Mucociliary function of eustachian tube in atrophic rhinitis

Atrophic rhinitis is a chronic inflammatory disease characterized by progressive atrophy of nasal mucosa and underlying turbinate bones. Atrophie changes may extend to the nasopharynx and subsequently Eustachian tube and middle ear system may also get involved. Mucociliary function of the Eustachian tube In cases of atrophie rhinitis has been measured by saccharine tut and 17.46% of cases showed a delayed clearance time. All these cases had prolonged duration of symptoms with advanced stage of the disease.     

Efficacy of various methods in evaluation of eustachian tube function

In the present study 35 patients with preforated and 15 cases with intact ear drums, were studied and eustachian tube function was assessed by Saccharine test. Bortnick-Miller test, and manual impedance audiometry. The merits and demerits of one over the other were evaluated. It was observed thal more than one test when employed provides better information as every test has its own advantages and limitations     

Oral submucous fibrosis with its possible effect on eustachian tube functions: A tympanometric study

Oral submucous fibrosis (OSMF) is a chronic inflammatory condition of oral cavity The common sites of involvement are cheek, tongue and soft palate The pathological changes not only involve the mucosa and submucosa but also extend deeper to involve the underlying muscles Atrophic and degenerative changes in the tubal and paratubal muscles have already been reported and involvement of these muscles may lead to eustachian tube dysfunction The present study was therefore, planned to assess the eustachian tube functions by tympanometry in cases of OSMF Out of 106 ears in 53 cases, 80 ears (75 5%) showed normal type-A curve Abnormal tympanograms included type-B curve in 17 (16 0%) and type-C curve in 9 (8 5%) ears On testing the compliance of middle ear there was shift in the compliance peaks in 78 (73 6%) ears with +200 daPa pressure change indicating normal eustachian tube functions In 28 (26 4%) ears, eustachian tube functions were found to be affected as there was no shift in the compliance peaks Similarly on-200 daPA pressure change in 24 (22 7%) ears there was no shift in compliance peaks An identical study was also carried out in 40 ears of 20 normal individuals The data derived were statistically much higher in the disease group Therefore, it was concluded that eustachian tube functions may be affected in OSMF     

Study of corelation between eustachian tube functions and result of myringoplasty

In the present study of 34 cases of dry central perforations, 26 cases of adhesive otitis media and 2 cases of adhesive otitis media with postero superior inpouching, the eustachian tube function was assessed pre-operatively in a qualitative & quantitative manner to evaluate there dependability in predicting the outcome of Myringoplasty. Amongst other tests valsalva & forced response tests gave the most reliable results.     

Assessment of eustachian tube functions in patients with ear drum perforation

Tubal malfunction is the most important factor in the development and persistence of otitis media. When the eustachian tube malfunction persists, the most carefully performed surgery will fail because the initiating pathogenetic factors of eustachian tube function and middle ear ventilation are still present. Measurement of the eustachian tube function is therefore an important part of the medical and surgical evaluation of the middle ear disease.     

The Bortnick Miller apparatus: a useful alternative to impedance audiometer for assessment of eustachian tube function in chronic suppurative otitis media

Eustachian tube function was assessed by impedance audiometer and Bortnick Miller apparatus in 60 ears with central perforation in pars tensa. Result of both the instruments were compared and presented.     

Bortnick miller apparatus as reliable as pump-manometer portion of impedance bridge for testing ventilatory function of eustachian tube in chronic suppurative otitis media

A comparative assessment of ventilatory function of Eustachian Tube was done in 50 cases having perforated tympanic membranes with the help of simple Bortnick-Miller apparatus and sophisticated Impedance Bridge. A highly significant correlation was obtained between these two tests. This proved the reliability of simple Bortnick-Miller Apparatus.     

Evaluation of Eustachian tube function tests

In modern times with the advances in otorhinolaryngology, the important role of a functioning Eustachian tube in the successful management of various diseases of the ear has been established beyond doubt. Various methods like Valsalva, Politzerisation, Eustachian tube catheterisation and radiographic study have been in practice to assess the tubal function for a long time. In recent years another test called the Bortnick Miller test has been evolved as a quantitative measure of the Eustachian tube function. An evaluation of the different tests, regarding their practica bility and accuracy in middle ear disease, is presented.     

The effect of cryodestruction of Vidian nasal branches on nasal mucus flow in vasomotor rhinitis

30 patients of vasomotor rhinitis were treated by cryo-destruction of Vidian nasal branches and the success of the treatment was evaluated by an objective parameter i.e. saccharine test done prior and after the cryoapplication. The prolonged saccharine time before the treatment returns to normal after the treatment.     

鼻腔腺样囊性癌的临床研究

目的　探讨影响鼻腔腺样囊性癌患者预后的因素。方法　原发于鼻腔的腺样囊性癌38例 ,对其治疗与预后进行统计分析。生存分析采用Kaplan Meier法 ,组间比较采用Logrank检验 ,多因素分析采用Cox比例风险模型。结果　临床治疗结束时肿瘤完全消失者 5、10年生存率分别为10 0 %和 88.9% ,临床治疗结束时残留者 5、10年生存率分别为 4 8.0 %和 0 % (P <0 .0 1)。早期 (Ⅰ、Ⅱ期 )患者 5、10年生存率分别为 86 .7%和 75 .8% ,晚期 (Ⅲ、Ⅳ期 )患者分别为 5 8. 6 %和 0 % (P <0 .0 1)。单纯手术者 5、10年生存率分别为 5 1.4 %和 2 5 .7% ,单纯放射治疗者均为 5 0 .0 % ,综合治疗者分别为 84 .4 %和 6 2 .0 % (P >0 .0 5 )。多因素分析表明临床治疗近期疗效、临床分期是影响预后的独立因素。结论　鼻腔腺样囊性癌的治疗以综合治疗为主 ,临床治疗近期疗效、临床分期和临床治疗方法对预后有重要影响。     

腹腔镜手术经阴道后壁中段切口取瘤对女性性功能影响的前瞻性研究

目的:探讨腹腔镜手术阴道后壁中段切口取瘤对女性性功能的影响。方法:前瞻性观察2017年6月至2018年3月沈阳市妇婴医院80例腹腔镜手术经阴道后壁中段切口取瘤患者的性功能变化情况。年龄26~49岁,平均(35.93±4.79)岁,体重指数19.2~28.6 kg/m2,平均（22.87±2.04）kg/m2。子宫肌瘤46例,附件区囊肿34例。采用女性性功能指数问卷（FSFI）对患者术前及术后6个月、12个月的性功能进行评价。结果:术前及术后6个月、12个月FSFI评分分别为（30.68±0.15）分,（30.70±1.47）分,（30.74±1.17）分,组间比较差异无统计学意义（P>0.05）。结论:腹腔镜手术阴道后壁中段切口取瘤对女性性功能无负面影响。     

鼻内镜联合低温等离子刀手术治疗鼻内翻性乳头状瘤的疗效观察

目的:探讨经鼻内镜下鼻腔鼻窦乳头状瘤切除的手术方式和经验,观察治疗效果。方法:对本院2010年2月至2015年2月收治的鼻腔鼻窦乳头状瘤48例患者的临床资料进行回顾性分析,患者均在鼻内镜下行低温等离子刀切除治疗或联合柯－陆式上颌窦入路或联合泪前隐窝入路切除肿瘤,其中鼻腔肿瘤29例,鼻窦肿瘤19例,对其临床疗效行追踪随访24~36个月,对手术方法和技巧进行总结分析。结果:本组48例患者均手术成功切除病变组织,4例患者在随访期间复发,复发率为8.33％,与国内报道鼻内镜鼻内翻乳头状瘤22%术后复发率相比较,复发率明显较低(P<0.05)。本组3例复发病例通过术后鼻内镜复查时发现,给予局部切除,经低温等离子刀局部电凝后治愈,1例经二次手术彻底清除病灶后治愈。无１例术中或术后严重并发症发生,达到了良好的临床疗效。结论:鼻内镜联合低温等离子刀切除鼻腔鼻窦乳头状瘤可取得较好的临床疗效,根据病变范围及分期选择合适的手术方式及术中准确判断切除瘤体的根蒂部对保证手术的成功具有重要意义,术后鼻内镜密切随访,联合低温等离子刀处理,对达到治愈的目的及降低二次手术概率具有重要的意义。     

34例鼻腔圆形细胞恶性肿瘤病理学特征

目的　研究鼻腔圆形细胞恶性肿瘤的临床病理组织学特征。方法　报告 34例鼻腔圆形细胞恶性肿瘤 ,观察其病理组织学表现 ,用免疫组织化学方法标记肿瘤。结果　鼻腔非何杰金氏恶性淋巴瘤 2 1例 ,嗅神经母细胞瘤 5例 ,未分化癌 5例 ,胚胎性横纹肌肉瘤 2例 ,恶性黑色素瘤 1例。结论　鼻腔圆形细胞恶性肿瘤的生存率与肿瘤类型和临床分期有关。     

Eustachian tube function test: a new dimension in the management of CSOM

Poor eustachian tube function is a major cause of both failure of tympanoplasty as well as the persistence of otorrhoea in chronic suppurative otiis media. In this study, Eustachian tube function tests were carried out on 631 ears of CSOM using an impedance audiometer and the results were analysed. The study showed that impaired tubal function is not only the major cause of persistent/recurrent otorrhoea in CSOM but is also an important contributory factor for failure of tympanoplasty: The results of tympanoplasty were found to be significantly poor when carried out in ears having poor tubal function as compared to ears with normal tubal function.     

柚皮苷对骨肉瘤细胞生物学功能的影响

目的:探讨柚皮苷对骨肉瘤细胞生物学功能的调节作用。方法:将骨肉瘤MG63细胞分成三组,分别用NaCl（对照组）、10 μmol/ml和20 μmol/ml浓度的柚皮苷作用于细胞,通过MTT实验观察不同时间不同浓度的柚皮苷对MG63细胞增殖的作用。流式细胞术分析10 μmol/ml和20 μmol/ml柚皮苷对MG63细胞细胞周期的影响。通过Western blot检测不同浓度柚皮苷对增殖相关蛋白（Cyclin D1）的调节作用。Transwell实验观察10 μmol/ml和20 μmol/ml柚皮苷对MG63细胞迁移能力的影响。通过Western blot检测不同浓度柚皮苷对侵袭转移相关蛋白（MMP2）的调节作用。结果:MTT检测结果发现10 μmol/ml和20 μmol/ml浓度的柚皮苷作用MG63细胞24 h后,对MG63细胞增殖的抑制率分别为（24.10±0.03）%和（46.94±0.03）%。流式细胞术结果发现柚皮苷可以对MG63细胞G1/S期的转导造成阻滞。Western blot结果指出,柚皮苷可以抑制Cyclin D1的表达。Transwell实验发现柚皮苷作用后可以显著抑制MG63细胞的迁移。Western blot检测发现,柚皮苷可以抑制MG63细胞中MMP2的表达。结论:柚皮苷可以抑制骨肉瘤细胞的增殖和迁移。