腹腔镜胰体尾切除术6例报告

目的探讨腹腔镜胰体尾切除术（laparoscopic distal pancreatectomy,LDP）治疗胰体尾肿瘤的临床价值。方法2008年6月～2013年6月,行LDP6例,年龄33～76岁,平均45．8岁。其中胰腺体尾部实性占位4例,囊实性占位2例。结果手术均在全腹腔镜下一次成功。手术时间125～365min,平均250min。出血量50～350ml,平均168ml。术后病理报告胰腺浆液性囊腺瘤1例,黏液性囊腺瘤1例,囊腺癌4例。1例术后胰漏,经保持引流通畅、抑制胰酶分泌等保守治疗痊愈。术后住院5～19d,平均7．8d。结论LDP创伤小,术后恢复快,是治疗胰体尾肿瘤安全、可行的方法,但术者需有丰富的腹腔镜手术和胰腺外科手术经验。     

保留脾脏的胰体尾切除术

1913年Ｍａｙｏ在胰体尾部肿瘤手术中首创远端胰腺切除术 ,同时合并脾脏切除 ,并作为标准术式流传至今。但随着大量基础研究的深入和临床实践经验的积累 ,“脾脏不再是可有可无的器官 ,而是具有重要保护功能的免疫器官”这一概念已被广大临床医师所接受 ,无辜性脾切除应尽量避免。越来越多的手术病例证实保留脾脏的胰体尾切除术在技术上是完全可行的。一、保留脾脏的胰体尾切除术的解剖学基础胰体尾 -脾区解剖结构毗邻紧密 ,脾动静脉为胰体尾和脾脏解剖联系的纽带。由于脾动静脉与胰体尾、脾门与胰尾的紧密联系 ,胰体尾与脾脏常视为一个解剖…     

胰体尾肿瘤原位手术切除体会

目的 探讨胰体尾部肿瘤原位切除的可行性及优越性.方法 自2003年2月～2006年11月对6例胰体尾部肿瘤进行了胰体尾部肿瘤的原位手术切除术.其中胰体尾部原发癌4例,转移癌2例.手术方法是在分离胰体尾部肿瘤和脾脏前,先在肿瘤的右侧离断胰腺、结扎切断脾动静脉及其与胃肠的交通支,再由右向左切除胰体尾部肿瘤、脾脏、Gerota's筋膜和受浸润的脏器.本组单纯的胰体尾部和脾脏切除2例,联合胃、横结肠系膜、左肾上腺等脏器切除4例.结果 本组6例均获得成功.手术时间120～240 min,平均180 min.无手术死亡,无严重的手术并发症,无术中大出血(平均出血量320 ml).结论 胰体尾部肿瘤原位切除术,在技术上是可行的.与传统的胰体尾肿瘤切除术相比,操作方便、安全,根治彻底,出血少.尤其适用于对累及邻近脏器的胰体尾肿瘤进行根治性联合脏器切除.     

腹腔镜下保留脾脏的胰体尾切除术4例

目的：探讨在腹腔镜下,对胰体尾部肿瘤患者进行保留脾脏的胰体尾切除术的可行性与安全性。方法：我院2008年2月—2010年4月对4例胰体尾良性病变施行腹腔镜下保留脾脏的胰体尾切除术。结果：4例手术均顺利完成,平均手术时间为235（115～305）min,术中平均出血量为200（100～450）mL,术后平均住院时间为12.8（10～21）d,术后有1例患者产生胰瘘,延迟拔管,治愈后出院。术后病理诊断为胰体尾浆液性囊腺瘤2例,黏液性囊腺瘤1例,胰岛细胞瘤1例。结论：对胰体尾部的良性病变行腹腔镜下保留脾脏的胰体尾切除术是微创并安全的,具有恢复快、并发症少等优点。     

腹腔镜胰体尾切除术与开腹胰体尾切除术临床疗效对比分析

目的 对比腹腔镜胰体尾切除术（laparoscopic distal pancreatectomy,LDP）与开腹胰体尾切除术（open distal pancreatectomy,ODP）的疗效,探讨腹腔镜胰体尾切除术的优缺点.方法 回顾性分析2011年1月至2014年4月施行的17例腹腔镜胰体尾切除术患者与20例开腹胰体尾切除术患者的临床资料,对比两组患者的手术及术后情况.结果 腹腔镜组术中出血量少于开腹组,差异具有统计学意义（P＜ 0.05）;腹腔镜组术后肛门排气时间、禁食时间、住院时间较开腹组短,差异具有统计学意义（P＜0.05）;腹腔镜组手术时间长于开腹组,差异具有统计学意义（P＜0.05）;两组保脾率、术后并发症发生率差异无统计学意义（P＞ 0.05）,开腹组5例胰漏,1例切口感染、1例肺部感染、1例腹腔感染,腹腔镜组4例胰漏.结论 腹腔镜胰体尾切除术是安全可靠的,短期预后优于开腹组,值得临床进一步推广.     

腹腔镜胰体尾切除术28例分析

目的探讨腹腔镜胰体尾切除术(laparoscopic distal pancreatectomy,LDP)的可行性及临床价值。方法回顾分析2014年5月至2016年9月28例施行LDP病人的临床资料。28例病人中,男性9例,女性19例,年龄17~69岁。结果 16例LDP联合脾脏切除,7例行Kimura法保脾LDP,5例行Warshaw法保脾LDP。术后病理:胰腺浆液性囊腺瘤2例,黏液性囊腺瘤9例,实性假乳头状瘤6例,导管内乳头状黏液性肿瘤(intraductal papillary mucinous neoplasm,IPMN)3例,胰岛素瘤3例,胰腺假性囊肿1例,慢性胰腺炎1例,胰腺癌3例。全组病人平均手术时间为(203±54)min;平均术中出血量为(115±138)ml。平均术后下床活动时间为(1.4±0.6)d;平均术后首次进食时间为(2.0±0.8)d;平均术后住院时间为(10±5)d。术后发生胰瘘9例(32.1%),其中A级胰瘘6例,未予特殊处理,自然痊愈;B级胰瘘3例,均经冲洗引流后痊愈。术后发生脾部分梗死2例,未予特殊处理,经3个月随访观察自然痊愈。结论 LDP安全可行,具有微创优势,值得推广应用。     

腹腔镜胰体尾切除术的临床应用（附4例报告）

目的 探讨腹腔镜胰体尾切除术(laparoscopic distal pancreatectomy，LDP)治疗胰体尾肿瘤的临床价值。方法 2002年6月～2004年12月行LDP的患者4例(保留脾脏1例)，平均年龄39．8岁(31～48岁)。其中胰腺体尾部实性占位2例，囊实性占位2例。结果 手术均在全腹腔镜下一次成功，平均手术时间305min(95～465min)，平均出血140ml(50～300ml)。1例发生胰漏，经保守治疗痊愈。术后平均住院9．8d(5～18d)。结论 LDP创伤小、术后恢复快，是治疗胰体尾肿瘤安全、可行的方法。     

全腹腔镜胰体尾切除术研究进展

[摘 要] 腹腔镜技术在胰腺外科的应用相对比较缓慢,且更具挑战性。随着腔镜手术器械的发展及术者手术经验的积累,腹腔镜胰体尾切除术在越来越多的肝胆胰诊疗中心相继开展,腹腔镜保留脾脏的胰体尾切除术被大多胰腺外科医生青睐。本文就腹腔镜保留脾脏的胰体尾部切除术的适应证和禁忌证、Warshaw与Kimura两种术式的优劣及手术并发症的防治等研究进展进行综述。     

腹腔镜胰体尾切除术18例

探讨腹腔镜胰体尾切除术的临床疗效及应用价值。回顾分析18例行LDP手术治疗的患者资料。其中男性7例,女性11例,平均年龄(54.1±13.6)岁。18例患者中,除1例中转开腹,其余均顺利完成LDP,其中13例行LDP联合脾脏切除术,5例采用Kimura法行腹腔镜保留脾脏胰体尾切除术。平均手术时间(270.8±98.9)min;平均术中出血量(258.3±269.1)m L;平均术后进食时间(4.0±1.5)d;平均术后排气时间(3.8±1.4)d;术后平均住院时间(15.1±6.6)d。术后11例患者发生胰瘘,均经保守治疗后痊愈。病理结果:黏液性囊性瘤3例(其中2例伴上皮轻-中度异形增生),浆液性囊性瘤4例,胰体尾假性囊肿伴脾动脉瘤1例,腹腔间质肿瘤(高危型)1例,胰腺神经内分泌肿瘤伴囊性变1例,胰体尾实性假乳头状瘤1例,胰腺微囊性囊腺瘤1例,胰体尾腺癌6例。对于胰体尾占位性病变,LDP治疗安全可行,值得推广开展。     

腹腔镜胰体尾切除术49例报告

目的:探讨腹腔镜胰体尾切除术的可行性及临床应用价值。方法:回顾分析2014年6月至2018年6月行腹腔镜胰体尾切除术49例患者的临床资料,其中男13例,女36例;25～72岁,平均(44.7±15.3)岁。结果:37例行腹腔镜胰体尾联合脾脏切除术,肿瘤直径(44.6±20.3)mm;12例采用Kimura法行腹腔镜保留脾脏胰体尾切除术(LSPDP),肿瘤直径平均(29.5±20.2)mm。21例良性、交界性及低度恶性肿瘤行腹腔镜胰体尾联合脾脏切除术,肿瘤直径平均(47.5±21.2)mm,其中8例肿瘤直径≤40 mm,13例>40 mm;10例良性、交界性及低度恶性肿瘤患者行LSPDP,肿瘤直径平均(45.8±16.3)mm,其中8例肿瘤直径≤40 mm,2例>40 mm。两组患者肿瘤直径差异无统计学意义,良性、交界性及低度恶性胰腺肿瘤患者,肿瘤直径>40 mm时,多与脾脏动静脉关系密切,不宜实施Kimura法保留脾血管LSPDP(χ~2=4.763,P=0.029)。49例腹腔镜胰体尾切除术患者中46例发生生化漏,3例B级胰瘘,无C级胰瘘发生,腹腔镜胰体尾切除术不增加手术并发症的发生风险。37例腹腔镜胰体尾联合脾脏切除术患者术后肛门排气时间平均(3.4±0.8)d,术后平均住院(11.6±2.8)d;12例LSPDP患者术后肛门排气时间平均(3.3±0.8)d,术后平均住院(10.2±2.0)d。两组患者术后肛门排气时间、住院时间差异无统计学意义(t=0.51,P=0.61;t=1.68,P=0.10)。结论:对于胰体尾良性、交界性或低度恶性肿瘤,选择腹腔镜胰体尾切除术是安全、可靠的,患者创伤小,术后康复快。     

改良腹腔镜胰体尾切除术12例报告

目的:探讨腹腔镜胰体尾切除术(laparoscopic distal pancreatectomy,LDP)中应用Endo-GIA一并闭合、离断胰腺及脾血管的安全性、可行性。方法:2010年3月至2011年11月共为12例患者行LDP,术中应用Endo-GIA一并闭合、离断胰腺及脾血管。术前8例诊断囊腺瘤,不排除恶变可能;4例胰尾部局限性癌变。结果:11例成功完成腹腔镜手术,1例中转开腹。手术时间115～210 min,平均153 min;术中出血量50～400 ml,平均187 ml;术后住院6～20天,平均9.6天。术后均未发生脾血管出血,2例发生胰漏,经充分引流后痊愈。结论:应用Endo-GIA一并闭合、离断胰腺及脾血管安全、可靠,LDP是治疗胰体尾低度恶性肿瘤及局限性癌变的可行术式。     

Clinical outcome of laparoscopic distal pancreatectomy

Background  Few studies have compared laparoscopic distal pancreatectomy (Lap-DP) and open distal pancreatectomy (open-DP). The aim of this study was to evaluate the clinical outcome of Lap-DP and compare it to that of open-DP. Methods  A total of 37 patients who underwent distal pancreatectomy (Lap-DP, 21 patients; open-DP, 16 patients) between January 2000 and March 2007 were enrolled in this study. Prior to January 2004, open-DP was the standard procedure for patients with a lesion in the distal pancreas without invasive ductal cancer; thereafter, Lap-DP was also an approved procedure. All 16 open-DP procedures were performed prior to January 2004. Results  The operating times for the Lap-DP and open-DP patients were 308.4 ± 124.6 and 281.5 ± 83.3 min, respectively, and these were not significantly different (P = 0.4635). Blood loss for the Lap-DP group (249.0 ± 239.8 ml) was significantly smaller than that for the open-DP group (714.1 ± 650.4 ml) (P = 0.0055), and none of the patients in the Lap-DP group received transfusions. The frequency of complications for the Lap-DP and open-DP groups was 0 and 18.8%, respectively, which is not significantly different (P = 0.0784). The average hospital stay for the Lap-DP group was significantly shorter than that for the open-DP group (10.0 ± 2.6 vs. 25.8 ± 8.8 days; P < 0.0001). Conclusion  In pancreatic diseases, other than invasive ductal cancer, arising in the distal pancreas, Lap-DP might be a more feasible and safer than open-DP.     

Clinical outcomes compared between laparoscopic and open distal pancreatectomy

Background Laparoscopic surgery for pancreatic disease has gained increasing popularity. A laparoscopic distal pancreatectomy is technically simple and has been adopted as the preferred method in many centers. However, there is limited information on the outcomes of the laparoscopic surgery compared with open surgery. Therefore, this study aimed to investigate the clinical outcomes of laparoscopic distal pancreatectomy and to evaluate its efficacy compared with open distal pancreatectomy. Methods From February 1995 to March 2006, 31 patients underwent laparoscopic distal pancreatectomy, and 167 patients underwent open distal pancreatectomy at Seoul National University Hospital and Bundang Seoul National University Hospital. A case–control design was used with 2:1 matching to compare laparoscopic surgery with open surgery. Among 167 patients who underwent open distal pancreatectomy, 62 patients whose age, gender, and pathology were similar to those of patients who underwent laparoscopic surgery were selected for this study. The operation time, intraoperative transfusion requirements, duration of postoperative hospitalization, complications, mortality, recurrence, and hospital charges were analyzed. Results There were no significant differences in operation time, rate of intraoperative transfusions, complications, recurrence, or mortality between the two groups. Laparoscopic distal pancreatectomy was associated with a statistically significant shorter hospital stay (11.5 days vs 13.5 days; p = 0.049), but with more expensive hospital charges than open distal pancreatectomy (p < 0.01). Conclusion Laparoscopic distal pancreatectomy is a clinically safe and effective procedure for benign and borderline pancreatic tumors.     

Initial experience with hand-assisted laparoscopic distal pancreatectomy

Background Hand-assisted laparoscopic distal pancreatectomy, with or without splenectomy, is gradually gaining acceptance, although its ultimate benefit is yet to be confirmed. This study aimed to report our initial experience with hand-assisted laparoscopic distal pancreatectomy. Methods A retrospective review of a prospectively collected database including 17 patients during the period 2002–2004 was conducted. The median age was 60 years (range, 29–85 years), and the female-to-male ratio was 13:4. The preoperative diagnoses included benign and malignant conditions. Besides two to three ports, a hand port was placed in the upper midline to aid in dissection. The pancreas was divided with a stapler in all the patients, and drains were placed in 10 patients (70%). Results One patient was found to be unresectable because of celiac artery involvement, and 2 of the remaining 16 patients underwent conversion to an open procedure. The median operating time was 196 min (range, 128–235 min). The mean tumor size was 4 cm (range, 2–7 cm), and the estimated blood loss was 125 ml (range, 50–1,250 ml). The median time to resumption of a regular diet was 3.5 days (range, 2–9 days), and the time to conversion to oral pain medications was 3 days (range, 2–9 days). The length of hospital stay was 5.5 days (range, 4–18 days), with a majority of the patients (11 patients, 78%) staying less than 7 days. There were no mortalities. The overall postoperative morbidity rate was 25%, and the morbidities consisted of pancreatic leak/fistula (2 patients, 14%) and fever (1 patient). The margins were negative in 10 (76%) of the relevant 13 patients. At a median follow-up period of 3.8 months (range, 5–14 months), 11 (84%) of 13 patients had no evidence of disease recurrence. Conclusions The minimally invasive approach to pancreatic disease is safe and technically feasible. Further large studies with longer follow-up periods are necessary to determine the role of laparoscopic surgery in the management of pancreatic disease.     

Safety and efficacy of laparoscopic distal pancreatectomy for the treatment of pancreatic disease

Background/purpose There are a few reports of laparoscopic distal pancreatectomy in the literature. We describe our experience with laparoscopic distal pancreatectomy and evaluate the safety and efficacy of the procedure in light of other reported findings.Methods A retrospective study was performed of all patients who underwent laparoscopic distal pancreatectomy between April 1996 and December 2002 at Oita University Faculty of Medicine.Results Laparoscopic distal pancreatectomy was attempted in seven patients (three men and four women) with a mean age of 65 years. One patient was converted to open surgery, and two patients required a hand-assistance procedure. There were no complications in any patients. Median operation time for all seven patients was 300min, and median blood loss was 330ml. Median postoperative hospital stay was 12 days (range, 7 to 21 days).Conclusions Our limited results, together with reported outcomes, suggest that laparoscopic distal pancreatectomy is safe and effective for selected patients. The potential advantages of this procedure include reduced morbidity and reduced hospital stay.     

The lasso technique for laparoscopic distal pancreatectomy

Background Laparoscopic distal pancreatectomy with or without splenectomy is becoming an acceptable alternative to open resection for selected pancreatic lesions. One of the difficulties with this approach is manipulating the pancreas with laparoscopic instruments to avoid unnecessary injury to the pancreas, and yet obtain adequate margins. The described technique accomplishes these goals. Methods Data from all patients who underwent laparoscopic distal pancreatectomy (always with splenectomy) were reviewed for age, gender, laparoscopic completion of the resection, postoperative complications, length of hosptial stay, and pathology. The essential component of the technique is use of a Penrose drain around the neck or proximal body of the pancreas as a “lasso” for atraumatic manipulation. This technique is described in detail. Results A total of 11 patients have undergone laparoscopic distal pancreatectomy with splenectomy using the lasso technique. Two patients (18%) underwent conversion to an open laparotomy: the because of bleeding from the pancreatic parenchyma and the other due to local invasion of a pancreatic adenocarcinoma. The average operating time was 162 ± 39 min, and the median length of hosptial stay was 3 days. There were two (18%) pancreatic leaks, both of which were treated conservatively with resolution. Pathologic examination, found six cystic neoplasms, two neuroendocrine tumors, two masses of chronic pancreatitis, and one adenocarcinoma. Conclusions The lasso technique simplifies intraoperative manipulation of the pancreas during laparoscopic distal pancreatectomy. It allows for safe manipulation of the pancreas and may expand the indications for the laparoscopic approach to pancreatic resection. This article contains a supplementary video. Presented in part at the 2004 Scientific Session of the Society of American Gastrointestinal Endoscopic Surgeons, (SAGES), Denver, Colorado, 31 March to 2 April, 2004     

腹腔镜保留脾脏和脾血管的胰体尾切除术

With the maturation of laparoscopic surgical technology and the development of surgical instruments,the scope of application for laparoscopie surgery has expanded constantly in recent years.It is now p...     

直线切割闭合器在胰体尾切除术中的作用

目的研究胰体尾切除术中传统手工缝合和直线切割闭合器处理胰腺残端对术后并发症的影响。方法回顾性分析2003年1月至2006年12月间109例接受胰体尾切除术患者的临床资料。结果109例患者中53例患者在开腹手术中手工缝合封闭胰腺残端;56例患者使用直线切割闭合器切断并封闭胰腺组织,其中31例在开腹手术中使用直线切割闭合器,25例在腹腔镜手术中使用腹腔镜直线切割闭合器。直线切割闭合器组患者的术后胰瘘以及腹腔感染发生率分别为21．4％和8．9％,低于手工缝合组的41．5％和28．3％（P=0．024和P=0．009）,但在手术持续时间、术后输血、术后再出血以及住院费用方面均无显著性差异。结论使用切割闭合器可以降低术后腹腔感染和胰瘘发生率。     

Case-control comparison of laparoscopic versus open distal pancreatectomy

Laparoscopic distal pancreatectomy is becoming an increasingly used modality in the surgical treatment of pancreatic disease. The assumption is that this will lead to shorter hospitalization and faster recovery. However, actual comparative data between open and laparoscopic distal pancreatectomy is lacking. The purpose of this study is to compare these surgical procedures. All patients who underwent either laparoscopic or open distal pancreatectomy/splenectomy were reviewed. Fifteen patients underwent laparoscopic resection, whereas 41 underwent an open resection. The 15 laparoscopic patients were matched to 15 open patients for age, gender, and pancreatic pathology. Data gathered included length of stay, pancreatic leak, postoperative complications, and return to normal activity. Of the 15 laparoscopic patients, three were converted to open operations. Laparoscopic patients had a median length of stay of 5 days (range, 3–9) compared with 8 days (range, 6–23) for the open patients (P = 0.02). The pancreatic leak rate was 13% in each group. Overall postoperative complication rate was 20% in the laparoscopic group compared with 27% in the open group. Laparoscopic patients reported a return to normal activity in 3 weeks (range, 2–7) compared with 6 weeks (range, 4–10) for open patients (P =0.03). Laparoscopic distal pancreatectomy/splenectomy does lead to shorter hospital stay and faster return to normal activity. Pancreatic leak rate and overall complication rate appear similar. Presented at the 2005 American Hepato-Pancreato-Biliary Association Congress, Hollywood, Florida, April 14–17, 2005 (poster presentation).