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1.
Armstrong K McMurphy S Dean LT Micco E Putt M Halbert CH Schwartz JS Sankar P Pyeritz RE Bernhardt B Shea JA 《Journal of general internal medicine》2008,23(6):827-833
Context Although health care-related distrust may contribute to racial disparities in health and health care in the US, current evidence
about racial differences in distrust is often conflicting, largely limited to measures of physician trust, and rarely linked
to multidimensional trust or distrust.
Objective To test the hypothesis that racial differences in health care system distrust are more closely linked to values distrust than
to competence distrust.
Design Cross-sectional telephone survey.
Participants Two hundred fifty-five individuals (144 black, 92 white) who had been treated in primary care practices or the emergency department
of a large, urban Mid-Atlantic health system.
Primary measures Race, scores on the overall health care system distrust scale and on the 2 distrust subscales, values distrust and competence
distrust.
Results In univariate analysis, overall health care system distrust scores were slightly higher among blacks than whites (25.8 vs
24.1, p = .05); however, this difference was driven by racial differences in values distrust scores (15.4 vs 13.8, p = .003) rather than in competence distrust scores (10.4 vs 10.3, p = .85). After adjustment for socioeconomic status, health/psychological status, and health care access, individuals in the
top quartile of values distrust were significantly more likely to be black (odds ratio = 2.60, 95% confidence interval = 1.03–6.58),
but there was no significant association between race and competence distrust.
Conclusions Racial differences in health care system distrust are complex with far greater differences seen in the domain of values distrust
than in competence distrust. This framework may be useful for explaining the mixed results of studies of race and health care-related
distrust to date, for the design of future studies exploring the causes of racial disparities in health and health care, and
for the development and testing of novel strategies for reducing these disparities. 相似文献
2.
Peter J. Cunningham 《Journal of general internal medicine》2009,24(3):415-420
BACKGROUND The financial burden of medical care expenses is increasing for American families. However, the association between high medical
cost burdens and patient trust in physicians is not known.
OBJECTIVE To examine the association between high medical cost burdens and self-reported measures of patient trust and perceived quality
of care.
METHODS Cross-sectional household survey based on random-digit dialing and conducted largely by telephone, supplemented by in-person
interviews of households with no telephones. The sample for this analysis includes 32,210 adults who reported having a physician
as their regular source of care. Measures of patient trust include overall trust, confidence in being referred to a specialist,
and belief that the physician uses more services than necessary. Perceived quality measures include thoroughness of exam,
ability to listen, and ability to explain.
RESULTS In adjusted analyses, persons with high medical cost burdens had greater odds of lacking trust in their physician to put their
needs above all else (OR = 1.43, CI = 1.19, 1.73), not referring them to specialists (OR = 1.39, CI = 1.22, 1.58), and performing
unnecessary tests (OR = 1.42, CI = 1.20, 1.62). Patients with high medical cost burdens also had more negative assessments
of the thoroughness of care they receive from their physician (OR = 1.26, CI = 1.02, 1.56). The association of high medical
cost burdens with patient trust and perceived quality of care was greatest for privately insured persons.
CONCLUSION The rising cost of medical care threatens a vital aspect of the effective delivery of medical care–patient trust in their
physician and continuity of care. Exposing patients to more of the costs could lead to greater skepticism and less trust of
physicians’ decision-making, thereby making health-care delivery less effective. 相似文献
3.
Casagrande SS Gary TL LaVeist TA Gaskin DJ Cooper LA 《Journal of general internal medicine》2007,22(3):389-395
Background Past research indicates that access to health care and utilization of services varies by sociodemographic characteristics,
but little is known about racial differences in health care utilization within racially integrated communities.
Objective To determine whether perceived discrimination was associated with delays in seeking medical care and adherence to medical
care recommendations among African Americans and whites living in a socioeconomically homogenous and racially integrated community.
Design A cross-sectional analysis from the Exploring Health Disparities in Integrated Communities Study.
Participants Study participants include 1,408 African-American (59.3%) and white (40.7%) adults (≥18 years) in Baltimore, Md.
Measurements An interviewer-administered questionnaire was used to assess the associations of perceived discrimination with help-seeking
behavior for and adherence to medical care.
Results For both African Americans and whites, a report of 1–2 and >2 discrimination experiences in one’s lifetime were associated
with more medical care delays and nonadherence compared to those with no experiences after adjustment for need, enabling,
and predisposing factors (odds ratio [OR] = 1.8, 2.6; OR = 2.2, 3.3, respectively; all P < .05). Results were similar for perceived discrimination occurring in the past year.
Conclusions Experiences with discrimination were associated with delays in seeking medical care and poor adherence to medical care recommendations
INDEPENDENT OF NEED, ENABLING, AND PREDISPOSING FACTORS, INCLUDING MEDICAL MISTRUST; however, a prospective study is needed.
Further research in this area should include exploration of other potential mechanisms for the association between perceived
discrimination and health service utilization. 相似文献
4.
Di Mario F Cavallaro LG Moussa AM Caruana P Merli R Maini A Bertolini S Dal Bó N Rugge M Cavestro GM Aragona G Plebani M Franzé A Nervi G 《Digestive diseases and sciences》2006,51(10):1791-1795
We sought to study the relationship between serum pepsinogens and different histopathologic features of Helicobacter pylori-related chronic gastritis. One hundred forty-nine consecutive dyspeptic patients underwent endoscopy with biopsies; serum
pepsinogens I and II were measured by immunoassay. Serum levels of pepsinogens (sPG) were significantly correlated with H. pylori density both of the corpus (sPGI: r = 0.32, P < .001; sPGII: r = 0.56, P < .001) and antrum (sPGI: r = 0.41, P < .001; sPGII: r = 0.43, P < .001) as well as with chronic inflammation (sPGI: r = 0.26, P < .001; sPGII: r = 0.49, P < .001) and activity (sPGI: r = 0.38, P < .001; sPGII: r = 0.50, P < .001) in the antrum. Only sPGII was correlated with chronic inflammation (r = 0.44, P < .001) and activity (r = 0.40, P < .001) in the corpus. SPGI was inversely correlated with atrophy (r = –0.33, P < .001) and intestinal metaplasia (r = –0.37, P < .001) in the corpus. sPGII levels could be considered as markers of gastric inflammation all over in the stomach. sPGI
levels are inversely related to atrophic body gastritis. 相似文献
5.
6.
Maria Paula Mota Francisco M. Peixoto Jorge F. Soares Pedro A. Figueiredo José C. Leitão Isabel Gaivão José A. Duarte 《Age (Dordrecht, Netherlands)》2010,32(3):337-346
The aim of this study was to analyze the influence of aerobic fitness (AF) on age-related lymphocyte DNA damage in humans,
giving special attention to the role of the mitochondrial respiratory chain and hydrogen peroxide production. Considering
age and AF (as assessed by VO2max), 66 males (19–59 years old) were classified as high fitness (HF) or low fitness (LF) and distributed into one of the
following groups: young adults (19–29 years old), adults (30–39 years old), and middle-aged adults (over 40 years old). Peripheral
lymphocytes obtained at rest were used to assess DNA damage (strand breaks and formamidopyrimidine DNA glycosylase (FPG) sites
through the comet assay), activity of mitochondrial complexes I and II (polarographically measured), and the hydrogen peroxide
production rate (assayed by fluorescence). Results revealed a significant interaction between age groups and AF for DNA strand
breaks (F = 8.415, p = .000), FPG sites (F = 11.766, p = .000), mitochondrial complex I activity (F = 7.555, p = .000), and H2O2 production (F = 7.500, p = .000). Except for mitochondrial complex II activity, the age variation of the remaining parameters was significantly attenuated
by HF. Considering each AF level, an increase in DNA strand breaks and FPG sites with age (r = 0.655, p = 0.000, and r = 0.738, p = 0.000, respectively) was only observed in LF. Moreover, decreased mitochondrial complex I activity with age (r = −.470, p = .009) was reported in LF. These results allow the conclusion that high AF seems to play a key role in attenuating the biological
aging process. 相似文献
7.
Erin E. Krebs Karl A. Lorenz Matthew J. Bair Teresa M. Damush Jingwei Wu Jason M. Sutherland Steven M. Asch Kurt Kroenke 《Journal of general internal medicine》2009,24(6):733-738
BACKGROUND Inadequate pain assessment is a barrier to appropriate pain management, but single-item “pain screening” provides limited
information about chronic pain. Multidimensional pain measures such as the Brief Pain Inventory (BPI) are widely used in pain
specialty and research settings, but are impractical for primary care. A brief and straightforward multidimensional pain measure
could potentially improve initial assessment and follow-up of chronic pain in primary care.
OBJECTIVES To develop an ultra-brief pain measure derived from the BPI.
DESIGN Development of a shortened three-item pain measure and initial assessment of its reliability, validity, and responsiveness.
PARTICIPANTS We used data from 1) a longitudinal study of 500 primary care patients with chronic pain and 2) a cross-sectional study of
646 veterans recruited from ambulatory care.
RESULTS Selected items assess average pain intensity (P), interference with enjoyment of life (E), and interference with general activity
(G). Reliability of the three-item scale (PEG) was α = 0.73 and 0.89 in the two study samples. Overall, construct validity
of the PEG was good for various pain-specific measures (r = 0.60–0.89 in Study 1 and r = 0.77–0.95 in Study 2), and comparable to that of the BPI. The PEG was sensitive to change and differentiated between patients
with and without pain improvement at 6 months.
DISCUSSION We provide strong initial evidence for reliability, construct validity, and responsiveness of the PEG among primary care and
other ambulatory clinic patients. The PEG may be a practical and useful tool to improve assessment and monitoring of chronic
pain in primary care. 相似文献
8.
To translate and cross-culturally adapt to the Brazilian-Portuguese language (BP), five items were added to Health Assessment
Questionnaire (HAQ) to validate the resulting HAQ-S BP version for ankylosing spondylitis (AS). The items were translated
into BP following translation and back-translation. To assess validity, 25 patients were evaluated using the HAQ, Bath AS
Functional Index (BASFI), Bath AS Disease Activity Index (BASDAI), Bath AS Metrology Index (BASMI), and laboratory variables
(erythrocyte sedimentation rate, C-reactive protein). One question required modification to adapt culturally to Brazilian
conditions. The test–retest and interobserver correlation coefficients were 0.990 (p < 0.05) and 0.993 (p < 0.05), respectively. HAQ-S BP correlated to BASFI (r = 0.574; p < 0.05) and to HAQ (r = 0.963; p < 0.05), but not to BASDAI (r = 0.282), BASMI (r = 0.194), and laboratory variable. Individually, the fifth item referring to driving correlated highly to neck rotation (r = 0.900; p < 0.05), while the HAQ-S BP correlated to the neck rotation component (r = 0.303), but did not reach statistical significance. The HAQ-S BP version demonstrated adequate reproducibility, internal
consistency and validity, confirming its utility in the research of AS in Brazil. 相似文献
9.
Bonomi AE Anderson ML Rivara FP Cannon EA Fishman PA Carrell D Reid RJ Thompson RS 《Journal of general internal medicine》2008,23(3):294-299
Background Physical and sexual childhood abuse is associated with poor health across the lifespan. However, the association between these
types of abuse and actual health care use and costs over the long run has not been documented.
Objective To examine long-term health care utilization and costs associated with physical, sexual, or both physical and sexual childhood
abuse.
Design Retrospective cohort.
Participants Three thousand three hundred thirty-three women (mean age, 47 years) randomly selected from the membership files of a large
integrated health care delivery system.
Measurements
Automated annual health care utilization and costs were assembled over an average of 7.4 years for women with physical only, sexual
only, or both physical and sexual childhood abuse (as reported in a telephone survey), and for women without these abuse histories (reference group).
Results Significantly higher annual health care use and costs were observed for women with a child abuse history compared to women
without comparable abuse histories. The most pronounced use and costs were observed for women with a history of both physical
and sexual child abuse. Women with both abuse types had higher annual mental health (relative risk [RR] = 2.07; 95% confidence
interval [95%CI] = 1.67–2.57); emergency department (RR = 1.86; 95%CI = 1.47–2.35); hospital outpatient (RR = 1.35 = 95%CI = 1.10–1.65);
pharmacy (incident rate ratio [IRR] = 1.57; 95%CI = 1.33–1.86); primary care (IRR = 1.41; 95%CI = 1.28–1.56); and specialty
care use (IRR = 1.32; 95%CI = 1.13–1.54). Total adjusted annual health care costs were 36% higher for women with both abuse
types, 22% higher for women with physical abuse only, and 16% higher for women with sexual abuse only.
Conclusions Child abuse is associated with long-term elevated health care use and costs, particularly for women who suffer both physical
and sexual abuse. 相似文献
10.
Screening for Posttraumatic Stress Disorder in VA Primary Care Patients with Depression Symptoms 下载免费PDF全文
Background Unrecognized posttraumatic stress disorder (PTSD) is common and may be an important factor in treatment-resistant depression.
Brief screens for PTSD have not been evaluated for patients with depression.
Objective The objective was to evaluate a 4-item screen for PTSD in patients with depression.
Design Baseline data from a depression study were used to evaluate sensitivity, specificity, and likelihood ratios (LRs) using the
PTSD checklist (PCL-17) as the reference standard.
Subjects Subjects are 398 depressed patients seen in Veterans Affairs (VA) primary care clinics.
Measures The Patient Health Questionnaire (PHQ) for depression, PCL-17, and 4-item screen for PTSD were used.
Results Patients had a mean PHQ score of 14.8 (SD 3.7). Using a conservative PCL-17 cut point “(>50)”, the prevalence of PTSD was
37%. PCL-17 scores were strongly associated with PHQ scores (r = 0.59, P < 0.001). Among the 342 (86%) patients endorsing trauma, a score of 0 on the remaining 3 symptom items had a LR = 0.21, score
of 1 a LR = .62, score of 2 a LR = 1.36, and score of 3 a LR = 4.38.
Conclusions Most depressed VA primary care patients report a history of trauma, and one third may have comorbid PTSD. Our 4-item screen
has useful LRs for scores of 0 and 3. Modifying item rating options may improve screening characteristics. 相似文献
11.
BACKGROUND Screening for substance abuse and mental health in primary care can improve detection. One way to advance screening is for
health plans to require it.
OBJECTIVES We developed national estimates of the prevalence and type of mental and substance-use condition screening health plans require
of primary care practitioners.
DESIGN In 1999 (N = 434, response rate = 92%) and 2003 (N = 368, response rate = 83%), we conducted a nationally representative health plan survey regarding alcohol, drug, and mental
health services, including screening requirements.
PARTICIPANTS Health plans reported on screening requirements of their top three private insurance products. Products were categorized by
type (HMO, POS, or PPO), behavioral health contracting arrangements, tax status, market area population, and region.
MEASUREMENTS We asked whether primary care practitioners are required to use a general health screening questionnaire (including mental
health, alcohol, or drugs items) and/or a screening questionnaire focused on mental health, alcohol, or drug problems.
RESULTS By 2003, 34% of products had any behavioral health screening requirements. Although there was no increase from 1999 to 2003
in requirements for any kind of behavioral health screening, requirements for using a standard screening instrument declined
for mental health but increased for alcohol and drug screening. PPOs showed the largest increase in prevalence of behavioral
health screening requirements. Products contracting with managed behavioral health organizations were more likely to require
screening.
CONCLUSIONS Most products do not require behavioral health screening in primary care. More screening could help to improve identification
of behavioral health conditions, a first step towards effective treatment. 相似文献
12.
Tarakci E Yeldan I Kaya Mutlu E Baydogan SN Kasapcopur O 《Clinical rheumatology》2011,30(11):1415-1420
The aim of this study was to assess the relationships between physical activity level and anxiety, depression, and functional
ability in children and adolescents with juvenile idiopathic arthritis (JIA). Cross-sectional study design including patients
with JIA aged between 8 and 17 years and healthy controls was used. Sociodemographic data and clinical features were assessed.
Physical activity level and energy expenditure were assessed with a 1-day activity diary. Anxiety was screened by The Screen
for Child Anxiety Related Emotional Disorders (SCARED) questionnaire. Depressive symptoms were assessed by the Children’s
Depression Inventory (CDI). Functional ability was assessed with the Childhood Health Assessment Questionnaire (CHAQ). Pain
and overall well-being were measured using a visual analog scale (VAS). Fifty-two patients and 48 controls were included with
a mean age of 12.13 ± 2.92 and 11.27 ± 1.59 years, respectively. The mean disease duration was 64 months. The JIA group had
significantly less time in physical activity (p = 0.000), decrease in energy expenditure (p = 0.04), and higher CHAQ scores (p = 0.000) compared with the control group. In the JIA group, significant relationships were found between the number of active
joint and disease duration (r = 0.44, p = 0.000) and VAS pain (r = 0.30, p = 0.02), between SCARED and CDI (r = 0.54, p = 0.000). Significant relationships were found between VAS overall well-being and CDI (r = 0.29, p = 0.03), CHAQ (r = 0.37, p = 0.000), and VAS pain (r = 0.41, p = 0.000). Correlation between CHAQ and CDI (r = 0.34, p = 0.01) was significant. The result of our study suggested that only depression was related to anxiety, functional ability,
and well-being in children and adolescents with JIA. 相似文献
13.
Valerie J. Lang Christopher J. Mooney Alec B. O’Connor Donald R. Bordley Stephen J. Lurie 《Journal of general internal medicine》2009,24(9):1018-1022
BACKGROUND Teaching hospitals increasingly rely on transfers of patient care to another physician (hand-offs) to comply with duty hour
restrictions. Little is known about the impact of hand-offs on medical students.
OBJECTIVE To evaluate the impact of hand-offs on the types of patients students see and the association with their subsequent Medicine
Subject Exam performance.
DESIGN Observational study over 1 year.
PARTICIPANTS Third-year medical students in an Inpatient Medicine Clerkship at five hospitals with night float systems.
MEASUREMENTS Primary outcome: Medicine Subject Exam at the end of the clerkship; explanatory variables: number of fresh (without prior
evaluation) and hand-off patients, diagnoses, subspecialty patients, and full evaluations performed during the clerkship,
and United Stated Medical Licensing Examination (USMLE) Step I scores.
MAIN RESULTS Of the 2,288 patients followed by 89 students, 990 (43.3%) were hand-offs. In a linear regression model, the only variables
significantly associated with students’ Subject Exam percentile rankings were USMLE Step I scores (B = 0.26, P < 0.001) and the number of full evaluations completed on fresh patients (B =0.20, P = 0.048; model r
2 = 0.58). In other words, for each additional fresh patient evaluated, Subject Exam percentile rankings increased 0.2 points.
For students in the highest quartile of Subject Exam percentile rankings, only Step I scores showed a significant association
(B = 0.22, P = 0.002; r
2 = 0.5). For students in the lowest quartile, only fresh patient evaluations demonstrated a significant association (B = 0.27, P = 0.03; r
2 = 0.34).
CONCLUSIONS Hand-offs constitute a substantial portion of students’ patients and may have less educational value than “fresh” patients,
especially for lower performing students.
An abstract from this paper was presented at the Clerkship Directors in Internal Medicine National Conference in October 2007
and is published in the proceedings of that conference. 相似文献
14.
15.
L. Sibal A. Aldibbiat S. C. Agarwal G. Mitchell C. Oates S. Razvi J. U. Weaver J. A. Shaw P. D. Home 《Diabetologia》2009,52(8):1464-1473
Aims/hypothesis Type 1 diabetes is associated with premature arterial disease. Bone-marrow derived, circulating endothelial progenitor cells
(EPCs) are believed to contribute to endothelial repair. The hypothesis tested was that circulating EPCs are reduced in young
people with type 1 diabetes without vascular injury and that this is associated with impaired endothelial function and increased
carotid intima–media thickness (CIMT).
Methods We compared 74 people with type 1 diabetes with 80 healthy controls. CD34, CD133, vascular endothelial (VE) growth factor
receptor-2 (VEGFR-2) and VE-cadherin antibodies were used to quantify EPCs and progenitor cell subtypes using flow-cytometry.
Ultrasound assessment of endothelial function by brachial artery flow-mediated dilatation (FMD) and CIMT was made. Circulating
endothelial markers, inflammatory markers and plasma plasminogen activator inhibitor-1 (PAI-1) levels were measured.
Results CD34+VE-cadherin+, CD133+VE-cadherin+ and CD133+VEGFR-2+ EPC counts were significantly lower in people with diabetes (46–69%;
p = 0.004–0.043). In people with type 1 diabetes, FMD was reduced by 45% (p < 0.001) and CIMT increased by 25% (p < 0.001), these being correlated (r = −0.25, p = 0.033). There was a significant relationship between FMD and CD34+VE-cadherin+ (r = 0.39, p = 0.001), CD133+VEGFR-2+ (r = 0.25, p = 0.037) and CD34+ (r = 0.34, p = 0.003) counts. Circulating high-sensitivity C-reactive protein, PAI-1, interleukin-6 and E-selectin were significantly
higher in the diabetes group (p < 0.001 to p = 0.049), the last two of these correlating with FMD (r = −0.27, p = 0.028 and r = −0.24, p = 0.048, respectively).
Conclusions/interpretation These findings suggest that abnormalities of endothelial function in addition to pro-inflammatory and pro-thrombotic states
are already common in people with type 1 diabetes before development of clinically evident arterial damage. Low EPC counts
confirm risk of macrovascular complications and may account for impaired endothelial function and predict future cardiovascular
events.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorised users. 相似文献
16.
Fortney JC Pyne JM Edlund MJ Williams DK Robinson DE Mittal D Henderson KL 《Journal of general internal medicine》2007,22(8):1086-1093
Background Evidence-based practices designed for large urban clinics are not necessarily portable into smaller isolated clinics. Implementing
practice-based collaborative care for depression in smaller primary care clinics presents unique challenges because it is often not feasible
to employ on-site psychiatrists.
Objective The purpose of the Telemedicine Enhanced Antidepressant Management (TEAM) study was to evaluate a telemedicine-based collaborative care model adapted for small clinics without on-site psychiatrists.
Design Matched sites were randomized to the intervention or usual care.
Participants Small VA Community-based outpatient clinics with no on-site psychiatrists, but access to telepsychiatrists. In 2003–2004,
395 primary care patients with PHQ9 depression severity scores ≥12 were enrolled, and followed for 12 months. Patients with
serious mental illness and current substance dependence were excluded.
Measures Medication adherence, treatment response, remission, health status, health-related quality of life, and treatment satisfaction.
Results The sample comprised mostly elderly, white, males with substantial physical and behavioral health comorbidity. At baseline,
subjects had moderate depression severity (Hopkins Symptom Checklist, SCL-20 = 1.8), 3.7 prior depression episodes, and 67%
had received prior depression treatment. Multivariate analyses indicated that intervention patients were more likely to be
adherent at both 6 (odds ratio [OR] = 2.1, p = .04) and 12 months (OR = 2.7, p = .01). Intervention patients were more likely to respond by 6 months (OR = 2.0, p = .02), and remit by 12 months (OR = 2.4, p = .02). Intervention patients reported larger gains in mental health status and health-related quality of life, and reported
higher satisfaction.
Conclusions Collaborative care can be successfully adapted for primary care clinics without on-site psychiatrists using telemedicine technologies. 相似文献
17.
Chen-Liang Chou Min-Jung Wu Chia-Li Yu Ming-Chi Lu Song-Chou Hsieh Tsai-Hung Wu Chung-Tei Chou Chang-Youh Tsai 《Clinical rheumatology》2010,29(8):875-881
Anti-agalactosyl IgG antibody (anti-Gal(0) IgG) has been regarded as a useful serological marker for rheumatoid arthritis
(RA). It is unknown whether it is also elevated in serum and implicated in the pathogenesis of joint inflammation in seronegative
spondyloarthropathy (SpA) such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Sera were collected from 43 patients
with AS or PsA with axial joint involvement, 22 patients with RA, and 25 healthy normal individuals for the detection of anti-Gal(0)
IgG with a cup-type lectin enzyme immunoassay (Eitest CA.RF). The disease activity of the AS/PsA was evaluated by Bath Ankylosing Spondylitis Disease Activity Score (BASDAI), the
serum C-reactive protein (CRP) and IgA were measured by nephelometry, and erythrocyte sedimentation rate (ESR) was measured
by Westergren’s method. The median titers of anti-Gal(0) IgG were significantly elevated in patients with RA (167.85, 15.73∼797.58 AU/mL)
and AS/PsA (186.15, 34.71∼651.19 AU/mL), compared to those of the normal controls (13.04, 12.00∼202.43 AU/mL). The titers
of the anti-Gal(0) IgG in patients with AS/PsA were correlated to the BASDAI scores (r
2 = 0.422, SEE = 1.443, p < 0.001) and serum CRP (r
2 = 0.345, SEE = 2.434, p < 0.001) but not to IgA (r
2 = 0.0259, SEE = 126.30, p < 0.001) or ESR (r
2 = 0.171, SEE = 31.053, p = 0.0059). Collectively, the anti-Gal(0) IgG is elevated and vaguely correlated with the disease activity of AS/PsA although
its titers in these patients were erratic. The result of the present investigation has suggested that anti-Gal(0) IgG may
be more ubiquitously present in inflammatory arthritides including RA or SpA. 相似文献
18.
McCloskey LA Williams CM Lichter E Gerber M Ganz ML Sege R 《Journal of general internal medicine》2007,22(8):1067-1072
BACKGROUND Some providers observe that partners interfere with health care visits or treatment. There are no systematic investigations
of the prevalence of or circumstances surrounding partner interference with health care and intimate partner violence (IPV).
OBJECTIVE To determine whether abused women report partner interference with their health care and to describe the co-occurring risk
factors and health impact of such interference.
DESIGN A written survey of women attending health care clinics across 5 different medical departments (e.g., emergency, primary care,
obstetrics–gynecology, pediatrics, addiction recovery) housed in 8 hospital and clinic sites in Metropolitan Boston.
PARTICIPANTS Women outpatients (N = 2,027) ranging in age, 59% White, 38% married, 22.6% born outside the U.S.
MEASUREMENT Questions from the Severity of Violence and Abuse Assessment Scale, the SF-36, and questions about demographics.
RESULTS One in 20 women outpatients (4.6%) reported that their partners prevented them from seeking or interfered with health care.
Among women with past-year physical abuse (n = 276), 17% reported that a partner interfered with their health care in contrast to 2% of women without abuse (adjusted
odds ratios [OR] = 7.5). Further adjusted risk markers for partner interference included having less than a high school education
(OR = 3.2), being born outside the U.S. (OR = 2.0), and visiting the clinic with a man attending (OR = 1.9). Partner interference
raised the odds of women having poor health (OR = 1.8).
CONCLUSIONS Partner interference with health care is a significant problem for women who are in abusive relationships and poses an obstacle
to health care. Health care providers should be alert to signs of patient noncompliance or missed appointments as stemming
from abusive partner control tactics. 相似文献
19.
de Souza MC de Ávila Fernandes E Jones A Lombardi I Natour J 《Clinical rheumatology》2011,30(6):831-836
Rheumatoid arthritis (RA) is characterized by inflammation of the synovial membrane, which can lead to deformities and functional
disability. Unlike the dorsal and lumbar spine, the cervical spine is often affected by RA. The objective of this paper is
to assess cervical pain and function in patients with RA and correlate these variables with overall function, quality of life,
and radiographic findings on the cervical spine. One hundred individuals aged 18 to 65 years were divided into study group
(50 patients with rheumatoid arthritis) and control group (50 healthy individuals, paired for gender and age). Patients with
prior surgery, prior trauma or other symptomatic cervical spine condition were excluded. The visual analogue pain scale (VAS),
Neck Pain and Disability Scale (NPDS), SF-36, HAQ and X-rays were used for evaluation purposes. Mean disease duration was
11.1 years. The cervical VAS was 2.4 cm and 1.3 cm for the study and control groups, respectively (p = 0.074). Statistical differences were found in NPDS scores, mean = 26.7 and 6.9, and HAQ scores, mean = 1.1 and 0.1, for
the study and control groups, respectively (p < 0.001). SF-36 scores were statistically worse in the study group, except for the vitality, social aspects and mental health
subscales. There was a positive correlation between the NPDS and VAS (r = 0.54) and between the NPDS and HAQ (r = 0.67). There was a negative correlation between the NPDS and SF-36 functional capacity domain (r = −0.53) and physical limitation domain (r = −0.58). The radiographic findings revealed more prevalent anterior atlanto-axial subluxation (p = 0.030), listhesis in neutral posture (p = 0.037), listhesis in extension (p = 0.007), degenerative alteration of C4–C5 segment (p = 0.023), size of C2 spinal canal (p = 0.002) and C3 spinal canal (p = 0.029) in the study group. Patients with RA have poorer cervical function than healthy individuals, although there is no
difference in cervical pain. 相似文献
20.
Background Research suggests mentoring is related to career satisfaction and success. Most studies have focused on junior faculty.
Objective To explore multiple aspects of mentoring at an academic medical center in relation to faculty rank, track, and gender.
Design Cross-sectional mail survey in mid-2003.
Participants Faculty members, 1,432, at the University of Pennsylvania School of Medicine
Measurements Self-administered survey developed from existing instruments and stakeholders.
Results Response rate was 73% (n = 1,046). Most (92%) assistant and half (48%) of associate professors had a mentor. Assistant professors in the tenure track
were most likely to have a mentor (98%). At both ranks, the faculty was given more types of advice than types of opportunities.
Satisfaction with mentoring was correlated with the number of types of mentoring received (r = .48 and .53, P < .0001), job satisfaction (r = .44 and .31, P < .0001), meeting frequency (r = .53 and .61, P < .0001), and expectation of leaving the University within 5 years (Spearman r = −.19 and −.18, P < .0001), at the assistant and associate rank, respectively. Significant predictors of higher overall job satisfaction were
associate rank [Odds ratio (OR) = 2.04, CI = 1.29–3.21], the 10-point mentoring satisfaction rating (OR = 1.27, CI = 1.17–1.35),
and number of mentors (OR = 1.60, CI = 1.20–2.07).
Conclusions Having a mentor, or preferably, multiple mentors is strongly related to satisfaction with mentoring and overall job satisfaction.
Surprisingly, few differences were related to gender. Mentoring of clinician–educators, research track faculty, and senior
faculty, and the use of multiple mentors require specific attention of academic leadership and further study. 相似文献