Rapport Rein 2011 – Synthèse

Incident patientsIn 2011, in France, we estimate that 9 400 patients started a treatment by dialysis (incidence of dialysis: 144 per million inhabitants) and 335 patients with a pre-emptive graft without previous dialysis (incidence of pre-emptive graft: 5 per million inhabitants). As in 2010, incidence rate seems to stabilize. Elders provide the majority of new patients (median age at RRT start: 71 years old). New patients present a high rate of disabilities especially diabetes (41% of the new patients) and cardiovascular disabilities (>50% of the new patients) that increase with age. Considering treatment and follow-up, the first treatment remains center's hemodialysis and we do not notice any progression of self-dialysis. RRT started in emergency in 33% of the patients. This finding contrasts with the fact that 56% of patients started hemodialysis on a catheter. This, together with the major inter-region variability, suggests that different strategies of management exist. Finally, the hemoglobin level at RRT start seems to be an interesting indicator of good management and follow-up since 13% of patients presenting an underprovided follow-up have a hemoglobin level under 10 g/dl, whereas only 2.5% of patients with an appropriate follow-up presented such a condition.Prevalent patientsOn December 31, 2011, in France, we estimate that 70.700 patients were receiving a renal replacement therapy, 39.600 (56%) on dialysis and 31.100 (44%) living with a functional renal transplant. The overall crude prevalence was 1091 per million inhabitants. It was 1.6 higher in males.

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Renal replacement therapy for End-stage renal disease in 2011 in France

Prevalence was subject to regional variations with 5 regions (3 overseas) above the national rate. Renal transplant share varied from 33% in Nord-Pas de Calais to 53% in Pays de Loire, and from 16 to 25% in overseas regions. The study of temporal variations for 18 regions contributing to the registry since 2007 demonstrated a +4% increase in standardized prevalence of ESRD patients with a functional transplant vs. +2% increase for dialysis, resulting in a decreasing gap between dialysis and transplantation prevalence, due to an increase number of renal transplant and a longer survival of transplanted patients.The main dialysis technique was hemodialysis (93.3% of patients). Even if an important inter-region variability remains considering the choices of treatment, more than 50% of the patients are undergoing hemodialysis in a hospital-based incenter unit, and we noticed an increase in hemodialysis in a medical satellite unit with time whereas the rate of self-care hemodialysis decreases. The rate of peritoneal dialysis remains stable. When comparing guidelines to real-life treatments, 77.5% of patients receive adequate dose of treatment (12 H/week, KT/ V>1.2), the rate of patients with a hemoglobin blood-level lower than 10 g/dl and without erythropoietin treatment is 1.3%, which confirmed a good management of anemia. On the contrary, 34% of patients have a BMI lower than 23 kg/m² and only 23% have an albumin blood-level over 40 g/l, which underlines that nutritional management of ESRD patients can be improved.MortalityAge strongly influences survival on dialysis. Thus, one year survival of patients under age 65 is over 90%. After 5 years, among patients over 85 years, it is more than 15%. The presence of diabetes or one or more cardiovascular comorbidities also significantly worse patient survival. In terms of trend, we do not find significant improvement in the 2-year survival between patients in the cohort 2006–2007 and the 2008–2009 cohort. Cardiovascular diseases account for 27% of causes of death to infectious diseases (12%) and cancer (10%). Life expectancy of patients is highly dependent on their treatment. Thus, a transplant patient aged 30 has a life expectancy of 41 years versus 23 years for a dialysis patient.ESRD pediatric patientsIn 2011, the incidence and the prevalence of ESRD among patients under 20 years old remained stable at 8 and 53 per million inhabitants respectively. The first causes of ESDR remain uropathies and hypodysplasia followed by glomerulonephritis and genetic diseases. Considering the initial treatment, we found a high rate of hemodialysis and a low rate of peritoneal dialysis that is mainly used in younger children. In 2011, 31 preemptive transplantations were performed accounting for 27.7% of new patients. Finally, survival analysis confirm that younger children (under 4 years old) have the highest risk of death (88% survival rate at 2 years vs. 98% in patients over 4 years old) and that the treatment of choice remains the renal transplantation since it increases the expected remaining lifetime of 20 to 40 years depending on the considered age.TransplantationAccess to the waiting list is evaluated on a cohort of 51,846 new patients who started dialysis between 2002 and 2011 in 25 regions. The probability of first wait-listing was of 3.7% at the start of dialysis (pre-emptive registrations), 15% at 12, 22% at 36 and 24% to 60 months. Patient older than 60 had a very poor access to the waiting list, whatever their diabetes status was. Among 13,653 patients less than 60 years old, the probability of being registered was 11% at the start of dialysis, 43% to 12 months, 62% to 36 months and 66% to 60 months (median dialysis duration: 16 months). Seventeen regions with up to 5 years follow-up show an increase of 8 to 15% in pre-emptive registrations between 2007 and 2001, without change at 1 year.Access to kidney transplant is evaluated on a cohort of 53,301 new patients who started a renal replacement therapy (dialysis or pre-emptive renal transplant) between 2002 and 2011 in 25 regions. The probability of first kidney transplant was of 7% at 12, 17% at 36 and 21% at 60 months. 8,633 patients (16,2%) had received a first renal transplant within 14.7 month median time; 1,455 (2.7%) had received a pre-emptive graft. Among the 14.770 new patients less than 60 years old, the probability of being transplanted was of 21% at 12, 46% at 36 and 58% at 60 months (median dialysis duration: 42 months). When pre-emptive graft were excluded, the probability of being transplanted was of 5% at 12, 15% to 36 and 19% to 60 monthsFlow between treatment modalitiesAmong the 36.849 patients on dialysis at 31/10/2010, 79% were already on RRT at 31/12/2009. Respectively 91%, 85% and 93% of the patients on HD in-center, HD self-care unit and peritoneal dialysis were in the same modality of treatment the year before. Among the 29.758 patients with a functioning graft at 31/12/2010, 98% were already on RRT at 31/12/2009, 95% of them with a functioning graft.72%, 72% and 74% of the patients with in-center HD, out-center HD and self-care unit were in the same modality of treatment at 31/12/2011. But 37% of the patients on PD at 31/12/2010 were not on PD at 31/12/2011. In 2011, new patients represented 89% of the entries in peritoneal dialysis. Renal transplantation represented 10% of the outcomes of the HD patients in self-care unit or at home.     

Arthrodèse tibiotalocalcanéenne par enclouage transplantaire rétrograde en milieu septique : note technique ; à propos de six cas

Transplantar intramedullary nailing is a good osteosynthesis to stabilize a tibio-talo-navicular arthrodesis. Nevertheless, in the case of infected ankle joint, a hardware material going from calcaneus until tibia diaphysis through two joints may facilitate a spreading of the infection. A good cleaning and curettage of the infected joint after several bacteriological samplings, a stable osteosynthesis, and a specific antibiotherapy can lead to a fusion of the bone and a healing of the infection as demonstrated by this short series. On a technical point of view, it seems necessary to systematically make a curettage of the subtalar joint.     

Prothèse de genou à charnière "AXEL"

Résumé L'AXEL est une prothèse à charnière qui présente deux caractéristiques essentielles. Elle autorise une rotation limitée qui supprime les contraintes rotatoires au niveau des tiges et améliore la stabilité rotulienne. Elle assure, du fait de l'appui permanent des condyles sur les plateaux polyéthylène, une bonne dispersion des contraintes qui limite l'usure des axes. Une série homogène de 142 prothèses de genou AXEL a servi de base à cette étude. Les indications sont celles de toute prothèse à charnière : les grandes déviations, les instabilités majeures, les raideurs serrées et les changements de prothèse. Les résultats sont analysés sur les 108 malades survivants, tous revus, totalisant 129 interventions avec un recul moyen de trois ans. On ne note dans cette série aucun accident per opératoire lié au scellement. Parmi les complications post opératoires, il faut retenir deux sepsis tardifs, une détérioration importante de l'axe, un descellement aseptique et quatre problèmes d'instabilité rotulienne. Toutes ces complications ont fait l'objet d'une réintervention, avec un sepsis residuel et deux rotules qui restent instables. La récupération fonctionnelle est toujours rapide et de bonne qualité quel que soit l'état pré-opératoire. La simplicité technique, l'absence d'accidents per opératoires ont conduit à proposer cet implant à des malades de plus de 80 ans qui représentent dans cette série 24 % des indications. Il apparaît en effet qu'à cet âge, en l'absence de risque particulier lié au type d'implant, la qualité et la rapidité de la récupération fonctionnelle priment largement sur l'importance du sacrifice osseux.     

Arthrodèse circonférentielle par voie mini-invasive dans la prise en charge des lésions rachidiennes thoracolombaires cyphosantes : note technique

IntroductionManagement of spinal kyphotic deformities remains challenging in order to achieve a complete correction of the deformity, stabilize the spine and restore a satisfactory sagittal alignment. The aim of this study was to report the results of a technique combining, during the same operative session: a percutaneous osteosynthesis (with or without decompression) and a minimal invasive corpectomy using an anterior approach.MethodsTwelve patients (mean age 54 years old) were included in this single center retrospective study. Kyphotic deformity was related to a trauma in 9 cases, to a tumor in 2 cases and was infectious in the last case. The level involved was L1 in 7 cases, T12 in 3 cases, T10 and L4 in 1 case each. First step of the surgical strategy was a routine posterior percutaneous osteosynthesis. In 5 cases, a complementary minimal invasive decompression was performed using tubular retractors. During the second step, an anterior corpectomy was performed and the vertebral reconstruction was done using telescopic vertebral body prosthesis. Once the last correction was achieved, final locking of the posterior instrumentation was performed.ResultsIn the entire series, a short construct was done in 2 cases and a long construct was decided for the 10 other cases depending on the lesion. Mean surgical time was 246 min [173–375] and postoperative blood transfusion was not necessary. Patients were discharged from the hospital on average at day 8 [4–25] according to associated lesions. Based on radiographic analyses, a significant restoration of the vertebral kyphosis (average 17°, P < 0.001) and vertebral body height (27% on average, P < 0.001) were obtained.ConclusionCombination of these two minimal invasive techniques allows a circumferential spinal fixation with a low rate of complications and a satisfactory restoration of local sagittal deformity. This strategy is, in our experience, a valuable alternative to conventional techniques. Further studies with a longer follow-up will therefore needed in order to confirm these results.     

Arthrodèse tibiotalocalcanéenne (TTC) par enclouage transplantaire (ETP): complications vasculaires et neurologiques. À propos de 11 cas

The aim of this article is to describe non-bony complications of tibiotalocalcaneal arthrodesis (TTC) performed by intramedullary nailing. Brief detail of such complications has previously been presented. Our retrospective report concerns 11 patients submitted to surgery between April 2004 and February 2008. These patients had involvement of both components of the ankle joint (tibiotalar and sub-talar) by rheumatoid arthritis, primary osteoarthritis or posttraumatic secondary osteoarthritis, post-traumatic necrosis of the talus, or failure of total ankle prosthesis. In all of them, one or more tissues was at risk. In all cases, the surgical technique (without pneumatic tourniquet) involved a combined plantar and lateral approach with distal osteotomy of the fibula. The nail was stabilized by proximal and distal locking. The lateral malleolus was not removed for graft purposes and was fixed as lateral support (Crawford-Adams). The vascular complications we encountered were as follows: three cases of damage to the peroneal artery, one to the lateral malleolar branch, and one case of acute post-operative ischaemia (corrected in 6 h with medical treatment). The neurological complications were all transitory: two involved the superficial peroneal nerve, one affected the medial plantar nerve, one the lateral plantar nerve, and one patient had dysesthesiae without clear anatomical localization. The only skin complications were two minor problems with scarring. Following this study, when TTC arthrodesis with pinning is being considered, we recommend a thorough clinical examination (skin condition, peripheral pulses), supported whenever appropriate, by additional investigative tests (arterial doppler of the lower limbs or even MRI-angiography). During the operation, the absence of a tourniquet facilitates controlled hemostasis. The presence of a vascular team may prove to be necessary in some cases. The advantages of the lateral trans-fibular approach (wide exposure, availability of bone for graft purposes, facilitation of axial correction) are such as to render the complications acceptable. The plantar approach must be via the axis of the third metatarsal bone or lateral to it, so as to avoid trauma to branches of the nerve and artery of the posterior tibial neurovascular bundle.