对国有医药企业改制的建言

当前，国有医药企业改革主要面临6个方面的问题：一是产权多元化，二是职工身份置换，三是企业内部结构调整，四是资产重组，五是债务重组，六是企业的信誉问题。从改革的实际情况分析，最核心的问题是如何实现产权主体多元化和国企职工身份置换。医药行业发展的主要趋势是重组促进公司治理结构改善，完善市场制度和监管环境。     

国有医药企业人力资源管理存在的问题及对策

目的 :为我国新世纪的医药企业人力资源管理发展战略提供建设性建议。方法 :参考有关文献 ,调查、分析国有医药企业人力资源管理现状。结果与结论 :国有医药企业只有不断提高人力资源管理水平 ,实践创新的管理方式 ,才能取得企业和社会的长期效益。     

国有医药企业工资状况分析

分析国有医药企业工资管理的现状和问题,在此基础上提出改进性策略,针对目前国有医药企业薪酬管理在制度体系上存在的问题,强调引进现代的管理思想和方法,从公平性、激励性等方面进行调整的必要性.     

国有医药企业面对"入世"的创新战略研究

随着中国加入ＷＴＯ步伐的临近，一个迫切的问题摆在了国有医药企业面前：加入ＷＴＯ就意味着我国融入了世界经济一体化之中，将与国际跨国公司展开竞争，如何迎接这一挑战呢？一、跨国公司在全球一体化中的作用世界经济发展到今天，国际贸易已经摆脱了在完全竞争假设条件下的比较利益和资源禀赋理论的影响，跨国公司的发展垄断了世界市场，国际贸易取决于跨国公司为获取最大限度的利润而确定的全球化市场战略。跨国公司对世界市场的垄断采取的一种策略是，进行一体化生产，为充分利用比较优势开发全球资源，利用发展中国家的廉价劳动力，跨…     

关注国有医药企业高层经理人员的报酬问题

企业高层经理人员是企业的主要决策者,对企业经营的好坏负有特殊的责任.如何调动经理人员的积极性,报酬是至关重要的因素之一.     

国家药品监督管理局关于认真贯彻党的十五届四中全会精神促进国有医药企业改革与发展的意见

党的十五届四中全会通过的《中共中央关于国有企业改革和发展若干重大问题的决定》（以下简称《决定》）,以邓小平理论和党的十五大精神为指导,全面总结了二十多年来国有企业改革和发展的基本经验,深刻阐述了国有企业改革和发展的重要性、紧迫性和艰巨性,明确了国有企业改革和发展的主要目标和指导方针,提出了搞好国有企业改革和发展的一系列重大政策举措,是动员全党、全社会推进国有企业改革和发展的纲领性文件,对搞好国有企业改革和发展具有重大的实现意义和深远的历史意义。为贯彻落实党的十五届四中全会精神,现就药品监督管理部…     

医药企业建立Internet网站之初探

本文根据我国医药信息化规划要求，为医药企业在Ｉｎｔｅｒｎｅｔ上建立网站提出一个经济、合理、实施性良好的方案。     

我国医药企业技术创新存在的问题及对策

科学技术的发展使医药技术的生命周期大大缩短。医药企业在医药产品的生产经营过程中,如果不能领先一步,就可能会使医药企业在市场竞争中处于被动地位。医药企业只有通过技术创新,使医药产品不断更新换代,才能满足医药市场的需求,也才能在竞争中取生存与发展。由此可见,技术创新是医药企业创新的核心。     

借鉴国外经验完善国有医药企业经营者年薪制

目的促进完善国有医药企业经营者年薪制。方法借鉴国外实施企业经营者年薪制的经验，结合我国国有医药企业实施经营者年薪制的现状，提出完善建议。结果与结论完善国有医药企业经营者年薪制需要明确其实施对象，确定合理年薪标准，建立客观、科学的薪酬评价体系，将长期激励与短期激励结合起来，物质激励与精神激励结合起来。     

An Overview Of New And Novel Pharmacotherapies For Use In Traumatic Brain Injury

1. Although a number of interventional pharmacotherapies have undergone clinical trial in traumatic brain injury (TBI), none has shown considerable promise. The present short review will examine some of the more novel compounds that have been proposed recently as potential therapeutic agents for use in TBI. 2. Previous experimental studies have demonstrated that brain intracellular free magnesium significantly declines following TBI and that the administration of magnesium salts attenuates the post-traumatic neurological deficits. More recent studies have established that magnesium salts administered after trauma enter the brain intracellular space and reduce the size of the lesion volume. Such protection could be afforded through attenuation of both necrotic and apoptotic cell death. Magnesium salts are currently on clinical trial in TBI. 3. Cyclosporine A is known to inhibit opening of the mitochondrial permeability transition pore. Administration of cyclosporine A after TBI has been shown to attenuate axonal injury and decrease the resultant lesion volume. Therefore, inhibitors of mitochondrial transition pore opening and resultant attenuation of apoptosis show some promise as neuroprotective agents. 4. Recent evidence has shown that substance P antagonists may decrease lesion volume and improve neurological outcome after ischaemia. Similar findings have recently been reported in TBI. The fact that substance P antagonists are known to reduce neurogenic inflammation, oedema formation and are clinically being trialed as both antidepressants and antinociceptive agents suggests that these agents warrant further investigation as therapeutic agents following TBI. 5. There are numerous contradictions in the literature regarding the potential neuroprotective effects of the hormones oestrogen and progesterone. Recent studies suggest that both hormones are protective in TBI and further studies are required to ascertain the mechanisms associated with this protection and any potential for clinical application.     

Overview Of Stability Study Designs

Stability requirements for the worldwide registration of pharmaceutical products have changed dramatically in the past few years. A series of guidelines on the design, conduct, and data analysis of stability studies of pharmaceuticals have been published by the International Conference on Harmonization (ICH); however, the statistical discussion on study design is limited. In this paper, stability designs including full, bracketing, and matrixing designs will be exemplified. The statistical aspects of these stability designs will be discussed in relation to the recent ICH guidelines. The statistical and regulatory considerations on the selection of stability design will also be presented. The stability study should be well designed so the shelf life of the drug product can be estimated with a high degree of accuracy and precision. Several commonly used criteria for design comparison will be presented. Finally, a case study is presented to illustrate the potential problems of an overreduced design from the statistical and regulatory perspectives.

     

利用合理用药监测系统构建网络信息环境下的合理用药平台

本文通过介绍我院利用合理用药监测系统提供药学服务的实际工作体会,对医院如何在网络信息环境下应用计算机信息技术构建合理用药平台,开展药学信息服务、促进合理用药,作一些初步探讨。     

Stable Atropine Loaded Film As a Potential Ocular Delivery System For Treatment Of Myopia

Pharmaceutical Research - The objective of the present study was to prepare stable and high bioavailability ocular atropine loaded films (ATR-films) as potential ocular drug delivery systems for...     

医疗费用纠纷的原因分析及对策

当前医疗收费问题引发的医患纠纷日益增多，预防和有效地处理医疗费用纠纷，成为医院管理工作中不容忽视的一个重要问题。作者通过对妇科近4年中59起患者及家属查询医疗费用所反映的问题进行调查，分析了导致纠纷的原因：患者对医疗费用不理解：对现时的医疗保险制度不适应；日清单欠完整；医务人员态度不佳；不合理收费；计费操作失误。提出了管理对策：强化服务意识，提高服务质量；完善日清单；加强收费管理，减少电脑医嘱出错；建立监督机制，积极处理医疗费用纠纷，为病人提供高效、低耗的优质服务。     

Ancova Approach For Shelf Life Analysis Of Stability Study Of Multiple Factor Designs

For a traditional multiple batch stability design with no other factor, the conventional analysis is analysis of covariance (ANCOVA) modeling using F-tests based on type I sum of squares to determine whether the batches may be pooled for a common estimate of the linear regression line(s). In the last decade, many multiple factor designs were proposed in stability studies. With the objective of model selection, the generalization of the conventional ANCOVA model using type I sum of squares to designs with multiple factors requires a prespecified hierarchical pooling test ordering to determine whether any of the factors may be eliminated. Different shelf life estimates may be derived using different hierarchical pooling test orderings. On the other hand, setting the hierarchical ordering can be subjective and controversial. The stepwise modeling based on F-tests using type III sum of squares for model determination and factor elimination is proposed to eliminate such difficulties.

     

镁离子对脑保护作用的前瞻性临床实验研究

目的探讨分析镁制剂在重型颅脑损伤临床治疗中的实用价值.方法对76例重型颅脑损伤患者按随机方法分成实验组和对照组,对照组按常规方法治疗,实验组在常规治疗的基础上加用大剂量硫酸镁.治疗后从颅内压、NSE、CT、GCS评分和G0S评级等几个方面进行统计分析.结果实验组与对照组比较,颅内压和NSE水平明显下降,CT显示脑水肿程度减轻,而GCS和G0S则有明显提高,经统计学检验有显著性差异(P＜0.01和P＜0.05).结论镁制剂对重型颅脑损伤治疗确有实用价值,且经济、安全,值得推广.     

关于高等医科院校学风建设的思考

本文着重分析了医科院校学风建设的现状,并提出了改进的建议和具体措施：教、学、管三管齐下;加强学生社区文化建设。     

神经阻滞麻醉在胸腔镜术后镇痛中的应用现状

胸腔镜手术虽有切口小、疼痛轻、术后恢复快等优点,但仍有术后疼痛特别是肋间神经痛,若不能及时镇痛,可形成慢性疼痛,严重影响患者生活质量。目前神经阻滞越来越多被用于胸腔镜术后镇痛,其方法较多,本文就肋间神经阻滞、胸段硬膜外阻滞和胸椎旁神经阻滞在胸腔镜术后镇痛中的应用进行综述。