Focal acral hyperkeratosis

We report fifteen cases showing focal acral hyperkeratosis. They were clinically identical to acrokeratoelastoidosis (AKE) but lacked the elastorrhexis which is a feature of AKE. The name focal acral hyperkeratosis is proposed for this condition which differs histologically from AKE.     

Ultrastructure of pitted keratolysis

A 20‐year‐old man presented with pitted keratolysis (PK), demonstrating the typical crateriform pits on the hallux ( Fig. 1 ), ball of the foot, and on the interdigital surface. The involved keratin specimen was obtained by a shaving technique and processed for transmission (TEM) and scanning (SEM) electron microscopy. The patient, who wore only sports shoes, had hyperhidrosis plantaris. He was treated with topical erythromycin with good results. Bacterial cultures from the lesions showed Corynebacterium sp.

Figure 1 Open in figure viewer PowerPoint Crateriform pits on the hallux     

窝状角质松解症一例

临床资料患者,男,18岁。因双足底皮疹2月于2011年1月11日来我院就诊。患者2月前无明显诱因双足底出现散在肤色浅表性环状和窝状凹陷,无明显自觉症状,未予以重视,后皮损逐渐增多,并伴轻微疼痛。     

Focal acral hyperkeratosis: a rare cutaneous disorder within the spectrum of Costa acrokeratoelastoidosis

Acrokeratoelastoidosis and focal acral hyperkeratosis share similar clinical features and identical histologic epidermal alterations. These disorders are distinguished solely on the basis of the absence of elastorrhexis in the latter. We present a case of focal acral hyperkeratosis in a 9-year-old girl. The lesions consisted of translucent polygonal papules clustered on the thenar regions of the palms and over the metacarpophalangeal and interphalangeal joints. Histopathologic examination revealed orthohyperkeratosis within focal clavus-like depressions of the epidermis and prominent hypergranulosis. There was no evidence of alterations in elastic tissue. The clinicopathologic distinction between focal acral hyperkeratosis and acrokeratoelastoidosis is blurred. There is enough evidence to consider the former as a histologic variant of Costa acrokeratoelastoidosis syndrome, and a better nomenclature for this disorder would be "acrokeratoelastoidosis without elastorrhexis."     

局灶性肢端角化过度

报告1例局灶性肢端角化过度.患者女,45岁.双手淡黄色扁平丘疹10余年,无自觉症状.组织病理检查可见表皮明显角化过度,颗粒层及棘层增厚,未见典型空泡细胞.弹性纤维染色示真皮弹性纤维大致正常.     

Scleredema adultorum associated with hyperkeratosis

Scleredema adultorum is a rare skin disorder reported to occur usually following streptococcal infections. It has characteristic clinical and histopathologic findings; however, associated hyperkeratosis is not known. We report a 6-year-old girl with scleredema adultorum and hyperkeratosis. The patient's disease had a benign course. To our knowledge, this patient is the first reported with scleredema adultorum associated with hyperkeratosis.     

Palmoplantar hyperkeratosis associated with losartan

Losartan belongs to the group of angiotensin II receptor antagonists and is used for the treatment of hypertension and heart failure. It acts in the renin angiotensin system (RAS) by blocking the angiotensin II receptor. There have been several reports on cutaneous side events by angiotensin antagonists due to their effect on the local cutaneous RAS. We review the case of palmoplantar lesions that developed in a patient taking losartan and the subsequent remission after treatment withdrawal. Since these reactions are being increasingly reported and as they can mimic a broad variety of classical skin disorders, they should be considered as the cause of sudden, inexplicable skin eruptions in patients taking angiotensin receptor antagonists.     

Concurrent punctate keratosis of the palmar creases and focal acral hyperkeratosis

We report a patient with punctate keratosis of the palmar creases appearing concurrently with focal acral hyperkeratosis. This presentation is a unique coexistence of 2 simple and punctate hereditary palmoplantar keratodermas.     

窝状角质松解症治疗方法的探索

窝状角质松解症（pitted keratolysis PK ）又名沟状跖部脚质松解痛（keratolysis plantare sulcaturn）.     

Epidermolytic hyperkeratosis associated with a dilated pore

A case of a dilated pore containing a histologic focus of epidermolytic hyperkeratosis was reported. Our case widened the spectrum to include the association of epidermolytic hyperkeratosis with acquired solitary skin lesions.