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光疗及光化学疗法治疗儿童皮肤病 总被引:1,自引:0,他引:1
临床实践证实,光疗及光化学疗法可以治疗儿童银屑病、白癜风、特应性皮炎及副银屑病等疾病,并且疗效肯定。另外,在一些少见皮肤病中也有应用。但是出于对光疗和光化学疗法长期应用的潜在不确切的致癌性的考虑,以及用于儿童治疗时所采用方法的不统一,和儿童依从性差等问题,限制了其在儿童中的应用。为此,介绍光疗及光化学疗法在儿童皮肤病的应用情况及其安全性和治疗特点等。 相似文献
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外用光化学疗法治疗儿童白癜风疗效及安全性评价 总被引:5,自引:1,他引:4
目的 评价外用光化学疗法治疗儿童白癜风的临床疗效和安全性。方法 以局部外用 8 甲氧补骨脂素配合局部照射UVA为治疗组 ,以单纯外用 8 甲氧补骨脂素为对照组 ,分别于治疗 3个月、6个月时进行疗效及不良反应的评价。结果 治疗组临床疗效明显优于对照组 (P <0 .0 5 ) ;治疗期间 ,两组患者均无严重不良反应发生。结论 外用光化学疗法治疗儿童白癜风疗效确切 ,安全性好 相似文献
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白癜风(vitligo)是一种常见的色素脱失性皮肤病,发病可能与遗传、神经、生化、病毒感染和自身免疫等因素有关.治疗白癜风主要有物理疗法、药物疗法及外科疗法,近年来一些新技术、新药物的出现,尤其是白癜风的细胞悬液移植技术给白癜风的治疗带来了新的希望.本文综述白癜风的外科疗法进展. 相似文献
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顾恒 《国际皮肤性病学杂志》1998,(6)
白癜风在儿童并不少见,口服PUVA治疗虽然对成人有效,但因有远期副作用而不推荐用于治疗儿童;外用PUVA虽是可选择疗法之一,在其不足之处是明显的光毒反应、不规则色素沉着和系统吸收。作者使用水浴PUVA,成功地治疗1例9岁进行期白癜风患儿,报告如 相似文献
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中国中西医结合学会皮肤性病专业委员会…… 《中华皮肤科杂志》2012,45(10):691-692
白癜风是一种常见的影响美容的获得性皮肤色素脱失性疾病,病因及发病机制仍然不清楚,临床治疗比较棘手.目前多采用综合疗法治疗白癜风,但是某些类型白癜风对药物治疗反应不好,甚至部分治疗有效的患者也存在某些皮损对治疗疗效不佳的现象.因此,外科治疗是对顽固性白癜风的有效手段之一,特别是对局限性稳定性白癜风皮损有良效. 相似文献
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儿童白癜风396例临床分析 总被引:3,自引:0,他引:3
目的 探讨汉族儿童白癜风的临床特点。方法 采用问卷调查方式对浙江省396例儿童白癜风及825例成人白癜风患者进行临床分析,用SPSS 10.0软件包对资料进行分析。结果 396例儿童白癜风患者中男183例占46.2%,女213例占53.8%,与成年患者相比,男女之间无性别差异。儿童患者中节段型的比例为33.3%,明显高于成人患者的13.5%,泛发型比例为4.3%,显著低于成人患者的11.6%。儿童患者家族史阳性比例为12.4%,成人患者家族史阳性比例为12.7%,两组间差异无统计学意义。有家族史患者一级亲属的发病率均明显高于二级亲属。儿童患者的诱发因素以外伤为主,伴发晕痣的比例明显高于成人患者;成人患者伴发甲状腺疾病的比例显著高于儿童患者。结论 儿童白癜风临床特点与成人相比有一定差异。 相似文献
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Childhood vitiligo differs from the adults by showing a higher incidence in females, segmental vitiligo being more common and less frequent association with other systemic autoimmune and endocrine disorders. Childhood vitiligo is often associated with a marked psychosocial and long lasting effect on the self-esteem of the affected children and their parents, hence an adequate treatment is very essential. Treatment of vitiligo is indeed a tough challenge for the dermatologists’ more so in the background of childhood vitiligo. Although multiple therapeutic modalities are available in the therapeutic armamentarium, not all can be used in children. This brief report updates regarding various therapies available in the treatment of childhood vitiligo. 相似文献
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Saurabh Agarwal M.D. Shalini Gupta M.B.B.S. Amit Ojha M.B.B.S. Rajesh Sinha M.D. 《Pediatric dermatology》2013,30(3):348-353
Childhood vitiligo differs from adult vitiligo in many clinical parameters. The objective of the current study was to study the clinicoepidemiologic profile of childhood vitiligo and to compare various clinical characteristics of childhood‐ and later‐onset vitiligo. The clinical presentation of vitiligo was examined and analyzed in 762 individuals attending the Dermatology Clinic of Government Medical College, Haldwani, a referral center for the Kumaun region of Uttarakhand state, India, between January 2006 and December 2010. Of the 762 individuals with vitiligo, 268 (35.2%) were children: 152 (56.7%) female and 116 (43.3%) male. The mean age of onset of vitiligo was 6.9 years. A family history of vitiligo was found in 24.3% of children. The most common site of onset was the head and neck (36.9%), followed by the lower limbs and trunk. The most common type of vitiligo observed was acrofacial vitiligo (38.1%), followed by vulgaris, segmental, focal, and mucosal. Leukotrichia was observed in 32.5% of children and Koebner's phenomenon in 24.3%. On comparison of childhood‐ and later‐onset vitiligo, there were statistically significant differences (p < 0.05) in sex, family history, type of vitiligo (segmental and vulgaris), and site of onset. Atopic dermatitis was one of the important cutaneous diseases associated with childhood‐onset vitiligo. Thirty‐five percent of all patients with vitiligo were children (≤12 yrs). Childhood‐onset vitilgo differs from later‐onset vitiligo in many clinical parameters such as sex, family history, types of vitiligo, and sites of onset. 相似文献
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目的 探讨3种胎盘制剂治疗儿童白癜风的临床疗效。方法 儿童白癜风182例,分为3组,分别采用黑素生成素、人胎盘组织液以及人胎盘脂多糖3种药物外用,3组均联合红外线照射,每天照射2次,每次20 min,照射期间每隔5 min搽药液1次。结果 黑素生成素治疗组治疗儿童白癜风有效率为75.65%;人胎盘组织液组有效率35.00%;人胎盘脂多糖组有效率44.44%,3种胎盘制剂的总有效率之间差异有统计学意义(P值均 < 0.05),尤其是对于头皮较大面积患者,黑素生成素组疗效明显优于其他两组。结论 3种胎盘制剂外用联合红外线照射治疗儿童白癜风有较好疗效。 相似文献
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Background: Numerous modalities have been used to treat vitiligo in children. Up to now, phototherapy and topical corticosteroids are the most commonly used treatments for adult vitiligo but studies evaluating the efficacy of these treatments in the pediatric population remain insufficient. Objective: This study was a retrospective review to evaluate the efficacy and safety of 308‐nm excimer laser treatment in 30 childhood vitiligo patients. Methods: Thirty vitiligo patients with 40 vitiligo patches were evaluated after the cessation of 308‐nm excimer laser treatment. Results: Seventeen patients (56.7%) with 20 patches (50%) achieved an acceptable degree (>50%) of repigmentation at the end of the treatment, with five patches (12.5%) showing >75% of repigmentation. The treatment response showed anatomical preferences, favoring the face, neck and trunk. However, the treatment response did not correlate to the cumulative dose or duration of treatment. Side effects occurred in nine patients, but were transient and minimal. Conclusion: The results of this study shows that the 308‐nm excimer laser can be an effective and promising device for the treatment of various vitiligo types, other than generalized, in childhood. 相似文献
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Linthorst Homan MW de Korte J Grootenhuis MA Bos JD Sprangers MA van der Veen JP 《The British journal of dermatology》2008,159(4):915-920
Background The onset of vitiligo occurs before the age of 20 years in 50% of patients. Having a chronic disease in childhood can impede a child’s health‐related quality of life (HRQL). Objectives Firstly, to compare the social and psychosexual development and current HRQL of young adult patients with childhood vitiligo with those of a group of healthy controls. Secondly, to compare these outcomes in patients reporting negative childhood experiences with those of patients not reporting negative childhood experiences. Methods Eligible patients were mailed questionnaires on (i) sociodemographic and clinical characteristics, (ii) social and psychosexual development, (iii) generic and dermatology‐specific HRQL, (iv) presence of negative childhood experiences related to vitiligo, (v) specification of these negative experiences and (vi) patients’ recommendations for further care. Results A total of 232 patients with vitiligo completed the questionnaires. Social and psychosexual development and generic HRQL in young adult patients with childhood vitiligo were not different from those of healthy controls. However, patients reporting negative childhood experiences reported significantly more problems in social development than those not reporting negative experiences. Furthermore, negative childhood experiences were significantly associated with more HRQL impairment in early adulthood. Conclusions Reporting negative experiences from childhood vitiligo appears to be associated with HRQL impairment in young adults with vitiligo. 相似文献
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白癜风是最常见的色素减退性皮肤病,临床治疗困难.胎盘制剂含有相对分子质量大于3000的蛋白,肽类和鞘脂,可以通过p38丝裂原活化蛋白激酶通路促进黑素合成.胎盘制剂也可以促进成黑素细胞增殖和分化,其治疗白癜风具有安全、有效、不良反应少的特点,尤其是治疗儿童头皮部白癜风的理想药物. 相似文献
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Berna Solak MD Bahar Sevimli Dikicier MD Nur C. Cosansu MD Teoman Erdem MD 《International journal of dermatology》2017,56(3):341-345
In patients with vitiligo, the clinical and laboratory features of the disease may vary according to time of onset. This is addressed in the literature by only a few studies with conflicting results. The aim of this study was to determine the demographic and clinical features of patients with non‐segmental vitiligo and to establish the association between vitiligo and autoimmune diseases with a focus on time of disease onset. A total of 224 vitiligo patients for whom complete medical records were available were evaluated retrospectively. Demographic data, scores on the Vitiligo Area Score Index (VASI), clinical features, vitiligo disease activity, repigmentation status, presence of any accompanying autoimmune disease, antinuclear antibody (ANA) titers, serum levels of glucose, thyroid‐stimulating hormone (TSH), thyroxine (T4) hormone, anti‐thyroid peroxidase (anti‐TPO), and anti‐thyroglobulin (anti‐TG) were recorded. The prevalence of halo nevi was significantly higher (P < 0.001) among children than in other patient groups. The prevalence of leukotrichia was higher in adults with adult‐onset disease than in either pediatric patients or adults with childhood‐onset disease (P = 0.002). Both anti‐TG and anti‐TPO levels were significantly higher in adults with adult‐onset disease than in pediatric patients and adult patients with childhood‐onset disease. The prevalence of autoimmune disease was 22.2%. Anti‐TG levels were significantly higher in patients with treatment‐related repigmentation than in those without repigmentation. This study shows that clinical features and associations with autoimmune disease may vary according to the age of onset of vitiligo. 相似文献
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Woo-Haing Shim Sung-Won Suh Seung-Wook Jwa Margaret Song Hoon-Soo Kim Hyun-Chang Ko Byung-Soo Kim Moon-Bum Kim 《ANNALS OF DERMATOLOGY》2013,25(2):168-172