Relationship between birth weight and total cholesterol concentration in adulthood: A meta-analysis

Background

Although a substantial number of studies have investigated the relationship between birth weight and serum cholesterol later in life, the results vary extensively. The aim of this study was to explore the relationship between birth weight and total cholesterol concentration in adulthood.

脑卒中患者血清总胆固醇与总胆汁酸水平测定

目的:检测脑卒中患者血清总胆同醇(TC)与总胆汁酸(TBA)水平.方法:用酶法检测43例脑卒中患者(脑卒中组)、39例脑卒中合并高血压组(并发高血压组)及45例健康人(对照组)血清中TC及TBA水平.结果:脑卒中组血清TBA、TC分别为(5.09±1.51)μmoL/L和(5.26±1.14)mmol/L,并发高血压组血清TBA、TC分别为(7.58 ±1.87)μmo[/L和(7.24 ±1.39)mmol/L,均高于对照组[血清TBA、TC分别为(2.29±1.45)μmol/L和(4.26 ±1.08)mmol/L](P<0.05).结论:脑卒中患者血清TBA水平升高,提示TBA在诊断脑卒中上有一定的价值.     

Effect of dietary cholesterol on plasma cholesterol concentration in subjects following reduced fat, high fibre diet

One hundred and sixty eight subjects participated in a randomised crossover study to determine whether halving or doubling the present dietary cholesterol intake from eggs had any influence on blood cholesterol concentration in people following current dietary recommendations. During the first eight weeks all participants were advised to follow a reduced fat diet (26% total energy for hyperlipidaemic patients, 35% total energy for normolipidaemic volunteers) with an increased ratio of polyunsaturated to saturated fatty acids. This background diet was continued throughout the 16 week experimental period, during which participants ate either two or seven eggs a week. A small but significant increase in total cholesterol was seen after four weeks in the group eating seven eggs a week compared with that in the group eating two eggs a week, but this was no longer apparent after eight weeks. Previous studies suggesting that dietary cholesterol has a greater effect on the serum cholesterol concentration either have been carried out against a background of a higher fat intake or have contrasted extreme cholesterol intakes. A further reduction in dietary cholesterol seems to be unnecessary in those people who have already reduced their intake of saturated fat and increased the ratio of polyunsaturated to saturated fatty acids and fibre rich carbohydrate.     

血总胆固醇与红细胞变形性测定及其关系探讨

目的 :探讨血浆总胆固醇浓度与红细胞变形性两者的关系。方法 :胆固醇测定用终点酶法全自动生化分析 ,红细胞变形性用激光衍射法。结果 :Y=3 78.0 6-1 9.3 0 X,r=-0 .5940 ,P<0 .0 5。血浆总胆固醇浓度与红细胞变形性呈真性负相关。结论 :说明胆固醇不但是形成动脉粥样硬化的重要因素 ,同时也是影响红细胞变形性的重要因素 ,而红细胞变形性减小可导致局部血流不畅甚至血栓等心脑血管疾病的发生。     

The effect of sulphonylurea therapy on serum total cholesterol and high density lipoprotein cholesterol.

A study was conducted on 50 cases comprising 25 patients of non-insulin dependent diabetes mellitus and 25 age and sex matched normal individuals. The diabetic state of the patients was controlled by glibenclamide, a sulphonylurea. The levels of serum total cholesterol and high density lipoprotein cholesterol were measured at the start and 15 and 30 days after glibenclamide therapy. There was a significant (p < 0.001) decrease in the levels of serum total cholesterol from initial 222.96 +/- 31.04 mg% to 218 +/- 28.99 mg% after 15 days and to 211.8 +/- 28.42 mg% after 30 days of therapy. In no case there was increase in serum total cholesterol level. There was a significant (p < 0.001) increase in the levels of serum high density lipoprotein cholesterol from initial 20.96 +/- 4.59 mg% to 21.8 +/- 4.78 mg% after 15 days to 23.72 +/- 5.07 mg% after 30 days of glibenclamide therapy and no case showed a fall in serum high density lipoprotein cholesterol level. This favourable alteration in serum total cholesterol and high density lipoprotein cholesterol was observed in patients of non-insulin dependent diabetes mellitus having ischaemic heart disease as well.     

婴儿胆固醇和糖化血红蛋白浓度的影响因素分析

目的 探究婴儿胆固醇和糖化血红蛋白浓度和母体因素及婴儿饮食因素的相关性。 方法 选取2016年1月—2019年1月于舟山市妇幼保健院门诊就诊的患儿524例。根据标准,最终纳入143例,其中出生6个月的婴儿84例,出生12个月的婴儿59例。对患儿与母亲进行饮食调查,并采取静脉血检测总胆固醇(TC)、糖化血红蛋白(HbA1c)水平,利用单因素和多因素回归对婴儿TC和HbA1c的影响因素进行分析。 结果 婴儿TC水平为2.3~6.6 mmol/L,平均浓度为(4.1±0.8)mmol/L,经过Spearman相关性分析显示,母亲TC水平和婴儿膳食蛋白质占比与婴儿TC呈正相关性(r分别为0.391和0.279,均P<0.05),多因素回归校正后母亲TC水平和婴儿膳食蛋白质占比与婴儿TC具有独立相关性(均P<0.05)。婴儿HbA1c水平为3.7~6.0 mmol/L,平均浓度为(4.9±0.4)mmol/L,经过单因素和多因素回归分析,暂未发现母体因素和膳食与婴儿HbA1c存在相关性(P>0.05)。 结论 母亲TC水平和婴儿膳食蛋白质占比会影响婴儿TC水平,因此需要控制母亲TC水平及婴儿膳食蛋白质合理占比,降低婴儿高TC血症发生情况。      

总胆固醇、甘油三酯和低密度脂蛋白胆固醇试剂对脂肪酶测定结果的影响

目的 探讨在自动生化分析仪上影响血清脂肪酶(LPS)测定结果的干扰项目及解决办法.方法 在混合血清中加入干扰试剂测定LPS,评价干扰情况;先测定干扰项目再测定LPS,评价交叉污染对LPS测定结果的影响程度;应用试剂针的特殊清洗程序后再测定LPS,观察交叉污染是否能消除.结果 总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)试剂对LPS测定结果均有显著的正干扰(P＜0.01),先测干扰项目后再测LPS的分析顺序对LPS的测定结果有明显影响,这种影响可持续到第2至第4管;应用特殊清洗程序也不能完全消除交叉污染对LPS测定的干扰.结论 在作LPS测定时应避开TC、TG和LDL-C等项目的 干扰.     

Plasma cholesterol concentration and extra lipid band in monoclonal gammopathies.

Plasma lipids and lipoproteins were studied in 21 patients with benign monoclonal gammopathy, 21 patients with multiple myeloma and seven patients with Waldenström''s macroglobulinaemia. Results were compared with those of a control group, age and sex matched. Low plasma cholesterol levels in all three patient groups were associated with low HDL-cholesterol concentrations. Apo A-I, but not apo B, was significantly reduced. Sixty per cent of the patients exhibited an extra lipid band on plasma lipoprotein electrophoresis, which could be an immunoglobulin-lipid complex. In these patients plasma and LDL-cholesterol levels were significantly lower than in those patients in whom this band was absent. No correlation was found between the severity of the disease and plasma lipid pattern.     

Distribution of blood total cholesterol in a national sample of Malaysian adults

We describe the distribution of capillary blood total cholesterol (BC) by age, sex and ethnicity in Malaysian adults. A national sample of 20,041 individuals aged 30 or older had usable data. They were selected by stratified 2-stage cluster sampling. BC was measured using reflectance photometer. Percentile tables and curves by age, sex and ethnicity are presented. The BC distribution was right skewed and showed the expected increase with age. There were ethnic differences. Malay had the highest BC concentration, followed by Indian, Chinese and other indigenous ethnic group. However, for all ethnic groups, BC concentrations were low in comparison those prevailing in Western populations.     

血清胆碱脂酶、总胆固醇和总胆汁酸评价肝硬化患者肝功能

肝硬化患者常因肝细胞破坏减少而出现细胞内丙氨酸氨基转移酶(ALT)释放入血减少，因此ALT检测结果多为正常。血清总胆红素(TB)升高及血清白蛋白(ALB)降低多出现在肝硬化晚期。笔者收集我院2000—2003年收治的肝硬化患者资料，观察血清胆碱脂酶(ChE)、总胆固醇(TC)和总胆汁酸(TBA)水平与肝功能变化的关系。     

大孔树脂富集续断中总皂苷的测定

续断又名龙豆、属折、和尚头、川续断等。为川续断科植物川续断DipsacusasperWall.exHenry的干燥根。广泛分布于四川、湖北、云南、西藏等地。资源极为丰富。在《神农本草经》中被列为上品,味苦、辛、微涩,性微温。功能为补肝肾、养筋骨、通关节、和血脉,安胎止血。生品续筋骨、通血脉力胜,多用于风湿痹痛,跌打损     

轮叶党参降血脂保健饮料中总黄酮的含量测定

[目的]建立降血脂保健饮料中总黄酮的测定方法.[方法]采用分光光度法,以芦丁为对照品,在波长为510 nm处测定总黄酮含量.[结果]芦丁在16.5~82.5μg之间线性关系良好,平均回收率为98.9%,RSD为2.29%.[结论]采用分光光度法测定轮叶党参降血脂保健饮料中总黄酮的含量简便易行,重复性好.     

Plasma cholesterol concentration and mortality. The Whitehall Study.

OBJECTIVE--To examine the relationship between plasma cholesterol concentration and mortality from major causes of death. DESIGN.--Cohort study. SETTING--Civil service offices in London, England. PARTICIPANTS--There were 17,718 male civil servants aged 40 through 64 years at the time of study entry between 1967 and 1969. MAIN OUTCOME MEASURE--Mortality from major cause groups. RESULTS--There were 4022 deaths in the cohort over the 18 years of follow-up. Total mortality increased with cholesterol level, although mortality in the small group with very low cholesterol levels (5% of study population) was nonsignificantly higher (P greater than .5) than that of the remainder of the lowest quintile cholesterol group. Coronary heart disease mortality increased with increasing cholesterol concentration from the lowest levels (P less than .001 for trend). The cancer mortality rate in the group below the fifth centile of the cholesterol distribution was higher than in the remainder of the cohort for lung (P less than .001), pancreas (P = .05), liver (P = .09), and all smoking-related cancers (P = .02). Only for lung cancer was there a consistent inverse trend with cholesterol level (P less than .01). Rates of mortality due to non-neoplastic respiratory disease were inversely related to cholesterol level (P less than .001). Health state at the time of examination and socioeconomic position were related to cholesterol concentration--subjects in lower employment grades, with disease at baseline, with a history of recent unexplained weight loss, or who had been widowed had lower initial cholesterol levels. These associations largely accounted for the relationships between cholesterol level and noncardiovascular mortality. CONCLUSIONS--The inverse associations between plasma cholesterol concentration and mortality from certain causes of death seen in cohort studies could be because the participants with low cholesterol levels possess other characteristics that place them at an elevated risk of death.     

慢性结石性胆囊炎胆汁胆固醇浓度与胆囊收缩素受体的特点及关系

目的 通过检测慢性结石性胆囊炎患者胆囊胆汁胆固醇浓度(biliary cholesterol concentration,BCC)及胆囊黏膜上皮A型胆固醇受体(cholecystokinin-A receptor,CCK-AR)蛋白表达强度,明确BCC与CCK-AR的特点及关系.方法 通过免疫组化的方法检测34例行腹腔镜手术的慢性结石性胆囊炎胆囊黏膜上皮CCK-AR蛋白表达强度,同时用生化方法检测胆囊内胆汁胆固醇浓度,观察结果特点并分析相关性.结果 所有标本胆囊黏膜上皮CCK-AR呈阳性表达,其中13例呈弱阳性表达,9例呈中阳性表达,12例呈强阳性表达.胆囊内胆汁胆固醇浓度在CCK-AR弱阳性组,CCK-AR中阳性组,CCK-AR强阳性组分别为(14.44±5.51) mmol/L,(11.68±3.41) mmol/L和(6.96±1.19) mmol/L,与CCK-AR表达强度呈负相关(r=-0.702,P=0.000).结论 胆汁胆固醇浓度可作为评估胆囊黏膜上皮CCK-AR分子蛋白表达的潜在指标.     

钙摄入对血浆胆固醇浓度的影响及作用机制

国家属常见病和多发病,近年来,这种疾病也成为危害我国人民健康的主要疾病。我国不同地区人群疾病死亡率统计数据表明:心脑血管病死亡率已成为我国居民死亡的首要原因。如1997年沈阳市男性和女性居民心脑血管疾病死亡率顺位均为第1位[1]。北京地区1984~1998年心脑血管病死亡是人群第1位的死亡原因(占总死亡人数的46.0%),而癌症为第2位死因(占总死亡人数的26.5%);该人群冠心病死亡比例15年期间有显著增加的趋势(年均0.52%)[2]。长沙市1991~2000年居民死因顺位前五位分别为脑血管病、心脏病、恶性肿瘤、呼吸系统疾病、损伤和中毒,分别占总死因…     

简单人体测量指数与肥胖相关性的再认识

目的:探讨南京地区人群中体重指数(BM I)、腰臀围比(WHR)、腰围这三项简单人体测量指数在评估肥胖中各自的特点。方法:对3 445例南京地区汉族人检测身高、体重、腰围、臀围,并测定空腹血清各项血脂指标和空腹血糖(FPG)、真胰岛素(TI)和瘦素(Leptin),以S i=1/(FPG×TI)作为胰岛素敏感指数,对人体测量指数和各种代谢指标的相关性分别进行分析。结果:利用目前的腰围切割点(男性为85 cm,女性为80 cm)来判断,男性超重率为24.6%,女性仅13.0%,显示BM I切割点和目前WHR及腰围切割点对人群肥胖状况的特异性和敏感性不在同一水平,而男性WHR为0.85,女性为0.80;男性腰围为80 cm,女性为75 cm,与BM I=24 kg/m2处于同一水平。BM I与糖代谢指标FPG、TI、S i、Leptin的相关性强于WHR和腰围,而WHR和腰围与脂代谢指标TG、LDL、apoB的相关性强于BM I。结论:应适当放宽以WHR和腰围为指标的肥胖诊断标准。WHR和腰围是反映内脏型肥胖的较好指标,而BM I是胰岛素抵抗的敏感因子,都是评估肥胖的良好指标,但侧重不同。