Allergy and occupational exposure to hydroquinone and to methionine

Respiratory manifestations have been reported after exposure to hydroquinone and to methionine. One hundred and three men in the same chemical plant were divided into three groups according to their exposure and compared by questionnaire, respiratory functional tests with methacholine then salbutamol challenges, and measurements of serum immunoglobulins G and E. Group H included 33 workers exposed to hydroquinone, trimethyl-hydroquinone, and retinene-hydroquinone. Group M included 15 workers exposed to methionine. Group C was a control group of 55 workers. The prevalence of respiratory symptoms was higher in the two exposed groups. Before challenges, pulmonary function values were significantly lower in groups H and M than those in group C. The challenges induced significant variations in the three groups but these variations were less pronounced in group M than in the other groups. The level of immunoglobulin G in group H (m +/- SD = 12.5 gram/liter +/- 2.6) was significantly higher than in group C (10.6 gram/liter +/- 2.4; p less than 0.002). The level of immunoglobulin E in group H (m = 140 IU/l) was also higher in group C (109 IU/l) but this difference was not significant. These findings suggest that exposure to methionine and to hydroquinone and its derivatives induce ventilatory impairment, perhaps by an immunological mechanism.     

Allergy and occupational exposure to hydroquinone and to methionine.

Respiratory manifestations have been reported after exposure to hydroquinone and to methionine. One hundred and three men in the same chemical plant were divided into three groups according to their exposure and compared by questionnaire, respiratory functional tests with methacholine then salbutamol challenges, and measurements of serum immunoglobulins G and E. Group H included 33 workers exposed to hydroquinone, trimethyl-hydroquinone, and retinene-hydroquinone. Group M included 15 workers exposed to methionine. Group C was a control group of 55 workers. The prevalence of respiratory symptoms was higher in the two exposed groups. Before challenges, pulmonary function values were significantly lower in groups H and M than those in group C. The challenges induced significant variations in the three groups but these variations were less pronounced in group M than in the other groups. The level of immunoglobulin G in group H (m +/- SD = 12.5 gram/liter +/- 2.6) was significantly higher than in group C (10.6 gram/liter +/- 2.4; p less than 0.002). The level of immunoglobulin E in group H (m = 140 IU/l) was also higher in group C (109 IU/l) but this difference was not significant. These findings suggest that exposure to methionine and to hydroquinone and its derivatives induce ventilatory impairment, perhaps by an immunological mechanism.     

Correlation between susceptibility to malaria and babesia parasites and to endotoxicity

Adult (185g) rats are about twice as sensitive to the harmful effects of injected endotoxin as are younger (65g) rats. This relationship correlates with an earlier report on the densities of Plasmodium berghei at which deaths occur in rats of these two age groups. Similarly lizards, which withstand very high parasitaemias of malaria parasites, are refractory to very large doses of endotoxin. This correlation appears to hold for malaria and babesiosis in all host species for which information is available, with man, for instance, very sensitive to these infections and to injected endotoxin.It is now realized that endotoxicity is not caused by the direct effects of endotoxin, but is the consequence of the release of a range of harmful soluble mediators, mainly from macrophages. Since the susceptibility of a host species to endotoxicity and to malaria and babesiosis correlate, and the illness produced in each case is very similar, these harmful mediators which cause endotoxicity are likely candidates for the origins of much of the pathology of malaria and babesiosis. This concept may also explain the relationship between parasite density and illness in these infections in man.     

From illness to symbol and symbol to illness.

This paper explores two aspects of the relationship between illness and social symbols: one in which illnesses become symbols; the other, in which symbols become implicated in processes that eventuate in illness. Illness is first discussed as a symbol of social beliefs, attitudes, norms, values, and other social phenomena conceptualized in relation to them. This symbolization is analyzed as it relates to various dimensions of illness that lend themselves to figurative thinking. The paper then turns to processes through which social symbols may generate illness. In this regard, ways in which social symbols may attract people to behavior that puts their health at risk are discussed. The paper concludes with an analysis of how the development of illness may be affected by the relationship between social symbols and somatization.     

How to prevent and cope with resistance to change

Resistance to workplace changes is always to be anticipated. It can be minimized by insightful planning, and overcome by competent leadership. This article provides practical advice for both planning and leadership tactics.     

Factors contributing to and strategies to combat emerging arboviruses

ABSTRACT

Less than half a century ago infectious diseases appeared to be destined to be extinguished via as a culmination of medical triumphs. As focus turned towards combating non-communicable diseases, emerging and re-emerging diseases (EIDs) have bloomed from those ashes. Five epidemic mosquito-borne arboviruses (Yellow Fever virus (YFV), Dengue virus, West Nile virus, Chikungunya virus, and Zika virus) have emerged in the recent past. Arboviruses are of the utmost importance with respect to EIDs due to intensive growth of globalisation, arthropod urban fitness/adaption, and environmental changes. We focus on recent outbreaks of the arthropod borne viruses (arboviruses) Zika virus and YFV. Factors contributing to the blossoming of EIDs (environmental, globalisation, and urbanisation) and combating strategies (surveillance, containment, and prevention) will be discussed. Specifically, Zika virus and YFV will be used in the context of these factors and strategies. YFV is discussed in detail as it pertains to these factors and strategies in the United States (US), 2017 Brazil Outbreak, 2016 Africa Outbreak, and global risk. Vigilance is needed to focus on, prevent, and control the current and next arbovirus EIDs.