苯系物对作业女工月经及妊娠结局的影响

苯系物对作业女工月经及妊娠结局的影响江苏省通州市卫生防疫站滕冲苯系物是一种性能良好的有机溶剂，在工业生产中已被广泛应用。苯系物对作业女工月经及妊娠结局的影响已引起关注。为此，我们对长期接触苯系物的女工月经和妊娠情况进行了调查，从而为女工卫生保健及制订...     

苯系物作业女工的月经状况及妊娠结局

苯系物作业女工的月经状况及妊娠结局本溪市职业病防治所王廷海，谢文黎苯系物对生殖系统的影响，国内外已有不少报道。本文通过时１５６名苯系物作业女工及７３名相应不接触苯系物及其它毒物女工（对照组）的调查，探讨了苯系物作业对女工月经及妊娠结局的影响。结果显示...     

接触低浓度苯对女工月经及妊娠的影响

接触低浓度苯对女工月经及妊娠的影响姜其德姜健倪永春杨英张希林接触低浓度苯及同系物甲苯、二甲苯能否对女工月经及妊娠产生影响尚未见明确的阐述。我们对接触不同浓度苯及同系物的女工进行了调查研究,结果如下。１对象与方法１．１对象选择接触苯及同系物超过最高容许...     

接触邻苯二甲酸酯对女工生殖系统的影响

目的探讨邻苯二甲酸酯(PAEs)暴露对女工生殖系统的影响及其影响因素分析。方法采用整群抽样法选取某地区在PAEs职业环境(塑料作业)中作业的女工300名作为接触组,另选非PAEs职业环境作业女工300名作为对照组。调查一般资料、生殖健康状况。结果接触组月经异常率、妊娠并发症发生率、不良妊娠结局、不良新生儿结局、生殖系统疾病发生率明显高于对照组(P0.05),且logistic回归分析显示,作业接触PAEs与月经异常密切相关(P0.05)。结论女工PAEs职业暴露可导致月经异常,与部分妊娠并发症、不良妊娠结局及生殖内分泌疾病有关。     

有机磷农药对作业女工生殖机能影响的调查

为探讨有机磷农药对作业女工生殖机能的影响,采用职业流行病学方法对２６４例有机磷农药作业女工及１１６例非有机磷农药作业女工进行了生殖机能（月经异常、不良妊娠结局）调查。结果显示,接触组女工月经先兆症状如乳房胀痛、嗜睡、失眠、乏力、烦躁不安的发生率显著高于对照组,接触组女工月经异常率显著高于对照组,其中以月经量少最为显著,但与工龄无线性相关,并且接触组的不良妊娠结局显著高于对照组。提示有机磷农药对作业     

混苯作业对女工脂质过氧化的影响

本文对混苯作业女工体内过氧化脂质(LPO)、超氧化物歧化酶(SOD)和谷胱甘过氧化物酶(GSHpx)进行了测定分析。其结果:(1)接触组女工LPO,SOD 的含量均明显高于对照组。说明混苯作业女工体内脂质过氧化反应增强。(2)白细胞(WBC)计数<4×10~9/L 组的脂质过氧化反应明显增强于WBC>4×10~9/L 组。并且,WBC 与LPO、SOD 和GSH-px 均呈负相关,提示随着脂质过氧化反应增强,WBC 计数减少,因此认为,脂质过氧化反应增强是苯导致WBC 计数减少的重要因素,LPO 和SOD 作为判断苯、甲苯对人体危害的早期监测指标具有一定的意义。     

超氧化物歧化酶,过氧化脂质和T淋巴细胞对判断苯职业危害的价值

本文对接触苯、甲苯作业女工血中超氧化物歧化酶(SOD)、过氧化脂质(LPO)和T淋巴细胞(TLC)数量进行了测定分析。结果:接触组女工血中SOD和LPO的含量明显高于对照组,TLC数量卸明显低于对照组。在WBC均值仍处正常范围时,SOD、LPO和TLC数量就已发生了明显的改变。这提示苯、甲苯对体内脂质过氧化和TLC的影响要早于WBC。因此,认为用SOD、LPO扣TLC计数三项指标作为判断苯对机体危害的早期监测指标具有一定的意义。     

职业接触苯及其同系物对女工月经的影响

苯及其同系物甲苯、二甲苯对女工生殖功能的影响已引起人们的关注。为了进一步探讨苯作业对女工月经机能的影响,现对成都市郊县部分厂矿408名苯作业女工的月经情况资料进行调查分析,其结果如下。对象和方法 1.对象 1.1 接触组:选成都市郊县接触苯及其同系物甲苯、二甲苯的机械行业喷漆工、刷漆工、配漆工及制鞋行业制帮、胶帮、配底女工共408人。平均工龄8.9年(1～25年)。平均年龄30.9岁(20～48岁) 1.2 对照组:选不接触苯及其同系物和其它职     

接触不同浓度苯对女工月经及妊娠影响的调查研究

接触苯及同系物甲苯、二甲苯对女工月经功能及妊娠结局的影响国内外有一些报道。但对接触低浓度苯能否对女工产生有关的影响尚未见明确的阐述。为了研究探讨有关接触水平与反应的关系,我们对     

苯及其同系物对职业女工生殖机能的影响

目的研究苯及其同系物对职业接触者月经及生殖机能的影响.方法对化工行业268名苯作业女工月经及生殖机能进行回顾性调查,探讨职业接触对女工的影响.结果月经周期延长、经量增多、经期腰痛明显高于对照组(X2=9.90,P＜0.005),且妊娠后自然流产、早产、胎儿失天缺陷等均高于对照组.结论苯职业接触可引起女工月经及生殖机能障碍.     

医疗服务操作分类与编码的设计与应用简

医疗服务操作分类与编码是医学信息标准化的重要组成部分,是临床数据提取、分析和应用的基础。世界卫生组织及世界多国一直致力于开发、更新和维护此分类与编码。我国此前一直沿袭美国准备在2014年停止使用的ICD-9-CM-3（卷3）,中国需要结合国际主流设计思路,根据国情开发出适宜的多轴、一体化的医疗服务操作分类与编码体系。     

Adenocarcinoma of the stomach and esophagus and drinking water and dietary sources of nitrate and nitrite

We conducted a population-based case-control study of adenocarcinoma of the stomach and esophagus in Nebraska, U.S.A. Nitrate concentrations in public drinking water supplies were linked to residential water source histories. Among those using private wells at the time of the interview, we measured nitrate levels in water samples from wells. Dietary nitrate and nitrite were estimated from a food-frequency questionnaire. Among those who primarily used public water supplies (79 distal stomach, 84 esophagus, 321 controls), average nitrate levels were not associated with risk (highest versus lowest quartile: stomach OR=1.2, 95% CI [0.5-2.7]; esophagus OR=1.3, 95% CI [0.6-3.1]). We observed the highest ORs for distal stomach cancer among those with higher water nitrate ingestion and higher intake of processed meat compared with low intakes of both; however, the test for positive interaction was not significant (p=0.213). We did not observe this pattern for esophagus cancer. Increasing intake of nitrate and nitrite from animal sources was associated with elevated ORs for stomach cancer and with a significant positive trend in risk of esophagus cancer (P-trend=0.325 and 0.015, respectively). Larger studies with higher exposures to drinking water sources of nitrate are warranted to further evaluate N-nitroso compound precursors as risk factors for these cancers.     

Drinking water and dietary sources of nitrate and nitrite and risk of glioma

OBJECTIVE: Dietary nitrite has been associated with increased glioma risk; however, drinking water nitrate has not been extensively evaluated. METHODS: We conducted a population-based case-control study of adult glioma in Nebraska. Water utility nitrate measurements were linked to residential water source histories. We computed average nitrate exposure over a 20-year period. A food frequency questionnaire was used to assess dietary nitrate and nitrite. RESULTS: Increasing quartiles of the average nitrate level in drinking water were not significantly associated with risk (adjusted odd ratios: 1.4, 1.2, 1.3). Risk was similar among those with both higher and lower intakes of vitamin C, an inhibitor of N-nitroso compound formation. Dietary nitrite intake was not associated with risk. CONCLUSIONS: Our study does not support a role for drinking water and dietary sources of nitrate and nitrite in risk of adult glioma.     

黄体功能不健的调控机理

主要就引起卵巢黄体功能不健的因素 ,分别从激素调节、细胞因子 (VEGF、TNF α、BFGF、IFN γ、IGF)、C myc、Fas、SGP 2基因调控以及细胞连接、细胞粘附分子、NO等对卵巢功能的调节及对黄体细胞的凋亡影响进行阐述 ,认为卵泡发育不良、颗粒细胞、黄体细胞的凋亡与黄体功能不足有密切的关系。且多种细胞因子、基因表达产物参与此过程的调控。深入的研究这一调控机制 ,对于进一步了解卵巢卵泡生长发育、卵泡闭锁及黄体细胞凋亡的内在机制有重要意义     

浸润性和转移性膀胱癌的诊断和评价

一、膀胱癌的分级与分期 1.膀胱癌的组织学类型:尿路被覆的上皮统称为尿路上皮(urothelium).传统上将尿路上皮称为移行上皮(transitional epithelium).目前在文献和习惯上这两个名词常常被交替使用.膀胱癌的组织学类型包括尿路上皮癌、鳞状细胞癌和腺癌,其次还有较少见的转移性癌、小细胞癌和癌肉瘤等.     

Absorption and excretion of cholecalciferol and of 25-hydroxycholecalciferol and metabolites in birds

The absorption and excretion in vivo of cholecalciferol or 25-hydroxycholecalciferol (25-HCC) were determined in chicks (Gallus domesticus) and turkeys (Meleagris gallopavo). The overall net cholecalciferol or 25-HCC absorption in chicks and cholecalciferol in turkey poults was 66.5 +/- 3.3, 74.9 +/- 3.7 and 83.6 +/- 7.1% of the intake, respectively. The absorption of cholecalciferol or 25-HCC in chicks and turkeys occurred at the upper part of the intestine. 25-HCC, esters and non-polar metabolites of cholecalciferol or 25-HCC, and their polar metabolites, were secreted in the duodenum of chicks and turkeys but were partially reabsorbed at the upper part of the jejunum.     

结核病的"复燃"及其防治对策

1 .国内外结核病疫情现状结核病在 2 0世纪 6 0年代曾被宣称“作为一个公共卫生问题将于 2 0 0 0年被消灭”[1] 。此后 ,由于各国对结核病控制工作的忽视、人口流动的增加、耐药结核病的增多以及结核病与艾滋病合并感染等原因 ,结核病在全球死灰复燃 ,严重危害了人类的健康 ,不仅成为严重的公共卫生问题 ,也是影响各国发展的重大的社会和经济问题。 1993年世界卫生组织(WHO)宣布“结核病全球紧急状态” ,全球每年约有2 0 0万人死于结核病 ,2 0 2 0年死亡总数估计将达到35 0 0万[2～ 3] 。我国是世界上 2 2个结核病高负担国家之一 ,结核病…