析

目的探讨子宫肌瘤子宫动脉栓塞治疗与子宫肌瘤剔除术治疗疗效.方法回顾分析40例(A组)经子宫动脉栓塞治疗、42例(B组)经腹腔镜子宫肌瘤剔除术、36例(C组)经阴式子宫肌瘤剔除术及30例(D组)经腹式子宫肌瘤剔除术治疗子宫肌瘤病例临床资料及随访情况,分析疗效.结果4组病例均保留子宫,临床症状均明显改善,且未出现明显并发症.术后随访3～24 个月(平均18个月),术后6个月,A组子宫及肌瘤体积缩小平均62%,6例肌瘤消失;B、C、D组子宫体积缩小平均84%.术后18个月,A组子宫及肌瘤体积缩小平均86%,子宫体积恢复正常大小23例,14例肌瘤消失,B、C、D组子宫体积恢复正常大小分别为30例、29例、23例,肌瘤复发分别为3例、2例、2例.结论子宫动脉栓塞治疗与子宫肌瘤剔除术治疗子宫肌瘤均有良好疗效,子宫肌瘤剔除术治疗子宫肌瘤后子宫体积恢复正常大小及肌瘤消失率较子宫动脉栓塞治疗法高,但近期复发率高于子宫动脉栓塞治疗法.     

双侧子宫动脉栓塞治疗妇产科疾病的疗效观察

目的分析双侧子宫动脉栓塞治疗育龄期子宫肌瘤的疗效。方法选取我院2014年5月~2015年5月收治的育龄期子宫肌瘤患者45例,选择明胶海绵颗粒、平阳霉素乳剂进行治疗。手术后3个月、6个月和12个月进行随访,观察患者疗效、并发症。结果经治疗,所有患者临床症状得以缓解,月经恢复正常42例,手术后对患者进行复查,术后3个月时肌瘤缩小率为36.5%,术后6个月时肌瘤缩小率为56.8%,术后12个月时肌瘤缩小率为76.3%。结论针对子宫肌瘤患者,给予双侧子宫动脉栓塞治疗,可减小肌瘤体积,有效改善临床症状,明显提升疗效。     

子宫动脉栓塞治疗子宫肌瘤的疗效和并发症分析

目的　探讨选择性子宫动脉栓塞治疗子宫肌瘤的临床疗效和并发症的发生情况。方法　 2 0 0 0年 10月～ 2 0 0 2年 5月选择 4 0例子宫肌瘤患者用PVA颗粒做栓塞剂行子宫动脉栓塞 ,栓塞后定期评价临床疗效和并发症 ,彩超监测子宫和最大肌瘤体积。根据SCVIR制订的并发症分级系统 ,评价并发症的严重性。结果　4 0例患者行子宫动脉栓塞 ,平均随访 18 9个月 ,97%临床症状改善。子宫和最大肌瘤体积平均缩小 4 3 8%和6 3 5 %。栓塞前子宫和最大肌瘤体积的中位数为 2 4 3 4cm3和 14 8cm3,栓塞后 6个月中位数为 10 7 1cm3和4 1 1cm3,(P <0 0 0 1)。 88 5 %的并发症为A、B级 ,1例 (2 5 % )D级并发症为阴道排瘤继发感染再入院治疗。7例 (17 5 % )较严重的栓塞后综合征。 1例 (2 5 % ) 2年后复发。 4例 (10 0 % )卵巢功能衰竭 ,发生在栓塞后2～ 18个月。 2 0例 (5 0 0 % )患者阴道排液。 92 5 %患者对治疗的结局表示满意。结论　子宫动脉栓塞治疗子宫肌瘤能有效的改善症状 ,缩小瘤体 ,失败率低 ,严重并发症少。术前严格选择适应症 ,术后预防感染是降低并发症的关键。     

经导管子宫动脉栓塞术治疗子宫肌瘤的临床观察

目的 探讨经导管子宫动脉栓塞（TUAE）治疗子宫肌瘤的疗效及安全性。方法 对38例子宫肌瘤患者经导管子宫动脉注射碘油－平阳霉素乳剂行TUAE治疗,其中5例于栓塞后1－3周行全子宫切除或肌瘤剔除术,标本送病理检查;对33例随访6－12个月者,观察肌瘤与子宫体积变化及卵巢内分泌功能改变。结果 行TUAE后,患者总的症状改善率为90．6％（29／32）,其中月经完全恢复正常为90．3％（28／31）,下腹部、腰腿胀痛消失为83．3％（25／30）,尿频、尿急等压迫症状消失为45．5％（5／11）。栓塞6个月后,肌瘤与子宫体积平均缩小为59．1％和49．3％,栓塞12个月后平均缩小为61．8％和49．9％。卵巢内分泌功能栓塞前后无显著变化。手术标本病理学检查,碘油仅分布于肌瘤组织,栓塞2周后肌瘤组织出现点状坏死,3周后出现大量片状坏死,而正常子宫肌组织未见异常。结论 行TAUE治疗子宫肌瘤,近期疗效明显,对卵巢内分泌功能及正常子宫肌组织无明显影响。     

子宫动脉栓塞术治疗子宫肌瘤42例临床分析

目的 探讨子宫动脉栓塞术（UAE）治疗子宫肌瘤的疗效。方法 选择42例子宫肌瘤患者,以Seldinger技术完成单侧股动脉插管,根据数字减影血管造影（DSA）检查结果,选用管径为4－5F（1F=0.33mm)的脾管、肝管或cobra导管,或选用3F微导管,插管至双侧子宫动脉并经DSA检查证实后,以携带有抗生素的明胶海绵颗粒栓塞该处血管。结果 DSA检查发现,子宫肌瘤血液供应丰富。UAE治疗6－12个月后,子宫肌瘤患者的临床症状明显缓解,月经量减少26．3％－75．2％;UAE治疗后第12个月、第18个月肌瘤体积分别缩小77．7％、83．0％,子宫体积分别缩小54．9％、62．7％。术后有不同程度的下腹痛、低热,持续1－3周,经对症处理后症状逐渐消失。结论 UAE可有效地缩小肌瘤及子宫的体积,并明显改善子宫肌瘤患者的临床症状。     

子宫动脉栓塞术治疗子宫肌瘤的疗效分析

目的:观察子宫动脉栓塞术(UAE)治疗子宫肌瘤的临床疗效。方法:对60例经临床、超声或MRI诊断为子宫肌瘤的患者进行UAE,采用Seldinger技术。结果:术后所有患者临床症状均有明显改善或消失,月经恢复正常,子宫肌瘤均有不同程度的缩小,无严重并发症出现。结论:子宫动脉栓塞治疗子宫肌瘤具有创伤小、愈合快、可保留子宫、缓解症状显著等特点。     

子宫动脉栓塞术治疗子宫肌瘤(附10例报告)

目的 评价子宫动脉栓塞(UAE)治疗子宫平滑肌瘤的疗效。方法 10例患者主要症状包括月经过多,尿频,盆腔疼痛等。子宫平滑肌瘤的诊断经影像学检查和专科医师检查确定,并排除与症状有关的其他妇科疾病。10例患者双侧子宫动脉栓塞9例,单侧者1例。栓塞剂为PVA微球。 结果 栓塞技术成功率为95％,无严重并发症。随访9例,术后症状均明显改善,术后4个月肿瘤体积平均缩小47％,1例术后肿瘤体积无明显变化,与仅行单侧栓塞有关。结论 UAE是一治疗子宫肌瘤的安全疗法,近期疗效好,远期疗效尚待观察。     

聚乙烯乙醇与真丝线段栓塞子宫动脉治疗子宫肌瘤的临床研究

目的 :评价聚乙烯乙醇 (polyvinylalcohol,PVA)与真丝线段栓塞子宫动脉治疗子宫肌瘤的临床疗效及副反应。方法 :50例子宫肌瘤患者随机分为PVA与真丝线段栓塞两组。采用Seldinger方法经皮股动脉穿刺 ,血管造影确认子宫动脉及肌瘤所在部位后 ,超选择性子宫动脉插管并经导管注入PVA颗粒或真丝线段 ,阻断子宫肌瘤血供。治疗前后均用B超测量子宫肌瘤体积。结果 :两组患者月经量恢复正常和明显减少 ,总有效率为 97.73% ;术后 3个月和6个月肌瘤体积较治疗前缩小 4 5.81%和 51.80 % ,差异有高度显著性 (P <0 .0 1)。两组月经量和子宫肌瘤体积变化差异无显著性。两组的主要副反应是术后缺血性盆腔疼痛。术后发热症状 ,真丝线段组明显高于PVA组 (P <0 .0 5) ,无严重并发症发生。结论 :使用PVA或真丝线段超选择性子宫动脉栓塞治疗子宫肌瘤创伤小 ,近期临床疗效好 ,远期疗效有待进一步观察     

子宫动脉栓塞术治疗粘膜下子宫肌瘤62例临床分析

目的:探讨子宫动脉栓塞术(UAE)治疗粘膜下子宫肌瘤的临床疗效。方法:回顾性分析UAE治疗粘膜下子宫肌瘤患者6 2例的疗效及临床转归。结果:6 2例患者随访1～6 3月,全部患者经量及经期恢复正常,粘膜下子宫肌瘤经阴道自然脱落排出4 0例,钳夹排出16例,进行性缩小消失4例,体积缩小>80 % 2例。术中、术后有不同程度的下腹痛(6 2例)、低热(12例)、阴道分泌物增多(6 2例,经对症处理后症状逐渐消失。结论:UAE可有效治疗粘膜下子宫肌瘤,并显著改善粘膜下子宫肌瘤的临床症状。     

子宫动脉栓塞术治疗子宫腺肌病15例

目的:探讨子宫动脉栓塞术治疗子宫腺肌病的临床疗效。方法:选择15例子宫腺肌病患者进行介入性子宫动脉栓塞。术后随访疗效。结果:子宫动脉栓塞术治疗后3个月,7例患者痛经完全缓解,5例明显缓解,1例部分缓解。所有病例治后经量均减少,平均减少50%。经期平均由7.7天缩短至6.5天。子宫体积缩小33.14%。所有病例子宫结合层变薄,子宫内膜弧形压迹消失。结论:子宫动脉栓塞术治疗子宫腺肌病的近期疗效显著。副反应小,易被患者所接受,但远期疗效有待进一步观察。     

Uterine artery embolization in postabortion hemorrhage

OBJECTIVE: To summarize the efficacy of postabortion uterine artery embolization in cases of refractory hemorrhage. METHODS: Forty-two women were identified who had postabortion uterine artery embolization at San Francisco General Hospital between January 2000 and August 2007. Seven underwent embolization for hemorrhage caused by abnormal placentation. RESULTS: Embolization was successful in 90% (38 of 42) of cases. All failures (n=4) were in patients who had confirmed abnormal placentation. However, three of seven women (43%) with probable accreta diagnosed by ultrasonography were treated successfully with uterine artery embolization. Two patients experienced complications of uterine artery embolization. These complications-one contrast reaction and one femoral artery embolus-were treated without further sequelae. CONCLUSION: Uterine artery embolization is an alternative to hysterectomy in patients with postabortion hemorrhage refractory to conservative measures, especially when hemorrhage is caused by uterine atony or cervical laceration.     

Factors affecting early surgical intervention after uterine artery embolization

Uterine artery embolization (UAE) is an effective technique for the management of uterine myoma. However, complications of this procedure can be serious, including uterine infection and bowel necrosis in conjunction with necrosis of subserous or pedunculated myomas. Treatment failure is more likely to occur in the presence of submucosal myoma associated with a uterine infection or a large myoma of more than 8 cm. Accordingly, patients whose primary symptoms include submucosal myoma and menorrhagia are best treated with a hysteroscopic myomectomy or hysterectomy. The role of the gynecologist is crucial for most effective management and safe use of uterine artery embolization. TARGET AUDIENCE: Obstetricians & Gynecologists, Family Physicians LEARNING OBJECTIVES: After completion of this article, the reader will be able to list the complications of uterine artery embolization for fibroids, to describe postembolization syndrome, and identify the myomas that are more likely to fail uterine artery embolization.     

Selective uterine artery embolization in the management of uterine myomas

OBJECTIVE: To evaluate the effectiveness of uterine artery embolization in women with uterine myomas in terms of the clinical results for the relief of related symptoms. DESIGN: A pilot study on 26 women affected by uterine single myoma. SETTING: Tertiary level care in an university hospital. PATIENT(S): Twenty-six patients, aged 32 to 54 years, suffering of menorrhagia, pelvic pain, and abdominal mass for single myoma, intramural localization. INTERVENTION(S): Selective uterine artery embolization performed under peridural anesthesia. MAIN OUTCOME MEASURE(S): We measured the x-ray dose to which patients were exposed. Color power Doppler ultrasound examinations were performed during the follow-up evaluations at 1 to 6 months and 1 year after the procedure. RESULT(S): Uterine artery embolization was successfully performed in 100% of cases. The mean fluoroscopy time was of 20 minutes during the procedure. The mean dose of x-ray absorbed by the ovary was estimated at 18.7 cGy and the mean dose of x-ray absorbed by the skin was 126.7 cGy. A reduction of myoma volume of 55% was found at 6 months' ultrasound examination and 75% at the 1-year examination. CONCLUSION(S): Patients are well satisfied and have short recovery times with this procedure. Uterine artery embolization may be a valid alternative to traditional surgery.     

Uterine restoration after repeated expulsion of myomas after uterine artery embolization

A patient passed infarcted myomas 21, 27, and 35 days after uterine artery embolization. Transvaginal ultrasound examination did not reveal a myoma and her menstruation became normal with minimal bleeding. Uterine artery embolization and expulsion of myomas vaginally can eliminate intramural and submucous myomas.     

Uterine artery embolization for symptomatic uterine myomas

OBJECTIVE: To evaluate the role of uterine artery embolization as treatment for symptomatic uterine myomas. DESIGN: Medline literature review, cross-reference of published data, and review of selected meeting abstracts. RESULT(S): Results from clinical series have shown a consistent short-term reduction in uterine size, subjective improvement in uterine bleeding, and reduced pain following treatment. Posttreatment hospitalization and recovery tend to be shorter after uterine artery embolization compared with hysterectomy. Randomized controlled trials have not been conducted, and long-term efficacy has not been studied. A limited number of deliveries have been reported following uterine artery embolization for uterine myomas. CONCLUSION(S): Uterine artery embolization is a unique new treatment for symptomatic uterine myomas. Even without controlled studies, demand for this procedure has increased rapidly. Uterine artery embolization may be considered an alternative to hysterectomy, or perhaps myomectomy, in well-selected cases. At the present time, however, uterine artery embolization should not be routinely recommended for women who desire future fertility.     

子宫动脉栓塞治疗子宫肌瘤的疗效观察

目的:探讨子宫动脉栓塞术治疗症状性子宫肌瘤的中远期疗效。方法:对2000年1月至2004年12月上海市第八人民医院和上海市闸北区中心医院用子宫动脉栓塞术治疗的306例子宫肌瘤患者进行随访。结果:随访306例648个月,治愈42例(13.73%),显效207例(67.65%),有效40例(13.07%),无效17例(5.56%)。其中36例大于50岁的患者术后23个月出现闭经。224例患者术后性激素(E2、FSH、LH)值与治疗前无统计学差异(P>0.05)。结论:子宫动脉栓塞术是治疗症状性子宫肌瘤的又一种有效方法,中远期疗效确切,而且不影响其他治疗,术后可明显提高患者的生活质量。     

A uterine cavity-myoma communication after uterine artery embolization: two case reports

OBJECTIVE: To report two cases of uterine cavity-myoma fistula as a medical complication after uterine artery embolization. DESIGN: Case report. SETTING: Women's Medical Center/Viscomi Institute, Sao Paulo, Brazil. PATIENT(S): Two patients presenting with symptomatic myomatous uterus: a 40-year-old woman with increased abdominal volume and hypermenorrhea, and a 42-year-old woman with pelvic pain and infertility. INTERVENTION(S): Uterine artery embolization, hysteroscopic follow-up, and laparoscopic myomectomy. MAIN OUTCOME MEASURE(S): Hysteroscopic follow-up after uterine artery embolization. RESULT(S): The patients underwent uterine artery embolization. In the months that followed, a subsequent surgical hysteroscopic follow-up was performed to eliminate the necrotic material of the degenerated myomas. The two patients presented the same outcome 1 year after the uterine artery embolization had been performed: a communication between the uterine cavity and a degenerated myoma. Laparoscopic correction of the uterine wall defect was performed afterward. CONCLUSION(S): Because embolization is a growing option for the treatment of leiomyoma, it is important that potential complications be reported, especially if the patients want to become pregnant. The natural history of the fistula and its consequences are unknown, and physicians should be aware of these complications. Hysteroscopic follow-up was important in the diagnosis of the two cases.     

子宫动脉栓塞治疗妇产科良性疾病引起泌尿系统损伤的临床研究

目的探讨子宫动脉栓塞（uterine arterial embolization,UAE）治疗妇产科良性疾病引起泌尿系统损伤的原因、治疗及预防。方法对我院妇产科医学微创介入治疗中心收治的960例因妇产科良性疾病行UAE治疗患者的临床资料,进行回顾性分析,960例中,子宫肌瘤690例、子宫腺肌病244例、异位妊娠10例及产后出血16例。同时对损伤发生的血管解剖学、血管影像学及微导管的使用等问题进行分析总结。结果960例中,发生不同程度的泌尿系统损伤共5例,总发生率为0．5％（5／960）。其中中度损伤1例（0．1％）,为一侧输尿管节段性部分狭窄致肾积水;轻度损伤4例（0．4％）,为膀胱炎1例、膀胱黏膜部分坏死1例、一过性一侧肾轻度积水2例。5例中,子宫肌瘤4例、子宫腺肌病1例;5例均行双侧子宫动脉UAE术,术中均未使用微导管。行UAE引起泌尿系统损伤的原因,均为在栓塞动脉的过程中,栓塞剂进入子宫动脉中下段发出的输尿管支及膀胱支。结论对妇产科良性疾病进行UAE治疗,有发生泌尿系统损伤的危险;术中准确分辨血管及其分支、交通支,采用子宫动脉上行支进行栓塞,可以避免泌尿系统损伤的发生。     

Hysteroscopy after uterine fibroid embolization in women of fertile age

AIM: Uterine artery embolization for fibroids is a controversial issue for women with incomplete reproductive plans. Ovarian failure and uterine infection are the most dreaded complications of this procedure. The purpose of the present study was to assess the types and the frequency of intrauterine abnormalities and the histological features of the endometrium after embolization. METHODS: Uterine artery embolization was performed on 51 women (average age 34.5 years) with intramural fibroid/s larger than 4 cm. Hysteroscopy and endometrial biopsy was performed from 3 to 9 months later in the luteal phase of the cycle. RESULTS: Despite all women having no major symptoms prior to hysteroscopy, only 19 (37%) had completely normal hysteroscopic findings. There was intrauterine protrusion of fibroid/s in 19 cases (37%), yellowish coloration of the endometrium in 14 (28%), intrauterine or cervical adhesions in seven (14%), and communication between the myoma and the uterine cavity in five cases (10%). A normal, functional endometrium was histologically verified in 44 women of 49 (90%) who could be evaluated. Regressive changes (necrosis or hyalinization) of leiomyoma or of indefinite origin were found in 17 patients and embolization particles in five, including one patient with microspheres inside the endometrial vessel. No case of Asherman syndrome or endometrial atrophy was observed. CONCLUSION: The frequency of abnormal hysteroscopic findings after embolization is surprisingly high. The clinical significance, reversibility, and impact on fertility of abnormal hysteroscopic findings after embolization remain unclear. Regardless, hysteroscopy should be strongly recommended to all patients after uterine fibroid embolization, prior to conception.