Expression of OPG mRNA and ODF mRNA in the patients of hip fracture due to osteoporosis

ObjectiveTo investigate the gene expression of osteoprotegerin(OPG) and osteoclast differentiation factor(ODF) in the bone tissue of patients with hip fracture due to osteoporosis.MethodsOPG mRNA and ODF mRNA in the bone tissue in 50 cases of osteoporosis sufferers(over 50 years old) with hip fracture(Observer Group) and 30 cases of hip facture sufferers with no osteoporosis(Control group) were analyzed with the Semi-Quantitative RT-PCR method.ResultsThe mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight.ConclusionAged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.