Integrated bioinformatics analysis to identify key genes and pathways involved in the endometria of patients with recurrent implantation failure undergoing in vitro fertilization and embryo transfer

Objectives: Recurrent implantation failure (RIF) is a challenging clinical problem that occurs in approximately 10% of patients undergoingin vitro fertilization and embryo transfer. Because of the varied criteria for RIF, as well as differences in the time and methods of endometrial biopsy, previous studies have not reached an agreement regarding the key genes and pathways of RIF. In this study, bioinformatic analyses were performed in a homogeneous population with consistent biopsy conditions t...     

Disaster Recovery and Reconstruction Following the 2011 Great East Japan Earthquake and Tsunami: A Business Process Management Perspective

The Tohoku Regional Bureau(TRB) of the Ministry of Land, Infrastructure, Transport and Tourism(MLIT) performed various actions in response to the 2011 Great East Japan Earthquake and Tsunami. The total disaster recovery and reconstruction period is expected to last for 10 years, of which the first five years are regarded as the concentrated reconstruction period. As of 2013, a majority of the mega projects that involved restoration actions have been completed, which indicates a more effective rate of completion compared with the MLIT projects performed in normal non-disaster situations. This short article explains the management process of the recovery and reconstruction utilized by the TRB—an interorganizational process—from a business process management(BPM) perspective and creates a simple organization construction diagram of the entire process. The study focused on the transactions and actor roles to identify their strengths. The findings indicate the utilization of different operational procedures in some parts of the process, the importance of liaison role, as well as some obstacles. The lessons learned from this analysis can assist managers and researchers in designing and managing restoration processes for future disasters.     

Polymorphism of mitochondrial DNA genes involved in asthenozoospermia in infertile patients of C?te d'Ivoire

Objective: The relationship between mitochondrial DNA (mtDNA) polymorphisms and abnormalities in sperm quality has been the subject of several studies, with the objective of improving the treatment of male infertility. This study, which contributes to the identification of genetic markers of sperm abnormalities, was conducted to study mtDNA mutations in the asthenozoospermia profile.Methods: This case-control study included 30 patients with asthenozoospermia and 28 with normospermia after spermo...     

A Two-Stage Evolutionary Game Model for Collaborative Emergency Management Between Local Governments and Enterprises

Enterprises play a vital role in emergency management, but few studies have considered the strategy choices behind such participation or the collaborative relationship with the government. This study contended that enterprises have at least three strategies regarding emergency management: non-participation, short-term participation, and long-term participation. We constructed a two-stage evolutionary game model to explore the behavioral evolution rules and evolutionary stability strategies of th...     

A Heterogeneous Sampling Strategy to Model Earthquake-Triggered Landslides

Regional modeling of landslide hazards is an essential tool for the assessment and management of risk in mountain environments.Previous studies that have focused on modeling earthquake-triggered landslides report high prediction accuracies.However,it is common to use a validation strategy with an equal number of landslide and non-landslide samples,scattered homogeneously across the study area.Consequently,there are overestimations in the epicenter area,and the spatial pattern of modeled location...     

居住在赞比亚的侨民对疟疾预防教育的需求

Falciparum malaria is a major cause of mortality and morbidity amongst the indigenous as well as the expatriate population in Atica. Malaria prevention is based on health education regarding the seriousness of malaria, the several previous studies have however indicated that expatriates seem to ignore this advice in spite of being aware of the threat of malaria.     

The Role of Knowledge in Disaster Risk Reduction

Disaster risk reduction policy and practice require knowledge for informed decision making and coordinated action. Although the knowledge production and implementation processes are critical for disaster risk reduction, these issues are seldom systematically addressed in-depth in disaster studies and policy programs. While efforts and improvements have been made with regard to data and information, only limited resources are committed to improving knowledge management structures and integrating knowledge systems at different spatial levels. The recently adopted Sendai Framework for Disaster Risk Reduction 2015–2030 addresses knowledge-related issues and provides the opportunity to highlight the critical role of knowledge in disaster risk reduction. This article presents insights into potential conceptualizations of knowledge that would advance disaster research and policy. We use cases from France to illustrate challenges of and pathways to disaster risk reduction. We suggest to further strengthen efforts that improve our understanding of the connections between disaster risk, knowledge, and learning. A better integration of multiple scales, different societal actors,various knowledge sources, and diverse disciplines into disaster risk research will increase its relevance for decision-makers in policy and practice. Well-targeted incentives and political backing will improve the coherence,coordination, and sharing of knowledge among various actors and arenas.     

Closer look at white-coat hypertension

This review aims to clarify novel concepts regarding the clinical and laboratory aspects of white-coat hypertension(WCHT). Recent studies on the clinical and biological implications of WCHT were compared with existing knowledge. Studies were included if the WCHT patients were defined according to the 2013 European Society of Hypertension guidelines, i.e., an office blood pressure(BP) of ≥ 140/90 mm Hg, a home BP of ≤ 135/85 mm Hg, and a mean 24-h ambulatory BP of ≤ 130/80 mm Hg. WCHT studies published since 2000 were selected, although a few studies performed before 2000 were used for comparative purposes. True WCHT was defined as normal ABPM and home BP readings, and partial WCHT was defined as an abnormality in one of these two readings. The reported prevalence of WCHT was 15%-45%. The incidence of WCHT tended to be higher in females and in non-smokers. Compared with normotensive(NT) patients, WCHT was associated with a higher left ventricular mass index, higher lipid levels, impaired fasting glucose, and decreased arterial compliance. The circadian rhythm in WCHT patients was more variable than in NT patient's, with a higher pulse pressure and non-dipping characteristics. Compared with sustained hypertension patients, WCHT patients have a better 10-year prognosis; compared with NT patients, WCHT patients have a similar stroke risk, but receivemore frequent drug treatment. There are conflicting results regarding WCHT and markers of endothelial damage, oxidative stress and inflammation, and the data imply that WCHT patients may have a worse prognosis. Nitric oxide levels are lower, and oxidative stress parameters are higher in WCHT patients than in NT patients, whereas the antioxidant capacity is lower in WCHT patients than in NT patients. Clinicians should be aware of the risk factors associated with WCHT and patients should be closely monitored especially to identify target organ damage and metabolic syndrome.     

Toll样受体与慢性乙型肝炎的研究进展

Toll-like receptors (TLRs)are the major pattern recognization receptors of natural immune response. In recent years, studies have shown that HBV inhibits the expression of TLRs to escape from host's immune clearance in some way, then resulting in the persistent infection and chronicity of HBV. On the other hand, binding with their corresponding ligands, TLRs provide a protective immunity for our bodies and play a critical role in anti-HBV infection, through inducing the expression of anti-viral cytokine IFN-α/β, TNF-α, etc. The recent advances about TLRs and chronic hepatitis B are reviewed in this article.     

Toll样受体与慢性乙型肝炎的研究进展

Toll-like receptors (TLRs)are the major pattern recognization receptors of natural immune response. In recent years, studies have shown that HBV inhibits the expression of TLRs to escape from host's immune clearance in some way, then resulting in the persistent infection and chronicity of HBV. On the other hand, binding with their corresponding ligands, TLRs provide a protective immunity for our bodies and play a critical role in anti-HBV infection, through inducing the expression of anti-viral cytokine IFN-α/β, TNF-α, etc. The recent advances about TLRs and chronic hepatitis B are reviewed in this article.     

Role of the Wnt/β-catenin pathway in gastric cancer: An indepth literature review

Gastric cancer remains one of the most common cancers worldwide and one of the leading cause for cancerrelated deaths. Gastric adenocarcinoma is a multifactorial disease that is genetically, cytologically and architecturally more heterogeneous than other gastrointestinal carcinomas.The aberrant activation of the Wnt/β-catenin signaling pathway is involved in the development and progression of a significant proportion of gastric cancer cases. This review focuses on the participation of the Wnt/b-catenin pathway in gastric cancer by offering an analysis of the relevant literature published in this field. Indeed, it is discussed the role of key factors in Wnt/β-catenin signaling and their downstream effectors regulating processes involved in tumor initiation, tumor growth, metastasis and resistance to therapy. Available data indicate that constitutive Wnt signalling resulting from Helicobacter pylori infection and inactivation of Wnt inhibitors(mainly by inactivating mutations and promoter hypermethylation) play an important role in gastric cancer. Moreover, a number of recent studies confirmed CTNNB1 and APC as driver genes in gastric cancer. The identification of specific membrane, intracellular, and extracellular components of the Wnt pathway has revealed potential targets for gastric cancer therapy. High-throughput "omics" approaches will help in the search for Wnt pathway antagonist in the near future.     

自我护需求的应用进展

Presently nursing theories have fast development and wide application. The author reviewed the Orem Theory whicg is focuseh on applicaion of self-care. Dr. Dorothea E. Orem initiated the theoretical framework of self-care on 1950. In 1971, Orem proposed that individual should take responsibility for the self-care of their own health. In recent years, studies on self-care have made propress in the following aspects ①nursing theories; ②nursing ideas; ③clinical nursing; ④nursing education. Significant achievements have been made through the application of above theories.     

An In Vivo Proton MR Spectroscopy Study of Late Delayed Radiation Necrosis at the Temporal Lobes in Patients Treated for Nasopharyngeal Carcinoma

Introduction Nasopharyngeal carcinoma (NPC) is an epithelial-originated malignancy occuning with a high incidence in Southeast Asia, in particulat, in southern China. The molecular basis for the disease is not well understood and recent epidemiology studies have correlated the disease to Epstein-Barr virus (EBV) infection, consumption of salted fish, preserved foods and smoking'. NPC is almost entirely of the undiffenentiated squamous cell types and the discase is highly curable by radiation therapy, with survival rates of 80-90％~2. Despite this high disease-free survival race, the long term overall survival rate is not so good~3 because of late delayed radiation comphcations, Late delayed radiation injury, which     

Toxicologic Study of Monochloroacetic Acid

Monochloroacetic Acid （MCA） is a chlorinated analog of acetic acids. MCA and its sodium salt （SMCA） are widely used as a chemical intermediate （primarily in the manufacture of chlorophenoxy herbicides, carboxymethylcelluose, glycine and indigoid dyes ）. Moreover, MCA has been found as a common by-product of the chlorination of drinking water. Chloroacetates are ubiquitous in the environment, and MCA is the most abundant among chloroacetates. A background level of 0.1 - 1 μg/-L is expected to occur in precipitation Total world wide annual production of MCA reported was about 400 000 tons Many studies have showed that MCA not only caused acute or chronic damage to the skin , liver, kidney, heart, brain and other organs, but also caused acute death systemically under high eoncentration. So this article will discuss the toxic effect of Monochloroacetic Acid in Toxicology.     

The Sendai Framework for Disaster Risk Reduction and Persons with Disabilities

In this paper, the Sendai Framework for Disaster Risk Reduction 2015–2030(SFDRR) is evaluated with respect to its ramifications for persons with disabilities. In the SFDRR, persons with disabilities were referenced either directly or indirectly as part of the preamble,the guiding principles, the priorities for action, and the role of stakeholders. In addition, the 2015 World Conference on Disaster Risk Reduction, during which the SFDRR was adopted, incorporated explicit recommendations toward a disability-accessible and inclusive environment not evident in previous disaster risk reduction conferences. The infusion of disability-related terms and concepts such as accessibility, inclusion, and universal design throughout the SFDRR document was significant. These concepts,which have their origin in disability studies, are used in the SFDRR document to refer to the needs of all in disaster,not only to people with disabilities. These disability-related concepts will now serve the field of disaster risk reduction as important overarching disaster-related principles. The authors conclude that the SFDRR has firmly established people with disabilities and their advocacy organizations as legitimate stakeholders and actors in the design and implementation of international disaster risk reduction policies.     

ESPEN''s Nutritional Risk Screening (NRS 2002) "An Evidence-based Approach and the Application in Europe"

Nutritional deficiencies and malnutrition are a signifi-cant problem in clinical practice.Between 20 and 50 per-cent of hospitalized patients have signs of malnutrition.It iswell-known that a poor nutritional status influences the rateof in-hospital complications, length of hospital stay, mortal-ity, cost, and re-admissions.An adequate nutritional thera-py reduces infectious complications, mortality, and cost.Therefore, it is important that the nutritional statusmust be known in all patients.…     

Perceived Health Status and Influencing Factors for the Extreme Elderly in Rural Areas

Perceived health status is one of the important meansof evaluating quality of life,1 and has attracted increas-ing attention as a focus of research. Studies have pointedout that perceived health status is important in affectinghealth seeking behaviors because people will only seekmedical attention when they perceive that they areunhealthy. Furthermore, aside from age and sex, per-ceived health status has been recognized as the stron-gest “early-warning index” for pre-estimating deathrates.2-5 Prior studies ...     

Characterization of folic acid, 5-methyltetrahydrofolate and synthetic folinic acid in the high-affinity folate transporters: impact on pregnancy and development

Objectives: Folates are B vitamins that are essential for several molecular, cellular, and biological processes, including nucleotide synthesis, methylation, and methionine cycling. The physiological impacts of these processes on health also extend to cell proliferation, folate deficiency anemia, and reduction of the risk of birth defects during pregnancy. The primary objective of this study was to characterize the binding affinities of different folate forms, folic acid (FA), 5-methyltetrahydro...     

Role of microRNAs in embryo–endometrial interactions: biological functions and clinical applications

The human endometrium and embryo both produce microRNAs (miRNAs), which are involved in various physiological activities. Accumulating evident suggested that endometrial miRNAs are regulated by steroid hormones that modulate endometrial functions, whereas embryo-derived miRNAs play vital roles in maternal–embryo communication. The aberrant expression of endometriumor embryo-derived miRNAs can cause early pregnancy and gestational disorders, including repeated implantation failure, recurrent misc...