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The author discusses the role of “natural” hepatotoxic substances, derived from plants and fungi, in the etiology of liver disease, especially in tropical and subtropical countries. The hazards involved in even the occasional use of natural hepatotoxins and the difficulty in tracing the causative factors of chronic diseases are illustrated by the example of the pyrrolizidine (Senecio) alkaloids. The ingestion by rats of a single dose of these alkaloids can induce chronic liver lesions and even hepatoma which, however, may not become apparent for 1½-2½ years.  相似文献   

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In this paper the author reports the results of three months'' study of the saltwater-breeding member of the Anopheles gambiae complex of sibling species on Mauritius.  相似文献   

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