1天1粒,终结骨关节病

权威药科大学研制,美国权威认证——润骨素骨关节病,有"不死的癌症"之恶称。我国患有各种骨关节疾病的人数约为1.5亿左右,每10个50岁以上老人,就有8个正饱受骨关节病之苦。治骨病,欧美风行"氨糖疗法"欧美骨科专家研究发现:氨糖缺失导致的关节滑液缺失、关节软骨磨损是诱发各种骨关节病的罪魁祸首,美国FDA认证药科大学研制     

染发,1年别超过1次

宋大妈今年60岁,是社区老年合唱团的成员。眼看五一劳动节将至,离合唱团外出慰问演出的日子没几天了,宋大妈收拾妥当却没有急着出门去排练,而是站在镜子前左看右看,总觉得哪点不对劲。原来,她是对夹杂在黑发中的丝丝白发产生了不满。趁着训练后的休息时间,宋大妈一个人走进了理发店。看着自己的白发转眼间变成了黑发,听着理发师称赞自己年轻,宋大妈心里甭提多高兴了。可是,第二天一早起来,宋大妈觉得眼睛有点不舒服,脸也有些刺痛,冲到镜子前一看。宋大妈差点晕过去,昨天还好好的眼睛现在居然肿得老高,脸上也是红红的一片。宋大妈直奔旁边的社区医院。医生告诉她,这是染发剂过敏,要用药治疗……     

Effect of β-naphthoflavone on AhR-regulated genes (CYP1A1, 1A2, 1B1, 2S1, Nrf2, and GST) and antioxidant enzymes in various brain regions of pig

The constitutive and inducible expression of aryl hydrocarbon receptor (AhR) and of the AhR-regulated genes coding for CYP1A1, CYP1A2, CYP1B1, CYP2S1, and Nrf2 was investigated by real-time or traditional PCR in cerebral areas (cortex, cerebellum, midbrain, and hippocampus), blood–brain interfaces (meninges and brain microvessels) and liver obtained from control pigs and from pigs treated with β-naphthoflavone (βNF), a potent AhR agonist. The enzymatic activities of ethoxyresorufin-O-deethylase (EROD), and methoxyresorufin-O-deethylase (MEROD), marker for CYP1A1 and CYP1A2, the GST and various antioxidant enzymes (catalase, superoxide dismutase, GSSG-reductase, and GSH-peroxidase) were also determined in the same CNS regions. The AhR, CYP1A1, CYP1A2, CYP1B1, Nrf2 mRNAs were detected, although at different extent, in all the CNS regions, while CYP2S1 mRNA was detected only in midbrain. In the blood–brain interfaces, the constitutive basal expression of AhR and CYP1A1 was comparable to the hepatic one and even higher for CYP1B1 and Nrf2. The treatment with βNF determined the induction of CYP1A1 and 1B1 (but not of AhR, CYP1A2, and Nrf2) mRNA levels in various CNS areas; notably, CYP1A1 mRNA was increased to about 300-fold in the microvessels. The analysis of enzymatic activities revealed that EROD, but not MEROD, was induced in microsomes but not in mitochondria of all the CNS areas. However, the mitochondrial EROD activities were comparable (in midbrain, meninges) or higher (in cortex, cerebellum, hippocampus) than the microsomal ones, suggesting an important metabolic function of CYP1A1 in this subcellular localization. The activities of GST and antioxidant enzymes were detected in all CNS tissues, with levels lower than the hepatic ones, but found quite evenly distributed and marginally affected by βNF treatment. The high expression of metabolic enzymes found in blood–brain interfaces could represent a very important defence toward toxins of CNS.     

Tobacco smoke-dependent changes in cytochrome P450 1A1, 1A2, and 2E1 protein expressions in fetuses, newborns, pregnant rats, and human placenta

Tobacco smoke (TS) was described as a mixture of numerous cytochrome P450 (P450) substrates, inducers, and inhibitors. These inducers and inhibitors may modify drug clearance and xenobiotic or endogenous metabolism affecting P450s expression. In the present study, the effect of gestation and TS on: (1) cytochrome P450 CYP1A1, CYP1A2, and CYP2E1 protein expressions, and (2) cytochrome P450-linked microsomal enzyme activities, were studied in fetal rat liver, rat, and human placenta and in newborn and adult rat hepatic and extrahepatic tissues. Non-pregnant and pregnant 4-month-old female Wistar rats were exposed to TS (500, 1,000, or 1,500 mg carbon monoxide per m³ air) in a toxicological chamber for 3 weeks (6 h daily, 5 days weekly). Human placentas were sampled from non-smoking, passive smoking, or active smoking primiparas. The efficacy of exposure was assessed by measuring urine cotinine levels. The TS-dependent inductory effect on the expression of CYP1A1 and 1A2 and related monooxygenase activities, and the inhibitory/inductory effect on CYP2E1 expression in rat tissues were observed. Pregnancy was associated with decreased levels of constitutive CYP1A1 and 2E1 in hepatic and extrahepatic tissues, TS-inducible CYP1A2 expression in the liver, and CYP1A1 expression in lungs and heart, but had no inhibitory effect on TS-inducible CYP1A1 and 2E1 expression, EROD, and P450-cooperated enzyme activities in the liver, kidney, and, in the latter case, in the heart. The presence of TS-induced CYP1A1 protein was confirmed in rat and human placenta and showed in newborn liver and lungs. CYP1A2 and 2E1 proteins were detectable in fetal rat liver. It was concluded that the expression of CYP1A1, 1A2, and 2E1, which metabolize some drugs and activate carcinogens, is controlled by age-, pregnancy-, and tissue-specific regulatory mechanisms in rats. Gestational differences in the regulation of expression of CYP1A subfamily members are not excluded. CYP1A1 and 2E1, but not CYP1A2 inductory mechanisms seem to be functional in fetal liver at day 21 of pregnancy but they appeared to be uninducible under a TS exposure. In TS-exposed pregnant females and fetuses the effects of metabolic activation of CYP1A1 and 1A2 substrates might be reduced because of lower CYP expressions or poor induction, respectively.This paper was presented partially at the following congresses: 7th European ISSX Meeting, Budapest 1999; Eurotox 1999, Oslo; 11th World Conference on Tobacco OR Health, Chicago, 2000; EUROTOX 2001, Istanbul; 6th International ISSX Meeting, Munich, 2001     

1天1粒,告别骨关节病!

骨关节病,有"不死的癌症"之恶称。我国患有各种骨关节疾病的人数约为1.5亿左右,每10个50岁以上老人,就有8个正饱受骨关节病之苦。治骨病,欧美风行"氨糖疗法"欧美骨科专家研究发现:氨糖缺失导致的关节滑液缺失、关节软骨磨损是诱发各种骨关节病的罪魁祸首,关节变薄、发炎、水肿、钙化、增生,压     

1天1粒,告别骨关节病!

骨关节病,有"不死的癌症"之恶称。我国患有各种骨关节疾病的人数约为1.5亿左右,每10个50岁以上老人,就有8个正饱受骨关节病之苦。治骨病,欧美风行"氨糖疗法"欧美骨科专家研究发现:氨糖缺失导致的关节滑液缺失、关节软骨磨损是诱发各种骨关节病的罪魁祸首,关节变薄、发炎、水肿、钙化、增生,压     

水果麦片,1+1未必大于2

正一般来说,谷类、水果、牛奶、鸡蛋是一份理想早餐的好搭档。然而对于大多数人来说早餐的时间实在有限,于是,一种"融水果和谷类于一体"的食品——水果麦片就成了很多朋友的选择。不过,价格不菲的水果麦片是不是真的能集二者优点于一体呢?强强联合确有营养优势水果麦片亮点在于将两类原本营养价值不低的食物组合在一起,使得     

应用高效液相色谱从人参皂甙中分离人参甙-Rb_1,-Rb_2,-Rc,-Rd,-Re,-Rg_1

用高效液相色谱法从粗皂甙中分离了人参皂甙的主要成分人参皂甙-Rb_1,-Rb_2,-Rc,-Rd,-Re,-Rg_1。首先以硅胶进行 HPLC制备分离,然后用碳水化物为填料的分析柱进行HPLC半制备层析,这个方法使人参皂甙分离时间缩短。此外还用碳水化物分析柱进行人参皂甙的分析,对人参皂甙的     

A comparison of the central actions of prostaglandins A1, E1, E2, F1α, and F2α in the rat

The effect of prostaglandins (PGs) A₁, E₁, E₂, F₁, and F₂ administered intraventricularly at doses of 0.02–4.0 g/rat were studied in some behavioral, antinociceptive and anticonvulsant tests in rats. Exploratory and locomotor activity were decreased by all PGs except A₁ and F₂ which had no effect on locomotor activity. All PGs studied, except A₁, induced hyperthermia and afforded protection in the hot-plate analgesic test and against maximal electroshock seizures.     

A comparison of the central actions of prostaglandins A1, E1, E2, F1α, and F2α in the rat

Prostaglandins (PGs) injected into the right lateral brain ventricle (i.v.c.) of the rat increased the sleeping time induced by hexobarbital, chloral hydrate, and ethanol. PGE₁ and PGE₂ intensified chlorpromazine-induced catalepsy, inhibited amphetamine hyperactivity, and significantly depressed the amphetamine-induced stereotypy. NA concentrations were decreased by PGE₁ and PGE₂ and were increased by PGF₂. PGF₂ increased both 5-HT and 5-HIAA levels in rat brain. Total ACh concentrations were increased by PGF₁ and PGF₂. PGE₁, PGE₂, and PGF₂ enhanced the turnover of NA, DA, and 5-HT. PGE₂ counteracted the decreased activity induced by -MT and abolished the hypothermic action of -MT. PGF₂ had little effect on the activity of PCPA pretreated rats, whereas the higher doses of PGF₂ increased body temperature in these animals.     

体检,多长时间做1次

进行健康检查,应该间隔多长时间、检查哪些项目呢?这要因人而异,区别对待,要从实际出发,根据自己的年龄、性别、职业、健康状况和家族病史等,全面考虑来作出选择。     

46,X,I(Xq)1例

特纳(Turner)综合征是X染色体结构畸变综合征中的一种。本室发现一例特殊核型的Turner综合征46，X，I(Xq)。现报道如下：患者，女，19周岁，1.49米，体重35kg(出生时体重2.25kg)，生殖系统见幼稚型外生殖器，原发闭经；第二性征几乎不发育，无阴毛，腋毛稀少，乳头及乳腺发育差     

TLCS法测定生脉散颗粒剂中人参皂甙Rg1,Re,Rb1的含量

用薄层扫描法（ＴＬＣＳ）对人参制剂中的人参皂甙Ｒｇ１，人参皂甙Ｒｅ，人参皂甙Ｒｂ１进行含量测定，方法快速、简便；结果准确。     

ACTA PHARMACEUTICA SINICA ,Vol 35,No .1～ 1 2KEY WORDS INDEX

ＡＡ2 31 87 ( 1) :62Ａｃｅｔａｍｉｎｏｐｈｅｎ ( 4 ) :2 44Ａｃｅｔｏｎｉｔｒｉｌｅ,2 ,3 ｄｉｈｙｄｒｏ 4 ｈｙｄｒｏｘｙ 2 　ｏｘｏ ｉｎｄｏｌｅ 3 ( 7) :5 10Ａｃｅｔｙｌａｔｉｏｎ ( 1) :2 5Ａｃｅｔｙｌａｔｉｏｎ ,ｃｈｌｏｒｏ ( 1) :2 5Ａｃｅｔｙｌ ｔｅｕｓｐｉｎｉｎ ,19 ( 4 ) :2 96ＡｃｈｙｒａｎｔｈｅｓｂｉｄｅｎｔａｔａＢＬ . ( 4 ) :3 15 ;( 11) :870Ａｃｉｃｌｏｖｉｒ ( 4 ) :3 0 4Ａｃｏｎｉｔｕｍ ( 12 ) :93 8ＡｃｏｎｉｔｕｍｋｕｓｎｅｚｏｆｆｉｉＲｅｉｃｈｂ ( 3 ) :2 3 4Ａｃｏｎｉｔｕｍｓｉ…     

阻击甲型H1N1流感,藏医专家如是说

目前,甲型H1N1流感在欧美国家蔓延,并向其他国家扩展.根据目前掌握的资料,本次发生的甲型H1N1流感是由变异后的新型甲型H1N1流感病毒所引起的急性呼吸道传染病.由于它是一种新病毒,人类的免疫系统不具备预存免疫性,感染和患病率预期将高于普通流感的季节性流行.     

Montelukast, a leukotriene receptor antagonist, modulates lung CysLT1

AIM: To determine the expressions of cysteinyl leukotriene receptors, CysLT, and CysLT2 , in airway eosinophilic inflammation of OVA-induced asthmatic mice and the modulation by montelukast, a CysLT1 receptor antagonist. METHODS: Asthma model was induced by chronic exposure to ovalbumin (OVA) in C57BL/6 mice. The eosinophils in     

消除伤风感冒症状,只需1分钟

感冒人人免不了,而我自小体质瘦弱,特别是到了知天命之年,每月一两次感冒是常事。而且每次感冒少则1个星期,多则10余天才好转。中西药几乎吃遍了,吊针也常光顾,却始终没有找到好的治疗方法。后来在一次与朋友闲聊的时候,听他提到“二天油”治疗感冒效果很好,不过一定要在感冒刚     

每天1两麦片粥,预防糖尿病

正瑞典查尔默斯科技大学和丹麦癌症协会的一项联合新研究称,每天食用50克全谷物(黑麦、燕麦、小麦等谷粒的胚乳、胚芽和麸皮)能起到预防2型糖尿病的作用。研究人员选取5.5万名丹麦人的健康数据资料。研究开始时,这些人的年龄在50～65岁之间,在随后15年的调查期内,超过7000人患上了2型糖尿病。研究人员首先统计参试者每日全谷物总摄入量