电针董氏奇穴联合舒肛解郁止痛汤中药坐浴治疗功能性肛门直肠痛的临床研究

目的 观察电针董氏奇穴联合舒肛解郁止痛汤中药坐浴治疗功能性肛门直肠痛的临床疗效.方法 将60例功能性肛门直肠痛患者采用随机数字表法分为对照组与治疗组各30例.对照组采用中药舒肛解郁止痛汤温水坐浴,治疗组在中药温水坐浴的基础上联合电针董氏奇穴中双侧"三其穴(其门、其角、其正)"、灵骨、大白、肠门.比较两组患者临床疗效、疼...     

电针联合雷火灸治疗寒湿型膝骨性关节炎:随机对照试验

ObjectiveTo observe the clinical effect differences of knee osteoarthritis (KOA) with cold-damp type between electroacupuncture (EA) combined with thunder-fire moxibustion and medication.MethodsA total of 72 cases of KOA patients with cold-damp type were randomly divided into a combined treatment group of EA and thunder-fire moxibustion (combined treatment group) and a medication group, 36 cases in each group. In the combined treatment group, the acupoints for EA were Dúbí (犊鼻 ST35), Nèixīyăn (内膝眼 EX-LE4), Zúsānlĭ (足三里 ST36), Yánglíngquán (阳陵泉 GB34), Yīnlíngquán(阴陵泉 SP9), Xuèhăi (血海 SP10), Liángqiū (梁丘 ST34) and Hèdĭng (鹤顶 EX-LE2). During the period of EA, the suspending thunder-fire moxibustion was applied to Shénquè (神阙 CV8) and Guānyuán (关元 CV4). In the medication group, diclofenac sodium double release intestine-sol capsule and Fugui gutong capsules were prescribed for oral administration. The treatment for 14 days was taken as one course and the consecutive 2 courses of treatment were required in each group. Before and after treatment, as well as in the follow-up visit, the pain score (visual analogue scale, VAS), the knee function score(Western Ontario and McMaster University, WOMAC, the expressions of interleukin 6 (IL-6) and transforming growth factor β1 (TGF-β1) in the joint fluid as well as the difference in the clinical therapeutic effect were observed in the two groups separately.Results(1) The pain score: compared with those before treatment, the VAS scores were all reduced after treatment and in the follow-up in the two groups (all P < 0.05). After treatment and in the follow-up, VAS scores in the combined treatment group were lower than those in the medication group (both P < 0.05). (2) The knee function score: WOMAC score of each item, i.e. pain, stiffness and function, as well as the total score after treatment and the follow-up were all lower than those before treatment in the patients of the two groups (all P < 0.05). The score of each item, i.e. pain and function, as well as the total score in the combined treatment group were all lower than those in the medication group after treatment and the follow-up respectively (all P < 0.05). (3)The expressions of IL-6 and TGF-β1: the level of IL-6 in the joint fluid was reduced after treatment as compared with that before treatment in either group and the level of TGF-β1 was increased, indicating the statistical differences (all P < 0.05). After treatment, the level of IL-6 in the combined treatment group was lower than that in the medication group and the level of TGF-β1 was higher than that of the medicating group, indicating the statistical significance (both P < 0.05). (4)The total effective rate in the combined treatment group was 97.1%, higher than 78.8% in the medication group, indicating the statistical significance (P < 0.05).ConclusionThe clinical effect of the combined treatment of electroacupuncture and the thunder-fire moxibustion is remarkable on knee osteoarthritis of cold-damp type. The combined treatment presents a more advantageous at the sustainability of the therapeutic effect as compared with medication.     

Effect of electroacupuncture on anxiety and craving in heroin addicts during detoxification

Objective:To observe the effect of electroacupuncture at Jiaji (EX-B 2) points for anxiety and craving in heroin addicts during detoxification. Methods:A total of 60 cases were randomized into an electro-acupuncture group and a control group, 30 in each group. Cases in the electroacupuncture group were treated with electroacupuncture at Jiaji (EX-B 2) points, whereas cases in the control group were treated with Methadone and Doxepin. Then scores were graded using Zung self-rating anxiety score (SAS) and self-made visual analogue scale (VAS). The assessment was conducted once a day to record the adverse reactions. Results:After treatment, the SAS and VAS scores in the electro-acupuncture group were significantly lower than that in the control group (P<0.01). Conclusion:Electroacupuncture at Jiaji (EX-B 2) points can effectively alleviate anxiety and craving intensity in heroin addicts during detoxification.     

Clinical observations on electroacupuncture treatment of unstable bladder

目的:对电针治疗不稳定膀胱进行临床疗效评价.方法:将患者随机分为电针组和对照组,根据治疗前后临床症状积分和生活质量评分的改善情况进行疗效评价.结果:观察指标两组治疗后均较治疗前显著降低(P＜0.05),两组间比较临床症状积分无显著性差异(P＞0.05);生活质量评分电针组较手法组下降明显(P＜0.05).结论:两种治疗方法对不稳定膀胱均有改善,其中电针组生活质量满意度要优于手法组,临床症状积分有低于手法组的趋势.     

回旋正骨手法联合温阳通络胶囊治疗阳虚寒凝型膝骨关节炎的临床观察

目的 观察使用回旋正骨手法联合温阳通络胶囊治疗阳虚寒凝型膝骨关节炎（KOA）的短期疗效。方法 选取2018年10月—2020年2月于广东省第二中医院骨科门诊部收治的KOA患者71例,采用随机数字表法随机分为试验组（35例）和对照组（36例）,试验组使用回旋正骨手法（每周1次,连续治疗4周）联合温阳通络胶囊（每日3次,每次2粒,服用4周）治疗,对照组口服塞来昔布胶囊（2次/日,100 mg/次）治疗。比较两组患者治疗前后的视觉模拟评分法（VAS）评分、西安大略和麦克马斯特大学骨性关节炎指数（WOMAC）评分、焦虑自评量表（SAS）和抑郁自评量表（SDS）评分,同时对两组患者进行疗效评价。结果 试验组痊愈率为14.29%,总有效率为91.43%,对照组痊愈率为13.89%,总有效率为86.11%。两组痊愈率和总有效率比较,差异无统计学意义（P > 0.05）。治疗后两组疗效指标均较治疗前明显改善,VAS、WOMAC分数均下降,差异均有统计学意义（P < 0.05）,且两组之间VAS评分、WOMAC疼痛评分、僵硬评分比较,差异无统计学意义（P > 0.05）,试验组WOMAC的生活能力部分评分较对照组下降更明显（P < 0.05）。治疗后两组SAS、SDS评分均较治疗前明显改善（P < 0.05）,试验组SAS、SDS评分均较对照组改善更为明显（P < 0.05）。结论 回旋正骨手法配合口服温阳通络胶囊可有效减轻阳虚寒凝型KOA患者疼痛、改善关节功能,且对缓解患者抑郁、焦虑情绪有积极作用。     

艾司西酞普兰联合或不联合电针对男性酒依赖住院患者稽延性戒断症状的干预研究

ObjectiveThis study is conducted to investigate the effects differences of escitalopram with or without combined electroacupuncture (EA) among male inpatients with a diagnosis of alcohol dependence and comorbid protracted alcohol withdrawal symptoms (PAWS).MethodsA total of 62 participants who met the inclusion criteria were enrolled in a two-arm randomized, placebo controlled, patients-blind trial and allocated to an escitalopram with real-EA group (real-EA group, patients= 31) and an escitalopram with sham-EA group (sham-EA group, patients= 31), respectively. In addition to the oral administration of escitalopram for total four weeks, patients in each group received corresponding EA treatment five days per week and two days off for consecutive four weeks. Both serum homocysteine (Hcy) test and electrophysiological tests, including event-related potentials (ERPs) and exploratory eye movement (EEM) were performed at pre- and post-treatment. Additionally, the global scores of Penn Alcohol Craving Scale (PACS), 17-items Hamilton Depression Rating Scale (HAMD-17), and Hamilton Anxiety Scale (HAMA) were used for assessing the subjective emotion experience of patients, respectively. Meanwhile, adverse effects were monitored and recorded.ResultsAfter four-week treatment, the global scores of PACS and HAMD-17 declined significantly in both groups (both P<0.05). Furthermore, the decline in the real-EA group was superior to that in the sham-EA group (P<0.05). Meanwhile, the total scores of HAMA only decreased in the real-EA group (P<0.05) but not in the sham-EA group (P>0.05). According to the parameters of ERPs, significant declines for N₂PL, P₃PL, and P₃amp were observed in both two groups (all P<0.05), and the decreases for P₃PL and P₃amp in the real-EA group was much superior to that in the sham-EA group (both P<0.05). According to the parameters of EEM, significant increase for NEF was observed only in the real-EA group (P<0.05). Besides, there was a dramatic decline for serum Hcy level only in the real-EA group (P<0.05). One case in the sham-EA group withdrew from the trial due to self-reported nausea and bitter taste, and outcomes of the remaining 61 patients were adopted for analysis.Conclusion(1) Escitalopram with EA may be a potential alternative therapy for mitigating PAWS among male inpatients with alcohol dependence. (2) Escitalopram with EA might improve the alcohol-dependence induced cognitive dysfunctions via upregulating the expression of Hcy.     

Electroacupuncture for functional dyspepsia and the influence on serum Ghrelin,CGRP and GLP-1 levels

Objective

To observe the clinical efficacy of electroacupuncture for functional dyspepsia (FD), and explore the corresponding mechanism.

从心脑论治电针中风后焦虑障碍:随机对照试验

ObjectiveTo evaluate the differences in the clinical effect and the safety in the treatment of post-stroke anxiety disorder (PSAD) between electroacupuncture (EA) and paroxetine on the base of the heart-brain theory.MethodsA total of 70 patients of PSAD were randomized into an EA group and a medication group, 35 cases in each one. In the EA group, four acupoints were selected and divided into two pairs. In the Pair A, there were Băihuì (百会 GV20) and Fēngfŭ (风府 GV16). In the Pair B, there were Xīnshū (心俞 BL15) and Shénmén (神门 HT7). After acupuncture, the electroacupuncture apparatus was applied. The duration of needle retention was 20 min. EA was given three times a week, totally for 4 weeks. In the medication group, paroxetine tablets were administered orally, 10 mg daily in the first 4 days and 20 mg afterwards, totally for 4 weeks. Before and after treatment, as well as in the follow-up period, Hamilton anxiety scale (HAMA), Barthel index (BI) for daily life ability, and clinical global impression (CGI) were observed and the clinical therapeutic effect was evaluated separately.ResultsA total of 3 cases were dropped-out in the medication group. Finally, 35 cases in the EA group and 32 cases in the medication group were included in the analysis. Compared with the scores before treatment, the scores of HAMA and CGI-SI (severity of illness) were lower and the scores of BI were higher after treatment and during the follow-up in either the EA group or the medication group (all P < 0.05). Compared with the scores after treatment, the differences were not significant in HAMA and CGI-SI scores during the follow-up in either the EA group or the medication group (all P > 0.05). Compared with the medication group, BI score in the EA group was higher in the follow-up, indicating the statistical significance (P < 0.05). After treatment, CGI-SI score was different statistically between the EA group and the medication group (P < 0.05). There were 5 cases with adverse reactions in the EA group and 9 cases in the medication group.ConclusionsThe therapeutic effect of electroacupuncture on the base of heart-brain theory is similar to the oral administration of paroxetine in the treatment of post-stroke anxiety disorder. This therapy relieves anxious emotions, promotes the recovery of limb function and has less adverse reactions in the patients.     

Collateral-pricking and blood-letting cupping combined with electroacupuncture for post-herpetic neuralgia: 刺络放血拔罐结合电针围刺治疗带状疱疹后神经痛临床观察

ObjectiveTo explore the clinical efficacy of collateral-pricking and blood-letting cupping combined with surrounding needling technique electroacupuncture in the treatment of post-herpetic neuralgia (PHN).MethodsSeventy-two patients with post-herpetic neuralgia were randomized into observation group and control group. Of the 72 cases, 12 cases fell off, so finally 30 cases in each group. The observation group was treated with collateral-pricking and blood-letting cupping combined with surrounding needling technique electroacupuncture, while the control group was treated simply with pregabalin capsules for 20 consecutive days. On the basis of the western medication pregabalin capsules, the same as that of the control group, collateral-pricking and blood-letting cupping combined with electroacupuncture in a surrounding needling technique, was adopted for the observation group, once every two days, ten days as one course of treatment, a total of two courses. The immediate visual analogue scale (VAS) before and after treatment were observed in the two groups, and their clinical effects were compared.ResultsThe VAS scores of PHN patients in the two groups after treatment were lower than those before treatment (both P<0.01), and the scores of observation group were lower than those of control group (P<0.05). The total effective rate of the observation group was 86.7%, higher than 73.3% of the control group.ConclusionThe clinical effect of collateral-pricking and blood-letting cupping combined with electroacupuncture is relatively satisfactory in the treatment of post-herpetic neuralgia.     

Clinical observation of taking acupuncture at the acupoints based on "four seas theory" for post-stroke cognitive impairment 基于“四海理论”组穴针刺治疗脑卒中后认知障碍的临床观察

ObjectiveTo observe the clinical effect on post-stroke cognitive impairment (PSCI) treated by acupuncture at the acupoints composed in accordance with the "four seas theory".MethodsA total of 70 patients with PSCI were randomly divided into a treatment group (n = 35) and a control group (n = 35). In the control group, conventional basic treatment and rehabilitation training were adopted, while in the treatment group, on the base of the treatment as the control group, acupuncture was applied at the acupoints composed in accordance with "four seas theory", lasting 8 weeks. The scores of mini-mental state examination (MMSE) and the instantaneous memory, the scores of Montreal cognitive assessment (MoCA) and the delayed memory, the score of kidney essence insufficiency in syndrome differentiation scale of vascular dementia (SDSVD), event-related potentials (ERP) P300 and clinical therapeutic effect were compared in the patients between two groups before and after treatment separately.ResultsAfter treatment, MMSE score and the score of instantaneous memory were higher than the results before treatment in either group respectively (all P < 0.05), in which, MMSE score in the treatment group was higher than that in the control group (P < 0.05). After treatment, MoCA score and the score of delay recall were higher than the results before treatment in either group (all P < 0.05), in which, MoCA score in the treatment group was higher than that of the control group (P < 0.05). After treatment, the score of SDSVD was lower than that before treatment in either group (both P < 0.05), in which SDSVD score in the treatment group were lower than the control group (P < 0.05). There were no statistical changes in P300 latency and wave amplitude in the patients of the control group after treatment (both P > 0.05). However, in the treatment group, P300 latency was reduced and the wave amplitude was increased after treatment (both P < 0.05). The total effective rate was 88.57% in the treatment group, higher than 71.43% in the control group (P < 0.05).ConclusionAcupuncture at the acupoints composed on the base of the "four seas theory” effectively improves the cognitive function and traditional Chinese medicine syndrome scores in PSCI patients. This therapy is of great value in clinic in the future.