Open versus endovascular treatment of subclavian artery atherosclerotic disease

Objective

The aim of this study was to compare open and endovascular treatment of patients with subclavian artery atherosclerotic disease (SAAD) as far as early and late outcomes are concerned.

Modern management of traumatic subclavian artery injuries: a single institution's experience in the evolution of endovascular repair

Background

Subclavian artery injuries traditionally require morbid surgical procedures. Repair by way of an endovascular approach can potentially decrease the morbidity and mortality associated with these injuries.

Methods

A 2-year retrospective review of trauma patients with subclavian artery injuries was performed at our institution. Relevant data were extracted from patient records and analyzed. These results were then used to develop an algorithm for the management of trauma patients with subclavian artery injuries.

Results

Fifteen patients with subclavian artery injuries were identified. Five patients died in the emergency room. Of the 10 surviving patients, 8 had their diagnosis made at arteriogram. Six patients underwent endovascular repair, and 4 of these repairs were successful. Three patients were managed by way of open repair. Two deaths occurred in the endovascular group, and 1 death occurred in the open group.

Conclusions

Our findings suggest that endovascular management of subclavian artery injuries is an acceptable technique in appropriate candidates and compares favorably with open repair. However, as with open repair, the associated morbidity and mortality remains quite high. We propose an algorithm whereby hemodynamically stable patients with hard signs of vascular injury proceed directly to angiography, whereas open repair is reserved for those patients who are unstable or in whom a catheter-based approach has previously failed.     

A systematic review of the diagnosis,management, and outcomes of true profunda femoris artery aneurysm

ObjectiveTrue profunda femoris artery aneurysm (TPFAA) is rare. Most cases of profunda femoris artery aneurysm are classified as pseudoaneurysms. TPFAAs are mostly asymptomatic, but some are manifested with pain, swelling, paresthesia, gait and movement disturbances, thrombosis, and rupture. There is a paucity of evidence on the effectiveness of diagnostic and therapeutic measures for management of TPFAA. The aim of this paper was to systematically review the incidence, diagnosis, and management of TPFAA.MethodsA comprehensive systematic review on the diagnosis and management of TPFAAs was conducted by a search through PubMed, Cochrane, Embase, and Google Scholar databases to identify and to evaluate publications on TPFAA since 2012. Only publications on TPFAA were included in this review.ResultsA total of 19 publications published from 2012 were included in the review. The studies were 18 case reports and a cadaver study reporting 27 TPFAAs in 26 patients with a mean age of 69.6 years. Rupture was reported in 18.5% of the cases (n = 5); the conventional clinical presentation of unruptured TPFAA was reported in 48% of cases (n = 13), with 40.9% of unruptured aneurysms being asymptomatic (n = 9). Computed tomography angiography was used as a diagnostic tool in 85.2% of the cases (n = 23); Doppler ultrasound was applied in 33.3% of cases (n = 9). The common therapeutic approaches were resection and revascularization (n = 13 [48.1%]) and ligation or resection without reconstruction (n = 6 [22.2%]). Cumulative analysis for cases reported before and after 2012 yielded similar results.ConclusionsReview of the current literature supports that computed tomography angiography and Doppler ultrasound are the mainstay diagnostic approaches for TPFAA. Surgical repair through ligation, resection, and revascularization remains the most common and effective therapeutic procedure. Endovascular embolization is recommended for aneurysms when surgery is not tenable because of the patient's comorbidities and the aneurysm's anatomy.     

Association between surgical repair of aortic aneurysms and the diagnosis of intracranial aneurysms

ObjectiveAortic aneurysms (AAs) and intracranial aneurysms (IAs) share several clinical risk factors, a genetic predisposition, and molecular signaling pathways. Nonetheless, associations between IAs and AAs remain to be thoroughly validated in large-scale studies. In addition, no effective medical therapies exist for unruptured IAs or AAs.MethodsData for this nationwide, population-based, retrospective, cohort study described herein were obtained from the National Health Insurance Research Database in Taiwan. The study outcomes assessed were (1) the cumulative incidence of IAs, which was compared between AA and patients without an AA and (2) the cumulative incidence of IAs in patients with AAs during the 13-year follow-up period, which was further compared among those who underwent open surgical repair (OSR), endovascular aneurysm repair or nonsurgical treatment (NST).ResultsOur analyses included 20,280 patients with an AA and 20,280 propensity score-matched patients without an AA. Compared with the patients without an AA, patients with AA exhibited a significantly increased risk of an IA diagnosis (adjusted hazard ratio [HR], 3.395; P < .001). Furthermore, 6308 patients with AAs were treated with surgical intervention and another 6308 propensity score-matched patients with AAs were not. Patients with an AA who underwent OSR had a significantly lower risk of being diagnosed with an IA than patients with an AA who underwent endovascular aneurysm repair or NST (adjusted HR, 0.491 [P < .001] and adjusted HR, 0.473 [P < .001], respectively).ConclusionsWe demonstrated an association between IAs and AAs, even after adjusting for several comorbidities. We also found that OSR was associated with fewer recognized IAs than NST.     

Treatment of subclavian artery stenosis: A case series

IntroductionIn this case series, different modalities of treatment for patients with ischaemic symptoms of subclavian stenosis are described, including the different operative strategies that can be adopted in more challenging cases. This is the first case series describing these four management options.PresentationCase 1: A seventy-one year-old female presented with acute on chronic ischaemia of her left arm following a fall and developed dry gangrene of her left thumb. This was initially managed with a heparin infusion followed by stenting of the subclavian artery which relieved her symptoms. Case 2: A fifty-nine year-old male presented with chronic ischemia of the left arm secondary to an occlusion of the left subclavian artery. This was managed by transposition of the left subclavian artery onto the left common carotid artery. Case 3: A sixty-four year-old female presented with left subclavian steal syndrome secondary to subclavian artery stenosis. She underwent carotid subclavian artery bypass. Case 4: A fifty-six year-old female presented with acute left upper limb ischaemia secondary to acutely thrombosed subclavian artery on a CT-angiography. She underwent a carotid to axillary bypass.Discussion and conclusionThis case series demonstrates the treatment options available to vascular surgeons when managing symptomatic subclavian artery disease. Symptomatic subclavian artery occlusive disease should be treated with endovascular stenting and angioplasty as first line management. If it is not successful then open surgery should be considered. Bypassing the carotid to the subclavian or to the axillary artery are both good treatment modalities.     

胸主动脉疾病腔内修复术中封闭左锁骨下动脉的可行性分析

目的 探讨胸主动脉疾病腔内修复术中封闭左锁骨下动脉的可行性及效果.方法 2005年10月-2012年3月广州军区武汉总医院心胸外科对行胸主动脉腔内修复术需要封闭左锁骨下动脉的患者在术前进行脑循环、颈动脉、椎基底动脉及Willis环检查,如右侧椎动脉血供良好,颈动脉、Willis环无狭窄则选择在腔内修复术中直接封闭左锁骨下动脉.术后观察颅脑及上肢缺血并发症发生情况.结果 40例患者封闭了左锁骨下动脉,手术均获成功,28例术后未出现左上肢窃血症状和神经系统并发症,12例出现了轻微的左上肢窃血症状及神经系统并发症,但无需手术干预.结论 在有意封闭左锁骨下动脉前,必须注意潜在性主动脉弓上各分支动脉的病变和变异,这样才可能保证胸主动脉疾病患者进行主动脉腔内修复术时安全、有效.     

颈内动脉瘤合并锁骨下动脉瘤1例

患者女,45岁,7天前突然头痛、头晕伴恶心呕吐,既往健康。查体：生命体征平稳。头颅CT平扫双侧裂池、前纵裂略高密度影。DSA（图1～4）：右侧颈内动脉前床突段向后侧方囊状膨突动脉瘤10mm×9mm,可见附壁血栓,外缘不规则。左侧锁骨下动脉、椎动脉开口远端可见向上前方囊状膨突动脉瘤7．0mm×4．2mm,外缘光滑。     

术中自制髂动脉分支支架治疗主髂动脉瘤的单中心经验

目的:总结术中自制髂动脉分支支架(IBD)在主髂动脉瘤腔内修复术中保留髂内动脉的经验。方法:回顾性分析2018年1月至2018年12月在南京大学医学院附属鼓楼医院13例主髂动脉腔内修复术中使用自制髂动脉分支支架重建髂内动脉患者资料,其中2例重建双侧髂内动脉,11例单侧髂内动脉,术后观察盆腔缺血症状发生、髂内分支支架通畅率、有无内漏及瘤体扩张等情况。结果:应用自制IBD保留髂内动脉技术成功率为100%,术中出现2例Ⅲ型内漏,1例Ⅱ型内漏,围术期无其他并发症发生。术后平均随访9(4~12)个月,无瘤体扩张,支架内未见明显血栓形成,无瘤体相关性死亡,2例Ⅲ型内漏消失,1例Ⅱ型内漏持续存在,但瘤体无增大;IBD支架和髂内动脉通畅率为100%。1例对侧髂内栓塞患者术后出现对侧臀肌跛行,随访3个月后症状消失,无勃起、大小便功能障碍等症状出现。结论:术中自制IBD的应用是一种安全、有效的选择,近期效果理想,远期管腔通畅率还有待进一步随访。     

胸主动脉腔内修复术封堵左锁骨下动脉的前瞻性研究

目的 探讨胸主动脉腔内修复术(TEVAR)封堵左锁骨下动脉的安全性和可行性.方法 2007年12月至2008年12月共111例胸主动脉病变患者进入本研究.根据术中封堵左锁骨下动脉的情况分为完伞封堵、封堵<50%、封堵>50%和未封堵组.术前及术后第1、3、5和30天随访测量患者双卜肢的血压差值,同时评估有无脑卒中、偏瘫和截瘫以及左上肢缺血等情况.结果 完全封堵55例(49.6%),封堵<50%18例(16.2%),封堵>50%7例(6.3%),未封堵31例(27.9%).所有患者TEVAR均成功,无脑卒中、截瘫及偏瘫发生.完全封堵组与其余3组相比,双上肢血压差值的差异有统计学意义(P<0.01).术后1周内完全封堵组中13例出现与左上肢活动无关的头晕,其中5例伴黑矇;7例出现左上肢间歇性跛行症状.结论 TEVAR中,为延长近端锚定区对左锁骨下动脉的封堵是安全可行的,但在某些情况下应行血管重建,以提供更为持久的修复效果.     

Surgical approach to left subclavian artery aneurysm in Marfan syndrome

We present a case of left subclavian artery aneurysm in a 48-year-old man with Marfan syndrome. Aneurysmectomy and interposition with an artificial graft were successfully performed through an infraclavicular incision by dividing the clavicle at its midshaft. The clavicle bone was reconstructed with a steel plate, and the postoperative course was uneventful. Because the arterial wall is fragile in cases of connective tissue disorders such as Marfan syndrome, our surgical approach was considered to be helpful for gentle maneuvering in an adequate operative field.     

全弓置换和支架象鼻手术治疗A型主动脉夹层时左锁骨下动脉的处理分析

目的 总结选择性结扎左锁骨下动脉、仅重建无名动脉和左颈总动脉方法在A型主动脉夹层全弓置换和支架象鼻手术中应用的临床经验.方法 2008年1月至2010年6月,29例A型主动脉夹层患者在接受全弓置换和支架象鼻手术时,因左锁骨下动脉显露困难,术中将其直接结扎.本组男性21例,女性8例,年龄19～55岁,平均年龄(44±12)岁.其中急性夹层12例,亚急性夹层4例,慢性夹层13例.所有患者依据术前影像学和术中循环、压力指标判断患者大脑Willis环和双侧椎动脉的侧支循环情况,如侧支良好,则直接结扎左锁骨下动脉、仅重建无名动脉和左颈总动脉;如果侧支不足,则结扎后加行升主动脉-左腋动脉旁路术.结果 29例手术均顺利完成,1例术后死于肺部感染,其余恢复顺利.术后左上肢血压(78±17)mmHg(1 mmHg=0.133 kPa),明显低于右上肢的(126±24)mmHg(P＜0.01),但左侧指氧饱和度、皮温、肌力及感觉运动功能与右侧相比无明显差异.随访1～27个月,无左锁骨下动脉盗血综合征与左上肢肌萎缩发生.结论 在对A型主动脉夹层行全弓置换和支架象鼻手术时,如果动脉瘤体较大、左锁骨下动脉位置较深、显露困难时,可以在充分评估侧支循环的前提下直接予以结扎,可简化手术操作和手术难度,术后无明显不良后果.

Abstract：

Objective To summarize the experiences of ligating left subclavian artery(LSA)in total arch replacement and stented elephant trunk implantation for Stanford type A aortic dissection patients with difficulty in exposing the LSA. MethodsTotal arch replacement and stented elephant trunk implantation were performed on 79 consecutive patients from January 2008 to June 2010. Twenty-nine cases of the cohort undertook LSA ligation due to bad exposure. There were 21 males and 8 females patients, aged from 19 to 55 years with a mean of(44 ± 12)years. There were 12 acute dissections, 4 sub-acute dissections and 13 chronic dissections. Based on thoroughly evaluation of the Willis' circle and bilateral vertebral arteries through pre-operative imaging and inrto-operative circulative parameters, if the collateral circulation was considered sufficient, LSA was ligated directly and only the innominate artery and carotid artery were reconstructed; if considered insufficient, an additional bypass from ascending aorta to left axillary artery was performed. Results All the 29 operations were completed successfully. There was one patient died from pulmonary infection and the others recovered well. Blood pressure of left arms were lower than right postoperatively[(78 ± 17)mmHg vs.(126 ± 24)mmHg, 1 mmHg = 0. 133 kPa, P ＜ 0. 01], but oxygen saturation, skin temperature and strength of the left hand were normal compared to the right. All the survived patients have been followed 1-27 months and none of them presented with any symptoms of left subclavian artery steal syndrome and ischemia of left arms. Conclusions Ligation of LSA under strict evaluation of collateral circulation could be safe in Type A dissection patients with bad exposure due to big ascending aortic aneurysm and will simplify the procedure significantly.     

23例锁骨下动脉瘤的诊治经验

目的总结和探讨锁骨下动脉瘤的诊断和治疗方法。方法1990年1月至2006年8月诊治锁骨下动脉瘤23例,其中真性动脉瘤10例,假性动脉瘤13例。男15例,女8例,年龄16-68岁,平均26．8岁。病因包括：创伤性12例,动脉硬化性5例,感染性1例,动脉炎性2例,病因不清3例。合并动脉瘤破裂2例,动脉栓塞1例、外伤性动静脉瘘2例。本组行外科手术16例,采用锁骨上、下或开胸入路,15例重建锁骨下动脉,1例结扎;行腔内隔绝术3例;保守治疗4例。结果本组无手术死亡;重建的锁骨下动脉通畅率为100％;有1例因动脉炎出现吻合口假性动脉瘤,其余无复发。结论外科手术治疗锁骨下动脉瘤是很困难的,正确切口入路的选择是确保手术成功避免并发症的关键。腔内修复术治疗操作简单,但并不能完全替代外科手术,其远期疗效尚待观察。     

Evolution of open aneurysmorrhaphy for management of sac expansion after endovascular repair of abdominal aortic aneurysms

ObjectiveWe evaluated the perioperative and mid-term clinical outcomes of open aneurysmorrhaphy (OA) for the treatment of sac expansion after endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms.MethodsOA involves sac exposure without dissection of the proximal or distal neck, sacotomy and ligation of back-bleeding vessels, preservation of the prior stent graft, and tight closure of the sac around the stent graft. We performed a retrospective review of all patients who had undergone OA for nonruptured sac expansion after standard EVAR at our institution between January 2015 and June 2021. The primary end points were 30-day mortality and aneurysm-related death. The secondary end points were postoperative complications, overall survival, freedom from reintervention, and sac regrowth rate.ResultsA total of 28 patients had undergone OA. Their mean age was 76.9 ± 6.7 years. The median sac diameter at OA was 79 mm (interquartile range [IQR], 76-92 mm). The median duration from the index EVAR to OA was 82 months (IQR, 72-104 months). Preoperative computed tomography angiography confirmed a type II endoleak (EL) in 20 patients, 1 of whom had had a coexisting type Ia EL; a type IIIb EL was identified in 1 patient. Concomitant endovascular procedures had been performed in six patients to treat a type I or III EL or reinforce the proximal and distal seals. The OA technique has been modified since 2017, with the addition of more aggressive dissection of the sac and complete removal of the mural thrombus to further decrease the sac diameter. Postoperative complications occurred in two patients and included abdominal lymphorrhea and failed hemostasis of the common femoral artery requiring surgical repair in one patient each. The 30-day mortality was 0%. During the median follow-up of 36 months (IQR, 14-51 months), the overall survival was 92.7% and 86.9% at 12 and 36 months, respectively, without any aneurysm-related death. In the late (2017-2021) treatment group, the median sac diameter immediately after OA was smaller than that in the early (2015-2016) treatment group (early group: median, 50 mm; IQR, 39-57 mm; vs later group: median, 41 mm; IQR, 32-47 mm; P = .083). Furthermore, in the late group, the sac regrowth rate was lower (early group: median, 0.36 mm/mo; IQR, 0.23-0.83 mm/mo; vs late group: median, 0 mm/mo; IQR, 0-0.11 mm/mo; P = .0075) and the freedom from reintervention rate was higher (late group: 94.7% at both 12 and 36 months, respectively; early group: 71.4% and 53.6% at 12 and 36 months, respectively; log-rank P = .070).ConclusionsOur results have shown that OA for the management of post-EVAR sac expansion is feasible with acceptable mid-term outcomes. Aggressive dissection and tight plication of the sac might be imperative for better mid-term outcomes after OA.     

带髂内分支支架的腔内隔绝术治疗腹主动脉瘤伴双髂动脉瘤

目的探讨带髂内分支支架的腔内隔绝技术在腹主动脉瘤伴双髂动脉瘤治疗中的应用。方法回顾性分析2011年6月～2012年6月我院收治的10例腹主动脉瘤合并双髂动脉瘤患者的临床资料。患者均于术前行CT血管造影(CTA)检查,腹主动脉瘤均为肾下型;髂动脉瘤仅累及髂总动脉8例,累及髂内动脉开口处2例。手术先置入带髂内分支的髂动脉带膜支架,再置入腹主动脉瘤的分叉型带膜支架。结果患者均一次手术成功,无死亡。9例患者获得随访,随访时间3～6个月,患者腹部搏动性肿块均消失,均未出现臀部、骶尾部坏死,无明显性功能障碍,1例出现臀部的轻度间歇性跛行。8例术后3个月行腹主、双髂动脉彩超检查,未见明显内瘘,移植的髂内分支支架血流通畅。3例术后6个月行腹主、双髂动脉CTA检查,未见Ⅰ型、Ⅲ型内瘘,髂内分支支架内血流通畅。结论带髂内分支支架的腔内隔绝技术在腹主动脉瘤伴双髂动脉瘤的治疗中是安全、有效的;可以有效地保留一侧髂内动脉,减少或避免因髂内动脉封闭而带来的并发症。     

Treatment of internal iliac artery aneurysms: single‐centre experience

Background: The aim of the present study was to analyse the short‐term results of treatment of internal iliac artery aneurysms (IIAA). Methods: In a prospective single‐centre cohort study all patients with IIAA (symptomatic or maximal diameter ≥30 mm) were evaluated for endovascular repair, which included coil embolization of the run‐off vessels and coverage of the orifice of the IIAA with a stent graft. Open repair was performed with aneurysm excision or aneurysmorrhaphy. Outcome criteria were technical and clinical success and complications of treatment. Results: In a period of 40 months 11 patients underwent operation for 12 IIAA. Nine aneurysms were repaired endovascularly and three with open repair. Coil embolization was routinely performed in all cases. At a median follow up of 18 months, technical and clinical success was 100%. Major complications included two early limb thromboses, a contrast‐agent‐induced nephropathy, and an intraoperative ureteric injury. Conclusion: Despite the limited number of patients, the present series, with good short‐term results, further supports the trend towards endovascular repair of suitable IIAA.     

前交通动脉瘤破裂急性期的血管内栓塞治疗

目的探讨血管内栓塞治疗前交通动脉瘤的方法,技术特点及疗效。方法回顾性分析应用血管内栓塞治疗的54例破裂前交通动脉瘤患者的临床资料。结果54例中成功栓塞53例,其中32例100％栓塞,19例95％栓塞,2例90％栓塞;3例出现严重血管痉挛;2例死于脑疝及严重血管痉挛继发脑梗塞。随访6～24个月,无术后再出血病例。结论血管内栓塞是治疗前交通动脉瘤的一种微创、相对安全而有效的方法。     

Late surgical conversion of failed Multilayer Flow Modulator stenting in thoraco-abdominal aneurysms

 Open in a separate windowOBJECTIVESThe aim of this study was to report the outcomes of open or hybrid repair of failed thoraco-abdominal aortic aneurysm endovascular treatment with Multilayer Flow Modulator (MFM) stents.METHODSAll patients who underwent open or hybrid repair of a failed MFM aortic treatment were retrospectively analysed. Perioperative and postoperative data, as well as midterm survival, were assessed.RESULTSBetween 2013 and 2020, 39 patients received an open or hybrid conversion after endovascular treatment. Five of them [13%; 4 males; median age 68 years (interquartile range 66–76)] were previously treated with aortic MFM stents (Cardiatis, Isnes, Belgium). Among these, the median interval between index repair and conversion was 84 months (interquartile range 75–84). The median aneurysm diameter was 9.6 cm (interquartile range 8–10). Renovisceral vessels steno-occlusion was highly prevalent: 2 renal arteries were occluded; 3 coeliac trunks, 2 renal arteries and 1 superior mesenteric artery had a >70% ostial stenosis. Open standard thoraco-abdominal aneurysm conversion was performed in 3 fit patients, while a hybrid approach with visceral debranching and tube endografting was performed in 2 high-risk patients. Two patients (2 open repairs) died intraoperatively, and 1 (hybrid repair) postoperatively. The 2 successfully treated patients are alive at 4- and 34-month follow-up, respectively, with patent visceral branches.CONCLUSIONSOpen or hybrid thoraco-abdominal aortic aneurysm treatment after failed endovascular aortic repair with MFM stents might be the only surgical option to address sac enlargements and ruptures or branch-related failures. However, both procedures had a poor prognosis due to both the impaired preoperative patient’s status and the surgical complexity in the presented series.