Sex steroid receptors in the myometrium in cesarean section

The levels of estradiol and progesterone receptors in the myometrium of 19 patients subjected to planned cesarean section were studied. Nine of these patients had competent cicatrices on the uterus, which was confirmed by preoperative studies and during the operation. For comparison, the myometrium of patients at the same terms of gestation subjected to planned abdorninal delivery without history of cesarean section was examined. No significant differences were revealed in estradiol and progesterone reception in the myometria of parturients with and without competent cicatrices on the uterus. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 5, pp. 573–575, May, 1998     

Steroid receptor assay in various tissues and tumors

Four types of steroid receptors were assayed in 1715 tumors of various localization and in 101 normal tissue samples from the mammary gland, uterus, and endometrium; tissuespecific distribution of steroid receptors was demonstrated. Expression of steroid hormones (especially estrogen receptors) is enhanced in proliferating compared with resting tissues and in hormone-sensitive tumors compared with adjacent normal tissue. It is assumed that hormone sensitivity of the tumor reflects hormone sensitivity of parental organ. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 5, pp. 558–561, May, 1998     

Estradiol-17β receptors in cytosolic fraction of chondrosarcoma

Estradiol-17β receptors were detected in the cytosolic fraction of the majority of bone chondrosarcomas by protamine sulfate sedimentation of the hormone-receptor complex. The absolute number of receptors in tumors was higher in men than in women, but chondrosarcomas with estradiol-17β receptors more often occurred in women. The highest level of receptors was revealed in highly differentiated chondrosarcomas. No relationships between tumor location, size, type of the process, and the number of receptors was detected. We can state with assurance that the absence of estradiol-17β receptors in chondrosarcomas in women is a favorable prognostic sign with regard to metastases or local tumor relapses. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 2, pp. 201–203, February, 2000     

Functional interaction between various glutamate receptors

The interaction of glutamate with various receptors in glutamatergic neurons and functional interaction between glutamate receptors are reviewed. It is hypothesized that metabotropic receptors perform defensive functions in the brain by protecting neurons from neurotoxic effects caused by excessive glutamate release. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, 130, No. 9, pp. 244–251, September, 2000     

Functional interaction between various glutamate receptors

The interaction of glutamate with various receptors in glutamatergic neurons and functional interaction between glutamate receptors are reviewed. It is hypothesized that metabotropic receptors perform defensive functions in the brain by protecting neurons from neurotoxic effects caused by excessive glutamate release. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, 130, No. 9, pp. 244–251, September, 2000     

Synthesis of 5α-dihydrotestosterone in human bone tumors of various histological structure

In human primary bone tumors of various histological origins, metabolism of testosterone led to the formation of 5α-reduced metabolites (mainly 5α-androstane-3α, 17β-diol, and 5α-androstane-3β-17β-diol), but not 5α-dihydrotestosterone. Transformation of 5α-dihydrotestosterone to other metabolites in human primary osteosarcomas is assumed to be associated with its inactivation or involvement of metabolites of this androgen in unknown regulatory mechanisms in bone tumors. Therefore,in vitro evaluation of 5α-reductase activity in human primary osteosarcomas and other tumors by 5α-dihydrotestosterone formation could yield erroneous results. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 7, pp. 73–75, July, 1999     

Atrial cardiomyocytes of a heterothermic animal in various physiological states

Hormone-producing cardiomyocytes of the right atrium of suslik were studied in summer and winter periods (the torpidity and spontaneous awake states). The hormone was shown to be intensely synthesized in summer. The intensity of this process decreased during hypothermia and increased during winter spontaneous awakenings. The role of these changes in the maintenance of water and salt homeostasis is discussed. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 9, pp. 353–356, September, 1998     

Androgen receptors in the cytosolic fraction of malignant prostatic tumors and their clinical significance

The occurrence and mean content of androgen receptors in the cytosolic fraction of prostatic adenocarcinoma depend on the age of patients, stage of tumor anaplasia, tumor differentiation, type of therapy, and the concentration of androgen receptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 10, pp. 432–436, October, 1996     

Interaction of ceruloplasmin with the plasma membrane receptors of CV-1 cells and its feedback regulation

It is shown that cultured cells of the CV-1 line possess the capacity for high-affinity binding of ceruloplasmin, show a kinetics of saturation, and internalize ceruloplasmin. Propagation of cells in medium supplemented with fetal calf serum depleted of ceruloplasmin results in a two-fold increase of high-affinity receptor expression on the cell surface. This phenomenon is not accompanied by any change in the receptor-ligand affinity. Ceruloplasmin binding to the cell surface and subsequent internalization do not lead to its marked degradation. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 4, pp. 417–420, April, 1995 Presented by A. N. Klimov, Member of the Russian Academy of Medical Sciences     

Dependence of antitumor effect of hormonal cytostatic cortifen on expression of glucocorticoid receptors in brain tumor cells

Potent therapeutic effect of hormonal cytostatic cortifen on intracranial brain tumors in rats was demonstrated. The effect was seen after single cortifen course in glioblastoma expressing glucocorticoid receptors and after two courses in glucocorticoid receptor-negative anaplastic astrocytoma. These findings confirmed the concept that selectivity of antitumor drugs can be improved when hormones are used as the carries of cytotoxic groups. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 331–333, March, 1999     

Glutathione S-transferase activity in the liver in acute pancreatitis at various terms of disease and during treatment with inducers

Glutathione S-transferase activity increased in rats with acute pancreatitis: 2.2 times on day 2, 2-fold on day 4, and 1.5 times on day 10. Inducers of microsomal enzymes aroclor 1254 and phenobarbital notably inhibited glutathione S-transferase activity in animals with experimental pancreatitis on days 2–4 of the disease (3.1–2.5 times in comparison with sham-operated induced animals). Hence, the activity of enzymes of phase II of liver xenobiotic metabolism is altered in acute pancreatitis. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 5, pp. 542–543, May, 2000     

Interaction between 16α,17α-cyclopropane progesterone and progesterone receptors in rat uterus

Binding of³H-16α, 17α-cyclopropanoprogesterone (CPG) and³H-progesterone (PG) to progesterone receptors in soluble fraction of rat uterus is studied. It is shown that CPG and PG specifically bind to the protein with similar affinity and binding capacity. Unlabeled PG competitively inhibits the binding of CPG, and unlabeled CPG competitively inhibits the binding of PF with the same efficiency. Dissociation of CPG- and PG-receptor complexes is characterized by the same dissociation constant. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 5, pp. 532–534, May, 1998     

Cholesterol level in peripheral blood lymphocytes: Relationship with ischemic heart disease in patients with various forms of hyperlipidemia

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol.116, N ^o 11, pp. 476–479, November 1993     

Leukocyte migration inhibition test in patients with trophoblastic tumors

Inhibition of leukocyte migration under the influence of protein extract from a chorionepithelioma was investigated in 40 patients with trophoblastic tumors. Marked inhibition of leukocyte migration was found in patients with evidence of active tumor growth before and in the course of treatment. The exception was four patients in whom no inhibition was found either before or during treatment. The inhibition effect was absent in mos patients when the clinical course was favorable as a result of surgery and chemotherapy or of chemotherapy alone. Leukocytes of healthy donors did not react to the tumor extract in any of 24 cases.Group for Combined Methods of Treatment, Department of Gynecology, Oncologic Scientific Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR L. M. Shabad.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 5, pp. 580–582, May, 1978.     

Androgen metabolism in malignant and benign bone tumors

The comparison of activities of the key enzymes of androgen metabolism in morphological variants of bone sarcomas and benign tumors suggests that malignant tumors of different histogenesis not only metabolize the main androgen testosterone, but also inactivate 5α-dihydrotestosterone, the main regulatory androgen in bones. It is possible that androgen metabolism in bone tumors is aimed at the formation of other androgens, in particular, 3α-and 5β-diols, which can be involved in regulatory processes in bone tissue. Further studies will disclose clinical significance of androgen metabolism and individual androgens in human bone tumors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 1, pp. 90–92, January, 2000     

Interaction between multiply modified (desialylated) low-density lipoproteins isolated from blood of atherosclerotic patients and cell receptors

It is shown that binding of native LDL to fibroblasts expressing the B,E-receptors is twice as high as that of desialylated LDL. An excess of acetylated LDL inhibits binding, uptake, and degradation of¹²⁵I-desialylated LDL by macrophages, while an excess of desialylated LDL inhibits binding, uptake, and degradation of acetylated LDL. Desialylated LDL may interact with both B,E and scavenger receptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 1, pp. 53–55, January, 1994